PE20081893A1 - Subtipo de amidas selectivas de diazabicicloalcanos - Google Patents

Subtipo de amidas selectivas de diazabicicloalcanos

Info

Publication number
PE20081893A1
PE20081893A1 PE2008000461A PE2008000461A PE20081893A1 PE 20081893 A1 PE20081893 A1 PE 20081893A1 PE 2008000461 A PE2008000461 A PE 2008000461A PE 2008000461 A PE2008000461 A PE 2008000461A PE 20081893 A1 PE20081893 A1 PE 20081893A1
Authority
PE
Peru
Prior art keywords
diazabicycle
heptane
ilcarbonyl
methylfuran
diazabicicloalkanes
Prior art date
Application number
PE2008000461A
Other languages
English (en)
Inventor
Philips S Hammond
Anatoly A Mazurov
Lan Miao
Yun-De Xiao
Balwinder Bhatti
Jon-Paul Strachan
V Srinivasa Murthy
David C Kombo
Srinivasa Rao Akireddy
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PE20081893A1 publication Critical patent/PE20081893A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIAZABICICLOALCANOS DE FORMULA (1) A-C(O)-Ci DONDE A ES UN CENTRO DIAZABICICLICO DE 7, 8 O 9 MIEMBROS TALES COMO 2,6-DIAZABICICLO[3.2.0]HEPTANO, 3,7-DIAZABICICLO[4.2.0]OCTANO, 2,7-DIAZABICICLO[3.3.0]OCTANO, ENTRE OTROS; Ci ES UN HETEROARILO TAL COMO 2-FURANILO, 3-TIENILO, 2-OXAZOLILO, 1,3,4-OXADIAZOL-2-IL, 3-PIRIDINIL, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, CN, NO2, N3, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: 6-(FURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 2-(3-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 6-(3-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 2-(5-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES DE ACETILCOLINA NICOTINICOS NEURONALES SIENDO UTILES EN EL TRATAMIENTO DE DEMENCIA SENIL, ESQUIZOFRENIA, DISLEXIA
PE2008000461A 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos PE20081893A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90676207P 2007-03-13 2007-03-13

Publications (1)

Publication Number Publication Date
PE20081893A1 true PE20081893A1 (es) 2009-02-15

Family

ID=39580235

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000461A PE20081893A1 (es) 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos

Country Status (7)

Country Link
US (1) US20100144700A1 (es)
AR (1) AR065705A1 (es)
CL (1) CL2008000726A1 (es)
PE (1) PE20081893A1 (es)
TW (1) TW200840569A (es)
UY (1) UY30959A1 (es)
WO (1) WO2008112734A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110263629A1 (en) * 2008-09-05 2011-10-27 Targacept, Inc. Amides of diazabicyclooctanes and uses thereof
MX2011014019A (es) * 2009-06-19 2012-02-22 Abbott Lab Derivados de diazahomoadamantano y sus metodos de uso.
MX2012006484A (es) 2009-12-07 2012-08-01 Targacept Inc 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina.
WO2015191401A1 (en) * 2014-06-13 2015-12-17 Bristol-Myers Squibb Company Tricyclic compounds as alpha- 7 nicotinic acetylcholine receptor ligands
JP6736661B2 (ja) * 2015-09-04 2020-08-05 ヤンセン ファーマシューティカ エヌ．ベー． 治療化合物及び合成

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135484B2 (en) * 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
RS20060391A (en) * 2003-12-22 2008-11-28 Memory Pharmaceuticals Corporation, Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof
BRPI0614874A2 (pt) * 2005-08-22 2011-04-19 Targacept Inc diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos

Also Published As

Publication number Publication date
AR065705A1 (es) 2009-06-24
TW200840569A (en) 2008-10-16
UY30959A1 (es) 2009-09-30
WO2008112734A1 (en) 2008-09-18
CL2008000726A1 (es) 2008-06-06
US20100144700A1 (en) 2010-06-10

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Legal Events

Date Code Title Description
FX Voluntary withdrawal