JP2016522835A5 - - Google Patents

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JP2016522835A5
JP2016522835A5 JP2016516235A JP2016516235A JP2016522835A5 JP 2016522835 A5 JP2016522835 A5 JP 2016522835A5 JP 2016516235 A JP2016516235 A JP 2016516235A JP 2016516235 A JP2016516235 A JP 2016516235A JP 2016522835 A5 JP2016522835 A5 JP 2016522835A5
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fluoro
pyrido
methylpropyl
phenyl
indol
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JP2016516235A
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JP2016522835A (ja
JP6286031B2 (ja
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Priority claimed from PCT/GB2014/051607 external-priority patent/WO2014191726A1/en
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JP2016516235A 2013-05-28 2014-05-27 化合物 Expired - Fee Related JP6286031B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361827951P 2013-05-28 2013-05-28
US61/827,951 2013-05-28
US201361915685P 2013-12-13 2013-12-13
US61/915,685 2013-12-13
PCT/GB2014/051607 WO2014191726A1 (en) 2013-05-28 2014-05-27 Chemical compounds

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JP2016522835A JP2016522835A (ja) 2016-08-04
JP2016522835A5 true JP2016522835A5 (enExample) 2017-07-13
JP6286031B2 JP6286031B2 (ja) 2018-02-28

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US (4) US9155727B2 (enExample)
EP (2) EP3004090B1 (enExample)
JP (1) JP6286031B2 (enExample)
KR (1) KR20160013198A (enExample)
CN (1) CN105229004B (enExample)
AP (1) AP2015008858A0 (enExample)
AU (1) AU2014272856B2 (enExample)
BR (1) BR112015029455A8 (enExample)
CA (1) CA2911859A1 (enExample)
CL (1) CL2015003491A1 (enExample)
CR (1) CR20150629A (enExample)
CY (1) CY1120474T1 (enExample)
DK (1) DK3004090T3 (enExample)
DO (1) DOP2015000274A (enExample)
ES (1) ES2654161T3 (enExample)
HR (1) HRP20171961T1 (enExample)
HU (1) HUE035738T2 (enExample)
IL (1) IL242559B (enExample)
LT (1) LT3004090T (enExample)
ME (1) ME02892B (enExample)
MX (1) MX361538B (enExample)
NI (1) NI201500167A (enExample)
PE (1) PE20160874A1 (enExample)
PH (1) PH12015502615B1 (enExample)
PL (1) PL3004090T3 (enExample)
PT (1) PT3004090T (enExample)
RS (1) RS56678B1 (enExample)
RU (1) RU2664109C2 (enExample)
SG (1) SG11201509393VA (enExample)
SI (1) SI3004090T1 (enExample)
SM (1) SMT201700589T1 (enExample)
TN (1) TN2015000516A1 (enExample)
TW (1) TWI653235B (enExample)
UY (1) UY35590A (enExample)
WO (1) WO2014191726A1 (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5977837B2 (ja) 2011-12-21 2016-08-24 ノヴィラ・セラピューティクス・インコーポレイテッド B型肝炎抗ウイルス剤
CN104902885A (zh) 2012-08-28 2015-09-09 爱尔兰詹森科学公司 氨磺酰基-芳基酰胺和其作为药物用于治疗乙型肝炎的用途
BR112015020242A2 (pt) 2013-02-28 2017-07-18 Janssen Sciences Ireland Uc sulfamoil-arilamidas e seu uso como medicamentos para o tratamento da hepatite b
JP6419155B2 (ja) 2013-04-03 2018-11-07 ヤンセン・サイエンシズ・アイルランド・ユーシー N−フェニル−カルボキサミド誘導体およびb型肝炎を治療するための医薬品としてのその使用
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
MX366787B (es) 2013-05-17 2019-07-23 Janssen Sciences Ireland Uc Derivados de sulfamoiltiofenamida y su uso como medicamentos para tratar la hepatitis b.
