JP2014520885A5 - - Google Patents

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Publication number
JP2014520885A5
JP2014520885A5 JP2014521703A JP2014521703A JP2014520885A5 JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5 JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014521703 A JP2014521703 A JP 2014521703A JP 2014520885 A5 JP2014520885 A5 JP 2014520885A5
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JP
Japan
Prior art keywords
methyloxy
membered
pyrrolidin
oxo
acceptable salt
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JP2014521703A
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English (en)
Japanese (ja)
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JP2014520885A (ja
JP5987220B2 (ja
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Priority claimed from PCT/US2012/047024 external-priority patent/WO2013012844A1/en
Publication of JP2014520885A publication Critical patent/JP2014520885A/ja
Publication of JP2014520885A5 publication Critical patent/JP2014520885A5/ja
Application granted granted Critical
Publication of JP5987220B2 publication Critical patent/JP5987220B2/ja
Active legal-status Critical Current
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JP2014521703A 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル Active JP5987220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509155P 2011-07-19 2011-07-19
US61/509,155 2011-07-19
PCT/US2012/047024 WO2013012844A1 (en) 2011-07-19 2012-07-17 Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase

Publications (3)

Publication Number Publication Date
JP2014520885A JP2014520885A (ja) 2014-08-25
JP2014520885A5 true JP2014520885A5 (enExample) 2015-09-03
JP5987220B2 JP5987220B2 (ja) 2016-09-07

Family

ID=46551949

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014521703A Active JP5987220B2 (ja) 2011-07-19 2012-07-17 ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル

Country Status (4)

Country Link
US (1) US9139567B2 (enExample)
EP (1) EP2734516B1 (enExample)
JP (1) JP5987220B2 (enExample)
WO (1) WO2013012844A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551982B2 (en) 2011-03-14 2013-10-08 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
JP6080226B2 (ja) 2012-03-06 2017-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン
EP2822942B1 (en) 2012-03-06 2017-05-10 Boehringer Ingelheim International GmbH Benzodioxanes for inhibiting leukotriene production
WO2013142369A1 (en) 2012-03-23 2013-09-26 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pulmonary hypertension with leukotriene inhibitors
EP2885285B1 (en) 2012-07-17 2016-10-19 Boehringer Ingelheim International GmbH Pyrazole drivatives which inhibit leukotriene production
JP6353899B2 (ja) * 2013-07-15 2018-07-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
US9573957B2 (en) 2013-07-15 2017-02-21 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
WO2018167800A1 (en) * 2017-03-13 2018-09-20 Impetis Biosciences Limited Fused bicyclic compounds, compositions and applications thereof
GB201815018D0 (en) * 2018-09-14 2018-10-31 Univ Oxford Innovation Ltd Enantiomeric compounds
EP3908279B1 (en) * 2019-01-11 2024-08-28 Novartis AG Lta4h inhibitor for the treatment or prevention of hidradenitis suppurativa
KR20230051227A (ko) 2020-08-14 2023-04-17 노파르티스 아게 헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Family Cites Families (21)

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US4918092A (en) 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US5120758A (en) 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
DE19821003A1 (de) 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PL362919A1 (en) * 2000-10-26 2004-11-02 Pfizer Products Inc. Pyrimidine-2,4,6-trione metalloproteinase inhibitors
US20060019269A1 (en) 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
ATE441417T1 (de) 2002-12-20 2009-09-15 Glaxo Group Ltd Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
BRPI0518508A2 (pt) 2005-01-07 2008-11-25 Pfizer Prod Inc compostos de quinolina heteroaromÁticos e seu uso como inibidores de pde10
KR20080003385A (ko) 2005-03-31 2008-01-07 얀센 파마슈티카 엔.브이. 페닐 및 피리딜 ｌｔａ４ｈ 조절제
JP5133889B2 (ja) * 2005-09-21 2013-01-30 デコード ジェネティクス イーエイチエフ 炎症治療のためのビアリール基置換複素環ｌｔａ４ｈ阻害剤
AU2006327243A1 (en) 2005-12-21 2007-06-28 Decode Genetics Ehf N-linked aryl heteroaryl inhibitors of LTA4H for treating inflammation
US7576102B2 (en) * 2005-12-21 2009-08-18 Decode Genetics Ehf Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation
US7750012B2 (en) 2005-12-21 2010-07-06 Decode Genetics Ehf Biaryl nitrogen-heterocycle inhibitors of LTA4H for treating inflammation
CN102946877B (zh) 2010-03-18 2019-07-05 香港科技大学 乳突果及其分离的化合物在制备用于治疗神经疾病的药物中的用途
US8551982B2 (en) 2011-03-14 2013-10-08 Boehringer Ingelheim International Gmbh Benzodioxane inhibitors of leukotriene production
EP2734516B1 (en) 2011-07-19 2015-06-17 Boehringer Ingelheim International GmbH Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
JP6080226B2 (ja) 2012-03-06 2017-02-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン
EP2822942B1 (en) 2012-03-06 2017-05-10 Boehringer Ingelheim International GmbH Benzodioxanes for inhibiting leukotriene production
EP2885285B1 (en) 2012-07-17 2016-10-19 Boehringer Ingelheim International GmbH Pyrazole drivatives which inhibit leukotriene production

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