PL2139881T3 - Chinoliny i ich zastosowanie terapeutyczne - Google Patents

Chinoliny i ich zastosowanie terapeutyczne

Info

Publication number
PL2139881T3
PL2139881T3 PL08736891T PL08736891T PL2139881T3 PL 2139881 T3 PL2139881 T3 PL 2139881T3 PL 08736891 T PL08736891 T PL 08736891T PL 08736891 T PL08736891 T PL 08736891T PL 2139881 T3 PL2139881 T3 PL 2139881T3
Authority
PL
Poland
Prior art keywords
hydrogen
halogen
quinolines
therapeutic use
optionally substituted
Prior art date
Application number
PL08736891T
Other languages
English (en)
Inventor
John Gary Montana
Harry Finch
George Hynd
Michael Colin Cramp
Rosa Arienzo
Neville Mclean
Original Assignee
Pulmagen Therapeutics Asthma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0706636A external-priority patent/GB0706636D0/en
Priority claimed from GB0724430A external-priority patent/GB0724430D0/en
Application filed by Pulmagen Therapeutics Asthma Ltd filed Critical Pulmagen Therapeutics Asthma Ltd
Publication of PL2139881T3 publication Critical patent/PL2139881T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
PL08736891T 2007-04-04 2008-04-03 Chinoliny i ich zastosowanie terapeutyczne PL2139881T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0706636A GB0706636D0 (en) 2007-04-04 2007-04-04 Receptor ligands
GB0724430A GB0724430D0 (en) 2007-12-14 2007-12-14 Receptor ligands
PCT/GB2008/001201 WO2008122784A1 (en) 2007-04-04 2008-04-03 Quinolines and their therapeutic use
EP08736891A EP2139881B1 (en) 2007-04-04 2008-04-03 Quinolines and their therapeutic use

Publications (1)

Publication Number Publication Date
PL2139881T3 true PL2139881T3 (pl) 2012-04-30

Family

ID=39561800

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08736891T PL2139881T3 (pl) 2007-04-04 2008-04-03 Chinoliny i ich zastosowanie terapeutyczne

Country Status (22)

Country Link
US (2) US8173812B2 (pl)
EP (1) EP2139881B1 (pl)
JP (1) JP5187862B2 (pl)
CN (1) CN101679359B (pl)
AT (1) ATE532780T1 (pl)
AU (1) AU2008235282B2 (pl)
BR (1) BRPI0809983A2 (pl)
CA (1) CA2680682C (pl)
CY (1) CY1112679T1 (pl)
DK (1) DK2139881T3 (pl)
EA (1) EA017093B1 (pl)
ES (1) ES2375588T3 (pl)
HK (1) HK1142604A1 (pl)
HR (1) HRP20110987T1 (pl)
IL (1) IL201013A (pl)
MX (1) MX2009010461A (pl)
NZ (1) NZ579659A (pl)
PL (1) PL2139881T3 (pl)
PT (1) PT2139881E (pl)
SI (1) SI2139881T1 (pl)
WO (1) WO2008122784A1 (pl)
ZA (1) ZA200906384B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2139881E (pt) * 2007-04-04 2012-01-17 Pulmagen Therapeutics Asthma Ltd Quinolinas e a sua utilização terapêutica
NZ585888A (en) 2007-12-14 2012-02-24 Pulmagen Therapeutics Asthma Ltd Indoles and their therapeutic use
AU2011275417A1 (en) * 2010-07-05 2013-02-21 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
MX2014007688A (es) 2011-12-21 2014-07-28 Actelion Pharmaceuticals Ltd Derivados de heterociclilo y su uso como moduladores del receptor d2 de prostaglandina.
JP6127135B2 (ja) 2012-07-05 2017-05-10 アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd 1−フェニル置換ヘテロシクリル誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用
US9403830B2 (en) * 2012-07-17 2016-08-02 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
DK3111224T3 (en) * 2014-02-24 2019-03-18 Ventana Med Syst Inc Quinonmethidanalog-signal gain
WO2022175829A1 (en) * 2021-02-17 2022-08-25 Cellix Bio Private Limited Topical formulations and compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225065A (ja) * 1982-06-21 1983-12-27 Nippon Shinyaku Co Ltd 2−キノロン誘導体
TW297025B (pl) * 1992-02-14 1997-02-01 Squibb & Sons Inc
SA04250253B1 (ar) * 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
EA015358B1 (ru) * 2005-09-30 2011-06-30 Пульмаджен Терапьютикс (Эсме) Лимитед Хинолины и их терапевтическое применение
PT2139881E (pt) * 2007-04-04 2012-01-17 Pulmagen Therapeutics Asthma Ltd Quinolinas e a sua utilização terapêutica

Also Published As

Publication number Publication date
EA017093B1 (ru) 2012-09-28
ZA200906384B (en) 2010-11-24
BRPI0809983A2 (pt) 2014-10-14
JP2010523537A (ja) 2010-07-15
CA2680682C (en) 2015-05-26
CY1112679T1 (el) 2016-02-10
AU2008235282A8 (en) 2009-11-26
WO2008122784A1 (en) 2008-10-16
AU2008235282A1 (en) 2008-10-16
NZ579659A (en) 2012-01-12
US20120184579A1 (en) 2012-07-19
JP5187862B2 (ja) 2013-04-24
AU2008235282B2 (en) 2011-02-24
EP2139881B1 (en) 2011-11-09
EA200970911A1 (ru) 2010-04-30
CN101679359B (zh) 2013-03-06
EP2139881A1 (en) 2010-01-06
IL201013A (en) 2015-01-29
US8394830B2 (en) 2013-03-12
CN101679359A (zh) 2010-03-24
MX2009010461A (es) 2010-02-18
DK2139881T3 (da) 2012-01-30
US8173812B2 (en) 2012-05-08
ES2375588T3 (es) 2012-03-02
CA2680682A1 (en) 2008-10-16
IL201013A0 (en) 2010-05-17
SI2139881T1 (sl) 2012-05-31
HK1142604A1 (en) 2010-12-10
ATE532780T1 (de) 2011-11-15
HRP20110987T1 (hr) 2012-01-31
PT2139881E (pt) 2012-01-17
US20100144787A1 (en) 2010-06-10

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