ATE532780T1 - Chinoline und ihre therapeutische verwendung - Google Patents
Chinoline und ihre therapeutische verwendungInfo
- Publication number
- ATE532780T1 ATE532780T1 AT08736891T AT08736891T ATE532780T1 AT E532780 T1 ATE532780 T1 AT E532780T1 AT 08736891 T AT08736891 T AT 08736891T AT 08736891 T AT08736891 T AT 08736891T AT E532780 T1 ATE532780 T1 AT E532780T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- halogen
- quinolines
- therapeutic use
- optionally substituted
- Prior art date
Links
- 229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 102000009389 Prostaglandin D receptors Human genes 0.000 abstract 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0706636A GB0706636D0 (en) | 2007-04-04 | 2007-04-04 | Receptor ligands |
| GB0724430A GB0724430D0 (en) | 2007-12-14 | 2007-12-14 | Receptor ligands |
| PCT/GB2008/001201 WO2008122784A1 (en) | 2007-04-04 | 2008-04-03 | Quinolines and their therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE532780T1 true ATE532780T1 (de) | 2011-11-15 |
Family
ID=39561800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08736891T ATE532780T1 (de) | 2007-04-04 | 2008-04-03 | Chinoline und ihre therapeutische verwendung |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8173812B2 (de) |
| EP (1) | EP2139881B1 (de) |
| JP (1) | JP5187862B2 (de) |
| CN (1) | CN101679359B (de) |
| AT (1) | ATE532780T1 (de) |
| AU (1) | AU2008235282B2 (de) |
| BR (1) | BRPI0809983A2 (de) |
| CA (1) | CA2680682C (de) |
| CY (1) | CY1112679T1 (de) |
| DK (1) | DK2139881T3 (de) |
| EA (1) | EA017093B1 (de) |
| ES (1) | ES2375588T3 (de) |
| HR (1) | HRP20110987T1 (de) |
| IL (1) | IL201013A (de) |
| MX (1) | MX2009010461A (de) |
| NZ (1) | NZ579659A (de) |
| PL (1) | PL2139881T3 (de) |
| PT (1) | PT2139881E (de) |
| SI (1) | SI2139881T1 (de) |
| WO (1) | WO2008122784A1 (de) |
| ZA (1) | ZA200906384B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010461A (es) * | 2007-04-04 | 2010-02-18 | Argenta Oral Therapeutics Ltd | Quinolinas y su usoterapeutico. |
| JP5327762B2 (ja) | 2007-12-14 | 2013-10-30 | プルマジェン セラピューティクス（アズマ）リミテッド | インドールおよびその治療的使用 |
| CA2805452C (en) * | 2010-07-05 | 2018-07-31 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| EP2457900A1 (de) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten |
| TW201331179A (zh) | 2011-12-21 | 2013-08-01 | Actelion Pharmaceuticals Ltd | 雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途 |
| EP2885307A1 (de) | 2012-07-05 | 2015-06-24 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituierte heterocyclyl-derivate und ihre verwendung als prostaglandin-d2-rezeptormodulatoren |
| WO2014014874A1 (en) * | 2012-07-17 | 2014-01-23 | Boehringer Ingelheim International Gmbh | Pyrazole derivatives which inhibit leukotriene production |
| AU2015220750B2 (en) * | 2014-02-24 | 2020-04-16 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| EP2974729A1 (de) * | 2014-07-17 | 2016-01-20 | Abivax | Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten |
| WO2022175829A1 (en) * | 2021-02-17 | 2022-08-25 | Cellix Bio Private Limited | Topical formulations and compositions |
| CN118955546A (zh) * | 2024-07-31 | 2024-11-15 | 上海毕得医药科技股份有限公司 | 一种化合物1-异丙基吡唑-3-硼酸频哪醇酯的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58225065A (ja) * | 1982-06-21 | 1983-12-27 | Nippon Shinyaku Co Ltd | ２−キノロン誘導体 |
