UY30959A1 - Subtipo de amidas selectivas de diazabicicloalcanos - Google Patents

Subtipo de amidas selectivas de diazabicicloalcanos

Info

Publication number
UY30959A1
UY30959A1 UY030959A UY30959A UY30959A1 UY 30959 A1 UY30959 A1 UY 30959A1 UY 030959 A UY030959 A UY 030959A UY 30959 A UY30959 A UY 30959A UY 30959 A1 UY30959 A1 UY 30959A1
Authority
UY
Uruguay
Prior art keywords
compounds
subtipo
diazabicicloalcanos
amidas
selective
Prior art date
Application number
UY030959A
Other languages
English (en)
Inventor
Akireddy Srinivasa Rao
David C Kombo
Murthy V Srinivasa
Strachan Jon-Paul
Bhatti Balwinder
Xiao Yun-De
Miao Lan
Anatoly A Mazurov
Phillip S Hammond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY30959A1 publication Critical patent/UY30959A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de amida que pueden prepararse a partir de ácidos carboxílicos heteroarilos y diazabicicloalcanos, composiciones farmacéuticas incluyendo los compuestos, y métodos de preparación y uso de los mismos. Dichos compuestos exhiben selectividad y se unen con alta afinidad a receptores nicotínicos de subtipo a(alfa)4B(Beta)2 en el sistema nervioso central (SNC) y pueden utilizarse para tratar y/o prevenir enfermedades o trastornos del SNC. Se cree que alteran el número de receptores colinérgicos nicotínicos del cerebro del paciente, exhiben efectos neuroprotectores y no muestran efectos negativos en la presión sanguínea, en el tracto intestinal y en el músculo esquelético.
UY030959A 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos UY30959A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90676207P 2007-03-13 2007-03-13

Publications (1)

Publication Number Publication Date
UY30959A1 true UY30959A1 (es) 2009-09-30

Family

ID=39580235

Family Applications (1)

Application Number Title Priority Date Filing Date
UY030959A UY30959A1 (es) 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos

Country Status (7)

Country Link
US (1) US20100144700A1 (es)
AR (1) AR065705A1 (es)
CL (1) CL2008000726A1 (es)
PE (1) PE20081893A1 (es)
TW (1) TW200840569A (es)
UY (1) UY30959A1 (es)
WO (1) WO2008112734A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110263629A1 (en) * 2008-09-05 2011-10-27 Targacept, Inc. Amides of diazabicyclooctanes and uses thereof
MX2011014019A (es) * 2009-06-19 2012-02-22 Abbott Lab Derivados de diazahomoadamantano y sus metodos de uso.
MX2012006484A (es) 2009-12-07 2012-08-01 Targacept Inc 3,6-diazabiciclo [3.1.1] heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina.
WO2015191401A1 (en) * 2014-06-13 2015-12-17 Bristol-Myers Squibb Company Tricyclic compounds as alpha- 7 nicotinic acetylcholine receptor ligands
JP6736661B2 (ja) * 2015-09-04 2020-08-05 ヤンセン ファーマシューティカ エヌ．ベー． 治療化合物及び合成

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135484B2 (en) * 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
RS20060391A (en) * 2003-12-22 2008-11-28 Memory Pharmaceuticals Corporation, Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof
BRPI0614874A2 (pt) * 2005-08-22 2011-04-19 Targacept Inc diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos

Also Published As

Publication number Publication date
AR065705A1 (es) 2009-06-24
TW200840569A (en) 2008-10-16
WO2008112734A1 (en) 2008-09-18
PE20081893A1 (es) 2009-02-15
CL2008000726A1 (es) 2008-06-06
US20100144700A1 (en) 2010-06-10

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20170912