|
US5538983A
(en)
|
1990-05-16 |
1996-07-23 |
The Rockefeller University |
Method of treating amyloidosis by modulation of calcium
|
|
WO1993003034A1
(en)
|
1991-07-29 |
1993-02-18 |
Warner-Lambert Company |
Quinazoline derivatives as acetylcholinesterase inhibitors
|
|
IT1255179B
(it)
|
1992-06-26 |
1995-10-20 |
Enzo Cereda |
Azaciclo e azabiciclo alchiliden idrossilamine
|
|
US5744476A
(en)
|
1994-06-27 |
1998-04-28 |
Interneuron Pharmaceuticals, Inc. |
Dopamine D1 agonists for the treatment of dementia
|
|
JP2992677B2
(ja)
|
1995-06-05 |
1999-12-20 |
武田薬品工業株式会社 |
骨形成促進医薬組成物
|
|
AU5716898A
(en)
|
1997-01-08 |
1998-08-03 |
Warner-Lambert Company |
Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
|
|
WO1999036384A1
(en)
*
|
1998-01-16 |
1999-07-22 |
Purdue Research Foundation |
Alkenyldiarylmethane non-nucleoside hiv-1 reverse transcriptase inhibitors
|
|
HUP0101810A3
(en)
|
1998-01-27 |
2002-05-28 |
Aventis Pharm Prod Inc |
Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them
|
|
JP2003529531A
(ja)
|
1998-11-25 |
2003-10-07 |
アヴェンティス ファーマシューティカルズ インコーポレイテッド |
置換オキソアザへテロシクリルＸａ因子阻害剤
|
|
JP4829449B2
(ja)
|
1999-07-28 |
2011-12-07 |
アベンティス・ファーマスーティカルズ・インコーポレイテツド |
置換オキソアザヘテロシクリル化合物
|
|
JP2001131173A
(ja)
*
|
1999-08-23 |
2001-05-15 |
Kyorin Pharmaceut Co Ltd |
二環式複素環誘導体
|
|
JP2005231995A
(ja)
|
1999-12-22 |
2005-09-02 |
Meiji Seika Kaisha Ltd |
オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物
|
|
US7084126B1
(en)
|
2000-05-01 |
2006-08-01 |
Healthpartners Research Foundation |
Methods and compositions for enhancing cellular function through protection of tissue components
|
|
AU2001268055A1
(en)
|
2000-06-30 |
2002-01-14 |
Eli Lilly And Company |
Combination for treating psychoses, comprising an antipsychotic and a muscarinic agonist
|
|
WO2002074293A2
(en)
|
2001-03-15 |
2002-09-26 |
Saegis Pharmaceuticals Inc |
Methods for restoring cognitive function following systemic stress
|
|
US20040023951A1
(en)
|
2001-06-18 |
2004-02-05 |
Bymaster Franklin Porter |
Combination therapy for treatment of psychoses
|
|
US20030004913A1
(en)
|
2001-07-02 |
2003-01-02 |
Koninklijke Philips Electronics N.V. |
Vision-based method and apparatus for detecting an event requiring assistance or documentation
|
|
HUP0402279A3
(en)
|
2001-11-26 |
2008-09-29 |
Cortex Pharmaceuticals |
Heterocondensated benzo[e][1,3]oxazin-4-one compounds for enhancing glutamatergic synaptic responses and pharmaceutical compositions containing them
|
|
US20040044023A1
(en)
|
2002-08-30 |
2004-03-04 |
Marc Cantillon |
Compositions and methods for treating or preventing memory impairment
|
|
US20060233843A1
(en)
|
2003-02-19 |
2006-10-19 |
Conn P J |
Treatment of psychosis with a muscarinic m1 receptor ectopic activator
|
|
BRPI0409523A
(pt)
|
2003-03-28 |
2006-04-18 |
Acadia Pharm Inc |
método para o tratamento da dor neuropática, método de identificação de um composto e composição farmacêutica
|
|
US20040266659A1
(en)
|
2003-06-27 |
2004-12-30 |
Stephen LaBerge |
Substances that enhance recall and lucidity during dreaming
|
|
GB0504019D0
(en)
|
2005-02-26 |
2005-04-06 |
Astrazeneca Ab |
Amide derivatives
|
|
JP2008537961A
(ja)
|
2005-04-15 |
2008-10-02 |
ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ |
Ｇｐｃｒモジュレーター
|
|
GB0516570D0
(en)
|
2005-08-12 |
2005-09-21 |
Astrazeneca Ab |
Amide derivatives
|
|
US20110319386A1
(en)
|
2005-08-26 |
2011-12-29 |
Braincells Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
