JP2014526435A5 - - Google Patents
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- Publication number
- JP2014526435A5 JP2014526435A5 JP2014511630A JP2014511630A JP2014526435A5 JP 2014526435 A5 JP2014526435 A5 JP 2014526435A5 JP 2014511630 A JP2014511630 A JP 2014511630A JP 2014511630 A JP2014511630 A JP 2014511630A JP 2014526435 A5 JP2014526435 A5 JP 2014526435A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- lower alkyl
- disorder
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 82
- 125000003545 alkoxy group Chemical group 0.000 claims 44
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 125000002947 alkylene group Chemical group 0.000 claims 17
- 125000005936 piperidyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 208000028698 Cognitive impairment Diseases 0.000 claims 10
- 208000010877 cognitive disease Diseases 0.000 claims 10
- 125000003277 amino group Chemical group 0.000 claims 9
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 9
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 8
- 201000000980 schizophrenia Diseases 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 6
- 208000024714 major depressive disease Diseases 0.000 claims 6
- 125000004193 piperazinyl group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 208000015114 central nervous system disease Diseases 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 208000031555 Treatment-Resistant Schizophrenia Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 4
- 208000029252 treatment-refractory schizophrenia Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- -1 phenyloxy group Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010003591 Ataxia Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000020706 Autistic disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 206010012218 Delirium Diseases 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 2
- 208000027534 Emotional disease Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 206010026749 Mania Diseases 0.000 claims 2
- 208000036626 Mental retardation Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 230000006978 adaptation Effects 0.000 claims 2
- 208000022531 anorexia Diseases 0.000 claims 2
- 230000001977 ataxic effect Effects 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 230000003542 behavioural effect Effects 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 235000014632 disordered eating Nutrition 0.000 claims 2
- 208000018459 dissociative disease Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 208000024732 dysthymic disease Diseases 0.000 claims 2
- 201000003104 endogenous depression Diseases 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 201000003995 melancholia Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000036651 mood Effects 0.000 claims 2
- 201000003152 motion sickness Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 2
- 208000015891 sexual disease Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000020685 sleep-wake disease Diseases 0.000 claims 2
- 230000000392 somatic effect Effects 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000016686 tic disease Diseases 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532393P | 2011-09-08 | 2011-09-08 | |
| US61/532,393 | 2011-09-08 | ||
| PCT/JP2012/073556 WO2013035892A1 (en) | 2011-09-08 | 2012-09-07 | Piperazine- substituted benzothiophene derivatives as antipsychotic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526435A JP2014526435A (ja) | 2014-10-06 |
| JP2014526435A5 true JP2014526435A5 (enExample) | 2015-10-29 |
| JP6193848B2 JP6193848B2 (ja) | 2017-09-06 |
Family
ID=46940565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511630A Active JP6193848B2 (ja) | 2011-09-08 | 2012-09-07 | 複素環化合物及びその用途 |
Country Status (31)
| Country | Link |
|---|---|
| US (9) | US9260420B2 (enExample) |
| EP (1) | EP2753617B9 (enExample) |
| JP (1) | JP6193848B2 (enExample) |
| KR (1) | KR101998441B1 (enExample) |
| CN (1) | CN103781783B (enExample) |
| AR (1) | AR087809A1 (enExample) |
| AU (1) | AU2012305212B2 (enExample) |
| BR (1) | BR112014005235B1 (enExample) |
