MA33502B1 - Composés pyrazolopyrimidine inhibiteurs des jak et procédés - Google Patents

Composés pyrazolopyrimidine inhibiteurs des jak et procédés

Info

Publication number
MA33502B1
MA33502B1 MA34594A MA34594A MA33502B1 MA 33502 B1 MA33502 B1 MA 33502B1 MA 34594 A MA34594 A MA 34594A MA 34594 A MA34594 A MA 34594A MA 33502 B1 MA33502 B1 MA 33502B1
Authority
MA
Morocco
Prior art keywords
methods
jak inhibitor
pyrazolopyrimidine compounds
disease
compound
Prior art date
Application number
MA34594A
Other languages
Arabic (ar)
English (en)
Inventor
Paul Gibbons
Emily Hanan
Wendy Liu
Joseph P Lyssikatos
Steven R Magnuson
Rohan Mendonca
Richard Pastor
Thomas E Rawson
Michael Siu
Mark E Zak
Aihe Zhou
Bing-Yan Zhu
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA33502B1 publication Critical patent/MA33502B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ DE FORMULE I, DES ÉNANTIOMÈRES, DES DIASTÉRÉOISOMÈRES, DES TAUTOMÈRES OU DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CELUI-CI, DANS LAQUELLE R1, R2 ET R3 SONT TELS QUE DÉFINIS ICI, QUI SONT UTILES COMME INHIBITEURS D'UNE OU PLUSIEURS PARMI LES JANUS KINASES. L'INVENTION CONCERNE ÉGALEMENT UNE COMPOSITION PHARMACEUTIQUE COMPRENANT UN COMPOSÉ DE FORMULE I ET UN TRANSPORTEUR, UN ADJUVANT OU UN VÉHICULE PHARMACEUTIQUEMENT ACCEPTABLE, ET DES PROCÉDÉS DE TRAITEMENT OU DE DIMINUTION DE LA SÉVÉRITÉ D'UNE MALADIE OU D'UN ÉTAT EN RÉPONSE À L'INHIBITION D'UNE ACTIVITÉ DE JANUS KINASE CHEZ UN PATIENT.
MA34594A 2009-07-02 2010-07-02 Composés pyrazolopyrimidine inhibiteurs des jak et procédés MA33502B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22291809P 2009-07-02 2009-07-02
PCT/US2010/040906 WO2011003065A2 (fr) 2009-07-02 2010-07-02 Composés pyrazolopyrimidine inhibiteurs des jak et procédés

Publications (1)

Publication Number Publication Date
MA33502B1 true MA33502B1 (fr) 2012-08-01

Family

ID=43411778

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34594A MA33502B1 (fr) 2009-07-02 2010-07-02 Composés pyrazolopyrimidine inhibiteurs des jak et procédés

Country Status (35)

Country Link
US (6) US8999998B2 (fr)
EP (3) EP2448941B1 (fr)
JP (4) JP5769261B2 (fr)
KR (3) KR20180108858A (fr)
CN (2) CN102482284B (fr)
AU (1) AU2010266188B2 (fr)
BR (1) BRPI1010197A2 (fr)
CA (1) CA2767097A1 (fr)
CL (1) CL2012000001A1 (fr)
CO (1) CO6491081A2 (fr)
CR (2) CR20170115A (fr)
DK (1) DK2448941T3 (fr)
EC (1) ECSP12011645A (fr)
ES (1) ES2657839T3 (fr)
HR (1) HRP20180157T1 (fr)
HU (1) HUE035537T2 (fr)
IL (3) IL217224B (fr)
IN (1) IN2012DN00755A (fr)
LT (1) LT2448941T (fr)
MA (1) MA33502B1 (fr)
MX (1) MX2012000169A (fr)
MY (1) MY160156A (fr)
NO (1) NO2448941T3 (fr)
NZ (4) NZ706218A (fr)
PE (2) PE20151249A1 (fr)
PH (1) PH12015500666A1 (fr)
PL (1) PL2448941T3 (fr)
PT (1) PT2448941T (fr)
RS (1) RS56671B1 (fr)
RU (2) RU2567238C2 (fr)
SG (2) SG10201509607XA (fr)
SI (1) SI2448941T1 (fr)
UA (1) UA110324C2 (fr)
WO (1) WO2011003065A2 (fr)
ZA (2) ZA201200490B (fr)

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