JP2019512535A5 - - Google Patents
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- Publication number
- JP2019512535A5 JP2019512535A5 JP2018551351A JP2018551351A JP2019512535A5 JP 2019512535 A5 JP2019512535 A5 JP 2019512535A5 JP 2018551351 A JP2018551351 A JP 2018551351A JP 2018551351 A JP2018551351 A JP 2018551351A JP 2019512535 A5 JP2019512535 A5 JP 2019512535A5
- Authority
- JP
- Japan
- Prior art keywords
- disorders
- compound
- alkyl
- pharmaceutically acceptable
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163571.9 | 2016-04-01 | ||
| EP16163571 | 2016-04-01 | ||
| PCT/EP2017/057765 WO2017167993A1 (en) | 2016-04-01 | 2017-03-31 | Fused pentacyclic imidazole derivatives as modulators of tnf activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512535A JP2019512535A (ja) | 2019-05-16 |
| JP2019512535A5 true JP2019512535A5 (enExample) | 2020-04-23 |
| JP6968092B2 JP6968092B2 (ja) | 2021-11-17 |
Family
ID=55650321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551351A Active JP6968092B2 (ja) | 2016-04-01 | 2017-03-31 | Ｔｎｆ活性のモジュレーターとしての縮合五環式イミダゾール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10669286B2 (enExample) |
| EP (1) | EP3436459B1 (enExample) |
| JP (1) | JP6968092B2 (enExample) |
| CN (1) | CN109195969B (enExample) |
| BR (1) | BR112018069936A2 (enExample) |
| CA (1) | CA3019026A1 (enExample) |
| EA (1) | EA201892153A1 (enExample) |
| WO (1) | WO2017167993A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
| BR112018001960A2 (pt) | 2015-08-03 | 2018-09-18 | Bristol-Myers Squibb Company | compostos heterocíclicos úteis como moduladores de tnf alfa |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
| CN108948034B (zh) * | 2018-06-05 | 2019-09-13 | 河南大学 | 一种色满桥环异吲哚酮及其制备方法 |
| PT3870586T (pt) * | 2018-10-24 | 2023-07-19 | UCB Biopharma SRL | Derivados de imidazole pentacíclico fundido como moduladores da atividade do tnf |
| WO2024129763A1 (en) * | 2022-12-13 | 2024-06-20 | Forward Therapeutics, Inc. | MODULATORS OF TNF-α ACTIVITY |
| US20260028348A1 (en) * | 2023-01-05 | 2026-01-29 | Forward Therapeutics, Inc. | Modulators of tnf-alpha activity |
| WO2024251282A1 (zh) * | 2023-06-09 | 2024-12-12 | 上海翰森生物医药科技有限公司 | 五环类衍生物抑制剂、其制备方法和应用 |
| TW202521544A (zh) | 2023-08-16 | 2025-06-01 | 美商雷瑟拉股份有限公司 | TNFα活性調節劑及其用途 |
| TW202547476A (zh) | 2024-04-03 | 2025-12-16 | 美商弗沃德醫療公司 | TNF-α活性調節劑 |
| WO2025218735A1 (zh) * | 2024-04-17 | 2025-10-23 | 上海翰森生物医药科技有限公司 | 五环类衍生物抑制剂、其制备方法和应用 |
| WO2025255096A1 (en) * | 2024-06-03 | 2025-12-11 | Dana-Farber Cancer Institute, Inc. | Cycloalkyl and heterocyclic modulators of tnf activity |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2517281A1 (en) | 2003-03-10 | 2004-10-14 | Pfizer Inc. | Phosphate/sulfate ester compounds and pharmaceutical compositions for inhibiting protein interacting nima (pin1) |
| TW200615273A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha |
| DE102008030206A1 (de) | 2008-06-25 | 2009-12-31 | Bayer Schering Pharma Aktiengesellschaft | 3-Cyanoalky- und 3-Hydroxyalkyl-Indole und ihre Verwendung |
| AR088728A1 (es) | 2011-03-25 | 2014-07-02 | Bristol Myers Squibb Co | Moduladores de lxr como prodroga de imidazol |
| EP2721026B1 (en) | 2011-06-20 | 2016-03-02 | Vertex Pharmaceuticals Incorporated | Phosphate esters of gyrase and topoisomerase inhibitors |
| US9550737B2 (en) | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| BR112015000675B1 (pt) | 2012-07-13 | 2022-07-12 | UCB Biopharma SRL | Derivados de imidazopiridina como moduladores da atividade de tnf |
| GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| GB201321730D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321728D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| GB201321729D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| CN107108672B (zh) | 2014-10-03 | 2019-11-08 | Ucb生物制药私人有限公司 | 稠合的五环咪唑衍生物 |
-
2017
- 2017-03-31 BR BR112018069936A patent/BR112018069936A2/pt not_active Application Discontinuation
- 2017-03-31 EP EP17714783.2A patent/EP3436459B1/en active Active
- 2017-03-31 EA EA201892153A patent/EA201892153A1/ru unknown
- 2017-03-31 CN CN201780033199.XA patent/CN109195969B/zh not_active Expired - Fee Related
- 2017-03-31 JP JP2018551351A patent/JP6968092B2/ja active Active
- 2017-03-31 WO PCT/EP2017/057765 patent/WO2017167993A1/en not_active Ceased
- 2017-03-31 US US16/086,418 patent/US10669286B2/en active Active
- 2017-03-31 CA CA3019026A patent/CA3019026A1/en not_active Abandoned
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