JP2013540712A5 - - Google Patents
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- Publication number
- JP2013540712A5 JP2013540712A5 JP2013526451A JP2013526451A JP2013540712A5 JP 2013540712 A5 JP2013540712 A5 JP 2013540712A5 JP 2013526451 A JP2013526451 A JP 2013526451A JP 2013526451 A JP2013526451 A JP 2013526451A JP 2013540712 A5 JP2013540712 A5 JP 2013540712A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound according
- optionally substituted
- ring
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1,3-oxazol-2-yl Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010076557 | 2010-09-02 | ||
| CNPCT/CN2010/076557 | 2010-09-02 | ||
| CNPCT/CN2011/000511 | 2011-03-28 | ||
| CN2011000511 | 2011-03-28 | ||
| CN2011001227 | 2011-07-26 | ||
| CNPCT/CN2011/001227 | 2011-07-26 | ||
| PCT/EP2011/064943 WO2012028629A1 (en) | 2010-09-02 | 2011-08-31 | 2 - (benzyloxy) benzamides as lrrk2 kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540712A JP2013540712A (ja) | 2013-11-07 |
| JP2013540712A5 true JP2013540712A5 (enExample) | 2014-10-02 |
| JP5781611B2 JP5781611B2 (ja) | 2015-09-24 |
Family
ID=44651698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526451A Expired - Fee Related JP5781611B2 (ja) | 2010-09-02 | 2011-08-31 | Ｌｒｒｋ２キナーゼ阻害剤としての２−（ベンジルオキシ）ベンズアミド類 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9365551B2 (enExample) |
| EP (1) | EP2611772B1 (enExample) |
| JP (1) | JP5781611B2 (enExample) |
| AR (1) | AR082827A1 (enExample) |
| ES (1) | ES2524892T3 (enExample) |
| TW (1) | TW201305109A (enExample) |
| WO (1) | WO2012028629A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105732639A (zh) | 2012-06-29 | 2016-07-06 | 辉瑞大药厂 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
| EP3010586A1 (en) | 2013-06-21 | 2016-04-27 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| EP3013810A1 (en) | 2013-06-24 | 2016-05-04 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| US10004751B2 (en) | 2014-07-10 | 2018-06-26 | The J. David Gladstone Institutes | Compositions and methods for treating Dengue virus infection |
| EP3233087B1 (en) | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| AU2016226036B2 (en) | 2015-03-04 | 2020-06-04 | Dana-Farber Cancer Institute, Inc. | Salicylate inhibitors of MELK and methods of use |
| JP2018516973A (ja) | 2015-06-10 | 2018-06-28 | フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物 |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
| CN108137586B (zh) | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
| KR102582626B1 (ko) | 2017-03-10 | 2023-09-22 | 화이자 인코포레이티드 | Lrrk2 억제제로서의 신규 이미다조[4,5-c]퀴놀린 유도체 |
| IL269215B (en) | 2017-03-10 | 2022-09-01 | Pfizer | Disubstituted imidazole[4,5-c]quinoline derivatives |
| WO2023076404A1 (en) | 2021-10-27 | 2023-05-04 | Aria Pharmaceuticals, Inc. | Methods for treating systemic lupus erythematosus |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5236931A (en) * | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
| DE60105023T2 (de) | 2000-06-28 | 2005-08-18 | Smithkline Beecham P.L.C., Brentford | Nassvermahlungsverfahren |
| ES2393926T3 (es) | 2004-10-21 | 2013-01-02 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Gen KASPP (LRRK2), su producción y uso para la detección y tratamiento de trastornos neurodegenerativos |
| NO323175B1 (no) | 2004-12-23 | 2007-01-15 | Jan O Aasly | Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme |
| KR20090019848A (ko) | 2006-06-20 | 2009-02-25 | 노파르티스 아게 | 알쯔하이머 병의 진행에 대한 생체마커 |
| WO2009127642A2 (en) * | 2008-04-15 | 2009-10-22 | Cellzome Limited | Use of lrrk2 inhibitors for neurodegenerative diseases |
| US8778939B2 (en) * | 2009-09-29 | 2014-07-15 | Glaxo Group Limited | Compounds |
-
2011
- 2011-08-31 AR ARP110103183A patent/AR082827A1/es not_active Application Discontinuation
- 2011-08-31 TW TW100131191A patent/TW201305109A/zh unknown
- 2011-08-31 JP JP2013526451A patent/JP5781611B2/ja not_active Expired - Fee Related
- 2011-08-31 WO PCT/EP2011/064943 patent/WO2012028629A1/en not_active Ceased
- 2011-08-31 US US13/820,184 patent/US9365551B2/en not_active Expired - Fee Related
- 2011-08-31 ES ES11757574.6T patent/ES2524892T3/es active Active
- 2011-08-31 EP EP11757574.6A patent/EP2611772B1/en not_active Not-in-force