JP2012532112A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012532112A5 JP2012532112A5 JP2012517917A JP2012517917A JP2012532112A5 JP 2012532112 A5 JP2012532112 A5 JP 2012532112A5 JP 2012517917 A JP2012517917 A JP 2012517917A JP 2012517917 A JP2012517917 A JP 2012517917A JP 2012532112 A5 JP2012532112 A5 JP 2012532112A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- oxo
- independently
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 134
- 229910052736 halogen Inorganic materials 0.000 claims 79
- 150000002367 halogens Chemical class 0.000 claims 77
- 125000004043 oxo group Chemical group O=* 0.000 claims 67
- 125000000623 heterocyclic group Chemical group 0.000 claims 60
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 239000001257 hydrogen Substances 0.000 claims 36
- 125000004429 atom Chemical group 0.000 claims 25
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 15
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- -1 C 1 -C 3 alkyl Chemical group 0.000 claims 3
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- BRBMJARZVFXESE-UHFFFAOYSA-N CC1=NN(C(=C1)N1CC=C2N1C=CC=N2)C2=CC=CC=C2 Chemical compound CC1=NN(C(=C1)N1CC=C2N1C=CC=N2)C2=CC=CC=C2 BRBMJARZVFXESE-UHFFFAOYSA-N 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- ZZIWHWXPXNFRSR-UHFFFAOYSA-N n-[5-methyl-4-(4-propylphenyl)-1,3-thiazol-2-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C1=CC(CCC)=CC=C1C1=C(C)SC(NC(=O)C2=C3N=CC=CN3N=C2)=N1 ZZIWHWXPXNFRSR-UHFFFAOYSA-N 0.000 claims 2
- XMRIUEGHBZTNND-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C1=CC=NC2=C(C(=O)N)C=NN21 XMRIUEGHBZTNND-UHFFFAOYSA-N 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010019842 Hepatomegaly Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 102000015617 Janus Kinases Human genes 0.000 claims 1
- 108010024121 Janus Kinases Proteins 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22291809P | 2009-07-02 | 2009-07-02 | |
| US61/222,918 | 2009-07-02 | ||
| PCT/US2010/040906 WO2011003065A2 (en) | 2009-07-02 | 2010-07-02 | Pyrazolopyrimidine jak inhibitor compounds and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122441A Division JP6312634B2 (ja) | 2009-07-02 | 2015-06-17 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532112A JP2012532112A (ja) | 2012-12-13 |
| JP2012532112A5 true JP2012532112A5 (enExample) | 2013-08-15 |
| JP5769261B2 JP5769261B2 (ja) | 2015-08-26 |
Family
ID=43411778
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517917A Active JP5769261B2 (ja) | 2009-07-02 | 2010-07-02 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
| JP2015122441A Active JP6312634B2 (ja) | 2009-07-02 | 2015-06-17 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
| JP2018000305A Withdrawn JP2018083828A (ja) | 2009-07-02 | 2018-01-04 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
| JP2019106948A Pending JP2019194199A (ja) | 2009-07-02 | 2019-06-07 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122441A Active JP6312634B2 (ja) | 2009-07-02 | 2015-06-17 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
| JP2018000305A Withdrawn JP2018083828A (ja) | 2009-07-02 | 2018-01-04 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
| JP2019106948A Pending JP2019194199A (ja) | 2009-07-02 | 2019-06-07 | ピラゾロピリミジンｊａｋ阻害剤化合物及び方法 |
Country Status (35)
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI630207B (zh) | 2005-12-13 | 2018-07-21 | 英塞特控股公司 | 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶 |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| RU2539568C2 (ru) | 2008-10-31 | 2015-01-20 | Дженентек, Инк. | Пиразолопиримидиновые соединения-ингибиторы jak и способы |
