RS20060391A - Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof - Google Patents

Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof

Info

Publication number
RS20060391A
RS20060391A YUP-2006/0391A YUP20060391A RS20060391A RS 20060391 A RS20060391 A RS 20060391A YU P20060391 A YUP20060391 A YU P20060391A RS 20060391 A RS20060391 A RS 20060391A
Authority
RS
Serbia
Prior art keywords
benzisoxazoles
benzisothiazoles
indazoles
indoles
preparation
Prior art date
Application number
YUP-2006/0391A
Other languages
Serbian (sr)
Inventor
Ashok Tehim
Brian Herbert
Wenge Xie
Jianguo Ma
Truc Nguyen
Richard Schumacher
Carla-Maria Gauss
Original Assignee
Memory Pharmaceuticals Corporation,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharmaceuticals Corporation, filed Critical Memory Pharmaceuticals Corporation,
Publication of RS20060391A publication Critical patent/RS20060391A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
YUP-2006/0391A 2003-12-22 2004-12-22 Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof RS20060391A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53089103P 2003-12-22 2003-12-22
US60689704P 2004-09-03 2004-09-03
PCT/US2004/042852 WO2005063767A2 (en) 2003-12-22 2004-12-22 Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof

Publications (1)

Publication Number Publication Date
RS20060391A true RS20060391A (en) 2008-11-28

Family

ID=34742980

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2006/0391A RS20060391A (en) 2003-12-22 2004-12-22 Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof

Country Status (22)