DK3024819T3 (en) 2013-07-25 2018-06-06 Janssen Sciences Ireland Uc GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
EA034448B1 (ru) 2013-10-23 2020-02-10 Янссен Сайенсиз Айрлэнд Юси Производные карбоксамида и их применение в качестве медикаментов для лечения гепатита b
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
CN106232136A (zh) 2014-02-05 2016-12-14 诺维拉治疗公司 用于治疗hbv感染的联合疗法
CA2932551A1 (en) 2014-02-06 2015-08-13 Janssen Sciences Ireland Uc Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
IL301960B2 (en) 2014-12-18 2024-08-01 Hoffmann La Roche Tetrahydro-pyrido[3, 4-b]indole estrogen receptor modulators and their uses
WO2016146591A1 (en) * 2015-03-16 2016-09-22 Astrazeneca Ab Combination treatment
CA2980298A1 (en) 2015-03-19 2016-09-22 Novira Therapeutics, Inc. Azocane and azonane derivatives and methods of treating hepatitis b infections
JP2018521988A (ja) * 2015-06-16 2018-08-09 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. ピペリジン誘導体およびその製造方法および医薬用途
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
AU2016301196B2 (en) 2015-08-06 2022-09-08 Dana-Farber Cancer Institute, Inc. Tunable endogenous protein degradation
CN108430971A (zh) 2015-09-29 2018-08-21 诺维拉治疗公司 乙型肝炎抗病毒剂的晶体形式
PL3355884T3 (pl) * 2015-10-01 2021-11-29 Olema Pharmaceuticals, Inc. Tetrahydro-1H-pirydo[3,4-b]indolowe leki antyestrogenowe
CA3011391C (en) * 2015-11-12 2021-02-09 Zhejiang Hisun Pharmaceutical Co., Ltd. Acrylic acid derivative, preparation method and use in medicine thereof
LT3386500T (lt) 2015-12-09 2022-12-27 The Board Of Trustees Of The University Of Illinois Selektyvūs estrogenų receptorių slopintojai benzotiofeno pagrindu
JP2019503346A (ja) 2015-12-22 2019-02-07 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. ベンゾピペリジン誘導体、その製造方法及びその医薬用途
WO2017136688A1 (en) * 2016-02-05 2017-08-10 Inventisbio Inc. Selective estrogen receptor degraders and uses thereof
JP6926189B2 (ja) * 2016-04-01 2021-08-25 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー エストロゲン受容体調節薬
CN109640980A (zh) 2016-04-15 2019-04-16 诺维拉治疗公司 包含壳体装配抑制剂的组合和方法
TW201803870A (zh) 2016-04-20 2018-02-01 阿斯特捷利康公司 化學化合物
EP3449017B1 (en) * 2016-04-29 2021-12-22 Board of Regents, The University of Texas System Targeted measure of transcriptional activity related to hormone receptors
WO2017197904A2 (zh) * 2016-05-08 2017-11-23 上海诚妙医药科技有限公司 帕布昔利布的新晶型及其制备方法及其用途
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
JP7018026B2 (ja) * 2016-06-16 2022-02-09 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト ヘテロアリールエストロゲン受容体モジュレーター及びその使用
EP3472159A1 (en) 2016-06-16 2019-04-24 F. Hoffmann-La Roche AG TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
CN109415361B (zh) * 2016-06-29 2022-03-08 浙江海正药业股份有限公司 丙烯酸类衍生物及其制备方法和其在医药上的用途
WO2018005860A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
US10149839B2 (en) 2016-07-25 2018-12-11 Astrazeneca Ab Chemical compounds
CN107814798B (zh) * 2016-09-14 2020-11-03 四川科伦博泰生物医药股份有限公司 3-取代丙烯酸类化合物及其制备方法和用途
WO2018065501A1 (en) 2016-10-05 2018-04-12 F. Hoffmann-La Roche Ag Methods for preparing antibody drug conjugates
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
SG11201903182XA (en) 2016-10-24 2019-05-30 Astrazeneca Ab 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
TWI823845B (zh) 2017-01-06 2023-12-01 美商G1治療公司 用於治療癌症的組合療法
WO2018130124A1 (zh) * 2017-01-11 2018-07-19 南京圣和药业股份有限公司 作为选择性雌激素受体下调剂的三环类化合物及其应用
WO2018130123A1 (zh) * 2017-01-11 2018-07-19 南京圣和药业股份有限公司 作为选择性雌激素受体下调剂的五环类化合物及其应用
LT3494116T (lt) * 2017-01-30 2020-01-10 Astrazeneca Ab Estrogeno receptorių moduliatoriai
JP7227912B2 (ja) 2017-02-08 2023-02-24 ダナ-ファーバー キャンサー インスティテュート,インコーポレイテッド キメラ抗原受容体の調節
TW201835064A (zh) 2017-02-10 2018-10-01 美商G1治療公司 苯并噻吩雌激素受體調節劑
CN108864080B (zh) * 2017-05-09 2021-10-15 南京圣和药业股份有限公司 作为选择性雌激素受体下调剂的四环类化合物及其应用
CN118440096A (zh) 2017-06-20 2024-08-06 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
CN110536888B (zh) * 2017-06-20 2022-07-26 江苏恒瑞医药股份有限公司 一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法
MX392531B (es) 2017-06-29 2025-03-24 G1 Therapeutics Inc Formas morficas de g1t38 y metodos de preparacion de las mismas.