| EP3643312A1 (en) | 2009-05-22 | 2020-04-29 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| EP3050882B1 (en) | 2010-03-10 | 2018-01-31 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| SG184475A1 (en) | 2010-04-07 | 2012-11-29 | Hoffmann La Roche | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| SG10201503983QA (en) | 2010-05-21 | 2015-06-29 | Incyte Corp | Topical Formulation for a JAK Inhibitor |
| KR101995013B1 (ko) | 2010-07-13 | 2019-07-02 | 에프. 호프만-라 로슈 아게 | Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체 |
| CN105360131A (zh) | 2010-11-03 | 2016-03-02 | 陶氏益农公司 | 杀虫组合物和与其相关的方法 |
| US8609669B2 (en) | 2010-11-16 | 2013-12-17 | Abbvie Inc. | Potassium channel modulators |
| CN103415515B (zh) | 2010-11-19 | 2015-08-26 | 因塞特公司 | 作为jak抑制剂的环丁基取代的吡咯并吡啶和吡咯并嘧啶衍生物 |
| EP2688872A4 (en) * | 2011-03-22 | 2014-08-27 | Merck Sharp & Dohme | AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES |
| WO2012158399A1 (en) | 2011-05-13 | 2012-11-22 | Abbott Laboratories | Condensed 2 - carbamoylpyridazinones as potassium channel modulators |
| PE20140832A1 (es) | 2011-06-20 | 2014-07-14 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US8614206B2 (en) | 2011-09-27 | 2013-12-24 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| DK2760867T3 (en) | 2011-09-30 | 2016-04-11 | Oncodesign Sa | Macrocyclic FLT3 kinase inhibitors |
| CA2852688C (en) | 2011-10-26 | 2021-06-29 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| WO2013086229A1 (en) | 2011-12-07 | 2013-06-13 | Amgen Inc. | Bicyclic aryl and heteroaryl sodium channel inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| NZ700595A (en) | 2012-04-27 | 2016-04-29 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| JP2015528435A (ja) * | 2012-08-10 | 2015-09-28 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾールカルボキサミド化合物、組成物及び使用方法 |
| CN103073549A (zh) * | 2012-09-07 | 2013-05-01 | 苏州康润医药有限公司 | 3-溴吡唑啉[1,5-α]吡嘧啶-2-甲酸的合成工艺 |
| CN104640850A (zh) * | 2012-10-26 | 2015-05-20 | 霍夫曼-拉罗奇有限公司 | 3,4-二取代的1h-吡唑和4,5-二取代的噻唑的syk抑制剂 |
| PL2919766T3 (pl) | 2012-11-15 | 2021-10-04 | Incyte Holdings Corporation | Postacie dawkowania ruksolitynibu o przedłużonym uwalnianiu |
| WO2014089379A1 (en) | 2012-12-07 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2014118388A1 (en) | 2013-02-04 | 2014-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for assaying jak2 activity in red blood cells and uses thereof |
| CN105189509B (zh) | 2013-03-06 | 2017-12-19 | 因赛特公司 | 用于制备jak抑制剂的方法及中间体 |
| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2970288A1 (en) * | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2970289A1 (en) * | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| SG10201912203XA (en) | 2013-08-07 | 2020-02-27 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| MX389256B (es) | 2013-10-04 | 2025-03-20 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| MX2016004942A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
| CA2925952A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| KR20160074540A (ko) | 2013-10-17 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
| CN105636445B (zh) | 2013-10-17 | 2018-12-07 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| CA2925873A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| JP2016536295A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| CN105636442B (zh) | 2013-10-17 | 2018-04-27 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
| JP2016534076A (ja) | 2013-10-22 | 2016-11-04 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
| WO2015061146A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| KR102275655B1 (ko) | 2013-10-22 | 2021-07-09 | 코르테바 애그리사이언스 엘엘씨 | 살충 조성물 및 관련 방법 |
