HUE035537T2 - Pyrazolopyrimidine JAK inhibitor compounds and methods - Google Patents

Pyrazolopyrimidine JAK inhibitor compounds and methods Download PDF

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Publication number
HUE035537T2
HUE035537T2 HUE10794815A HUE10794815A HUE035537T2 HU E035537 T2 HUE035537 T2 HU E035537T2 HU E10794815 A HUE10794815 A HU E10794815A HU E10794815 A HUE10794815 A HU E10794815A HU E035537 T2 HUE035537 T2 HU E035537T2
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HU
Hungary
Prior art keywords
disease
chloro
methoxyphenyl
compound
carboxamide
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HUE10794815A
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English (en)
Hungarian (hu)
Inventor
Paul Gibbons
Emily Hanan
Wendy Liu
Joseph P Lyssikatos
Steven R Magnuson
Rohan Mendonca
Richard Pastor
Thomas E Rawson
Michael Siu
Mark E Zak
Aihe Zhou
Bing-Yan Zhu
Christopher Hurley
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HUE035537T2 publication Critical patent/HUE035537T2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE10794815A 2009-07-02 2010-07-02 Pyrazolopyrimidine JAK inhibitor compounds and methods HUE035537T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22291809P 2009-07-02 2009-07-02

Publications (1)

Publication Number Publication Date
HUE035537T2 true HUE035537T2 (en) 2018-05-28

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HUE10794815A HUE035537T2 (en) 2009-07-02 2010-07-02 Pyrazolopyrimidine JAK inhibitor compounds and methods

Country Status (35)

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US (6) US8999998B2 (enExample)
EP (3) EP3670514A1 (enExample)
JP (4) JP5769261B2 (enExample)
KR (3) KR101825754B1 (enExample)
CN (2) CN102482284B (enExample)
AU (1) AU2010266188B2 (enExample)
BR (1) BRPI1010197A2 (enExample)
CA (1) CA2767097A1 (enExample)
CL (1) CL2012000001A1 (enExample)
CO (1) CO6491081A2 (enExample)
CR (2) CR20170115A (enExample)
DK (1) DK2448941T3 (enExample)
EC (1) ECSP12011645A (enExample)
ES (1) ES2657839T3 (enExample)
HR (1) HRP20180157T1 (enExample)
HU (1) HUE035537T2 (enExample)
IL (3) IL217224B (enExample)
IN (1) IN2012DN00755A (enExample)
LT (1) LT2448941T (enExample)
MA (1) MA33502B1 (enExample)
MX (1) MX2012000169A (enExample)
MY (1) MY160156A (enExample)
NO (1) NO2448941T3 (enExample)
NZ (4) NZ719972A (enExample)
PE (2) PE20151249A1 (enExample)
PH (1) PH12015500666A1 (enExample)
PL (1) PL2448941T3 (enExample)
PT (1) PT2448941T (enExample)
RS (1) RS56671B1 (enExample)
RU (2) RU2675857C2 (enExample)
SG (2) SG177454A1 (enExample)
SI (1) SI2448941T1 (enExample)
UA (1) UA110324C2 (enExample)
WO (1) WO2011003065A2 (enExample)
ZA (2) ZA201200490B (enExample)

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