RU2019135690A - Терапевтическое средство для лечения болезни телец леви, содержащее производное пиразолохинолина - Google Patents
Терапевтическое средство для лечения болезни телец леви, содержащее производное пиразолохинолина Download PDFInfo
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- RU2019135690A RU2019135690A RU2019135690A RU2019135690A RU2019135690A RU 2019135690 A RU2019135690 A RU 2019135690A RU 2019135690 A RU2019135690 A RU 2019135690A RU 2019135690 A RU2019135690 A RU 2019135690A RU 2019135690 A RU2019135690 A RU 2019135690A
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- Prior art keywords
- disease
- treatment
- therapeutic agent
- dementia
- body containing
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 3
- 229940124597 therapeutic agent Drugs 0.000 title claims 3
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- CKJDCNZBABIEBZ-HNNXBMFYSA-N 7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-[(3S)-oxolan-3-yl]-5H-pyrazolo[4,3-c]quinolin-4-one Chemical compound COC1=NC=C(C)C(C=2C=C3NC(=O)C=4C=NN(C=4C3=CC=2)[C@@H]2COCC2)=C1C CKJDCNZBABIEBZ-HNNXBMFYSA-N 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 201000002832 Lewy body dementia Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000009829 Lewy Body Disease Diseases 0.000 claims 3
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (12)
1. Терапевтическое средство для лечения деменции с тельцами Леви или болезни Паркинсона с деменцией, содержащее (S)–7–(2–метокси–3,5–диметилпиридин–4–ил)–1–(тетрагидрофуран–3–ил)–1H–пиразолo[4,3–c]хинолин–4(5H)–он, представленный формулой (I):
или его фармацевтически приемлемую соль.
2. Способ лечения деменции с тельцами Леви или болезни Паркинсона с деменцией, включающий введение (S)–7–(2–метокси–3,5–диметилпиридин–4–ил)–1–(тетрагидрофуран–3–ил)–1H–пиразолo[4,3–c]хинолин–4(5H)–она, представленного формулой (I):
или его фармацевтически приемлемой соли пациенту, нуждающемуся в этом.
3. (S)–7–(2–Метокси–3,5–диметилпиридин–4–ил)–1–(тетрагидрофуран–3–ил)–1H–пиразолo[4,3–c]хинолин–4(5H)–он, представленный формулой (I):
или его фармацевтически приемлемая соль для применения в лечении деменции с тельцами Леви или болезни Паркинсона с деменцией.
4. Применение (S)–7–(2–метокси–3,5–диметилпиридин–4–ил)–1–(тетрагидрофуран–3–ил)–1H–пиразолo[4,3–c]хинолин–4(5H)–она, представленного формулой (I):
или его фармацевтически приемлемой соли для изготовления терапевтического средства для лечения деменции с тельцами Леви или болезни Паркинсона с деменцией.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762513727P | 2017-06-01 | 2017-06-01 | |
US62/513,727 | 2017-06-01 | ||
PCT/JP2018/020650 WO2018221551A1 (ja) | 2017-06-01 | 2018-05-30 | ピラゾロキノリン誘導体を含有するレビー小体病治療剤 |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2019135690A true RU2019135690A (ru) | 2021-07-13 |
RU2019135690A3 RU2019135690A3 (ru) | 2021-08-25 |
RU2802212C2 RU2802212C2 (ru) | 2023-08-23 |
Family
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Also Published As
Publication number | Publication date |
---|---|
JP7269875B2 (ja) | 2023-05-09 |
ES2961554T3 (es) | 2024-03-12 |
IL270357B2 (en) | 2024-02-01 |
IL270357B1 (en) | 2023-10-01 |
EP3632438A1 (en) | 2020-04-08 |
TW201902479A (zh) | 2019-01-16 |
RU2019135690A3 (ru) | 2021-08-25 |
US11311530B2 (en) | 2022-04-26 |
EP3632438B1 (en) | 2023-08-23 |
TWI784006B (zh) | 2022-11-21 |
IL270357A (ru) | 2020-02-27 |
US20200155541A1 (en) | 2020-05-21 |
CA3061884A1 (en) | 2019-10-29 |
MX2019013397A (es) | 2020-02-07 |
CN110612102A (zh) | 2019-12-24 |
AU2018278422A1 (en) | 2019-11-21 |
EP3632438A4 (en) | 2020-12-23 |
JPWO2018221551A1 (ja) | 2020-04-02 |
KR20200010220A (ko) | 2020-01-30 |
WO2018221551A1 (ja) | 2018-12-06 |
AU2018278422B2 (en) | 2022-03-17 |
BR112019023552A2 (pt) | 2020-06-02 |
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