| CA2927220A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| NZ719776A (en) | 2013-10-22 | 2017-06-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| CA2926433A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| WO2015061163A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| MX2016005310A (es) | 2013-10-22 | 2016-08-08 | Dow Agrosciences Llc | Composiciones pesticidas sinergicas y metodos relacionados. |
| AR098091A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones pesticidas sinérgicas y métodos relacionados |
| AU2014340416B2 (en) | 2013-10-22 | 2017-09-07 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| KR102286233B1 (ko) | 2013-10-22 | 2021-08-06 | 코르테바 애그리사이언스 엘엘씨 | 살충 조성물 및 관련 방법 |
| AR098097A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y métodos relacionados |
| WO2015061165A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| CN105828612A (zh) | 2013-10-22 | 2016-08-03 | 美国陶氏益农公司 | 协同杀虫组合物和相关方法 |
| US9549560B2 (en) | 2013-10-22 | 2017-01-24 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| WO2015061148A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| CA2926345A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| EP3066094B1 (en) * | 2013-11-08 | 2020-01-08 | Takeda Pharmaceutical Company Limited | Pyrazole for the treatment autoimmune disorders |
| CN104650092B (zh) * | 2013-11-16 | 2017-11-10 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| WO2015083028A1 (en) | 2013-12-05 | 2015-06-11 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
| JP2016540773A (ja) * | 2013-12-06 | 2016-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
| WO2015085132A1 (en) * | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| TW201620911A (zh) * | 2014-03-17 | 2016-06-16 | 雷西肯製藥股份有限公司 | 銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法 |
| EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US9493439B1 (en) | 2014-04-07 | 2016-11-15 | University Of Kentucky Research Foundation | Proteasome inhibitors |
| KR20240153401A (ko) * | 2014-04-08 | 2024-10-22 | 인사이트 홀딩스 코포레이션 | Ｊａｋ 및 ｐｉ3ｋ 억제제 조합에 의한 ｂ-세포 악성종양의 치료 |
| PE20211782A1 (es) | 2014-05-23 | 2021-09-08 | Hoffmann La Roche | Compuestos de 5-cloro-2-difluorometoxifenil pirazolopirimidina, composiciones y metodos de uso de los mismos |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
| JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｃｈｋ１阻害剤とａｔｒ阻害剤との組み合わせを使用してがんを処置する方法 |
| EP3186229A4 (en) | 2014-07-31 | 2018-01-10 | Dow AgroSciences LLC | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| AR098108A1 (es) | 2014-07-31 | 2016-05-04 | Dow Agrosciences Llc | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina |
| JP2017523163A (ja) | 2014-07-31 | 2017-08-17 | ダウ アグロサイエンシィズ エルエルシー | ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法 |
| CN107074774A (zh) | 2014-08-19 | 2017-08-18 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
| WO2016039781A1 (en) | 2014-09-12 | 2016-03-17 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2016202898A1 (en) * | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| EP3355926B1 (en) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using |
| NZ742200A (en) | 2015-11-06 | 2023-01-27 | Samumed Llc | Treatment of osteoarthritis |
| TW201720828A (zh) * | 2015-11-23 | 2017-06-16 | 赫孚孟拉羅股份公司 | 治療性化合物及組合物以及其使用方法 |
| EP3416967B1 (en) * | 2016-02-18 | 2022-02-09 | F. Hoffmann-La Roche AG | Therapeutic compounds, compositions and methods of use thereof |
| US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
