AU2008235282B2 - Quinolines and their therapeutic use - Google Patents

Quinolines and their therapeutic use Download PDF

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Publication number
AU2008235282B2
AU2008235282B2 AU2008235282A AU2008235282A AU2008235282B2 AU 2008235282 B2 AU2008235282 B2 AU 2008235282B2 AU 2008235282 A AU2008235282 A AU 2008235282A AU 2008235282 A AU2008235282 A AU 2008235282A AU 2008235282 B2 AU2008235282 B2 AU 2008235282B2
Authority
AU
Australia
Prior art keywords
acetic acid
preparation
difluoromethoxy
yloxy
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008235282A
Other languages
English (en)
Other versions
AU2008235282A1 (en
AU2008235282A8 (en
Inventor
Rosa Arienzo
Michael Colin Cramp
Harry Finch
George Hynd
Neville Mclean
John Gary Montana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pulmagen Therapeutics Asthma Ltd
Original Assignee
Pulmagen Therapeutics Asthma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0706636A external-priority patent/GB0706636D0/en
Priority claimed from GB0724430A external-priority patent/GB0724430D0/en
Application filed by Pulmagen Therapeutics Asthma Ltd filed Critical Pulmagen Therapeutics Asthma Ltd
Publication of AU2008235282A1 publication Critical patent/AU2008235282A1/en
Publication of AU2008235282A8 publication Critical patent/AU2008235282A8/en
Assigned to PULMAGEN THERAPEUTICS (ASTHMA) LIMITED reassignment PULMAGEN THERAPEUTICS (ASTHMA) LIMITED Alteration of Name(s) of Applicant(s) under S113 Assignors: ARGENTA ORAL THERAPEUTICS LIMITED
Application granted granted Critical
Publication of AU2008235282B2 publication Critical patent/AU2008235282B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AU2008235282A 2007-04-04 2008-04-03 Quinolines and their therapeutic use Ceased AU2008235282B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0706636.8 2007-04-04
GB0706636A GB0706636D0 (en) 2007-04-04 2007-04-04 Receptor ligands
GB0724430.4 2007-12-14
GB0724430A GB0724430D0 (en) 2007-12-14 2007-12-14 Receptor ligands
PCT/GB2008/001201 WO2008122784A1 (en) 2007-04-04 2008-04-03 Quinolines and their therapeutic use

Publications (3)

Publication Number Publication Date
AU2008235282A1 AU2008235282A1 (en) 2008-10-16
AU2008235282A8 AU2008235282A8 (en) 2009-11-26
AU2008235282B2 true AU2008235282B2 (en) 2011-02-24

Family

ID=39561800

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008235282A Ceased AU2008235282B2 (en) 2007-04-04 2008-04-03 Quinolines and their therapeutic use

Country Status (22)

Country Link
US (2) US8173812B2 (de)
EP (1) EP2139881B1 (de)
JP (1) JP5187862B2 (de)
CN (1) CN101679359B (de)
AT (1) ATE532780T1 (de)
AU (1) AU2008235282B2 (de)
BR (1) BRPI0809983A2 (de)
CA (1) CA2680682C (de)
CY (1) CY1112679T1 (de)
DK (1) DK2139881T3 (de)
EA (1) EA017093B1 (de)
ES (1) ES2375588T3 (de)
HK (1) HK1142604A1 (de)
HR (1) HRP20110987T1 (de)
IL (1) IL201013A (de)
MX (1) MX2009010461A (de)
NZ (1) NZ579659A (de)
PL (1) PL2139881T3 (de)
PT (1) PT2139881E (de)
SI (1) SI2139881T1 (de)
WO (1) WO2008122784A1 (de)
ZA (1) ZA200906384B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8173812B2 (en) * 2007-04-04 2012-05-08 Pulmagen Therapeutics (Asthma) Limited Quinolines and their therapeutic use
DE602008005796D1 (de) 2007-12-14 2011-05-05 Pulmagen Therapeutics Asthma Ltd Indole und ihre therapeutische verwendung
RU2013104506A (ru) * 2010-07-05 2014-08-10 Актелион Фармасьютиклз Лтд 1-фенилзамещенные производные гетероциклила и их применение в качестве модуляторов рецептора простагландина d2
EP2457900A1 (de) 2010-11-25 2012-05-30 Almirall, S.A. Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
RU2014129613A (ru) 2011-12-21 2016-02-10 Актелион Фармасьютиклз Лтд Гетероциклильные производные и их применение в качестве модуляторов рецептора простагландина d2
US9169270B2 (en) 2012-07-05 2015-10-27 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
TW201416354A (zh) * 2012-07-17 2014-05-01 Boehringer Ingelheim Int 白三烯生成抑制劑
EP3492919A3 (de) 2014-02-24 2019-07-10 Ventana Medical Systems, Inc. Quinone methide analoge signal amplifikation
WO2022175829A1 (en) * 2021-02-17 2022-08-25 Cellix Bio Private Limited Topical formulations and compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58225065A (ja) * 1982-06-21 1983-12-27 Nippon Shinyaku Co Ltd ２−キノロン誘導体
TW297025B (de) * 1992-02-14 1997-02-01 Squibb & Sons Inc
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
BRPI0616452B8 (pt) * 2005-09-30 2021-05-25 Argenta Discovery Ltd quinolinas e seu uso terapêutico
US8173812B2 (en) * 2007-04-04 2012-05-08 Pulmagen Therapeutics (Asthma) Limited Quinolines and their therapeutic use

Also Published As

Publication number Publication date
EA200970911A1 (ru) 2010-04-30
IL201013A0 (en) 2010-05-17
DK2139881T3 (da) 2012-01-30
CY1112679T1 (el) 2016-02-10
US20120184579A1 (en) 2012-07-19
BRPI0809983A2 (pt) 2014-10-14
AU2008235282A1 (en) 2008-10-16
MX2009010461A (es) 2010-02-18
EP2139881B1 (de) 2011-11-09
CA2680682A1 (en) 2008-10-16
US20100144787A1 (en) 2010-06-10
PL2139881T3 (pl) 2012-04-30
CA2680682C (en) 2015-05-26
PT2139881E (pt) 2012-01-17
CN101679359A (zh) 2010-03-24
ES2375588T3 (es) 2012-03-02
US8394830B2 (en) 2013-03-12
WO2008122784A1 (en) 2008-10-16
US8173812B2 (en) 2012-05-08
IL201013A (en) 2015-01-29
EP2139881A1 (de) 2010-01-06
EA017093B1 (ru) 2012-09-28
ZA200906384B (en) 2010-11-24
HRP20110987T1 (hr) 2012-01-31
JP2010523537A (ja) 2010-07-15
CN101679359B (zh) 2013-03-06
SI2139881T1 (sl) 2012-05-31
AU2008235282A8 (en) 2009-11-26
JP5187862B2 (ja) 2013-04-24
NZ579659A (en) 2012-01-12
ATE532780T1 (de) 2011-11-15
HK1142604A1 (en) 2010-12-10

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 23, NO 40, PAGE(S) 10523 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ARGENTA ORAL THERAPEUTICS LIMITED, APPLICATION NO. 2008235282, UNDER INID (72) CORRECT THE CO-INVENTOR TO MCLEAN, NEVILLE

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired