JP2015518491A5 - - Google Patents
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- JP2015518491A5 JP2015518491A5 JP2015510493A JP2015510493A JP2015518491A5 JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5 JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- substituted
- unsubstituted
- alkyl
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 208000030533 eye disease Diseases 0.000 claims 9
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004452 carbocyclyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010065534 Macular ischaemia Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 201000007917 background diabetic retinopathy Diseases 0.000 claims 1
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000038015 macular disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261643178P | 2012-05-04 | 2012-05-04 | |
| US201261643051P | 2012-05-04 | 2012-05-04 | |
| US201261643058P | 2012-05-04 | 2012-05-04 | |
| US61/643,051 | 2012-05-04 | ||
| US61/643,178 | 2012-05-04 | ||
| US61/643,058 | 2012-05-04 | ||
| US201361781907P | 2013-03-14 | 2013-03-14 | |
| US61/781,907 | 2013-03-14 | ||
| PCT/US2013/039562 WO2013166449A2 (en) | 2012-05-04 | 2013-05-03 | Methods for the treatment of diabetic retinopathy and other ophthalmic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Division JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518491A JP2015518491A (ja) | 2015-07-02 |
| JP2015518491A5 true JP2015518491A5 (enExample) | 2016-04-21 |
Family
ID=49515046
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510493A Pending JP2015518491A (ja) | 2012-05-04 | 2013-05-03 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9957224B2 (enExample) |
| EP (2) | EP3741742A1 (enExample) |
| JP (6) | JP2015518491A (enExample) |
| KR (1) | KR20150013240A (enExample) |
| CN (3) | CN104411678A (enExample) |
| AU (1) | AU2013256029A1 (enExample) |
| BR (1) | BR112014027571B1 (enExample) |
| CA (1) | CA2872433C (enExample) |
| EA (1) | EA201492031A1 (enExample) |
| ES (1) | ES2792923T3 (enExample) |
| HK (2) | HK1203478A1 (enExample) |
| IL (1) | IL235446A0 (enExample) |
| MX (2) | MX386024B (enExample) |
| PH (1) | PH12014502449A1 (enExample) |
| SG (1) | SG11201407162SA (enExample) |
| TW (1) | TW201406707A (enExample) |
| WO (1) | WO2013166449A2 (enExample) |
| ZA (1) | ZA201408592B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA110089C2 (uk) * | 2007-10-05 | 2015-11-25 | Ак'Юсела Інк. | Алкоксисполуки для лікування нейродегенеративних хвороб |
| EP2448569B1 (en) * | 2009-07-02 | 2021-10-27 | Acucela, Inc. | Pharmacology of visual cycle modulators |
| JP2015505536A (ja) | 2012-01-20 | 2015-02-23 | アクセラ インク． | 疾患の処置のための置換された複素環化合物 |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
| MX2015012435A (es) * | 2013-03-12 | 2016-01-25 | Acucela Inc | Derivados de 3-fenilpropilamina sustituidos para el tratamiento de enfermedades y trastornos oftalmicos. |
| EP3195838B1 (en) | 2013-03-14 | 2018-08-22 | Optimedica Corporation | Laser capsulovitreotomy |
| WO2015157644A1 (en) * | 2014-04-10 | 2015-10-15 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
| US10792374B2 (en) | 2015-10-09 | 2020-10-06 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| AU2018223810B2 (en) * | 2017-02-27 | 2022-04-21 | Case Western Reserve University | Visual cycle modulators |
| CN111526779B (zh) * | 2017-12-28 | 2023-07-11 | 株式会社尼康 | 图像处理方法、图像处理程序、图像处理装置、图像显示装置、以及图像显示方法 |
| MX2018008165A (es) * | 2018-06-29 | 2019-12-30 | Centro De Retina Medica Y Quirurgica S C | Sistema portátil para la identificación de casos potenciales de edema macular diabético mediante procesamiento de imagen e inteligencia artificial. |
| EP3817808A4 (en) | 2018-07-07 | 2022-04-06 | Acucela Inc. | Device to prevent retinal hypoxia |
| CN118403291A (zh) | 2018-07-30 | 2024-07-30 | 奥克塞拉有限公司 | 用于延缓近视进展的电子接触透镜的光学设计 |
| WO2020078865A1 (en) * | 2018-10-16 | 2020-04-23 | F. Hoffmann-La Roche Ag | Use of akt inhibitors in ophthalmology |
| US11154540B2 (en) * | 2018-10-19 | 2021-10-26 | Medicinova, Inc. | Methods of treating ophthalmic disease/disorder or injury with ibudilast |
| US12256994B2 (en) * | 2019-05-31 | 2025-03-25 | Nikon Corporation | Systems and methods for combining fundus images of an eye |
| EP4003250A4 (en) | 2019-07-31 | 2023-08-23 | Acucela Inc. | DEVICE FOR PROJECTING IMAGES ONTO THE RETINA |
| US11733545B2 (en) | 2019-09-16 | 2023-08-22 | Acucela Inc. | Assembly process for an electronic soft contact lens designed to inhibit progression of myopia |
| CN115336113A (zh) | 2020-02-21 | 2022-11-11 | 奥克塞拉有限公司 | 用于电子隐形眼镜的充电盒 |
| CN111617313B (zh) * | 2020-04-29 | 2022-09-06 | 天津医科大学眼科医院 | 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用 |
| AU2021270577A1 (en) | 2020-05-13 | 2022-12-08 | Acucela Inc. | Electro-switchable spectacles for myopia treatment |
| CN115916331A (zh) | 2020-06-08 | 2023-04-04 | 奥克塞拉有限公司 | 在周边视网膜上投射散焦图像来治疗屈光不正 |