| SI3464285T1 (sl) | 2016-06-01 | 2023-02-28 | Biosplice Therapeutics, Inc. | Postopek za pripravo N-(5-(3-(7-(3-fluorofenil)-3H-imidazo(4,5-C)piridin-2-il)-1H-indazol-5- il)piridin-3-il)-3-metilbutanamida |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN106008525B (zh) * | 2016-06-16 | 2018-08-07 | 南京工业大学 | 一种小分子有机纳米肿瘤光热治疗试剂及其制备方法 |
| CR20190310A (es) * | 2016-12-29 | 2019-08-21 | Hoffmann La Roche | Compuestos de pirazolopirimidina y métodos de uso de los mismos |
| CN110139853B (zh) | 2016-12-29 | 2023-06-16 | 美国陶氏益农公司 | 用于制备杀有害生物化合物的方法 |
| CN110325036B (zh) | 2016-12-29 | 2021-10-26 | 美国陶氏益农公司 | 用于制备杀虫化合物的方法 |
| SMT202300051T1 (it) * | 2017-01-17 | 2023-03-17 | Astrazeneca Ab | Inibitori selettivi di jak1 |
| JP2020510061A (ja) * | 2017-03-14 | 2020-04-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ピラゾロクロロフェニル化合物、組成物及びその使用方法 |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
| PL233595B1 (pl) | 2017-05-12 | 2019-11-29 | Celon Pharma Spolka Akcyjna | Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK |
| RU2769696C2 (ru) * | 2017-05-22 | 2022-04-05 | Ф. Хоффманн-Ля Рош Аг | Терапевтические соединения и композиции и способы их применения |
| EP3630767A1 (en) * | 2017-05-22 | 2020-04-08 | H. Hoffnabb-La Roche Ag | Therapeutic compounds and compositions, and methods of use thereof |
| CA3070010A1 (en) | 2017-07-18 | 2019-01-24 | Bayer Cropscience Aktiengesellschaft | Substituted 3-heteroaryloxy-1h-pyrazoles and salts thereof and their use as herbicidal active substances |
| CN107686456B (zh) * | 2017-07-25 | 2018-10-23 | 杭州师范大学 | 一种喹喏酮关键中间体乙酯胺化物及其制备方法和应用 |
| CN109422751B (zh) * | 2017-09-03 | 2022-04-22 | 上海美志医药科技有限公司 | 一类具有降解酪氨酸蛋白激酶jak3活性的化合物 |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| EP3740488A1 (en) * | 2018-01-15 | 2020-11-25 | F. Hoffmann-La Roche AG | Pyrazolopyrimidine compounds as jak inhibitors |
| SG11202006453SA (en) * | 2018-01-17 | 2020-08-28 | Glaxosmithkline Ip Dev Ltd | Pi4kiiibeta inhibitors |
| EP3746429B1 (en) | 2018-01-30 | 2022-03-09 | Incyte Corporation | Processes for preparing (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
| CN110476009A (zh) | 2018-03-07 | 2019-11-19 | 三菱化学株式会社 | 透明树脂组合物、树脂成型体、灯罩、车辆用灯罩、组合灯罩和车辆 |
| PT3773593T (pt) | 2018-03-30 | 2024-06-25 | Incyte Corp | Tratamento da hidradenite supurativa com inibidores de jak |
| SG11202010092XA (en) * | 2018-04-13 | 2020-11-27 | Incyte Corp | Biomarkers for graft-versus-host disease |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| WO2020150552A2 (en) * | 2019-01-17 | 2020-07-23 | Samumed, Llc | Methods of treating cartilage disorders through inhibition of clk and dyrk |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| CN114008050B (zh) * | 2019-06-18 | 2024-12-31 | 豪夫迈·罗氏有限公司 | Jak激酶的吡唑并嘧啶芳基醚抑制剂及其用途 |
| PE20220577A1 (es) | 2019-06-18 | 2022-04-20 | Hoffmann La Roche | Inhibidores de jak cinasas basados en pirazolopirimidina sulfona y usos de los mismos |
| TW202115069A (zh) | 2019-06-18 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | Ｊａｋ激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| US12360120B2 (en) | 2019-10-10 | 2025-07-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| JP2022551649A (ja) | 2019-10-10 | 2022-12-12 | インサイト・コーポレイション | 移植片対宿主病のバイオマーカー |
| CA3159348A1 (en) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115003667B (zh) * | 2020-02-26 | 2025-04-15 | 百济神州有限公司 | Tyk-2抑制剂 |
| CA3177830A1 (en) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| WO2022256358A1 (en) | 2021-06-03 | 2022-12-08 | Genentech, Inc. | Process for preparing medicaments |
| CN115466227B (zh) * | 2022-06-30 | 2024-07-19 | 杭州国瑞生物科技有限公司 | 一种3-(氯甲基)-1-甲基-1h-1,2,4-三唑盐酸盐的制备方法 |
