JP2014523851A5 - - Google Patents
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- JP2014523851A5 JP2014523851A5 JP2013546480A JP2013546480A JP2014523851A5 JP 2014523851 A5 JP2014523851 A5 JP 2014523851A5 JP 2013546480 A JP2013546480 A JP 2013546480A JP 2013546480 A JP2013546480 A JP 2013546480A JP 2014523851 A5 JP2014523851 A5 JP 2014523851A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- optionally substituted
- ring
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013546480A JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011084100 | 2011-04-05 | ||
| JP2011084100 | 2011-04-05 | ||
| JP2013546480A JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
| PCT/JP2012/059949 WO2012137982A2 (en) | 2011-04-05 | 2012-04-05 | Sulfonamide derivative and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014523851A JP2014523851A (ja) | 2014-09-18 |
| JP2014523851A5 true JP2014523851A5 (enExample) | 2015-05-21 |
| JP5976011B2 JP5976011B2 (ja) | 2016-08-23 |
Family
ID=46028103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546480A Active JP5976011B2 (ja) | 2011-04-05 | 2012-04-05 | スルホンアミド誘導体およびその用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9527807B2 (enExample) |
| EP (1) | EP2694472B1 (enExample) |
| JP (1) | JP5976011B2 (enExample) |
| WO (1) | WO2012137982A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6134654B2 (ja) | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JO3225B1 (ar) * | 2012-11-27 | 2018-03-08 | Lilly Co Eli | 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8 |
| ES2663614T3 (es) | 2014-03-24 | 2018-04-16 | Bayer Cropscience Aktiengesellschaft | Procedimiento de preparación de derivados de 3,5-bis(haloalquil)pirazol a partir de alfa, alfa-dihaloaminas y cetiminas |
| EP3015458A1 (en) * | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| HRP20220127T1 (hr) | 2016-02-04 | 2022-04-15 | Takeda Pharmaceutical Company Limited | Supstituirani spoj piperidina i njegova uporaba |
| WO2018009256A1 (en) | 2016-03-29 | 2018-01-11 | Respirerx Pharmaceuticals, Inc. | Compositions and methods for treating attention deficit disorders |
| AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
| WO2018164191A1 (ja) | 2017-03-08 | 2018-09-13 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| US11034700B2 (en) | 2017-03-08 | 2021-06-15 | Takeda Pharmaceutical Company Limited | Substituted pyrrolidine compound and use thereof |
| MY202221A (en) * | 2017-08-03 | 2024-04-17 | Takeda Pharmaceuticals Co | Heterocyclic compound and use thereof |
| EP3663281B1 (en) * | 2017-08-03 | 2022-12-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| US11407748B2 (en) | 2017-10-06 | 2022-08-09 | Takeda Pharmaceutical Company Limited | Substituted pyrido[1,2-a]pyrimidines and pyrazino[1,2-a]pyrimidines for enhancing AMPA receptor function |
| JP7250687B2 (ja) | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
| JP7526096B2 (ja) | 2017-12-19 | 2024-07-31 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸イソキサゾールアジン |
| KR20200100713A (ko) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 트리아졸 아졸 |
| US10662172B2 (en) | 2017-12-19 | 2020-05-26 | Bristol-Myers Squibb Company | Triazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
| TW202017918A (zh) | 2017-12-19 | 2020-05-16 | 美商必治妥美雅史谷比公司 | 作為lpa拮抗劑之環己基酸三唑吖 |
| KR102697358B1 (ko) | 2017-12-19 | 2024-08-20 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산 |
| CN112074515B (zh) | 2017-12-19 | 2025-01-10 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸异噁唑唑类 |
| EP3728210B1 (en) | 2017-12-19 | 2026-02-11 | Bristol-Myers Squibb Company | Isoxazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
