HK1203478A1 - Methods for the treatment of diabetic retinopathy and other ophthalmic diseases - Google Patents

Methods for the treatment of diabetic retinopathy and other ophthalmic diseases

Info

Publication number
HK1203478A1
HK1203478A1 HK15103833.8A HK15103833A HK1203478A1 HK 1203478 A1 HK1203478 A1 HK 1203478A1 HK 15103833 A HK15103833 A HK 15103833A HK 1203478 A1 HK1203478 A1 HK 1203478A1
Authority
HK
Hong Kong
Prior art keywords
treatment
methods
diabetic retinopathy
ophthalmic diseases
ophthalmic
Prior art date
Application number
HK15103833.8A
Other languages
English (en)
Chinese (zh)
Inventor
克拉斯‧奧洛夫‧貝文
蘇珊‧海斯‧亨利
遼‧洼田
弗拉基米拉‧
‧庫克薩
Original Assignee
Acucela Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acucela Inc filed Critical Acucela Inc
Publication of HK1203478A1 publication Critical patent/HK1203478A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
HK15103833.8A 2012-05-04 2015-04-21 Methods for the treatment of diabetic retinopathy and other ophthalmic diseases HK1203478A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261643051P 2012-05-04 2012-05-04
US201261643058P 2012-05-04 2012-05-04
US201261643178P 2012-05-04 2012-05-04
US201361781907P 2013-03-14 2013-03-14
PCT/US2013/039562 WO2013166449A2 (en) 2012-05-04 2013-05-03 Methods for the treatment of diabetic retinopathy and other ophthalmic diseases

Publications (1)

Publication Number Publication Date
HK1203478A1 true HK1203478A1 (en) 2015-10-30

Family

ID=49515046

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18106035.4A HK1246646A1 (zh) 2012-05-04 2015-04-21 用於治療糖尿病性視網膜病及其他眼科疾病的方法
HK15103833.8A HK1203478A1 (en) 2012-05-04 2015-04-21 Methods for the treatment of diabetic retinopathy and other ophthalmic diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18106035.4A HK1246646A1 (zh) 2012-05-04 2015-04-21 用於治療糖尿病性視網膜病及其他眼科疾病的方法

Country Status (18)

Country Link
US (4) US9957224B2 (xx)
EP (2) EP3741742A1 (xx)
JP (5) JP2015518491A (xx)
KR (1) KR20150013240A (xx)
CN (3) CN107865830A (xx)
AU (1) AU2013256029A1 (xx)
BR (1) BR112014027571B1 (xx)
CA (1) CA2872433C (xx)
EA (1) EA201492031A1 (xx)
ES (1) ES2792923T3 (xx)
HK (2) HK1246646A1 (xx)
IL (1) IL235446A0 (xx)
MX (2) MX2020001835A (xx)
PH (1) PH12014502449A1 (xx)
SG (1) SG11201407162SA (xx)
TW (1) TW201406707A (xx)
WO (1) WO2013166449A2 (xx)
ZA (1) ZA201408592B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX354184B (es) * 2007-10-05 2018-02-16 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
EP2804605A4 (en) 2012-01-20 2015-07-08 Acucela Inc SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASES
TW201406707A (zh) 2012-05-04 2014-02-16 Acucela Inc 用以治療糖尿病性視網膜病變及其他眼部疾病之方法
AU2014248878A1 (en) * 2013-03-12 2015-09-24 Acucela Inc. Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders
EP3195838B1 (en) 2013-03-14 2018-08-22 Optimedica Corporation Laser capsulovitreotomy
JP6692795B2 (ja) * 2014-04-10 2020-05-13 ランケナー インスティテュート フォー メディカル リサーチ 眼疾患および眼障害の治療のための方法および組成物
US10792374B2 (en) 2015-10-09 2020-10-06 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
AU2018223810B2 (en) * 2017-02-27 2022-04-21 Case Western Reserve University Visual cycle modulators
JP6947226B2 (ja) * 2017-12-28 2021-10-13 株式会社ニコン 画像処理方法、画像処理プログラム、画像処理装置、画像表示装置、及び画像表示方法
MX2018008165A (es) * 2018-06-29 2019-12-30 Centro De Retina Medica Y Quirurgica S C Sistema portátil para la identificación de casos potenciales de edema macular diabético mediante procesamiento de imagen e inteligencia artificial.
US11624937B2 (en) 2018-07-07 2023-04-11 Acucela Inc. Device to prevent retinal hypoxia
CN112740099B (zh) 2018-07-30 2024-05-14 奥克塞拉有限公司 用于延缓近视进展的电子接触透镜的光学设计
JP2022512706A (ja) * 2018-10-16 2022-02-07 エフ．ホフマン－ラ ロシュ アーゲー 眼科におけるＡｋｔ阻害剤の使用
JP7430719B2 (ja) * 2018-10-19 2024-02-13 メディシノバ・インコーポレイテッド イブジラストを用いて眼疾患／障害または損傷を治療する方法
WO2020240867A1 (ja) * 2019-05-31 2020-12-03 株式会社ニコン 画像処理方法、画像処理装置、及び画像処理プログラム
EP4003250A4 (en) 2019-07-31 2023-08-23 Acucela Inc. DEVICE FOR PROJECTING IMAGES ONTO THE RETINA
CN114730098A (zh) 2019-09-16 2022-07-08 奥克塞拉有限公司 用于被设计来抑制近视发展的电子软隐形眼镜片的组装工艺
EP4107820A4 (en) 2020-02-21 2024-04-17 Acucela Inc. CHARGING CASE FOR ELECTRONIC CONTACT LENS
CN111617313B (zh) * 2020-04-29 2022-09-06 天津医科大学眼科医院 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用
WO2021231684A1 (en) 2020-05-13 2021-11-18 Acucela Inc. Electro-switchable spectacles for myopia treatment
KR20230020951A (ko) 2020-06-08 2023-02-13 어큐셀라 인코포레이티드 굴절 이상을 치료하기 위한 주변 망막에 대한 디포커스된 이미지의 투영
CN115769128A (zh) 2020-06-08 2023-03-07 奥克塞拉有限公司 使用周边散焦治疗进展型屈光不正的贴戴式器件
EP4162317A4 (en) 2020-06-08 2024-08-21 Acucela Inc ASYMMETRICAL PROJECTION LENS FOR TREATING ASTIGMATISM
US11281022B2 (en) 2020-06-10 2022-03-22 Acucela Inc. Apparatus and methods for the treatment of refractive error using active stimulation
US11209672B1 (en) 2021-04-06 2021-12-28 Acucela Inc. Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens
US11366341B1 (en) 2021-05-04 2022-06-21 Acucela Inc. Electronic case for electronic spectacles
EP4340896A1 (en) * 2021-05-16 2024-03-27 Metanoia Bio Inc. Methods and compositions for treating ocular neovascular disease
US20240274295A1 (en) * 2021-06-03 2024-08-15 Osaka University Method for screening for retinopathy of prematurity, apparatus for screening for retinopathy of prematurity, and learned model

