JP2014523851A5 - - Google Patents
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- JP2014523851A5 JP2014523851A5 JP2013546480A JP2013546480A JP2014523851A5 JP 2014523851 A5 JP2014523851 A5 JP 2014523851A5 JP 2013546480 A JP2013546480 A JP 2013546480A JP 2013546480 A JP2013546480 A JP 2013546480A JP 2014523851 A5 JP2014523851 A5 JP 2014523851A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- optionally substituted
- ring
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000005843 halogen group Chemical group 0.000 claims 50
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 47
- 125000001424 substituent group Chemical group 0.000 claims 40
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 125000004043 oxo group Chemical group O=* 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- -1 pyrrolidyl Chemical group 0.000 claims 5
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 4
- AWEGTPPFDJUPRI-UHFFFAOYSA-N 8-oxabicyclo[3.2.1]octane Chemical group C1CCC2CCC1O2 AWEGTPPFDJUPRI-UHFFFAOYSA-N 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 3
- YPWFISCTZQNZAU-UHFFFAOYSA-N Thiane Chemical group C1CCSCC1 YPWFISCTZQNZAU-UHFFFAOYSA-N 0.000 claims 3
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 3
- 150000001924 cycloalkanes Chemical class 0.000 claims 3
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 125000003566 oxetanyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 150000003527 tetrahydropyrans Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 102000003678 AMPA Receptors Human genes 0.000 claims 2
- 108090000078 AMPA Receptors Proteins 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical group C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- QZHPTGXQGDFGEN-UHFFFAOYSA-N chromene Chemical compound C1=CC=C2C=C[CH]OC2=C1 QZHPTGXQGDFGEN-UHFFFAOYSA-N 0.000 claims 1
- 150000008371 chromenes Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- ZQOIMHOVNYHCJG-WBMJQRKESA-N n-[(3r,4s)-3-[[4-(4-chloropyrazol-1-yl)phenoxy]methyl]oxan-4-yl]methanesulfonamide Chemical compound CS(=O)(=O)N[C@H]1CCOC[C@@H]1COC1=CC=C(N2N=CC(Cl)=C2)C=C1 ZQOIMHOVNYHCJG-WBMJQRKESA-N 0.000 claims 1
- KSZRADIOKHDYGB-KUHUBIRLSA-N n-[(3r,4s)-4-[[4-(5-chloro-3-fluoropyridin-2-yl)phenoxy]methyl]oxan-3-yl]cyclopropanesulfonamide Chemical compound FC1=CC(Cl)=CN=C1C(C=C1)=CC=C1OC[C@@H]1[C@@H](NS(=O)(=O)C2CC2)COCC1 KSZRADIOKHDYGB-KUHUBIRLSA-N 0.000 claims 1
- NSBCQSCGEOPIJR-UHFFFAOYSA-N n-[3-[[4-[5-(trifluoromethyl)pyridin-2-yl]phenoxy]methyl]oxan-4-yl]ethanesulfonamide Chemical compound CCS(=O)(=O)NC1CCOCC1COC1=CC=C(C=2N=CC(=CC=2)C(F)(F)F)C=C1 NSBCQSCGEOPIJR-UHFFFAOYSA-N 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940043274 prophylactic drug Drugs 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013546480A JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011084100 | 2011-04-05 | ||
| JP2011084100 | 2011-04-05 | ||
| PCT/JP2012/059949 WO2012137982A2 (en) | 2011-04-05 | 2012-04-05 | Sulfonamide derivative and use thereof |
| JP2013546480A JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523851A JP2014523851A (ja) | 2014-09-18 |
| JP2014523851A5 true JP2014523851A5 (enExample) | 2015-05-21 |
| JP5976011B2 JP5976011B2 (ja) | 2016-08-23 |
Family
ID=46028103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546480A Active JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9527807B2 (enExample) |
| EP (1) | EP2694472B1 (enExample) |
| JP (1) | JP5976011B2 (enExample) |
| WO (1) | WO2012137982A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2813508B1 (en) | 2012-02-08 | 2018-01-31 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JO3225B1 (ar) * | 2012-11-27 | 2018-03-08 | Lilly Co Eli | 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8 |
