KR101825754B1 - 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법 - Google Patents

피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법 Download PDF

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Publication number
KR101825754B1
KR101825754B1 KR1020127002790A KR20127002790A KR101825754B1 KR 101825754 B1 KR101825754 B1 KR 101825754B1 KR 1020127002790 A KR1020127002790 A KR 1020127002790A KR 20127002790 A KR20127002790 A KR 20127002790A KR 101825754 B1 KR101825754 B1 KR 101825754B1
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South Korea
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alkyl
mmol
pyrazolo
compound
pyrimidine
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Korean (ko)
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KR20120097473A (ko
Inventor
폴 지본스
에밀리 하난
웬디 리우
조셉 피. 리시카토스
스티븐 알. 맥누손
로한 멘돈카
리차드 파스토
토마스 이. 로손
마이클 시우
마크 이. 자크
아이헤 조우
빙-얀 주
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127002790A 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법 Expired - Fee Related KR101825754B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22291809P 2009-07-02 2009-07-02
US61/222,918 2009-07-02
PCT/US2010/040906 WO2011003065A2 (en) 2009-07-02 2010-07-02 Pyrazolopyrimidine jak inhibitor compounds and methods

Related Child Applications (1)

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KR1020177012984A Division KR101903305B1 (ko) 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법

Publications (2)

Publication Number Publication Date
KR20120097473A KR20120097473A (ko) 2012-09-04
KR101825754B1 true KR101825754B1 (ko) 2018-02-06

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KR1020127002790A Expired - Fee Related KR101825754B1 (ko) 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법
KR1020177012984A Expired - Fee Related KR101903305B1 (ko) 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법
KR1020187027109A Ceased KR20180108858A (ko) 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법

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KR1020187027109A Ceased KR20180108858A (ko) 2009-07-02 2010-07-02 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법

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US (6) US8999998B2 (enExample)
EP (3) EP2448941B1 (enExample)
JP (4) JP5769261B2 (enExample)
KR (3) KR101825754B1 (enExample)
CN (2) CN104910161B (enExample)
AU (1) AU2010266188B2 (enExample)
BR (1) BRPI1010197A2 (enExample)
CA (1) CA2767097A1 (enExample)
CL (1) CL2012000001A1 (enExample)
CO (1) CO6491081A2 (enExample)
CR (2) CR20170115A (enExample)
DK (1) DK2448941T3 (enExample)
EC (1) ECSP12011645A (enExample)
ES (1) ES2657839T3 (enExample)
HR (1) HRP20180157T1 (enExample)
HU (1) HUE035537T2 (enExample)
IL (3) IL217224B (enExample)
IN (1) IN2012DN00755A (enExample)
LT (1) LT2448941T (enExample)
MA (1) MA33502B1 (enExample)
MX (1) MX2012000169A (enExample)
MY (1) MY160156A (enExample)
NO (1) NO2448941T3 (enExample)
NZ (4) NZ738778A (enExample)
PE (2) PE20120575A1 (enExample)
PH (1) PH12015500666A1 (enExample)
PL (1) PL2448941T3 (enExample)
PT (1) PT2448941T (enExample)
RS (1) RS56671B1 (enExample)
RU (2) RU2567238C2 (enExample)
SG (2) SG177454A1 (enExample)
SI (1) SI2448941T1 (enExample)
UA (1) UA110324C2 (enExample)
WO (1) WO2011003065A2 (enExample)
ZA (2) ZA201200490B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024262911A1 (ko) * 2023-06-19 2024-12-26 주식회사 에이조스바이오 신규 피라졸로 피리미딘계 화합물 및 이의 용도

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KR101903305B1 (ko) 2018-10-01
SG177454A1 (en) 2012-02-28
JP2018083828A (ja) 2018-05-31
AU2010266188A1 (en) 2012-02-02
RU2675857C2 (ru) 2018-12-25
IL242999B (en) 2019-05-30
SI2448941T1 (en) 2018-02-28
RS56671B1 (sr) 2018-03-30
JP2015218175A (ja) 2015-12-07
ZA201200490B (en) 2013-03-27
NO2448941T3 (enExample) 2018-04-07
US20120190665A1 (en) 2012-07-26
JP2012532112A (ja) 2012-12-13
CL2012000001A1 (es) 2013-01-25
CN102482284A (zh) 2012-05-30
US20170283424A1 (en) 2017-10-05

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