JP5976011B2 - スルホンアミド誘導体およびその用途 - Google Patents

スルホンアミド誘導体およびその用途 Download PDF

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JP5976011B2
JP5976011B2 JP2013546480A JP2013546480A JP5976011B2 JP 5976011 B2 JP5976011 B2 JP 5976011B2 JP 2013546480 A JP2013546480 A JP 2013546480A JP 2013546480 A JP2013546480 A JP 2013546480A JP 5976011 B2 JP5976011 B2 JP 5976011B2
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alkyl
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JP2014523851A5 (enExample
JP2014523851A (ja
Inventor
正司 福本
正司 福本
治 宇治川
治 宇治川
真二 森本
真二 森本
恭臣 浅野
恭臣 浅野
達 味上
達 味上
礼仁 ▲とく▼永
礼仁 ▲とく▼永
正城 郡
郡　　正城
稔博 今枝
稔博 今枝
耕一朗 福田
耕一朗 福田
信二 中村
信二 中村
幸一 岩永
幸一 岩永
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C323/26—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
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    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118845A1 (ja) 2012-02-08 2013-08-15 武田薬品工業株式会社 複素環化合物およびその用途
JO3225B1 (ar) * 2012-11-27 2018-03-08 Lilly Co Eli 6-((s)-1-{1-[5-(2-هيدروكسي-إيثوكسي)-بيريدين-2-يل]-1h-بيرازول-3-يل}إيثيل)-3h-1 ، 3-بنزو ثيازول-2- أون باعتباره مضاد مستقبل ampa يعتمد على tarp- جاما 8
EP3015458A1 (en) * 2014-11-03 2016-05-04 Bayer CropScience AG Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
JP6431088B2 (ja) 2014-03-24 2018-11-28 バイエル・クロップサイエンス・アクチェンゲゼルシャフト α，α−ジハロアミン類およびケチミン類からの３，５−ビス（ハロアルキル）ピラゾール誘導体の製造方法
EP3984994B1 (en) * 2016-02-04 2024-07-03 Takeda Pharmaceutical Company Limited Substituted piperidine compound as orexin type 2 agonist for the treatment of narcolepsy
WO2018009256A1 (en) * 2016-03-29 2018-01-11 Respirerx Pharmaceuticals, Inc. Compositions and methods for treating attention deficit disorders
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
JP7012703B2 (ja) 2017-03-08 2022-02-14 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
JP6957598B2 (ja) 2017-03-08 2021-11-02 武田薬品工業株式会社 置換ピロリジン化合物およびその用途
PE20200935A1 (es) 2017-08-03 2020-09-17 Takeda Pharmaceuticals Co Compuestos derivados de 2-((bifenil)pirrolidin o piperidin) sulfonamida o carboxamida agonistas de receptores de orexina 2
EP3663281B1 (en) * 2017-08-03 2022-12-28 Takeda Pharmaceutical Company Limited Heterocyclic compound and application thereof
JP7250686B2 (ja) 2017-10-06 2023-04-03 武田薬品工業株式会社 複素環化合物
US11447488B2 (en) 2017-10-06 2022-09-20 Takeda Pharmaceutical Company Limited Heterocyclic compounds
EP3728240B1 (en) 2017-12-19 2022-06-29 Bristol-Myers Squibb Company Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
WO2019126090A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Triazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
KR102777148B1 (ko) 2017-12-19 2025-03-05 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 트리아졸 아진
US11319309B2 (en) 2017-12-19 2022-05-03 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as LPA antagonists
JP7256807B2 (ja) 2017-12-19 2023-04-12 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸イソキサゾールアゾール
WO2019126099A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Isoxazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
CA3085938A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Cyclohexyl acid triazole azoles as lpa antagonists
EA039459B1 (ru) * 2017-12-25 2022-01-28 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение в качестве средства для лечения заболеваний, связанных с рецептором орексина 2 типа
MX2020009100A (es) 2018-03-20 2020-12-03 Eisai R&D Man Co Ltd Agente de tratamiento de la epilepsia.
