SG11201400148QA - Piperazine- substituted benzothiophene derivatives as antipsychotic agents - Google Patents

Piperazine- substituted benzothiophene derivatives as antipsychotic agents

Info

Publication number
SG11201400148QA
SG11201400148QA SG11201400148QA SG11201400148QA SG11201400148QA SG 11201400148Q A SG11201400148Q A SG 11201400148QA SG 11201400148Q A SG11201400148Q A SG 11201400148QA SG 11201400148Q A SG11201400148Q A SG 11201400148QA SG 11201400148Q A SG11201400148Q A SG 11201400148QA
Authority
SG
Singapore
Prior art keywords
piperazine
antipsychotic agents
benzothiophene derivatives
substituted benzothiophene
substituted
Prior art date
Application number
SG11201400148QA
Other languages
English (en)
Inventor
Hiroshi Yamashita
Yohji Sakurai
Motoyuki Miyamoto
Yuichi Nakamura
Hideaki Kuroda
Takuya Minowa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SG11201400148QA publication Critical patent/SG11201400148QA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/695Silicon compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
SG11201400148QA 2011-09-08 2012-09-07 Piperazine- substituted benzothiophene derivatives as antipsychotic agents SG11201400148QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161532393P 2011-09-08 2011-09-08
PCT/JP2012/073556 WO2013035892A1 (en) 2011-09-08 2012-09-07 Piperazine- substituted benzothiophene derivatives as antipsychotic agents

Publications (1)

Publication Number Publication Date
SG11201400148QA true SG11201400148QA (en) 2014-03-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201400148QA SG11201400148QA (en) 2011-09-08 2012-09-07 Piperazine- substituted benzothiophene derivatives as antipsychotic agents
SG10201601731RA SG10201601731RA (en) 2011-09-08 2012-09-07 Piperazine-substituted benzothiophene derivatives as antipsychotic agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201601731RA SG10201601731RA (en) 2011-09-08 2012-09-07 Piperazine-substituted benzothiophene derivatives as antipsychotic agents

Country Status (31)

Country Link
US (9) US9260420B2 (it)
EP (1) EP2753617B9 (it)
JP (1) JP6193848B2 (it)
KR (1) KR101998441B1 (it)
CN (1) CN103781783B (it)
AR (1) AR087809A1 (it)
AU (1) AU2012305212B2 (it)
BR (1) BR112014005235B1 (it)
CA (1) CA2847339C (it)
CO (1) CO6930362A2 (it)
CY (1) CY1118753T1 (it)
DK (1) DK2753617T3 (it)
EA (1) EA028160B1 (it)
ES (1) ES2572934T3 (it)
HK (1) HK1195550A1 (it)
HR (1) HRP20160824T2 (it)
HU (1) HUE027746T2 (it)
IL (1) IL231116B (it)
JO (1) JO3227B1 (it)
MX (1) MX359515B (it)
MY (1) MY196864A (it)
PL (1) PL2753617T3 (it)
PT (1) PT2753617T (it)
RS (1) RS54894B9 (it)
SG (2) SG11201400148QA (it)
SI (1) SI2753617T1 (it)
SM (1) SMT201600205B (it)
TW (1) TWI568728B (it)
UA (1) UA112993C2 (it)
WO (1) WO2013035892A1 (it)
ZA (1) ZA201401433B (it)

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TW201332572A (zh) * 2011-12-28 2013-08-16 Otsuka Pharma Co Ltd 具有經取代的β-環糊精之藥物製劑
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
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CN104829603A (zh) * 2015-05-19 2015-08-12 杭州新博思生物医药有限公司 A晶型依匹唑派盐酸盐及其制备方法
WO2017162536A1 (en) 2016-03-21 2017-09-28 H. Lundbeck A/S Vortioxetine prodrugs
PL233778B1 (pl) 2016-07-19 2019-11-29 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu
DE112016007124T5 (de) * 2016-09-08 2019-05-16 Ford Motor Company Verfahren und Vorrichtungen zur Überwachung eines Aktivitätsniveaus eines Fahrers
CN106699745A (zh) * 2016-12-14 2017-05-24 上海博志研新药物技术有限公司 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用
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CN110218209B (zh) * 2018-03-02 2022-09-30 上海现代药物制剂工程研究中心有限公司 一种依匹哌唑月桂酸酯的晶型a、其制备方法及应用
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CN114044772A (zh) * 2021-11-29 2022-02-15 浙江国邦药业有限公司 一种依匹哌唑合成方法及其中间体

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Also Published As

Publication number Publication date
IL231116A0 (en) 2014-04-30
KR20140069109A (ko) 2014-06-09
MX359515B (es) 2018-10-01
US20160143905A1 (en) 2016-05-26
HUE027746T2 (en) 2016-10-28
MY196864A (en) 2023-05-05
DK2753617T3 (en) 2016-07-25
AU2012305212A1 (en) 2014-04-24
MX2014002254A (es) 2014-04-30
IL231116B (en) 2019-09-26
SMT201600205B (it) 2016-08-31
SI2753617T1 (sl) 2016-08-31
US9539252B2 (en) 2017-01-10
BR112014005235A2 (pt) 2017-04-11
CY1118753T1 (el) 2017-07-12
EP2753617B9 (en) 2017-01-25
EP2753617A1 (en) 2014-07-16
TWI568728B (zh) 2017-02-01
US20180318294A1 (en) 2018-11-08
SG10201601731RA (en) 2016-04-28
RS54894B1 (sr) 2016-10-31
EA201490585A1 (ru) 2014-08-29
JP6193848B2 (ja) 2017-09-06
NZ621837A (en) 2015-06-26
US20200061056A1 (en) 2020-02-27
HRP20160824T2 (hr) 2017-05-19
CA2847339A1 (en) 2013-03-14
US20170071933A1 (en) 2017-03-16
HRP20160824T1 (hr) 2016-08-26
EP2753617B1 (en) 2016-04-13
CN103781783A (zh) 2014-05-07
KR101998441B1 (ko) 2019-07-09
JO3227B1 (ar) 2018-03-08
CN103781783B (zh) 2016-12-07
CA2847339C (en) 2020-03-10
US20180092907A1 (en) 2018-04-05
ZA201401433B (en) 2015-05-27
PL2753617T3 (pl) 2016-10-31
PT2753617T (pt) 2016-07-13
EA028160B1 (ru) 2017-10-31
AU2012305212B2 (en) 2016-12-08
US9260420B2 (en) 2016-02-16
US20190167672A1 (en) 2019-06-06
HK1195550A1 (zh) 2014-11-14
CO6930362A2 (es) 2014-04-28
JP2014526435A (ja) 2014-10-06
UA112993C2 (uk) 2016-11-25
RS54894B9 (sr) 2019-12-31
AR087809A1 (es) 2014-04-16
WO2013035892A1 (en) 2013-03-14
TW201326160A (zh) 2013-07-01
ES2572934T9 (es) 2017-05-08
US20150045356A1 (en) 2015-02-12
US20210052575A1 (en) 2021-02-25
ES2572934T3 (es) 2016-06-03
US20230099694A1 (en) 2023-03-30
BR112014005235B1 (pt) 2022-03-29

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