ATE538099T1 - 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden - Google Patents

2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden

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Publication number
ATE538099T1
ATE538099T1 AT07867264T AT07867264T ATE538099T1 AT E538099 T1 ATE538099 T1 AT E538099T1 AT 07867264 T AT07867264 T AT 07867264T AT 07867264 T AT07867264 T AT 07867264T AT E538099 T1 ATE538099 T1 AT E538099T1
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Austria
Prior art keywords
phenyl
hydroxy
methyl
derivatives
glucocorticoid receptor
Prior art date
Application number
AT07867264T
Other languages
English (en)
Inventor
Christopher J Bungard
Jesse J Manikowski
James J Perkins
Robert Meissner
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Merck Sharp & Dohme
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Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
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Publication of ATE538099T1 publication Critical patent/ATE538099T1/de

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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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AT07867264T 2006-10-23 2007-10-23 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden ATE538099T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85365506P 2006-10-23 2006-10-23
US92333707P 2007-04-13 2007-04-13
PCT/US2007/022449 WO2008060391A2 (en) 2006-10-23 2007-10-23 2- [l-phenyl-5-hydr0xy-4alpha-methyl-hexahydr0cycl0penta[f] indaz0l-5-yl] ethyl phenyl derivatives as glucocorticoid receptor ligands

Publications (1)

Publication Number Publication Date
ATE538099T1 true ATE538099T1 (de) 2012-01-15

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AT07867264T ATE538099T1 (de) 2006-10-23 2007-10-23 2-ä1-phenyl-5-hydroxy-4-alpha-methyl- hexahydrocyclopentaäfüindazol-5- ylüethylphenylderivate als glucocorticoidrezeptorliganden

Country Status (19)

Country Link
US (1) US8119681B2 (de)
EP (2) EP2091922B1 (de)
JP (1) JP5271911B2 (de)
KR (1) KR20090068345A (de)
CN (1) CN101528707B (de)
AT (1) ATE538099T1 (de)
AU (1) AU2007309507A1 (de)
BR (1) BRPI0718505A2 (de)
CA (1) CA2667007A1 (de)
CO (1) CO6190517A2 (de)
CR (1) CR10771A (de)
EA (1) EA200970401A1 (de)
IL (1) IL198226A0 (de)
MA (1) MA30870B1 (de)
MX (1) MX2009004385A (de)
NO (1) NO20092004L (de)
SV (1) SV2009003233A (de)
TN (1) TN2009000149A1 (de)
WO (2) WO2008051532A1 (de)

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TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2009050136A2 (en) * 2007-10-17 2009-04-23 Laboratoire Hra Pharma Glucocorticoid receptor antagonists such as mifepristone for treating cushing' s syndrome
EP2212294A1 (de) * 2007-10-23 2010-08-04 Merck Sharp & Dohme Corp. Verfahren zur herstellung von glucocorticoidrezeptorliganden
UY31832A (es) 2008-05-20 2010-01-05 Astrazeneca Ab Derivados de indazol sustituidos con fenilo y benzodioxinilo
WO2010138421A1 (en) * 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. HEXAHYDROCYCLOPENTYL[f]INDAZOLE REVERSED AMIDES AND DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
EP2459190A4 (de) 2009-06-02 2012-12-12 Merck Sharp & Dohme Hexahydrocyclopentyl-[?]indazol-5-hydroxymethyl-ethanole und derivate davon als selektive glucocorticoid-rezeptor-modulatoren
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