| CA (1) | CA2847339C (enExample) |
| CO (1) | CO6930362A2 (enExample) |
| CY (1) | CY1118753T1 (enExample) |
| DK (1) | DK2753617T3 (enExample) |
| EA (1) | EA028160B1 (enExample) |
| ES (1) | ES2572934T3 (enExample) |
| HR (1) | HRP20160824T2 (enExample) |
| HU (1) | HUE027746T2 (enExample) |
| IL (1) | IL231116B (enExample) |
| JO (1) | JO3227B1 (enExample) |
| MX (1) | MX359515B (enExample) |
| MY (1) | MY196864A (enExample) |
| PH (1) | PH12014500496A1 (enExample) |
| PL (1) | PL2753617T3 (enExample) |
| PT (1) | PT2753617T (enExample) |
| RS (1) | RS54894B9 (enExample) |
| SG (2) | SG10201601731RA (enExample) |
| SI (1) | SI2753617T1 (enExample) |
| SM (1) | SMT201600205B (enExample) |
| TW (1) | TWI568728B (enExample) |
| UA (1) | UA112993C2 (enExample) |
| WO (1) | WO2013035892A1 (enExample) |
| ZA (1) | ZA201401433B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| TW201332572A (zh) * | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | 具有經取代的β－環糊精之藥物製劑 |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| JP2014196292A (ja) * | 2013-03-07 | 2014-10-16 | 大塚製薬株式会社 | 医薬 |
| CN104447723A (zh) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法 |
| CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
| WO2017162536A1 (en) | 2016-03-21 | 2017-09-28 | H. Lundbeck A/S | Vortioxetine prodrugs |
| PL233778B1 (pl) | 2016-07-19 | 2019-11-29 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu |
| DE112016007124B4 (de) * | 2016-09-08 | 2025-09-11 | Ford Motor Company | Verfahren, Vorrichtungen und computerlesbares Speichermedium zur Überwachung eines Aktivitätsniveaus eines Fahrers |
| CN106699745A (zh) * | 2016-12-14 | 2017-05-24 | 上海博志研新药物技术有限公司 | 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用 |
| US20180265472A1 (en) * | 2017-03-17 | 2018-09-20 | Scinopharm Taiwan, Ltd. | Process for preparing aripiprazole lauroxil and intermediates thereof |
| CN107628999B (zh) * | 2017-10-25 | 2019-07-02 | 苏州华健瑞达医药技术有限公司 | 阿立哌唑十二烷酸酯的制备方法 |
| CN109988162A (zh) * | 2017-12-29 | 2019-07-09 | 武汉兴华智慧医药科技有限公司 | 一种依匹哌唑衍生物及其制备方法 |
| CN110218209B (zh) * | 2018-03-02 | 2022-09-30 | 上海现代药物制剂工程研究中心有限公司 | 一种依匹哌唑月桂酸酯的晶型a、其制备方法及应用 |
| CN108947990A (zh) * | 2018-07-20 | 2018-12-07 | 成都苑东生物制药股份有限公司 | 一种苯并噻吩类化合物的制备方法 |
| MX2021006029A (es) * | 2019-01-11 | 2021-09-23 | Alar Pharmaceuticals Inc | Pamoato de ketamina y su uso. |
| CN116096715A (zh) * | 2020-07-06 | 2023-05-09 | 泰科根公司 | 用于精神障碍或精神增强的有益苯并噻吩组合物 |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
| CN114044772A (zh) * | 2021-11-29 | 2022-02-15 | 浙江国邦药业有限公司 | 一种依匹哌唑合成方法及其中间体 |
| CN116410186B (zh) * | 2021-12-30 | 2025-03-04 | 上海现代药物制剂工程研究中心有限公司 | 依匹哌唑甲基脂肪酸酯及其制备方法 |
| CN116407539B (zh) * | 2021-12-30 | 2025-01-10 | 上海现代药物制剂工程研究中心有限公司 | 依匹哌唑甲基脂肪酸酯的用途 |
| CN116891465A (zh) * | 2022-03-30 | 2023-10-17 | 苏州旺山旺水生物医药有限公司 | 一类n-取代的喹啉酮化合物、其制备方法和用途 |
| JP2023173950A (ja) * | 2022-05-27 | 2023-12-07 | 同仁医薬化工株式会社 | 経口液剤 |
| EP4673217A1 (en) * | 2023-02-27 | 2026-01-07 | Otsuka Pharmaceutical Co., Ltd. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
| AU2024266462A1 (en) * | 2023-05-02 | 2025-08-28 | Otsuka Pharmaceutical Co., Ltd. | Heterocyclic compound and use thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006503106A (ja) * | 2002-09-17 | 2006-01-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 統合失調症を処置するためのヘテロ環式置換ピペラジン |
| RU2356554C2 (ru) | 2002-12-27 | 2009-05-27 | Оцука Фармасьютикал Ко., Лтд. | Производные карбостирила и ингибиторы обратного захвата серотонина для лечения эмоциональных расстройств |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| US20050254575A1 (en) | 2004-05-12 | 2005-11-17 | Nokia Corporation | Multiple interoperability points for scalable media coding and transmission |
| DE102004031052A1 (de) | 2004-06-25 | 2006-01-12 | Bühler AG | System und Verfahren zur Mahlgut-Charakterisierung in einem Walzenstuhl |
| US7802705B2 (en) | 2004-07-29 | 2010-09-28 | Magie Pression Co., Ltd. | Method for forming pleat on fabric composed of polylactic acid yarn, and pleated fabric |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| WO2006111246A1 (de) | 2005-04-18 | 2006-10-26 | Loi Thermprocess Gmbh | Industrieofen |