Country Link
US (4) US7396833B2 (en)
EP (1) EP1697378B1 (en)
JP (1) JP4824578B2 (en)
KR (1) KR20060120694A (en)
AU (1) AU2004309367B2 (en)
BR (1) BRPI0417323A (en)
CA (1) CA2550689A1 (en)
CR (1) CR8472A (en)
DE (1) DE602004010299T2 (en)
DK (1) DK1697378T3 (en)
EC (1) ECSP066669A (en)
ES (1) ES2295973T3 (en)
IL (1) IL176283A0 (en)
MA (1) MA28228A1 (en)
NO (1) NO20063392L (en)
NZ (1) NZ548228A (en)
PL (1) PL1697378T3 (en)
PT (1) PT1697378E (en)
RS (1) RS20060391A (en)
RU (1) RU2389729C2 (en)
SG (1) SG149830A1 (en)
WO (1) WO2005063767A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007534692A (en) * 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション Indole, 1H-indazole, 1,2-benzisoxazole, 1,2-benzisothiazole, and their preparation and use
WO2006089168A2 (en) * 2005-02-18 2006-08-24 Cornell Research Foundation, Inc. Methods for modulating ion channels
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
AU2006295397A1 (en) * 2005-09-23 2007-04-05 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2007056582A1 (en) * 2005-11-09 2007-05-18 Memory Pharmaceuticals Corporation 1 h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
CN101466703A (en) * 2006-04-11 2009-06-24 弗·哈夫曼-拉罗切有限公司 Heterocyclic GABA alpha subtype selective receptor modulators
WO2008005910A2 (en) * 2006-07-06 2008-01-10 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
TW200840569A (en) * 2007-03-13 2008-10-16 Targacept Inc Sub-type selective amides of diazabicycloalkanes
NZ579645A (en) 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
ES2407647T3 (en) 2008-10-13 2013-06-13 F. Hoffmann-La Roche Ag Diazonium free method to obtain an indazole intermediate in the synthesis of bicyclic acid amides 5- (trifluoromethoxy) -1H-3-carboxylic indazole
JO3250B1 (en) 2009-09-22 2018-09-16 Novartis Ag Use of nicotinic acetylcholine receptor alpha 7 activators
WO2011044506A2 (en) 2009-10-09 2011-04-14 Zafgen Corporation Sulphone compounds and methods of making and using same
MX2012006484A (en) * 2009-12-07 2012-08-01 Targacept Inc 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands.
WO2011085389A1 (en) * 2010-01-11 2011-07-14 Astraea Therapeutics, Llc Nicotinic acetylcholine receptor modulators
US20110172428A1 (en) 2010-01-12 2011-07-14 Shan-Ming Kuang Methods for the preparation of indazole-3-carboxylic acid and n-(s)-1-azabicyclo[2.2.2]oct-3-yl-1h-indazole-3-carboxamide hydrochloride salt
US8242276B2 (en) 2010-06-30 2012-08-14 Hoffmann-La Roche Inc. Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
AU2011281037B2 (en) 2010-07-22 2014-11-27 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2825408A1 (en) 2011-01-26 2012-08-02 Zafgen, Inc. Tetrazole compounds and methods of making and using same
WO2012154676A1 (en) 2011-05-06 2012-11-15 Zafgen Corporation Partially saturated tricyclic compounds and methods of making and using same
BR112013028666A2 (en) 2011-05-06 2017-08-08 Zafgen Inc tricyclic pyrazolo sulfonamide compounds and methods for making and using the same
CA2835195A1 (en) 2011-05-06 2012-11-15 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
US9365495B2 (en) 2011-12-23 2016-06-14 Basf Se Process for manufacturing aryloxyacetamides
MX2014008706A (en) 2012-01-18 2015-03-05 Zafgen Inc Tricyclic sulfonamide compounds and methods of making and using same.
KR20140112566A (en) 2012-01-18 2014-09-23 자프겐 인크. Tricyclic sulfone compounds and methods of making and using same
MX2014012236A (en) * 2012-04-10 2014-11-25 Sumitomo Dainippon Pharma Co Ltd Novel 1-substituted indazole derivative.
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
UY34893A (en) 2012-07-10 2014-02-28 Takeda Pharmaceutical DERIVATIVES OF AZAINDOL
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
AU2013337282A1 (en) 2012-11-05 2015-05-21 Zafgen, Inc. Tricyclic compounds and methods of making and using same
CA2890343A1 (en) 2012-11-05 2014-05-08 Zafgen, Inc. Tricyclic compounds useful in the treatment of liver disorders
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
TW201620904A (en) 2014-01-09 2016-06-16 武田藥品工業有限公司 Azaindole derivatives
KR101532211B1 (en) * 2014-04-30 2015-06-30 세종대학교산학협력단 Pharmaceutical composition and method for treating stoke based on the inhibition of AMPK
WO2016054123A1 (en) 2014-09-30 2016-04-07 Lightner Derek Methods of producing heteropolycycles via bis-epoxidation
DE102015012050A1 (en) * 2015-09-15 2017-03-16 Merck Patent Gmbh Compounds as ASIC inhibitors and their uses
CN111892599B (en) * 2020-08-14 2023-01-13 黄芳 Synthesis method of 2,5-diazabicyclo [2.2.2] octane-2-tert-butyl carboxylate
CN116568678A (en) * 2020-12-08 2023-08-08 达萨玛治疗公司 Benzopyrazole inhibitors of SARM1