| BR112016021874B1 (pt) | 2014-03-24 | 2021-03-23 | Bayer Cropscience Aktiengesellschaft | Processo para preparar derivados de 3,5-bis(haloalquil)pirazol a partir de alfa,alfa-dihaloaminas e cetiminas e compostos |
| EP3015458A1 (en) * | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| ES2907373T3 (es) * | 2016-02-04 | 2022-04-25 | Takeda Pharmaceuticals Co | Compuesto de piperidina sustituida y uso de la misma |
| WO2018009256A1 (en) * | 2016-03-29 | 2018-01-11 | Respirerx Pharmaceuticals, Inc. | Compositions and methods for treating attention deficit disorders |
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| EP3663281B1 (en) * | 2017-08-03 | 2022-12-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| JP7250687B2 (ja) | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2019070043A1 (ja) | 2017-10-06 | 2019-04-11 | 武田薬品工業株式会社 | 複素環化合物 |
| JP7301840B2 (ja) | 2017-12-19 | 2023-07-03 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのイソキサゾールｎ結合カルバモイルシクロヘキシル酸 |
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| AU2018392324A1 (en) | 2017-12-19 | 2020-08-06 | Bristol-Myers Squibb Company | Cyclohexyl acid triazole azines as LPA antagonists |
| KR102828422B1 (ko) | 2017-12-19 | 2025-07-01 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 이속사졸 아진 |
| CN112041316B (zh) | 2017-12-19 | 2024-11-22 | 百时美施贵宝公司 | 作为lpa拮抗剂的异噁唑o-连接的氨基甲酰基环己基酸 |
| AU2018392325A1 (en) | 2017-12-19 | 2020-07-30 | Bristol-Myers Squibb Company | Cyclohexyl acid triazole azoles as LPA antagonists |
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| US11655241B2 (en) | 2018-06-29 | 2023-05-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| WO2020004536A1 (ja) | 2018-06-29 | 2020-01-02 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
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| WO2020122092A1 (ja) | 2018-12-12 | 2020-06-18 | 武田薬品工業株式会社 | 複素環化合物 |
| CN118271298A (zh) * | 2019-01-31 | 2024-07-02 | 武田药品工业株式会社 | 杂环化合物及其用途 |
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| US11098029B2 (en) | 2019-02-13 | 2021-08-24 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| KR20220024549A (ko) | 2019-06-18 | 2022-03-03 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 이속사졸 카르복실산 |
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| EP4508027A1 (en) | 2022-04-12 | 2025-02-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP4543447A2 (en) * | 2022-06-21 | 2025-04-30 | Alkermes, Inc. | Substituted fused bicyclic compounds and related methods of treatment |
| CA3260221A1 (en) * | 2022-06-21 | 2023-12-28 | Alkermes, Inc. | Substituted Fused Bicyclic Compounds and Associated Treatment Processes |
| JP2025521503A (ja) * | 2022-06-21 | 2025-07-10 | アルカームス インコーポレーテッド | 置換ピロリジニル及びピペリジニル化合物並びに関連する治療方法 |
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| CN115433102B (zh) * | 2022-10-16 | 2024-02-27 | 大连双硼医药化工有限公司 | 一种反式-(1r,2r)-2-氨基环己烷羧酸乙酯盐酸盐的制备方法 |
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| AU2023403030A1 (en) | 2022-11-30 | 2025-06-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| WO2024189597A1 (en) | 2023-03-16 | 2024-09-19 | Takeda Pharmaceutical Company Limited | Macrocyclic heterocycle compounds and use thereof |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
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-
2012
- 2012-04-05 US US14/009,456 patent/US9527807B2/en active Active
- 2012-04-05 EP EP12719088.2A patent/EP2694472B1/en active Active
- 2012-04-05 JP JP2013546480A patent/JP5976011B2/ja active Active
- 2012-04-05 WO PCT/JP2012/059949 patent/WO2012137982A2/en not_active Ceased