| EA202192934A1 (ru) * | 2017-12-25 | 2022-02-09 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение и его применение |
| BR112020017835A2 (pt) | 2018-03-20 | 2020-12-29 | Eisai R&D Management Co., Ltd. | Agente de tratamento de epilepsia |
| US12077522B2 (en) | 2018-06-29 | 2024-09-03 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| EP3816153B1 (en) | 2018-06-29 | 2023-10-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| ES2948793T3 (es) | 2018-09-18 | 2023-09-19 | Bristol Myers Squibb Co | Acidos cicloheptílicos como antagonistas de LPA |
| ES2946657T3 (es) | 2018-09-18 | 2023-07-24 | Bristol Myers Squibb Co | Acidos ciclopentílicos como antagonistas de LPA |
| WO2020122092A1 (ja) | 2018-12-12 | 2020-06-18 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3896060B1 (en) | 2018-12-12 | 2023-08-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| LT3917616T (lt) | 2019-01-31 | 2025-08-11 | Takeda Pharmaceutical Company Limited | Heterocikliniai junginiai ir jų naudojimas |
| EP3924058B1 (en) | 2019-02-13 | 2026-01-07 | Merck Sharp & Dohme LLC | 5-alkyl pyrrolidine orexin receptor agonists |
| US12331018B2 (en) | 2019-02-13 | 2025-06-17 | Merck Sharp & Dohme Llc | Pyrrolidine orexin receptor agonists |
| EP3986552B1 (en) | 2019-06-18 | 2024-09-18 | Bristol-Myers Squibb Company | Isoxazole carboxylic acids as lpa antagonists |
| US12466804B2 (en) | 2019-06-18 | 2025-11-11 | Bristol-Myers Squibb Company | Cyclobutyl carboxylic acids as LPA antagonists |
| ES3054967T3 (en) | 2019-06-18 | 2026-02-09 | Bristol Myers Squibb Co | Triazole carboxylic acids as lpa antagonists |
| US12312332B2 (en) | 2019-08-08 | 2025-05-27 | Merck Sharp & Dohme Llc | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| PT4065585T (pt) | 2019-11-25 | 2025-09-30 | Alkermes Inc | Compostos macrocíclicos substituídos e métodos de tratamento relacionados |
| CA3163200A1 (en) | 2019-11-27 | 2021-06-03 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US20230365533A1 (en) | 2020-08-18 | 2023-11-16 | Merck Sharp & Dohme Llc | Bicycloheptane pyrrolidine orexin receptor agonists |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN118946554A (zh) | 2022-03-28 | 2024-11-12 | 拜耳公司 | 制备顺式-4-氨基四氢呋喃-2-羧酸酯的方法 |
| US20250250230A1 (en) | 2022-04-12 | 2025-08-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN119730843A (zh) * | 2022-06-21 | 2025-03-28 | 阿尔克姆斯有限公司 | 取代的吡咯烷基和哌啶基化合物以及相关的治疗方法 |
| JP2025521507A (ja) * | 2022-06-21 | 2025-07-10 | アルカームス インコーポレーテッド | 置換縮合二環式化合物および関連する治療方法 |
| JP2025521504A (ja) * | 2022-06-21 | 2025-07-10 | アルカームス インコーポレーテッド | 置換縮合二環式化合物および関連する治療方法 |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| CN115433102B (zh) * | 2022-10-16 | 2024-02-27 | 大连双硼医药化工有限公司 | 一种反式-(1r,2r)-2-氨基环己烷羧酸乙酯盐酸盐的制备方法 |
| KR20250097917A (ko) | 2022-10-31 | 2025-06-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 복소환식 화합물 |
| WO2024116086A1 (en) | 2022-11-30 | 2024-06-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| EP4680611A1 (en) | 2023-03-16 | 2026-01-21 | Takeda Pharmaceutical Company Limited | Macrocyclic heterocycle compounds and use thereof |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
| WO2025229494A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2025229495A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2765322A (en) | 1953-03-03 | 1956-10-02 | Rohm & Haas | Preparation of bis(4-glycidyloxyphenyl)-sulfone |
| US5315013A (en) | 1988-01-07 | 1994-05-24 | E. I. Du Pont De Nemours And Company | Substituted pyrazole angiotensin II antagonists |
| DE69726745T2 (de) | 1996-07-31 | 2004-09-30 | Shionogi & Co., Ltd. | NEUE p-TERPHENYL VERBINDUNGEN |
| DE19803396A1 (de) | 1998-01-29 | 1999-08-05 | Bayer Ag | Substituierte Phenyluracile |