WO2007025177A2
(en)
|
2005-08-26 |
2007-03-01 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
WO2007044937A2
(en)
|
2005-10-13 |
2007-04-19 |
President And Fellows Of Harvard College |
Compositions and methods to modulate memory
|
|
WO2007075567A1
(en)
|
2005-12-21 |
2007-07-05 |
Janssen Pharmaceutica, N.V. |
Triazolopyridazines as tyrosine kinase modulators
|
|
GB0607949D0
(en)
|
2006-04-21 |
2006-05-31 |
Minster Res The Ltd |
Mono and combination therapy
|
|
GB0607946D0
(en)
|
2006-04-21 |
2006-05-31 |
Minster Res The Ltd |
Mono and combination therapy
|
|
GB0607952D0
(en)
|
2006-04-21 |
2006-05-31 |
Minster Res Ltd |
Novel treatment
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20121506A1
(es)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
|
US7834023B2
(en)
|
2006-09-20 |
2010-11-16 |
Portola Pharmaceuticals, Inc. |
Substituted dihydroquinazolines as platelet ADP receptor inhibitors
|
|
SG163545A1
(en)
|
2007-01-03 |
2010-08-30 |
Servier Lab |
3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
|
|
WO2008113072A2
(en)
|
2007-03-15 |
2008-09-18 |
Board Of Regents, The University Of Texas System |
Gpcr enhanced neuroprotection to treat brain injury
|
|
AU2008295484B2
(en)
|
2007-08-29 |
2013-09-26 |
Merck Sharp & Dohme Llc |
Substituted indole derivatives and methods of use thereof
|
|
KR20100049667A
(ko)
|
2007-08-29 |
2010-05-12 |
쉐링 코포레이션 |
바이러스 감염 치료용 2,3-치환된 인돌 유도체
|
|
AR068108A1
(es)
|
2007-08-29 |
2009-11-04 |
Schering Corp |
Derivados azaindol 2,3-sustituidos y una composicion farmaceutica
|
|
US20090082342A1
(en)
|
2007-09-21 |
2009-03-26 |
Acadia Pharmaceuticals, Inc. |
N-substituted piperidine derivatives as serotonin receptor agents
|
|
WO2009039460A2
(en)
|
2007-09-21 |
2009-03-26 |
Acadia Pharmaceuticals, Inc. |
Co-administration of pimavanserin with other agents
|
|
CN102099351A
(zh)
|
2007-11-16 |
2011-06-15 |
先灵公司 |
3-杂环取代的吲哚衍生物及其使用方法
|
|
US8377928B2
(en)
|
2007-11-16 |
2013-02-19 |
Merck Sharp & Dohme Corp. |
3-aminosulfonyl substituted indole derivatives and methods of use thereof
|
|
US20110024198A1
(en)
|
2008-02-19 |
2011-02-03 |
Baker Hughes Incorporated |
Bearing systems containing diamond enhanced materials and downhole applications for same
|
|
WO2010042603A1
(en)
|
2008-10-08 |
2010-04-15 |
Cingulate Neuro Therapeutics, Llc |
Amyloid and depression
|
|
PT2358686E
(pt)
*
|
2008-11-20 |
2012-12-06 |
Merck Sharp & Dohme |
Moduladores alostéricos positivos do recetor m1 de aril metil benzoquinazolinona
|
|
JP2012518640A
(ja)
|
2009-02-23 |
2012-08-16 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピラゾロ［４，３−ｃ］シンノリン−３−オンＭ１受容体陽性アロステリックモジュレーター
|
|
CA2754203A1
(en)
|
2009-03-05 |
2010-09-10 |
Mithridion, Inc. |
Compounds and compositions for cognition-enhancement, methods of making, and methods of treating
|
|
WO2010123716A1
(en)
|
2009-04-20 |
2010-10-28 |
Merck Sharp & Dohme Corp. |
Heterocyclic fused cinnoline m1 receptor positive allosteric modulators
|
|
ES2353093B1
(es)
|
2009-05-20 |
2012-01-03 |
Consejo Superior De Investigaciones Científicas (Csic) |
Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
|
|
EP3061821B1
(en)
|
2009-07-22 |
2019-07-10 |
Puretech Health LLC |
Compositions for treatment of disorders ameliorated by muscarinic receptor activation
|
|
US10265311B2
(en)
|
2009-07-22 |
2019-04-23 |
PureTech Health LLC |
Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
|
|
ES2537979T3
