SMT201600205B - DERIVATI BENZOTIOFENICI SOSTITUITI CON PIPERAZINA COME AGENTI ANTlPSICOTICI - Google Patents
DERIVATI BENZOTIOFENICI SOSTITUITI CON PIPERAZINA COME AGENTI ANTlPSICOTICIInfo
- Publication number
- SMT201600205B SMT201600205B SM201600205T SM201600205T SMT201600205B SM T201600205 B SMT201600205 B SM T201600205B SM 201600205 T SM201600205 T SM 201600205T SM 201600205 T SM201600205 T SM 201600205T SM T201600205 B SMT201600205 B SM T201600205B
- Authority
- SM
- San Marino
- Prior art keywords
- psicotic
- benzotiophen
- piperazine
- agents
- derivatives substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161532393P | 2011-09-08 | 2011-09-08 | |
PCT/JP2012/073556 WO2013035892A1 (en) | 2011-09-08 | 2012-09-07 | Piperazine- substituted benzothiophene derivatives as antipsychotic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201600205B true SMT201600205B (it) | 2016-08-31 |
Family
ID=46940565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201600205T SMT201600205B (it) | 2011-09-08 | 2016-06-30 | DERIVATI BENZOTIOFENICI SOSTITUITI CON PIPERAZINA COME AGENTI ANTlPSICOTICI |
Country Status (31)
Country | Link |
---|---|
US (9) | US9260420B2 (it) |
EP (1) | EP2753617B9 (it) |
JP (1) | JP6193848B2 (it) |
KR (1) | KR101998441B1 (it) |
CN (1) | CN103781783B (it) |
AR (1) | AR087809A1 (it) |
AU (1) | AU2012305212B2 (it) |
BR (1) | BR112014005235B1 (it) |
CA (1) | CA2847339C (it) |
CO (1) | CO6930362A2 (it) |
CY (1) | CY1118753T1 (it) |
DK (1) | DK2753617T3 (it) |
EA (1) | EA028160B1 (it) |
ES (1) | ES2572934T3 (it) |
HK (1) | HK1195550A1 (it) |
HR (1) | HRP20160824T2 (it) |
HU (1) | HUE027746T2 (it) |
IL (1) | IL231116B (it) |
JO (1) | JO3227B1 (it) |
MX (1) | MX359515B (it) |
MY (1) | MY196864A (it) |
PL (1) | PL2753617T3 (it) |
PT (1) | PT2753617T (it) |
RS (1) | RS54894B9 (it) |
SG (2) | SG10201601731RA (it) |
SI (1) | SI2753617T1 (it) |
SM (1) | SMT201600205B (it) |
TW (1) | TWI568728B (it) |
UA (1) | UA112993C2 (it) |
WO (1) | WO2013035892A1 (it) |
ZA (1) | ZA201401433B (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
TW201332572A (zh) * | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | 具有經取代的β-環糊精之藥物製劑 |
JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
JP2014196292A (ja) * | 2013-03-07 | 2014-10-16 | 大塚製薬株式会社 | 医薬 |
CN104447723A (zh) * | 2014-11-28 | 2015-03-25 | 瑞阳制药有限公司 | 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法 |
CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
WO2017162536A1 (en) | 2016-03-21 | 2017-09-28 | H. Lundbeck A/S | Vortioxetine prodrugs |
PL233778B1 (pl) | 2016-07-19 | 2019-11-29 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu |
CN109716411B (zh) * | 2016-09-08 | 2021-06-25 | 福特汽车公司 | 用以监测驾驶员的活动水平的方法和设备 |
CN111233848A (zh) * | 2016-12-14 | 2020-06-05 | 上海博志研新药物技术有限公司 | 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用 |
US20180265472A1 (en) * | 2017-03-17 | 2018-09-20 | Scinopharm Taiwan, Ltd. | Process for preparing aripiprazole lauroxil and intermediates thereof |
CN107628999B (zh) * | 2017-10-25 | 2019-07-02 | 苏州华健瑞达医药技术有限公司 | 阿立哌唑十二烷酸酯的制备方法 |
CN109988162A (zh) * | 2017-12-29 | 2019-07-09 | 武汉兴华智慧医药科技有限公司 | 一种依匹哌唑衍生物及其制备方法 |
CN110218209B (zh) * | 2018-03-02 | 2022-09-30 | 上海现代药物制剂工程研究中心有限公司 | 一种依匹哌唑月桂酸酯的晶型a、其制备方法及应用 |
CN108947990A (zh) * | 2018-07-20 | 2018-12-07 | 成都苑东生物制药股份有限公司 | 一种苯并噻吩类化合物的制备方法 |
PT3908570T (pt) * | 2019-01-11 | 2024-03-15 | Alar Pharmaceuticals Inc | Pamoato de cetamina e sua utilização |
US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
CN114044772A (zh) * | 2021-11-29 | 2022-02-15 | 浙江国邦药业有限公司 | 一种依匹哌唑合成方法及其中间体 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0314393A (pt) | 2002-09-17 | 2005-07-19 | Warner Lambert Co | Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia |
ATE376419T1 (de) | 2002-12-27 | 2007-11-15 | Otsuka Pharma Co Ltd | Carbostyril-derivate mit selektiven serotonin- aufnahme inhibitoren, zur behandlung von gemütskrankheiten |
US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
US20050254575A1 (en) | 2004-05-12 | 2005-11-17 | Nokia Corporation | Multiple interoperability points for scalable media coding and transmission |