| JP4540700B2 (ja) | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
| JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| ES2885698T3 (es) | 2009-06-25 | 2021-12-15 | Alkermes Pharma Ireland Ltd | Profármacos de compuestos nh-ácidos |
| HUE033442T2 (en) * | 2009-06-25 | 2017-11-28 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| WO2011084846A1 (en) | 2010-01-07 | 2011-07-14 | Alkermes, Inc. | Quaternary ammonium salt prodrugs |
| CA2802733C (en) | 2010-06-24 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| EP2655314B1 (en) | 2010-12-23 | 2018-02-07 | Alkermes Pharma Ireland Limited | Multi-api loading prodrugs |
| DK2685979T3 (da) | 2011-03-18 | 2016-12-19 | Alkermes Pharma Ireland Ltd | Injicerbare farmaceutiske sammensætninger, omfattende et vand-uopløseligt, antipsykotisk sorbitanlaurat og polysorbat 20. |
| JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
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2012
- 2012-09-06 JO JOP/2012/0253A patent/JO3227B1/ar active
- 2012-09-07 PT PT127664852T patent/PT2753617T/pt unknown
- 2012-09-07 SG SG10201601731RA patent/SG10201601731RA/en unknown
- 2012-09-07 AR ARP120103307A patent/AR087809A1/es not_active Application Discontinuation
- 2012-09-07 PH PH1/2014/500496A patent/PH12014500496A1/en unknown
- 2012-09-07 ES ES12766485.2T patent/ES2572934T3/es active Active
- 2012-09-07 BR BR112014005235-2A patent/BR112014005235B1/pt active IP Right Grant
- 2012-09-07 CA CA2847339A patent/CA2847339C/en active Active
- 2012-09-07 MY MYPI2014700554A patent/MY196864A/en unknown
- 2012-09-07 DK DK12766485.2T patent/DK2753617T3/en active
- 2012-09-07 SI SI201230630A patent/SI2753617T1/sl unknown
- 2012-09-07 JP JP2014511630A patent/JP6193848B2/ja active Active
- 2012-09-07 TW TW101132738A patent/TWI568728B/zh active
- 2012-09-07 HR HRP20160824TT patent/HRP20160824T2/hr unknown
- 2012-09-07 MX MX2014002254A patent/MX359515B/es active IP Right Grant
- 2012-09-07 CN CN201280043980.2A patent/CN103781783B/zh active Active
- 2012-09-07 UA UAA201403486A patent/UA112993C2/uk unknown
- 2012-09-07 AU AU2012305212A patent/AU2012305212B2/en active Active
- 2012-09-07 US US14/343,579 patent/US9260420B2/en active Active
- 2012-09-07 PL PL12766485.2T patent/PL2753617T3/pl unknown
- 2012-09-07 KR KR1020147009258A patent/KR101998441B1/ko active Active
- 2012-09-07 EA EA201490585A patent/EA028160B1/ru not_active IP Right Cessation
- 2012-09-07 WO PCT/JP2012/073556 patent/WO2013035892A1/en not_active Ceased
- 2012-09-07 HU HUE12766485A patent/HUE027746T2/en unknown
- 2012-09-07 SG SG11201400148QA patent/SG11201400148QA/en unknown
- 2012-09-07 RS RS20160492A patent/RS54894B9/sr unknown
- 2012-09-07 EP EP12766485.2A patent/EP2753617B9/en active Active
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2014
- 2014-02-24 IL IL231116A patent/IL231116B/en active IP Right Grant
- 2014-02-25 ZA ZA2014/01433A patent/ZA201401433B/en unknown
- 2014-04-03 CO CO14071857A patent/CO6930362A2/es unknown
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2015
- 2015-12-29 US US14/982,807 patent/US9539252B2/en active Active
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2016
- 2016-06-30 SM SM201600205T patent/SMT201600205B/it unknown
- 2016-07-04 CY CY20161100617T patent/CY1118753T1/el unknown
- 2016-11-23 US US15/359,809 patent/US20170071933A1/en not_active Abandoned
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2017
- 2017-07-07 US US15/643,969 patent/US20180092907A1/en not_active Abandoned
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2018
- 2018-07-12 US US16/033,749 patent/US20180318294A1/en not_active Abandoned
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2019
- 2019-02-06 US US16/268,827 patent/US20190167672A1/en not_active Abandoned
- 2019-10-29 US US16/666,546 patent/US20200061056A1/en not_active Abandoned
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2020
- 2020-06-09 US US16/896,329 patent/US20210052575A1/en not_active Abandoned
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2022
- 2022-01-18 US US17/577,465 patent/US20230099694A1/en not_active Abandoned