JP7339250B2 (ja) 2018-06-29 2023-09-05 武田薬品工業株式会社 複素環化合物およびその用途
US11655241B2 (en) 2018-06-29 2023-05-23 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
KR20210061383A (ko) 2018-09-18 2021-05-27 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로펜틸 산
US20220041572A1 (en) 2018-09-18 2022-02-10 Bristol-Myers Squibb Company Cycloheptyl acids as lpa antagonists
WO2020122092A1 (ja) 2018-12-12 2020-06-18 武田薬品工業株式会社 複素環化合物
WO2020122093A1 (ja) 2018-12-12 2020-06-18 武田薬品工業株式会社 複素環化合物
EP3917616B1 (en) * 2019-01-31 2025-06-11 Takeda Pharmaceutical Company Limited Heterocyclic compounds and use thereof
US12331018B2 (en) 2019-02-13 2025-06-17 Merck Sharp & Dohme Llc Pyrrolidine orexin receptor agonists
WO2020167706A1 (en) 2019-02-13 2020-08-20 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
EP3986553A1 (en) 2019-06-18 2022-04-27 Bristol-Myers Squibb Company Cyclobutyl carboxylic acids as lpa antagonists
ES2989887T3 (es) 2019-06-18 2024-11-28 Bristol Myers Squibb Co Acidos isoxazol carboxílicos como antagonistas del LPA
WO2020257135A1 (en) 2019-06-18 2020-12-24 Bristol-Myers Squibb Company Triazole carboxylic acids as lpa antagonists
WO2021026047A1 (en) 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
FI4065585T3 (fi) 2019-11-25 2025-09-26 Alkermes Inc Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä
CN115003670A (zh) 2019-11-27 2022-09-02 武田药品工业株式会社 杂环化合物
CR20230089A (es) 2020-08-18 2023-04-11 Merck Sharp & Dohme Llc Agonistas de bicicloheptano pirrolidina de los receptores de orexina
US12006330B2 (en) 2020-12-21 2024-06-11 Alkermes, Inc. Substituted macrocyclic compounds and related methods of treatment
US11760747B2 (en) * 2020-12-21 2023-09-19 Alkermes, Inc. Substituted piperidino compounds and related methods of treatment
EP4499620A1 (de) 2022-03-28 2025-02-05 Bayer Aktiengesellschaft Verfahren zur herstellung von cis-4-aminotetrahydrofuran-2-carbonsäureestern
EP4508027A1 (en) 2022-04-12 2025-02-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
CA3260225A1 (en) * 2022-06-21 2023-12-28 Alkermes Inc Fused, Substituted Bicyclic Compounds and Associated Treatment Methods
JP2025521507A (ja) * 2022-06-21 2025-07-10 アルカームス インコーポレーテッド 置換縮合二環式化合物および関連する治療方法
CN119730843A (zh) * 2022-06-21 2025-03-28 阿尔克姆斯有限公司 取代的吡咯烷基和哌啶基化合物以及相关的治疗方法
TW202409023A (zh) 2022-07-14 2024-03-01 美商富曼西公司 除草苯并𠯤
CN115433102B (zh) * 2022-10-16 2024-02-27 大连双硼医药化工有限公司 一种反式-(1r,2r)-2-氨基环己烷羧酸乙酯盐酸盐的制备方法
US11987586B1 (en) 2022-10-31 2024-05-21 Takeda Pharmaceutical Company Limited Pyrrolo[1,2-c]imidazole derivatives as orexin type 2 receptor agonists
AR131202A1 (es) 2022-11-30 2025-02-26 Takeda Pharmaceuticals Co Compuesto heterocíclico y uso del mismo
TW202444345A (zh) 2023-03-16 2024-11-16 日商武田藥品工業股份有限公司 大環雜環化合物及其用途
WO2025111184A1 (en) 2023-11-21 2025-05-30 Fmc Corporation Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides
WO2025229494A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2025229495A1 (en) 2024-04-29 2025-11-06 Takeda Pharmaceutical Company Limited Heterocyclic compound

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2765322A (en) 1953-03-03 1956-10-02 Rohm & Haas Preparation of bis(4-glycidyloxyphenyl)-sulfone