(es)
*
|
2009-08-31 |
2015-06-16 |
Merck Sharp & Dohme Corp. |
Moduladores alostéricos positivos del receptor M1 de piranilarilmetilbenzoquinazolinona
|
|
EP2490692B1
(en)
|
2009-10-21 |
2016-11-16 |
Merck Sharp & Dohme Corp. |
Quinolinone-pyrazolone m1 receptor positive allosteric modulators
|
|
US8664387B2
(en)
|
2009-12-14 |
2014-03-04 |
Merck Sharp & Dohme Corp. |
Pyridoquinazolinone M1 receptor positive allosteric modulators
|
|
US8383638B2
(en)
|
2009-12-21 |
2013-02-26 |
Merck Sharp & Dohme |
Aminobenzoquinazolinone M1 receptor positive allosteric modulators
|
|
WO2011159553A1
(en)
|
2010-06-15 |
2011-12-22 |
Merck Sharp & Dohme Corp. |
Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators
|
|
EP2588104B1
(en)
|
2010-07-01 |
2014-12-10 |
Merck Sharp & Dohme Corp. |
Isoindolone m1 receptor positive allosteric modulators
|
|
US8664234B2
(en)
|
2010-10-04 |
2014-03-04 |
Merck Sharp & Dohme Corp. |
Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators
|
|
US9549928B2
(en)
|
2011-04-29 |
2017-01-24 |
The University Of Toledo |
Muscarinic agonists as enhancers of cognitive flexibility
|
|
EP2709624B1
(en)
*
|
2011-05-17 |
2016-04-27 |
Merck Sharp & Dohme Corp. |
N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators
|
|
WO2012170599A1
(en)
|
2011-06-10 |
2012-12-13 |
Braincells, Inc. |
Neurogenesis by muscarinic receptor modulation
|
|
US9403802B2
(en)
|
2012-03-02 |
2016-08-02 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use therefor
|
|
EP2828247B1
(en)
|
2012-03-23 |
2019-01-16 |
PTC Therapeutics, Inc. |
4h-chromen-4-one derivatives for treating spinal muscular atrophy
|
|
US20130289019A1
(en)
|
2012-04-26 |
2013-10-31 |
Amazing Grace, Inc. |
Methods of treating behaviorial and/or mental disorders
|
|
US9777005B2
(en)
|
2012-11-19 |
2017-10-03 |
Takeda Pharmaceutical Company Limited |
Bicyclic heterocyclic compound containing a substituted pyrrole ring
|
|
JP6075408B2
(ja)
|
2012-11-22 |
2017-02-08 |
株式会社デンソー |
物標検出装置
|
|
RU2642779C2
(ru)
|
2012-12-27 |
2018-01-26 |
Ф.Хоффманн-Ля Рош Аг |
Ингибиторы сомт
|
|
CN104955826B
(zh)
|
2013-02-04 |
2019-05-31 |
默克专利股份公司 |
可用于治疗神经学疾病和病症的螺-喹唑酮衍生物
|
|
US10738024B2
(en)
|
2013-05-06 |
2020-08-11 |
Indiana University Research And Technology Corporation |
Compounds for treatment of angiogenesis-mediated diseases
|
|
JP6063400B2
(ja)
|
2014-01-08 |
2017-01-18 |
株式会社日立ビルシステム |
エレベータの異常監視装置
|
|
ES2811088T3
(es)
|
2014-04-23 |
2021-03-10 |
Takeda Pharmaceuticals Co |
Derivados de isoindolin-1-ona como actividad del modulador alostérico positivo del receptor M1 muscarínico colinérgico para el tratamiento de la enfermedad de Alzheimer
|
|
JP6531093B2
(ja)
|
2014-05-16 |
2019-06-12 |
武田薬品工業株式会社 |
含窒素複素環化合物
|
|
WO2015190564A1
(ja)
|
2014-06-13 |
2015-12-17 |
武田薬品工業株式会社 |
含窒素複素環化合物
|
|
KR20180019234A
(ko)
*
|
2015-06-26 |
2018-02-23 |
다케다 야쿠힌 고교 가부시키가이샤 |
콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체
|
|
US20180250270A1
(en)
|
2015-09-11 |
2018-09-06 |
Chase Pharmaceuticals Corporation |
Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
|
|
US10548899B2
(en)
|
2015-10-20 |
2020-02-04 |
Takeda Pharmaceutical Company Limited |
Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity
|
|
JP6860551B2
(ja)
|
2016-03-11 |
2021-04-14 |
武田薬品工業株式会社 |
芳香環化合物
|
|
WO2018122845A1
(en)
|
2016-12-29 |
2018-07-05 |
Rvx Therapeutics Ltd. |
Methods and compositions for potentiating cns drugs and reducing their side effects
|