JP2016515582A5 - - Google Patents
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- Publication number
- JP2016515582A5 JP2016515582A5 JP2016505551A JP2016505551A JP2016515582A5 JP 2016515582 A5 JP2016515582 A5 JP 2016515582A5 JP 2016505551 A JP2016505551 A JP 2016505551A JP 2016505551 A JP2016505551 A JP 2016505551A JP 2016515582 A5 JP2016515582 A5 JP 2016515582A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazol
- pyridin
- carbonyl
- hydroxy
- methylbenzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
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- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
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| AU2009225869B2 (en) * | 2008-03-18 | 2014-01-23 | Merck Sharp & Dohme Llc | Substituted 4-hydroxypyrimidine-5-carboxamides |
| US8268834B2 (en) * | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| MY155244A (en) * | 2008-12-29 | 2015-09-30 | Sanofi Sa | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof |
| SG172803A1 (en) * | 2008-12-29 | 2011-08-29 | Sanofi Sa | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators |
| AP2015008783A0 (en) * | 2013-03-29 | 2015-10-31 | Takeda Pharmaceutical | 6-(5-hydroxy-1h-pyrazol-1-yl) nicotinamida derivatives and their use as phd inhibitors |
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