US5315013A (en) 1988-01-07 1994-05-24 E. I. Du Pont De Nemours And Company Substituted pyrazole angiotensin II antagonists
JP4008498B2 (ja) 1996-07-31 2007-11-14 塩野義製薬株式会社 新規パラテルフェニル化合物
DE19803396A1 (de) 1998-01-29 1999-08-05 Bayer Ag Substituierte Phenyluracile
JP4854112B2 (ja) 1998-05-20 2012-01-18 株式会社Ｋｒｉ リチウムイオン電池及びその制御方法
KR100682276B1 (ko) * 1998-07-24 2007-02-28 데이진 가부시키가이샤 안트라닐산 유도체
BR0012068A (pt) * 1999-06-30 2002-05-14 Daiichi Seiyaku Co Compostos inibidores de vla-4
KR100926839B1 (ko) 2002-02-01 2009-11-12 다이닛본 스미토모 세이야꾸 가부시끼가이샤 ２－퓨란 카르복시산 하이드라지드 화합물 및 그것을함유하는 의약 조성물
JP2003238538A (ja) 2002-02-12 2003-08-27 Nippon Nohyaku Co Ltd 新規４−置換フェニル−５−ハロピリミジン誘導体及びこれを有効成分とする除草剤
JP2005060385A (ja) 2003-07-31 2005-03-10 Dainippon Pharmaceut Co Ltd ２−フランカルボン酸ヒドラジド化合物からなる医薬
US20070270471A1 (en) 2004-08-09 2007-11-22 Glaxo Group Limited Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine
DE602005015119D1 (de) 2004-08-09 2009-08-06 Glaxo Group Ltd Verbindungen, die den glutamatrezeptor verstärken und anwendungen davon in der medizin
GB0417709D0 (en) 2004-08-09 2004-09-08 Glaxo Group Ltd Compounds
WO2006088246A1 (ja) 2005-02-18 2006-08-24 Takeda Pharmaceutical Company Limited Ｇｐｒ３４受容体機能調節剤
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
DE602006003661D1 (de) 2005-06-06 2008-12-24 Lilly Co Eli Ampa-rezeptoren-verstärker
EP1906952A4 (en) 2005-07-01 2010-04-14 Jenrin Discovery MAO-B INHIBITORS USEFUL IN THE TREATMENT OF OBESITY
JP5014334B2 (ja) * 2005-10-06 2012-08-29 イーライ リリー アンド カンパニー Ａｍｐａ受容体増強剤
GB0602560D0 (en) 2006-02-08 2006-03-22 Glaxo Group Ltd Compounds
WO2007090840A1 (en) 2006-02-08 2007-08-16 Glaxo Group Limited 4-phenyl-3-(2-propylsulfonylamino) tetrahydrofuran derivatives which potentiate glutamate receptors and are useful in the treatment of schizophrenia
KR20090082278A (ko) 2006-12-11 2009-07-29 일라이 릴리 앤드 캄파니 Ａｍｐａ 수용체 강화제
WO2008113795A1 (en) 2007-03-20 2008-09-25 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
WO2008120093A1 (en) 2007-04-03 2008-10-09 Pfizer Inc. Sulfonamides and pharmaceutical compositions thereof
UY31544A1 (es) 2007-12-19 2009-07-17 Compuestos que potencian el receptor de ampa y usos de los mismos en medicina
GB0801265D0 (en) 2008-01-23 2008-02-27 Glaxo Group Ltd Compounds
GB0801220D0 (en) 2008-01-23 2008-02-27 Glaxo Group Ltd Compounds
EP2269990A4 (en) 2008-03-25 2012-04-18 Takeda Pharmaceutical Heterocyclic compound
TW201012803A (en) * 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
WO2010041162A1 (en) 2008-10-08 2010-04-15 Pfizer Inc. Tetrahydrofuranyl sulfonamides for use as ampa modulators in the treatment of cns disorders
US8633237B2 (en) * 2009-04-09 2014-01-21 Merck Sharp & Dohme B.V. Indane derivatives
MX2011013884A (es) 2009-06-26 2012-02-01 Pfizer Sulfonamidas heterociclicas, usos y composiciones farmaceuticas de las mismas.
CA2768333A1 (en) 2009-07-23 2011-01-27 Novartis Ag 1h-quinazoline-2, 4 -diones for use in the treatment of neuronal ceroid lipofuscinosis
JP5788496B2 (ja) 2010-08-10 2015-09-30 武田薬品工業株式会社 複素環化合物およびその用途

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