| TW297025B (de) * | 1992-02-14 | 1997-02-01 | Squibb & Sons Inc | |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| ES2399061T3 (es) * | 2005-09-30 | 2013-03-25 | Pulmagen Therapeutics (Asthma) Limited | Quinolinas y su uso terapéutico |
| MX2009010461A (es) * | 2007-04-04 | 2010-02-18 | Argenta Oral Therapeutics Ltd | Quinolinas y su usoterapeutico. |
-
2008
- 2008-04-03 MX MX2009010461A patent/MX2009010461A/es active IP Right Grant
- 2008-04-03 PT PT08736891T patent/PT2139881E/pt unknown
- 2008-04-03 SI SI200830512T patent/SI2139881T1/sl unknown
- 2008-04-03 CA CA2680682A patent/CA2680682C/en not_active Expired - Fee Related
- 2008-04-03 NZ NZ579659A patent/NZ579659A/en not_active IP Right Cessation
- 2008-04-03 WO PCT/GB2008/001201 patent/WO2008122784A1/en not_active Ceased
- 2008-04-03 US US12/531,935 patent/US8173812B2/en not_active Expired - Fee Related
- 2008-04-03 EA EA200970911A patent/EA017093B1/ru not_active IP Right Cessation
- 2008-04-03 AU AU2008235282A patent/AU2008235282B2/en not_active Ceased
- 2008-04-03 HR HR20110987T patent/HRP20110987T1/hr unknown
- 2008-04-03 DK DK08736891.6T patent/DK2139881T3/da active
- 2008-04-03 AT AT08736891T patent/ATE532780T1/de active
- 2008-04-03 EP EP08736891A patent/EP2139881B1/de not_active Not-in-force
- 2008-04-03 JP JP2010501594A patent/JP5187862B2/ja not_active Expired - Fee Related
- 2008-04-03 ES ES08736891T patent/ES2375588T3/es active Active
- 2008-04-03 CN CN2008800110606A patent/CN101679359B/zh not_active Expired - Fee Related
- 2008-04-03 PL PL08736891T patent/PL2139881T3/pl unknown
- 2008-04-03 BR BRPI0809983-9A2A patent/BRPI0809983A2/pt not_active Application Discontinuation
-
2009
- 2009-09-14 ZA ZA2009/06384A patent/ZA200906384B/en unknown
- 2009-09-17 IL IL201013A patent/IL201013A/en active IP Right Grant
-
2012
- 2012-01-17 CY CY20121100048T patent/CY1112679T1/el unknown
- 2012-03-30 US US13/435,242 patent/US8394830B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SI2139881T1 (sl) | 2012-05-31 |
| JP5187862B2 (ja) | 2013-04-24 |
| PT2139881E (pt) | 2012-01-17 |
| EA017093B1 (ru) | 2012-09-28 |
| CA2680682A1 (en) | 2008-10-16 |
| AU2008235282B2 (en) | 2011-02-24 |
| AU2008235282A8 (en) | 2009-11-26 |
| BRPI0809983A2 (pt) | 2014-10-14 |
| JP2010523537A (ja) | 2010-07-15 |
| ES2375588T3 (es) | 2012-03-02 |
| DK2139881T3 (da) | 2012-01-30 |
| CN101679359B (zh) | 2013-03-06 |
| IL201013A0 (en) | 2010-05-17 |
| NZ579659A (en) | 2012-01-12 |
| CY1112679T1 (el) | 2016-02-10 |
| EP2139881A1 (de) | 2010-01-06 |
| US8394830B2 (en) | 2013-03-12 |
| ZA200906384B (en) | 2010-11-24 |
| AU2008235282A1 (en) | 2008-10-16 |
| MX2009010461A (es) | 2010-02-18 |
| US8173812B2 (en) | 2012-05-08 |
| EP2139881B1 (de) | 2011-11-09 |
| HK1142604A1 (en) | 2010-12-10 |
| WO2008122784A1 (en) | 2008-10-16 |
| PL2139881T3 (pl) | 2012-04-30 |
| EA200970911A1 (ru) | 2010-04-30 |
| US20120184579A1 (en) | 2012-07-19 |
| HRP20110987T1 (hr) | 2012-01-31 |
| US20100144787A1 (en) | 2010-06-10 |
| CN101679359A (zh) | 2010-03-24 |
| CA2680682C (en) | 2015-05-26 |
| IL201013A (en) | 2015-01-29 |
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