JP2015518491A5 - - Google Patents
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- Publication number
- JP2015518491A5 JP2015518491A5 JP2015510493A JP2015510493A JP2015518491A5 JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5 JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- substituted
- unsubstituted
- alkyl
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 208000030533 eye disease Diseases 0.000 claims 9
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004452 carbocyclyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010065534 Macular ischaemia Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 201000007917 background diabetic retinopathy Diseases 0.000 claims 1
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000038015 macular disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261643178P | 2012-05-04 | 2012-05-04 | |
| US201261643058P | 2012-05-04 | 2012-05-04 | |
| US201261643051P | 2012-05-04 | 2012-05-04 | |
| US61/643,178 | 2012-05-04 | ||
| US61/643,051 | 2012-05-04 | ||
| US61/643,058 | 2012-05-04 | ||
| US201361781907P | 2013-03-14 | 2013-03-14 | |
| US61/781,907 | 2013-03-14 | ||
| PCT/US2013/039562 WO2013166449A2 (en) | 2012-05-04 | 2013-05-03 | Methods for the treatment of diabetic retinopathy and other ophthalmic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Division JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518491A JP2015518491A (ja) | 2015-07-02 |
| JP2015518491A5 true JP2015518491A5 (enExample) | 2016-04-21 |
Family
ID=49515046
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510493A Pending JP2015518491A (ja) | 2012-05-04 | 2013-05-03 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9957224B2 (enExample) |
| EP (2) | EP2844636B1 (enExample) |
| JP (6) | JP2015518491A (enExample) |
| KR (1) | KR20150013240A (enExample) |
| CN (3) | CN104411678A (enExample) |
| AU (1) | AU2013256029A1 (enExample) |
| BR (1) | BR112014027571B1 (enExample) |
| CA (1) | CA2872433C (enExample) |
| EA (1) | EA201492031A1 (enExample) |
| ES (1) | ES2792923T3 (enExample) |
| HK (2) | HK1203478A1 (enExample) |
| IL (1) | IL235446A0 (enExample) |
| MX (2) | MX2014013341A (enExample) |
| PH (1) | PH12014502449A1 (enExample) |
| SG (1) | SG11201407162SA (enExample) |
| TW (1) | TW201406707A (enExample) |
| WO (1) | WO2013166449A2 (enExample) |
| ZA (1) | ZA201408592B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200922548A (en) | 2007-10-05 | 2009-06-01 | Acucela Inc | Alkoxy compounds for disease treatment |
| EP2448569B1 (en) * | 2009-07-02 | 2021-10-27 | Acucela, Inc. | Pharmacology of visual cycle modulators |
| AU2012294342B2 (en) | 2011-08-10 | 2017-07-27 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of autoimmune and inflammatory diseases |
| HK1210969A1 (en) | 2012-01-20 | 2016-05-13 | 奥克塞拉有限公司 | Substituted heterocyclic compounds for disease treatment |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
| JP2016512528A (ja) * | 2013-03-12 | 2016-04-28 | アクセラ インコーポレイテッド | 眼疾患及び眼障害を治療するための置換された３−フェニルプロピルアミン誘導体 |
| EP3195838B1 (en) | 2013-03-14 | 2018-08-22 | Optimedica Corporation | Laser capsulovitreotomy |
| US11447568B2 (en) | 2014-04-10 | 2022-09-20 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