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2531083B1 (en) 1982-06-29 1986-11-28 Sandoz Sa NOVEL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
JPS5936675A (en) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト Cyclic carboxylic acid piperidyl ester and amide derivative
FR2548666A1 (en) 1983-07-08 1985-01-11 Delalande Sa New nortropane and granatane derivatives, process for their preparation and their application in therapeutics
DE3429830A1 (en) 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach AUTOMATIC CARBONIC ACID AND SULPHONIC ACID ESTERS OR AMIDES
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
GB8623142D0 (en) 1986-09-26 1986-10-29 Beecham Group Plc Compounds
EP0498466B1 (en) * 1985-04-27 2002-07-24 F. Hoffmann-La Roche Ag Indazole-3-carboxamide and -3-carboxylic acid derivatives
US4937247A (en) * 1985-04-27 1990-06-26 Beecham Group P.L.C. 1-acyl indazoles
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8520616D0 (en) * 1985-08-16 1985-09-25 Beecham Group Plc Compounds
IN166416B (en) * 1985-09-18 1990-05-05 Pfizer
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
GB8701022D0 (en) 1987-01-19 1987-02-18 Beecham Group Plc Treatment
JPH02502185A (en) * 1987-11-14 1990-07-19 ビーチヤム　グループ　ピーエルシー 5-HT3 receptor antagonist for the treatment of cough and bronchoconstriction
US4950759A (en) * 1988-07-07 1990-08-21 Duphar International Research B.V. Substituted 1,7-annelated 1H-indazoles
US4895943A (en) * 1988-10-25 1990-01-23 Pfizer Inc. Preparation of 1,4-diazabicyclo(3.2.2)nonane
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0377238A1 (en) 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
AU5650890A (en) 1989-05-24 1990-12-18 Nippon Shinyaku Co. Ltd. Indole derivatives and medicine
US5446050A (en) * 1989-11-17 1995-08-29 Pfizer Inc. Azabicyclo amides and esters as 5-HT3 receptor antagonists
GB8928837D0 (en) 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5098889A (en) * 1990-09-17 1992-03-24 E. R. Squibb & Sons, Inc. Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors
US5192770A (en) * 1990-12-07 1993-03-09 Syntex (U.S.A.) Inc. Serotonergic alpha-oxoacetamides
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
EP0566609A1 (en) 1991-01-09 1993-10-27 Smithkline Beecham Plc Azabicydic and azatricydic derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
GB9121835D0 (en) 1991-10-15 1991-11-27 Smithkline Beecham Plc Pharmaceuticals
US5273972A (en) * 1992-03-26 1993-12-28 A. H. Robins Company, Incorporated [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
US5679673A (en) * 1992-09-24 1997-10-21 The United States Of America, Represented By The Department Of Health And Human Services Aralkyl bridged diazabicycloalkane derivatives for CNS disorders
IT1256623B (en) * 1992-12-04 1995-12-12 Federico Arcamone TACHYCHININ ANTAGONISTS, PROCEDURE FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL FORMULATIONS
GB9406857D0 (en) * 1994-04-07 1994-06-01 Sandoz Ltd Improvements in or relating to organic compounds
SE9600683D0 (en) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
US5952363A (en) * 1997-03-04 1999-09-14 Novo Nordisk A/S Pyrrolidine compounds useful in the treatment of diabetes
US6624173B1 (en) * 1997-06-30 2003-09-23 Targacept, Inc. Pharmaceutical compositions for treating and/or preventing CNS disorders
US6277870B1 (en) 1998-05-04 2001-08-21 Astra Ab Use
US6953855B2 (en) * 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US7265115B2 (en) * 1999-01-29 2007-09-04 Abbott Laboratories Diazabicyclic CNS active agents
EP1147112B1 (en) * 1999-01-29 2003-10-29 Abbott Laboratories Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
FR2788982B1 (en) 1999-02-02 2002-08-02 Synthelabo PHARMACEUTICAL COMPOSITIONS CONTAINING NICOTINE AND THEIR APPLICATION IN SMOKING WITHDRAWAL
FR2791678B1 (en) 1999-03-30 2001-05-04 Synthelabo 1,4-DIAZABICYCLO [3.2.2] NONANE-4-CARBOXYLATES AND -CARBOXAMIDES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN100466134C (en) 1999-07-12 2009-03-04 三菱电机株式会社 Electromagnetic contactor
SE9903760D0 (en) 1999-10-18 1999-10-18 Astra Ab New compounds
CA2399791A1 (en) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
GB0010955D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
PT1289996E (en) 2000-05-25 2005-07-29 Targacept Inc HETEROARILDIAZABICICLOALCANOS AS NICOTINIC COLINERGIC RECEPTOR LIGANDS