| WO2024262911A1 (ko) * | 2023-06-19 | 2024-12-26 | 주식회사 에이조스바이오 | 신규 피라졸로 피리미딘계 화합물 및 이의 용도 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8401486A1 (es) | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
| US4602035A (en) | 1983-12-07 | 1986-07-22 | Hoechst-Roussel Pharmaceuticals Inc. | Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines |
| US4847256A (en) | 1986-10-16 | 1989-07-11 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines |
| US5728536A (en) | 1993-07-29 | 1998-03-17 | St. Jude Children's Research Hospital | Jak kinases and regulation of Cytokine signal transduction |
| US6136595A (en) | 1993-07-29 | 2000-10-24 | St. Jude Children's Research Hospital | Jak kinases and regulations of cytokine signal transduction |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| US5705625A (en) | 1994-12-15 | 1998-01-06 | The Johns Hopkins University School Of Medicine | Nucleic Acid Encoding novel protein tyrosine kinase |
| US7070972B1 (en) | 1995-01-13 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Janus family kinases and identification of immune modulators |
| US7091020B1 (en) | 1995-12-05 | 2006-08-15 | Incyte Corporation | Human Jak2 kinase |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| US6235741B1 (en) | 1997-05-30 | 2001-05-22 | Merck & Co., Inc. | Angiogenesis inhibitors |
| FR2791562B1 (fr) | 1999-03-29 | 2004-03-05 | Oreal | Composition tinctoriale contenant une pyrazolo-[1,5-a]- pyrimidine et une polyaminopyrimidine monocyclique a titre de bases d'oxydation et un coupleur, et procedes de teinture |
| NZ516260A (en) | 1999-07-02 | 2004-08-27 | Eisai Co Ltd | Fused imidazole compounds and remedies for diabetes mellitus |
| PT1382339E (pt) * | 1999-12-10 | 2008-02-06 | Pfizer Prod Inc | Composições que contêm derivados de pirrolo[2,3-d]- pirimidina |
| US7662826B2 (en) | 2002-04-23 | 2010-02-16 | Shionogi & Co., Ltd. | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same |
| US7161003B1 (en) | 2002-09-04 | 2007-01-09 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
| WO2004052315A2 (en) | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US20070270408A1 (en) | 2003-04-11 | 2007-11-22 | Novo Nordisk A/S | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines |
| WO2004089471A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF |
| SE0301372D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| EP1643960A2 (en) * | 2003-07-02 | 2006-04-12 | Merck & Co., Inc. | Arylsulfonamide derivatives |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| NZ584499A (en) * | 2004-03-30 | 2011-08-26 | Vertex Pharma | Azaindoles Useful as Inhibitors of Jak and Other Protein Kinases |
| US7306631B2 (en) | 2004-03-30 | 2007-12-11 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| WO2005110477A2 (en) | 2004-04-09 | 2005-11-24 | University Of South Florida | Combination therapies for cancer and proliferative angiopathies |
| JP2007535560A (ja) | 2004-04-28 | 2007-12-06 | シーブイ・セラピューティクス・インコーポレイテッド | Ａ１アデノシンレセプターアンタゴニスト |
| US20050288502A1 (en) | 2004-06-25 | 2005-12-29 | Andersen Denise L | Substituted heterocyclic compounds and methods of use |
| EP1812440B1 (en) | 2004-11-04 | 2010-09-22 | Vertex Pharmaceuticals, Inc. | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases |
| EP1910369A1 (en) | 2005-07-29 | 2008-04-16 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
| WO2007039797A1 (en) | 2005-10-03 | 2007-04-12 | Pfizer Products Inc. | Use of cannabinoid receptor-1 antagonist for treating inflammation and arthritis |
| AR057979A1 (es) | 2005-10-06 | 2008-01-09 | Schering Corp | PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS. |