| US10792374B2 (en) | 2015-10-09 | 2020-10-06 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| EP3585366A4 (en) | 2017-02-27 | 2021-08-04 | Case Western Reserve University | VISUAL CYCLE MODULATORS |
| EP3733050B1 (en) * | 2017-12-28 | 2025-02-26 | Nikon Corporation | Image processing method, image processing program, image processing device, image display device, and image display method |
| MX2018008165A (es) * | 2018-06-29 | 2019-12-30 | Centro De Retina Medica Y Quirurgica S C | Sistema portátil para la identificación de casos potenciales de edema macular diabético mediante procesamiento de imagen e inteligencia artificial. |
| JP2021529068A (ja) | 2018-07-07 | 2021-10-28 | アキュセラ インコーポレイテッド | 網膜低酸素症を防止するためのデバイス |
| US11402662B2 (en) | 2018-07-30 | 2022-08-02 | Acucela Inc. | Optical designs of electronic contact lens to decrease myopia progression |
| WO2020078865A1 (en) * | 2018-10-16 | 2020-04-23 | F. Hoffmann-La Roche Ag | Use of akt inhibitors in ophthalmology |
| CN112804999B (zh) * | 2018-10-19 | 2024-03-15 | 美迪诺亚公司 | 通过异丁司特治疗眼科疾病/病症或损伤的方法 |
| JPWO2020240867A1 (enExample) * | 2019-05-31 | 2020-12-03 | ||
| MA54325A (fr) | 2019-06-05 | 2022-05-11 | Regeneron Pharma | Dispositifs et procédés pour l'administration précise de doses |
| JP2022542965A (ja) | 2019-07-31 | 2022-10-07 | アキュセラ インコーポレイテッド | 画像を網膜上に投影するためのデバイス |
| US11733545B2 (en) | 2019-09-16 | 2023-08-22 | Acucela Inc. | Assembly process for an electronic soft contact lens designed to inhibit progression of myopia |
| TW202203521A (zh) | 2020-02-21 | 2022-01-16 | 美商艾尤席拉有限公司 | 電子隱形眼鏡之充電盒 |
| CN111617313B (zh) * | 2020-04-29 | 2022-09-06 | 天津医科大学眼科医院 | 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用 |
| EP4150398A4 (en) | 2020-05-13 | 2024-10-09 | Acucela Inc. | ELECTRO-SWITCHABLE GLASSES FOR MYOPIA TREATMENT |
| KR20230020951A (ko) | 2020-06-08 | 2023-02-13 | 어큐셀라 인코포레이티드 | 굴절 이상을 치료하기 위한 주변 망막에 대한 디포커스된 이미지의 투영 |
| EP4162316A4 (en) | 2020-06-08 | 2024-10-23 | Acucela Inc. | Stick on devices using peripheral defocus to treat progressive refractive error |
| AU2021288457A1 (en) | 2020-06-08 | 2023-01-05 | Acucela Inc. | Lens with asymmetric projection to treat astigmatism |
| US11281022B2 (en) * | 2020-06-10 | 2022-03-22 | Acucela Inc. | Apparatus and methods for the treatment of refractive error using active stimulation |
| US11209672B1 (en) | 2021-04-06 | 2021-12-28 | Acucela Inc. | Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens |
| US11366341B1 (en) | 2021-05-04 | 2022-06-21 | Acucela Inc. | Electronic case for electronic spectacles |
| WO2022245697A1 (en) * | 2021-05-16 | 2022-11-24 | Metanoia Bio Inc. | Methods and compositions for treating ocular neovascular disease |
| US20240274295A1 (en) * | 2021-06-03 | 2024-08-15 | Osaka University | Method for screening for retinopathy of prematurity, apparatus for screening for retinopathy of prematurity, and learned model |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2024258981A2 (en) * | 2023-06-12 | 2024-12-19 | Synaptogenix, Inc. | Methods for repairing nerve damage using pkc activating therapeutic agents |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| HRP20040406A2 (en) * | 2001-11-09 | 2005-02-28 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
| US9421175B2 (en) * | 2004-03-17 | 2016-08-23 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| WO2008131368A2 (en) * | 2007-04-20 | 2008-10-30 | Acucela Inc. | Styrenyl derivative compounds for treating ophthalmic diseases and disorders |