| JP2023528307A (ja) | 2020-06-08 | 2023-07-04 | アキュセラ インコーポレイテッド | 周辺脱焦点化を使用して進行性屈折異常を治療するための貼付式デバイス |
| KR20230020510A (ko) | 2020-06-08 | 2023-02-10 | 어큐셀라 인코포레이티드 | 난시 치료를 위한 비대칭 투사 렌즈 |
| US11281022B2 (en) | 2020-06-10 | 2022-03-22 | Acucela Inc. | Apparatus and methods for the treatment of refractive error using active stimulation |
| US11209672B1 (en) | 2021-04-06 | 2021-12-28 | Acucela Inc. | Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens |
| US11366341B1 (en) | 2021-05-04 | 2022-06-21 | Acucela Inc. | Electronic case for electronic spectacles |
| CA3218950A1 (en) * | 2021-05-16 | 2022-11-24 | Metanoia Bio Inc. | Methods and compositions for treating ocular neovascular disease |
| US20240274295A1 (en) * | 2021-06-03 | 2024-08-15 | Osaka University | Method for screening for retinopathy of prematurity, apparatus for screening for retinopathy of prematurity, and learned model |
| US20240408056A1 (en) * | 2023-06-12 | 2024-12-12 | Synaptogenix, Inc. | Methods for repairing nerve damage using pkc activating therapeutic agents |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| BR0213975A (pt) * | 2001-11-09 | 2005-05-10 | Eyetech Pharmaceuticals | Métodos para tratar doenças neovasculares oculares |
| KR20070011379A (ko) * | 2004-03-17 | 2007-01-24 | 라스 미카엘 라르센 | 시각 사이클 억제에 의한 망막증의 예방 |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| WO2008131368A2 (en) * | 2007-04-20 | 2008-10-30 | Acucela Inc. | Styrenyl derivative compounds for treating ophthalmic diseases and disorders |
| BRPI0812755A2 (pt) * | 2007-06-29 | 2014-09-30 | Acucela Inc | Compostos de derivados de fenil alquinila para tratar doenças, e desordens oftálmicas |
| UA110089C2 (uk) | 2007-10-05 | 2015-11-25 | Ак'Юсела Інк. | Алкоксисполуки для лікування нейродегенеративних хвороб |
| GB2455176A (en) | 2007-11-01 | 2009-06-03 | Acucela Inc | Amine derivatives useful for treating ophthalmic diseases and disorders |
| KR101395952B1 (ko) | 2008-09-05 | 2014-05-21 | 어큐셀라 인코포레이티드 | 안과 질환 및 장애 치료를 위한 황-연결 화합물 |
| CN102197023B (zh) * | 2008-10-22 | 2015-12-16 | 奥克塞拉有限公司 | 治疗眼科疾病和紊乱的化合物 |
| EP2448569B1 (en) * | 2009-07-02 | 2021-10-27 | Acucela, Inc. | Pharmacology of visual cycle modulators |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
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2013
- 2013-04-30 TW TW102115446A patent/TW201406707A/zh unknown
- 2013-05-03 WO PCT/US2013/039562 patent/WO2013166449A2/en not_active Ceased
- 2013-05-03 BR BR112014027571-8A patent/BR112014027571B1/pt active IP Right Grant
- 2013-05-03 CN CN201380035735.1A patent/CN104411678A/zh active Pending
- 2013-05-03 SG SG11201407162SA patent/SG11201407162SA/en unknown
- 2013-05-03 HK HK15103833.8A patent/HK1203478A1/xx unknown
- 2013-05-03 ES ES13784718T patent/ES2792923T3/es active Active
- 2013-05-03 MX MX2020001835A patent/MX386024B/es unknown
- 2013-05-03 MX MX2014013341A patent/MX2014013341A/es active IP Right Grant
- 2013-05-03 EP EP20169968.3A patent/EP3741742A1/en active Pending
- 2013-05-03 AU AU2013256029A patent/AU2013256029A1/en not_active Abandoned
- 2013-05-03 JP JP2015510493A patent/JP2015518491A/ja active Pending
- 2013-05-03 CA CA2872433A patent/CA2872433C/en active Active
- 2013-05-03 US US13/887,243 patent/US9957224B2/en active Active
- 2013-05-03 EP EP13784718.2A patent/EP2844636B1/en active Active
- 2013-05-03 CN CN202310810454.4A patent/CN116850163A/zh active Pending
- 2013-05-03 EA EA201492031A patent/EA201492031A1/ru unknown
- 2013-05-03 KR KR1020147034091A patent/KR20150013240A/ko not_active Withdrawn
- 2013-05-03 CN CN201710706410.1A patent/CN107865830A/zh active Pending
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2014
- 2014-11-02 IL IL235446A patent/IL235446A0/en unknown
- 2014-11-03 PH PH12014502449A patent/PH12014502449A1/en unknown
- 2014-11-21 ZA ZA2014/08592A patent/ZA201408592B/en unknown
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2015
- 2015-04-21 HK HK18106035.4A patent/HK1246646A1/zh unknown
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2017
- 2017-11-07 JP JP2017214372A patent/JP2018024702A/ja active Pending
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2018
- 2018-04-30 US US15/967,080 patent/US10730825B2/en active Active
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2019
- 2019-10-11 JP JP2019187273A patent/JP2020023535A/ja active Pending
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2020
- 2020-07-21 US US16/934,715 patent/US11795136B2/en active Active
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2021
- 2021-02-18 JP JP2021024721A patent/JP2021075576A/ja active Pending
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2023
- 2023-02-28 JP JP2023029073A patent/JP2023059991A/ja active Pending
- 2023-10-11 US US18/379,142 patent/US20240308951A1/en active Pending
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2025
- 2025-02-04 JP JP2025017056A patent/JP2025069362A/ja active Pending