| CA2332452C (en) | 1998-05-20 | 2009-09-08 | Osaka Gas Company Limited | Nonaqueous secondary cell and method for controlling the same |
| CA2337098C (en) * | 1998-07-24 | 2008-08-05 | Teijin Limited | Anthranilic acid derivatives |
| WO2001000206A1 (en) | 1999-06-30 | 2001-01-04 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitor compounds |
| WO2003064404A1 (en) | 2002-02-01 | 2003-08-07 | Dainippon Pharmaceutical Co., Ltd. | 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same |
| JP2003238538A (ja) | 2002-02-12 | 2003-08-27 | Nippon Nohyaku Co Ltd | 新規4−置換フェニル−5−ハロピリミジン誘導体及びこれを有効成分とする除草剤 |
| JP2005060385A (ja) | 2003-07-31 | 2005-03-10 | Dainippon Pharmaceut Co Ltd | 2−フランカルボン酸ヒドラジド化合物からなる医薬 |
| MX2007001678A (es) | 2004-08-09 | 2007-04-12 | Glaxo Group Ltd | Compuestos que potencian el receptor de glutamato y sus usos en medicina. |
| GB0417709D0 (en) | 2004-08-09 | 2004-09-08 | Glaxo Group Ltd | Compounds |
| US20070270471A1 (en) | 2004-08-09 | 2007-11-22 | Glaxo Group Limited | Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine |
| US20100130737A1 (en) | 2005-02-18 | 2010-05-27 | Takeda Pharmaceutical Company Limited | Regulating Agent of GPR34 Receptor Function |
| UA92007C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| DE602006003661D1 (de) | 2005-06-06 | 2008-12-24 | Lilly Co Eli | Ampa-rezeptoren-verstärker |
| WO2007005845A1 (en) | 2005-07-01 | 2007-01-11 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| JP5014334B2 (ja) * | 2005-10-06 | 2012-08-29 | イーライ リリー アンド カンパニー | Ampa受容体増強剤 |
| US20090221643A1 (en) | 2006-02-08 | 2009-09-03 | Kevin Michael Thewlis | 4-phenyl-3-(2-propylsulfonylamino) tetrahydrofuran derivatives which potentiate glutamate receptors and are useful in the treatment of schizophrenia |
| GB0602560D0 (en) | 2006-02-08 | 2006-03-22 | Glaxo Group Ltd | Compounds |
| KR20090082278A (ko) | 2006-12-11 | 2009-07-29 | 일라이 릴리 앤드 캄파니 | Ampa 수용체 강화제 |
| WO2008113795A1 (en) | 2007-03-20 | 2008-09-25 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
| CA2682849C (en) | 2007-04-03 | 2012-05-29 | Pfizer Inc. | Sulfonamides and pharmaceutical compositions thereof |
| AR069781A1 (es) | 2007-12-19 | 2010-02-17 | Glaxo Group Ltd | Compuestos de n-(2,3-dihidro-inden-2-il) propanosulfonamida, composicion farmaceutica que los comprenden y su uso para el tratamiento de la ezquizofrenia. |
| GB0801220D0 (en) * | 2008-01-23 | 2008-02-27 | Glaxo Group Ltd | Compounds |
| GB0801265D0 (en) | 2008-01-23 | 2008-02-27 | Glaxo Group Ltd | Compounds |
| JPWO2009119088A1 (ja) | 2008-03-25 | 2011-07-21 | 武田薬品工業株式会社 | 複素環化合物 |
| TW201012803A (en) | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| EP2356099A1 (en) | 2008-10-08 | 2011-08-17 | Pfizer Inc. | Tetrahydrofuranyl sulfonamides for use as ampa modulators in the treatment of cns disorders |
| EP2417101B1 (en) * | 2009-04-09 | 2013-10-23 | Merck Sharp & Dohme B.V. | Indane derivatives |
| AP3066A (en) | 2009-06-26 | 2014-12-31 | Pfizer | Heterocyclic sulfonamides, uses and pharmaceuticalcompositions thereof |
| EP2456442A1 (en) * | 2009-07-23 | 2012-05-30 | Novartis AG | 1h-quinazoline-2, 4 -diones for use in the treatment of neuronal ceroid lipofuscinosis |
| PE20131116A1 (es) * | 2010-08-10 | 2013-10-24 | Takeda Pharmaceutical | Compuestos heterociclicos potenciadores de ampa |
-
2012
- 2012-04-05 US US14/009,456 patent/US9527807B2/en active Active
- 2012-04-05 EP EP12719088.2A patent/EP2694472B1/en active Active
- 2012-04-05 WO PCT/JP2012/059949 patent/WO2012137982A2/en not_active Ceased
- 2012-04-05 JP JP2013546480A patent/JP5976011B2/ja active Active
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