| CN103664637B (zh) * | 2007-06-29 | 2016-02-03 | 奥克塞拉有限公司 | 用于治疗眼科疾病和紊乱的炔基苯基衍生化合物 |
| TW200922548A (en) | 2007-10-05 | 2009-06-01 | Acucela Inc | Alkoxy compounds for disease treatment |
| CL2008003120A1 (es) | 2007-11-01 | 2009-10-09 | Acucela Inc | Compuestos derivados de fenilalquil-, fenilalquenil-, fenilalquinil- amina, feniltioalquilamina, fenilaminoalquilamina, fenilalcoxiamina y fenilalquilguanidina; composicion farmaceutica; y uso de los compuestos para tratar un trastorno o enfermedad oftalmologica tal como retinopatia, maculopatia, retinitis pigmentosa, uveitis, entre otras. |
| GB2463151A (en) | 2008-09-05 | 2010-03-10 | Acucela Inc | Amine derivative compounds for treating ophthalmic diseases and disorders |
| WO2010048332A2 (en) | 2008-10-22 | 2010-04-29 | Acucela, Inc. | Compounds for treating ophthalmic diseases and disorders |
| EP2448569B1 (en) * | 2009-07-02 | 2021-10-27 | Acucela, Inc. | Pharmacology of visual cycle modulators |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
-
2013
- 2013-04-30 TW TW102115446A patent/TW201406707A/zh unknown
- 2013-05-03 MX MX2014013341A patent/MX2014013341A/es active IP Right Grant
- 2013-05-03 JP JP2015510493A patent/JP2015518491A/ja active Pending
- 2013-05-03 BR BR112014027571-8A patent/BR112014027571B1/pt active IP Right Grant
- 2013-05-03 CA CA2872433A patent/CA2872433C/en active Active
- 2013-05-03 KR KR1020147034091A patent/KR20150013240A/ko not_active Withdrawn
- 2013-05-03 CN CN201380035735.1A patent/CN104411678A/zh active Pending
- 2013-05-03 ES ES13784718T patent/ES2792923T3/es active Active
- 2013-05-03 US US13/887,243 patent/US9957224B2/en active Active
- 2013-05-03 SG SG11201407162SA patent/SG11201407162SA/en unknown
- 2013-05-03 WO PCT/US2013/039562 patent/WO2013166449A2/en not_active Ceased
- 2013-05-03 EP EP13784718.2A patent/EP2844636B1/en active Active
- 2013-05-03 EP EP20169968.3A patent/EP3741742A1/en active Pending
- 2013-05-03 CN CN201710706410.1A patent/CN107865830A/zh active Pending
- 2013-05-03 HK HK15103833.8A patent/HK1203478A1/xx unknown
- 2013-05-03 AU AU2013256029A patent/AU2013256029A1/en not_active Abandoned
- 2013-05-03 MX MX2020001835A patent/MX386024B/es unknown
- 2013-05-03 EA EA201492031A patent/EA201492031A1/ru unknown
- 2013-05-03 CN CN202310810454.4A patent/CN116850163A/zh active Pending
-
2014
- 2014-11-02 IL IL235446A patent/IL235446A0/en unknown
- 2014-11-03 PH PH12014502449A patent/PH12014502449A1/en unknown
- 2014-11-21 ZA ZA2014/08592A patent/ZA201408592B/en unknown
-
2015
- 2015-04-21 HK HK18106035.4A patent/HK1246646A1/zh unknown
-
2017
- 2017-11-07 JP JP2017214372A patent/JP2018024702A/ja active Pending
-
2018
- 2018-04-30 US US15/967,080 patent/US10730825B2/en active Active
-
2019
- 2019-10-11 JP JP2019187273A patent/JP2020023535A/ja active Pending
-
2020
- 2020-07-21 US US16/934,715 patent/US11795136B2/en active Active
-
2021
- 2021-02-18 JP JP2021024721A patent/JP2021075576A/ja active Pending
-
2023
- 2023-02-28 JP JP2023029073A patent/JP2023059991A/ja active Pending
- 2023-10-11 US US18/379,142 patent/US20240308951A1/en active Pending
-
2025
- 2025-02-04 JP JP2025017056A patent/JP2025069362A/ja active Pending
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