| US7776865B2 (en) * | 2005-10-06 | 2010-08-17 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| JP5119157B2 (ja) | 2005-10-21 | 2013-01-16 | エクセリクシス， インク． | カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピラゾロ−ピリミジン類 |
| AU2006322187A1 (en) | 2005-12-08 | 2007-06-14 | Novartis Ag | Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors |
| US8541406B2 (en) * | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
| TW200800997A (en) | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
| CN101460499A (zh) * | 2006-04-05 | 2009-06-17 | 沃泰克斯药物股份有限公司 | 可用作janus激酶抑制剂的去氮杂嘌呤 |
| KR20150140872A (ko) | 2006-06-02 | 2015-12-16 | 니뽄 신야쿠 가부시키가이샤 | 9,10-세코프레그난 유도체 및 의약 |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| JP2010508315A (ja) | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 抗炎症剤としてのヘテロ環式化合物 |
| CA2670083A1 (en) | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
| WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| CA2702008A1 (en) * | 2007-10-12 | 2009-04-16 | Ingenium Pharmaceuticals Gmbh | Inhibitors of protein kinases |
| MX2010005671A (es) | 2007-11-28 | 2010-06-25 | Dana Farber Cancer Inst Inc | Inhibidores de miristato de moleculas pequeñas contra bcr-abl y metodos de uso. |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8252791B2 (en) | 2008-08-13 | 2012-08-28 | Jenrin Discovery, Inc. | Purine compounds as cannabinoid receptor blockers |
| RU2539568C2 (ru) * | 2008-10-31 | 2015-01-20 | Дженентек, Инк. | Пиразолопиримидиновые соединения-ингибиторы jak и способы |
| WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| WO2010089292A1 (en) | 2009-02-06 | 2010-08-12 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
| TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| UA110324C2 (en) | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| AU2010309882B2 (en) | 2009-10-20 | 2016-01-28 | Cellzome Limited | Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors |
| US20130096104A1 (en) | 2010-03-17 | 2013-04-18 | Genentech, Inc. | Imidazopyridine compounds, compositions and methods of use |
| EP2566867A1 (en) | 2010-04-30 | 2013-03-13 | Cellzome Limited | Pyrazole compounds as jak inhibitors |
-
2010
- 2010-02-07 UA UAA201201035A patent/UA110324C2/uk unknown
- 2010-07-02 RU RU2015133989A patent/RU2675857C2/ru not_active IP Right Cessation
- 2010-07-02 PL PL10794815T patent/PL2448941T3/pl unknown
- 2010-07-02 AU AU2010266188A patent/AU2010266188B2/en not_active Ceased
- 2010-07-02 RU RU2012103487/04A patent/RU2567238C2/ru not_active IP Right Cessation
- 2010-07-02 KR KR1020177012984A patent/KR101903305B1/ko not_active Expired - Fee Related
- 2010-07-02 LT LTEP10794815.0T patent/LT2448941T/lt unknown
- 2010-07-02 CR CR20170115A patent/CR20170115A/es unknown
- 2010-07-02 NZ NZ738778A patent/NZ738778A/en not_active IP Right Cessation
- 2010-07-02 CN CN201080039041.1A patent/CN102482284B/zh active Active
- 2010-07-02 KR KR1020127002790A patent/KR101825754B1/ko not_active Expired - Fee Related
- 2010-07-02 HU HUE10794815A patent/HUE035537T2/en unknown
- 2010-07-02 WO PCT/US2010/040906 patent/WO2011003065A2/en not_active Ceased
- 2010-07-02 HR HRP20180157TT patent/HRP20180157T1/hr unknown
- 2010-07-02 DK DK10794815.0T patent/DK2448941T3/en active
- 2010-07-02 MX MX2012000169A patent/MX2012000169A/es active IP Right Grant
- 2010-07-02 US US13/382,145 patent/US8999998B2/en active Active
- 2010-07-02 EP EP19211640.8A patent/EP3670514A1/en not_active Withdrawn
- 2010-07-02 NZ NZ622283A patent/NZ622283A/en not_active IP Right Cessation
- 2010-07-02 NZ NZ719972A patent/NZ719972A/en not_active IP Right Cessation
