JP2018530591A5 - - Google Patents

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Publication number
JP2018530591A5
JP2018530591A5 JP2018519425A JP2018519425A JP2018530591A5 JP 2018530591 A5 JP2018530591 A5 JP 2018530591A5 JP 2018519425 A JP2018519425 A JP 2018519425A JP 2018519425 A JP2018519425 A JP 2018519425A JP 2018530591 A5 JP2018530591 A5 JP 2018530591A5
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JP
Japan
Prior art keywords
carbonyl
dimethoxyphenyl
pyridine
diol
butyl
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JP2018519425A
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English (en)
Japanese (ja)
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JP6837482B2 (ja
JP2018530591A (ja
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Priority claimed from PCT/US2016/056769 external-priority patent/WO2017066402A1/en
Publication of JP2018530591A publication Critical patent/JP2018530591A/ja
Publication of JP2018530591A5 publication Critical patent/JP2018530591A5/ja
Application granted granted Critical
Publication of JP6837482B2 publication Critical patent/JP6837482B2/ja
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JP2018519425A 2015-10-14 2016-10-13 Apjアゴニストとしての2,4−ジヒドロキシ−ニコチンアミド Active JP6837482B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562241367P 2015-10-14 2015-10-14
US62/241,367 2015-10-14
US201562270659P 2015-12-22 2015-12-22
US62/270,659 2015-12-22
PCT/US2016/056769 WO2017066402A1 (en) 2015-10-14 2016-10-13 2,4-dihydroxy-nicotinamides as apj agonists

Publications (3)

Publication Number Publication Date
JP2018530591A JP2018530591A (ja) 2018-10-18
JP2018530591A5 true JP2018530591A5 (enExample) 2019-11-21
JP6837482B2 JP6837482B2 (ja) 2021-03-03

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ID=57178558

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JP2018519425A Active JP6837482B2 (ja) 2015-10-14 2016-10-13 Apjアゴニストとしての2,4−ジヒドロキシ−ニコチンアミド

Country Status (20)

Country Link
US (1) US10392347B2 (enExample)
EP (1) EP3362442B1 (enExample)
JP (1) JP6837482B2 (enExample)
KR (1) KR102707502B1 (enExample)
CN (1) CN108368087B (enExample)
AU (1) AU2016340264B2 (enExample)
BR (1) BR112018007395A2 (enExample)
CA (1) CA3001974A1 (enExample)
CL (1) CL2018000953A1 (enExample)
CO (1) CO2018004968A2 (enExample)
EA (1) EA034857B1 (enExample)
ES (1) ES2774945T3 (enExample)
IL (1) IL258577B (enExample)
MX (1) MX376824B (enExample)
PE (1) PE20181197A1 (enExample)
SG (1) SG10201908839QA (enExample)
TW (1) TW201720796A (enExample)
UY (1) UY36949A (enExample)
WO (1) WO2017066402A1 (enExample)
ZA (1) ZA201802451B (enExample)

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US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
WO2018097944A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
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MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
MA52487A (fr) 2018-05-01 2021-03-10 Amgen Inc Pyrimidinones substituées en tant qu'agonistes du récepteur apj
WO2025153720A1 (en) * 2024-01-19 2025-07-24 Scenic Biotech Bv Pla2g15 inhibitors
WO2026077457A1 (zh) * 2024-10-12 2026-04-16 珠海联邦制药股份有限公司 一种apj受体激动剂类化合物的制备及其应用

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CA2988147C (en) 2015-06-03 2023-06-13 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
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BR112018010720A8 (pt) 2015-12-04 2019-02-26 Bristol Myers Squibb Co agonistas do receptor de apelina e métodos de uso
ES2854733T3 (es) 2015-12-16 2021-09-22 Bristol Myers Squibb Co Heteroarilhidroxipirimidinonas como agonistas del receptor APJ
TWI744301B (zh) 2016-03-24 2021-11-01 美商必治妥美雅史谷比公司 做為apj促效劑之6-羥基-4-側氧-1,4-二氫嘧啶-5-甲醯胺
WO2017218633A1 (en) 2016-06-14 2017-12-21 Bristol-Myers Squibb Company 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1h)-one as apj agonists
ES2844184T3 (es) 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ
CN110072850B (zh) 2016-10-14 2023-07-21 百时美施贵宝公司 3-磺酰基-5-氨基吡啶-2,4-二醇apj激动剂

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