DE102004031052A1 (de) | 2004-06-25 | 2006-01-12 | Bühler AG | System und Verfahren zur Mahlgut-Charakterisierung in einem Walzenstuhl |
WO2006011246A1 (ja) | 2004-07-29 | 2006-02-02 | Magie Pression Co., Ltd. | ポリ乳酸糸で構成された布帛のプリーツ形成法およびプリーツ布帛 |
JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
TWI320783B (en) * | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
WO2006111246A1 (de) | 2005-04-18 | 2006-10-26 | Loi Thermprocess Gmbh | Industrieofen |
JP4540700B2 (ja) * | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
NZ597107A (en) * | 2009-06-25 | 2013-12-20 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
US8686009B2 (en) * | 2009-06-25 | 2014-04-01 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
JP6076740B2 (ja) | 2010-01-07 | 2017-02-08 | アルカーメス ファーマ アイルランド リミテッド | 第四級アンモニウム塩プロドラッグ |
CA2802733C (en) | 2010-06-24 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
EP2655314B1 (en) | 2010-12-23 | 2018-02-07 | Alkermes Pharma Ireland Limited | Multi-api loading prodrugs |
EP2685979B1 (en) | 2011-03-18 | 2016-08-24 | Alkermes Pharma Ireland Limited | Injectable pharmaceutical compositions comprising a water-insoluble anti-psychotic, sorbitan laurate and polysorbate 20 |
JO3227B1 (ar) * | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
-
2012
- 2012-09-06 JO JOP/2012/0253A patent/JO3227B1/ar active
- 2012-09-07 SG SG10201601731RA patent/SG10201601731RA/en unknown
- 2012-09-07 EA EA201490585A patent/EA028160B1/ru not_active IP Right Cessation
- 2012-09-07 SG SG11201400148QA patent/SG11201400148QA/en unknown
- 2012-09-07 DK DK12766485.2T patent/DK2753617T3/en active
- 2012-09-07 CN CN201280043980.2A patent/CN103781783B/zh active Active
- 2012-09-07 MY MYPI2014700554A patent/MY196864A/en unknown
- 2012-09-07 PT PT127664852T patent/PT2753617T/pt unknown
- 2012-09-07 AR ARP120103307A patent/AR087809A1/es not_active Application Discontinuation
- 2012-09-07 CA CA2847339A patent/CA2847339C/en active Active
- 2012-09-07 US US14/343,579 patent/US9260420B2/en active Active
- 2012-09-07 UA UAA201403486A patent/UA112993C2/uk unknown
- 2012-09-07 MX MX2014002254A patent/MX359515B/es active IP Right Grant
- 2012-09-07 BR BR112014005235-2A patent/BR112014005235B1/pt active IP Right Grant
- 2012-09-07 RS RS20160492A patent/RS54894B9/sr unknown
- 2012-09-07 JP JP2014511630A patent/JP6193848B2/ja active Active
- 2012-09-07 AU AU2012305212A patent/AU2012305212B2/en active Active
- 2012-09-07 HU HUE12766485A patent/HUE027746T2/en unknown
- 2012-09-07 PL PL12766485.2T patent/PL2753617T3/pl unknown
- 2012-09-07 EP EP12766485.2A patent/EP2753617B9/en active Active
- 2012-09-07 ES ES12766485.2T patent/ES2572934T3/es active Active
- 2012-09-07 SI SI201230630A patent/SI2753617T1/sl unknown
- 2012-09-07 WO PCT/JP2012/073556 patent/WO2013035892A1/en active Application Filing
- 2012-09-07 TW TW101132738A patent/TWI568728B/zh active
- 2012-09-07 KR KR1020147009258A patent/KR101998441B1/ko active IP Right Grant
-
2014
- 2014-02-24 IL IL231116A patent/IL231116B/en active IP Right Grant
- 2014-02-25 ZA ZA2014/01433A patent/ZA201401433B/en unknown
- 2014-04-03 CO CO14071857A patent/CO6930362A2/es unknown
- 2014-08-29 HK HK14108815.0A patent/HK1195550A1/zh unknown
-
2015
- 2015-12-29 US US14/982,807 patent/US9539252B2/en active Active
-
2016
- 2016-06-30 SM SM201600205T patent/SMT201600205B/it unknown
- 2016-07-04 CY CY20161100617T patent/CY1118753T1/el unknown
- 2016-07-08 HR HRP20160824TT patent/HRP20160824T2/hr unknown
- 2016-11-23 US US15/359,809 patent/US20170071933A1/en not_active Abandoned
-
2017
- 2017-07-07 US US15/643,969 patent/US20180092907A1/en not_active Abandoned
-
2018
- 2018-07-12 US US16/033,749 patent/US20180318294A1/en not_active Abandoned
-
2019
- 2019-02-06 US US16/268,827 patent/US20190167672A1/en not_active Abandoned
- 2019-10-29 US US16/666,546 patent/US20200061056A1/en not_active Abandoned
-
2020
- 2020-06-09 US US16/896,329 patent/US20210052575A1/en not_active Abandoned
-
2022
- 2022-01-18 US US17/577,465 patent/US20230099694A1/en active Pending
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