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022788D0 (en) 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
US20030181531A1 (en) * 2003-02-11 2003-09-25 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
RS35404A (xx) * 2001-11-09 2006-10-27 Eyetech Pharmaceuticals Postupci za tretiranje okularnih neovaskularnih bolesti
NZ550340A (en) * 2004-03-17 2010-08-27 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle using a retinoid
US8969415B2 (en) * 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
BRPI0810063A2 (pt) * 2007-04-20 2014-10-14 Acucela Inc Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina
CN103664637B (zh) * 2007-06-29 2016-02-03 奥克塞拉有限公司 用于治疗眼科疾病和紊乱的炔基苯基衍生化合物
MX354184B (es) * 2007-10-05 2018-02-16 Acucela Inc Compuestos alcoxi para el tratamiento de enfermedades.
WO2009058216A1 (en) 2007-11-01 2009-05-07 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
BRPI0919327A2 (pt) 2008-09-05 2019-09-24 Acucela Inc compostos ligados a enxofre para tratar doenças e distúrbios oftálmicos
EA201100654A1 (ru) * 2008-10-22 2012-01-30 Акусела, Инк. Соединения для лечения офтальмологических заболеваний и расстройств
WO2011003103A2 (en) * 2009-07-02 2011-01-06 Acucela, Inc. Pharmacology of visual cycle modulators
TW201406707A (zh) 2012-05-04 2014-02-16 Acucela Inc 用以治療糖尿病性視網膜病變及其他眼部疾病之方法

Also Published As

Publication number Publication date
CN107865830A (zh) 2018-04-03
JP2015518491A (ja) 2015-07-02
TW201406707A (zh) 2014-02-16
JP2021075576A (ja) 2021-05-20
CA2872433A1 (en) 2013-11-07
MX2020001835A (es) 2021-09-09
US11795136B2 (en) 2023-10-24
BR112014027571A2 (pt) 2017-07-18
CN116850163A (zh) 2023-10-10
JP2018024702A (ja) 2018-02-15
EP3741742A1 (en) 2020-11-25
SG11201407162SA (en) 2014-11-27
WO2013166449A2 (en) 2013-11-07
CN104411678A (zh) 2015-03-11
US10730825B2 (en) 2020-08-04
MX2014013341A (es) 2015-06-02
BR112014027571B1 (pt) 2021-08-31
JP2023059991A (ja) 2023-04-27
EP2844636A2 (en) 2015-03-11
IL235446A0 (en) 2014-12-31
US20140039048A1 (en) 2014-02-06
JP2020023535A (ja) 2020-02-13
US20180346407A1 (en) 2018-12-06
HK1246646A1 (zh) 2018-09-14
EP2844636B1 (en) 2020-04-22
ZA201408592B (en) 2017-09-27
AU2013256029A1 (en) 2014-12-04
WO2013166449A3 (en) 2014-01-30
US20210171435A1 (en) 2021-06-10
US9957224B2 (en) 2018-05-01
US20240308951A1 (en) 2024-09-19
ES2792923T3 (es) 2020-11-12
EP2844636A4 (en) 2016-03-09
PH12014502449A1 (en) 2015-01-12
KR20150013240A (ko) 2015-02-04
CA2872433C (en) 2022-06-28
EA201492031A1 (ru) 2015-05-29

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