FR2809732B1 (en) 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVATIVES OF 4 (-2-PHENYLTHIAZOL-5-yl) -1,4-DIAZABICYCLO- [3.2.2] NONANE, THEIR PREPARATION AND THEIR THERAPY APPLICATION
JP4616971B2 (en) 2000-07-18 2011-01-19 田辺三菱製薬株式会社 1-azabicycloalkane compounds and pharmaceutical uses thereof
US6492385B2 (en) * 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
AU2002211176A1 (en) 2000-11-01 2002-05-15 Respiratorius Ab Composition comprising serotonin receptor antagonists, 5 ht-2 and 5 ht-3
US20020086871A1 (en) 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
ATE348829T1 (en) * 2001-02-06 2007-01-15 Pfizer Prod Inc PHARMACEUTICAL COMPOSITIONS FOR TREATING CNS DISORDERS OR OTHER DISEASES
PE20021019A1 (en) 2001-04-19 2002-11-13 Upjohn Co SUBSTITUTED AZABYCLE GROUPS
JP2004538268A (en) * 2001-06-01 2004-12-24 ニューロサーチ、アクティーゼルスカブ Novel heteroaryl-diazabicycloalkanes as CNS-modulators
AR036040A1 (en) 2001-06-12 2004-08-04 Upjohn Co MULTICICLIC HETEROARYL COMPOUNDS REPLACED WITH QUINUCLIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR036041A1 (en) 2001-06-12 2004-08-04 Upjohn Co HETEROCICLIC AROMATIC COMPOUNDS REPLACED WITH QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPWO2002100833A1 (en) 2001-06-12 2004-09-24 住友製薬株式会社 Rho kinase inhibitor
JP2005527472A (en) 2001-09-12 2005-09-15 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Substituted 7-aza [2.2.1] bicycloheptane for the treatment of disease
DK1432707T3 (en) * 2001-10-02 2012-06-11 Pharmacia & Upjohn Co Llc AZABICYCLIC-SUBSTITUTED CONDENSED HETEROARYL COMPOUNDS FOR TREATMENT OF DISEASES
US6849620B2 (en) * 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
WO2003037896A1 (en) 2001-10-26 2003-05-08 Pharmacia & Upjohn Company N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists
US6951868B2 (en) 2001-11-09 2005-10-04 Pfizer Inc. Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
DE10156719A1 (en) * 2001-11-19 2003-05-28 Bayer Ag New N-(aza-bicycloalkyl)-benzo-heterocyclic carboxamides, useful as Alpha-7-nicotinic acetylcholine receptor ligands for e.g. improving attention, concentration, learning and/or memory performance
DE10162375A1 (en) 2001-12-19 2003-07-10 Bayer Ag Bicyclic N-aryl amides
DE10305922A1 (en) 2002-06-10 2004-03-04 Bayer Ag New N-azabicyclooctyl bicyclic heteroaryl carboxamides, are alpha 7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance
JP3985139B2 (en) 2002-02-06 2007-10-03 日本ゼオン株式会社 Modified polymers and coating materials
US6894042B2 (en) 2002-02-19 2005-05-17 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
MXPA04007083A (en) * 2002-02-20 2004-10-29 Upjohn Co Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity.
DE10211415A1 (en) 2002-03-15 2003-09-25 Bayer Ag New azabicycloalkyl carboxylic acid N-biarylamides, are alpha-7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance
ES2197001B1 (en) 2002-03-26 2004-11-16 Laboratorios Vita, S.A. PROCEDURE FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND.
NZ535641A (en) 2002-05-07 2006-10-27 Neurosearch As Novel azacyclic ethynyl derivatives
MXPA04011858A (en) 2002-05-30 2005-03-31 Neurosearch As 3-substituted quinuclidines and their use.
EP1515967B1 (en) 2002-06-10 2006-11-02 Bayer HealthCare AG 2-heteroaryl carboxamides
JP2006502133A (en) 2002-08-10 2006-01-19 アステックス、セラピューティックス、リミテッド 3- (Carbonyl) 1H-indazole compounds as cyclin dependent kinase (CDK) inhibitors
GB0218625D0 (en) 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
SE0202465D0 (en) 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
SE0202430D0 (en) 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
FR2845388B1 (en) 2002-10-08 2004-11-12 Sanofi Synthelabo 1,4-DIAZABICYCLO [3.2.2] NONANECARBOXAMIDES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US7456171B2 (en) * 2002-10-08 2008-11-25 Sanofi-Aventis 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof
US6945618B2 (en) 2003-06-02 2005-09-20 Accuride International Inc. Drawer slide adjustment mechanism
TW200529860A (en) * 2003-12-22 2005-09-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
JP2005230084A (en) 2004-02-17 2005-09-02 Olympus Corp Balloon attaching tool
JP2007534692A (en) * 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション Indole, 1H-indazole, 1,2-benzisoxazole, 1,2-benzisothiazole, and their preparation and use