- 2010-07-02 JP JP2012517917A patent/JP5769261B2/ja active Active
- 2010-07-02 SI SI201031625T patent/SI2448941T1/en unknown
- 2010-07-02 PE PE2015000692A patent/PE20151249A1/es not_active Application Discontinuation
- 2010-07-02 PT PT107948150T patent/PT2448941T/pt unknown
- 2010-07-02 EP EP10794815.0A patent/EP2448941B1/en active Active
- 2010-07-02 RS RS20171278A patent/RS56671B1/sr unknown
- 2010-07-02 MA MA34594A patent/MA33502B1/fr unknown
- 2010-07-02 KR KR1020187027109A patent/KR20180108858A/ko not_active Ceased
- 2010-07-02 PE PE2012000003A patent/PE20120575A1/es active IP Right Grant
- 2010-07-02 IN IN755DEN2012 patent/IN2012DN00755A/en unknown
- 2010-07-02 NO NO10794815A patent/NO2448941T3/no unknown
- 2010-07-02 SG SG10201509607XA patent/SG10201509607XA/en unknown
- 2010-07-02 EP EP17192475.6A patent/EP3333169B1/en active Active
- 2010-07-02 BR BRPI1010197A patent/BRPI1010197A2/pt not_active Application Discontinuation
- 2010-07-02 MY MYPI2011006384A patent/MY160156A/en unknown
- 2010-07-02 NZ NZ706218A patent/NZ706218A/en not_active IP Right Cessation
- 2010-07-02 ES ES10794815.0T patent/ES2657839T3/es active Active
- 2010-07-02 SG SG2011097623A patent/SG177454A1/en unknown
- 2010-07-02 CA CA2767097A patent/CA2767097A1/en not_active Abandoned
- 2010-07-02 CN CN201510276276.7A patent/CN104910161B/zh active Active
-
2011
- 2011-12-27 IL IL217224A patent/IL217224B/en not_active IP Right Cessation
-
2012
- 2012-01-02 CL CL2012000001A patent/CL2012000001A1/es unknown
- 2012-01-20 ZA ZA2012/00490A patent/ZA201200490B/en unknown
- 2012-01-25 CO CO12011326A patent/CO6491081A2/es active IP Right Grant
- 2012-01-30 CR CR20120053A patent/CR20120053A/es unknown
- 2012-02-02 EC ECSP12011645 patent/ECSP12011645A/es unknown
-
2013
- 2013-10-02 ZA ZA2013/07356A patent/ZA201307356B/en unknown
-
2015
- 2015-02-06 US US14/615,873 patent/US20150152117A1/en not_active Abandoned
- 2015-03-25 PH PH12015500666A patent/PH12015500666A1/en unknown
- 2015-06-17 JP JP2015122441A patent/JP6312634B2/ja active Active
- 2015-12-09 IL IL242999A patent/IL242999B/en not_active IP Right Cessation
-
2017
- 2017-06-20 US US15/627,847 patent/US20170283424A1/en not_active Abandoned
-
2018
- 2018-01-04 JP JP2018000305A patent/JP2018083828A/ja not_active Withdrawn
- 2018-01-15 IL IL256921A patent/IL256921A/en unknown
-
2019
- 2019-06-07 JP JP2019106948A patent/JP2019194199A/ja active Pending
- 2019-09-05 US US16/561,432 patent/US20200002345A1/en not_active Abandoned
-
2022
- 2022-01-14 US US17/648,045 patent/US20220389020A1/en not_active Abandoned
-
2023
- 2023-11-13 US US18/507,678 patent/US20240150364A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012532112A5 (enExample) | ||
| RU2012103487A (ru) | Ингибирующие jak соединения на основе пиразолопиримидина и способы | |
| JP2014037426A5 (enExample) | ||
| JP2019031560A5 (enExample) | ||
| JP2015508749A5 (enExample) | ||
| JP2019034943A5 (enExample) | ||
| JP2013542261A5 (enExample) | ||
| JP2019524883A5 (enExample) | ||
| JP2017535550A5 (enExample) | ||
| JP2019510787A5 (enExample) | ||
| JP2012502067A5 (enExample) | ||
| JP2013502431A5 (enExample) | ||
| JP2013532652A5 (enExample) | ||
| JP2014506907A5 (enExample) | ||
| JP2010502751A5 (enExample) | ||
| JP2010523522A5 (enExample) | ||
| JP2014507455A5 (enExample) | ||
| JP2011509309A5 (enExample) | ||
| JP2017533968A5 (enExample) | ||
| JP2016540749A5 (enExample) | ||
| JPWO2023099623A5 (enExample) | ||
| JP2017517538A5 (enExample) | ||
| JP2019512535A5 (enExample) | ||
| JP2019505529A5 (enExample) | ||
| AU2018350980A1 (en) | Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-y gamma inhibitors |