Also Published As

Publication number Publication date
US20110312989A1 (en) 2011-12-22
DE602004010299D1 (en) 2008-01-03
WO2005063767A3 (en) 2005-08-25
CR8472A (en) 2007-09-07
EP1697378B1 (en) 2007-11-21
ECSP066669A (en) 2006-10-25
JP4824578B2 (en) 2011-11-30
RU2389729C2 (en) 2010-05-20
US7964600B2 (en) 2011-06-21
RU2006126540A (en) 2008-01-27
DE602004010299T2 (en) 2008-09-18
IL176283A0 (en) 2006-10-05
CA2550689A1 (en) 2005-07-14
PL1697378T3 (en) 2008-04-30
MA28228A1 (en) 2006-10-02
PT1697378E (en) 2008-02-28
US7790722B2 (en) 2010-09-07
US7396833B2 (en) 2008-07-08
NZ548228A (en) 2009-04-30
SG149830A1 (en) 2009-02-27
US8158629B2 (en) 2012-04-17
KR20060120694A (en) 2006-11-27
ES2295973T3 (en) 2008-04-16
US20090088437A1 (en) 2009-04-02
NO20063392L (en) 2006-09-21
US20110028483A1 (en) 2011-02-03
BRPI0417323A (en) 2007-03-27
AU2004309367B2 (en) 2010-04-01
EP1697378A2 (en) 2006-09-06
WO2005063767A2 (en) 2005-07-14
AU2004309367A1 (en) 2005-07-14
DK1697378T3 (en) 2008-03-17
US20050176754A1 (en) 2005-08-11
JP2007515424A (en) 2007-06-14

Similar Documents

Publication Publication Date Title
RS20060391A (en) Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof
RS20050248A (en) Indazole, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
MX2007007328A (en) Nicotinic alpha-7 receptor ligands and preparation and uses thereof.
WO2005111038A3 (en) 1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
SG165199A1 (en) Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
DE602005024677D1 (en) INDOLE, 1H-INDAZOLE, 1,2-BENZOOXAZOLE, 1,2-BENZOISOTHIAZOLE, THEIR PREPARATION AND USES
SG165417A1 (en) Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
WO2005080343A3 (en) 3-substituted 1,5-diphenylpyrazole derivatives useful as cb1 modulators
WO2006067428A3 (en) 1, 2-diphenyl-imidazole derivatives and their use as cb1 receptor ligands
TW200635903A (en) Therapeutic agents
WO2005089118A3 (en) Novel bicyclic compounds as modulators of androgen receptor function and method
TW200612892A (en) Novel compounds
TW200504034A (en) Therapeutic agents
EP1590336A4 (en) Substituted pyrazoles, compositions containing such compounds and methods of use
TW200505837A (en) Novel compounds
TW200519075A (en) Novel compounds
MX2007010414A (en) Pyridine-2-carboxamide derivatives as mglur5 antagonists.
WO2004089366A8 (en) Bicyclic compounds as nr2b receptor antagonists
TW200509933A (en) Therapeutic agents
TW200734324A (en) Therapeutic agents
TNSN06301A1 (en) Indazoles,benzothiazoles,benzoisothiazoles,benzisoxazoles,and preparation and uses thereof
MX2008002065A (en) Pyrazole derivatives as therapeutic agents.
MX2010004300A (en) (1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methanone ligands for nicotinic acetylcholine receptors, useful for the treatment of disease.
WO2006018708A3 (en) Pyrrolidine derivatives as muscarinic receptor antagonists
GB0514811D0 (en) Compounds