US11999802B2 (en) 2017-10-18 2024-06-04 Novartis Ag Compositions and methods for selective protein degradation
EA038160B1 (ru) * 2017-11-30 2021-07-15 Астразенека Аб Модуляторы рецептора эстрогена
CN109867659A (zh) * 2017-12-04 2019-06-11 江苏恒瑞医药股份有限公司 苯并哌啶类衍生物的制备方法
US10519152B2 (en) * 2017-12-21 2019-12-31 Astrazeneca Ab Compounds and their use in treating cancer
EP3755683A1 (en) * 2018-02-23 2020-12-30 Center for Intelligent Research in Crystal Engineering, S.L. Cocrystals of ubiquinol and compositions comprising them
EA202092171A1 (ru) 2018-03-14 2020-12-01 Янссен Сайенсиз Айрлэнд Анлимитед Компани Схема дозирования модулятора сборки капсида
AU2019271129B2 (en) 2018-05-14 2023-03-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
TW202016084A (zh) * 2018-05-30 2020-05-01 大陸商迪哲(江蘇)醫藥有限公司 選擇性雌激素受體下調劑和其用途
FI3810283T3 (fi) 2018-06-21 2023-08-11 Hoffmann La Roche 3-((1r,3r)-1-(2,6-difluori-4-((1-(3-fluoripropyyli)atsetidin-3-yyli)amino)fenyyli)-3-metyyli-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yyli)-2,2-difluoripropan-1-olin tartraattisuolan kiinteitä muotoja, niiden valmistusmenetelmä ja menetelmiä niiden käyttämiseksi syöpien hoidossa
MA53105A (fr) 2018-07-03 2021-05-12 Univ Illinois Activateurs de la réponse à une protéine non dépliée
CN120698983A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解
AU2018454987B2 (en) 2018-12-24 2025-05-29 InventisBio Co., Ltd. Novel salts of selective estrogen receptor degraders
MX2021010145A (es) 2019-02-22 2021-09-14 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb.
EP3959320A1 (en) 2019-04-24 2022-03-02 Novartis AG Compositions and methods for selective protein degradation
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv
WO2020232119A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
AU2020311337A1 (en) 2019-07-07 2022-01-20 Olema Pharmaceuticals, Inc. Regimens of estrogen receptor antagonists
EP3993787A4 (en) 2019-08-06 2023-07-12 Recurium IP Holdings, LLC Estrogen receptor modulators for treating mutants
BR112022008520A2 (pt) * 2019-11-04 2022-07-26 Recurium Ip Holdings Llc Sais e formas de um modulador de receptor de estrogênio
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
MX2022007659A (es) 2019-12-20 2022-07-19 C4 Therapeutics Inc Compuestos de isoindolinona e indazol para la degradacion del receptor del factor de crecimiento epidermico (egfr).
US12428428B2 (en) 2020-01-10 2025-09-30 Jiangsu Hengrui Medicine Co., Ltd. Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine
JP7746278B2 (ja) 2020-03-05 2025-09-30 シーフォー セラピューティクス, インコーポレイテッド Brd9の標的分解のための化合物
EP4114391B1 (en) 2020-03-06 2025-07-09 Olema Pharmaceuticals, Inc. Compositions for use in a method of treating an estrogen receptor associated cancer
EP4138834A1 (en) 2020-04-24 2023-03-01 Astrazeneca AB Dosage regimen for the treatment of cancer
PH12022552755A1 (en) 2020-04-24 2024-03-25 Astrazeneca Ab Pharmaceutical formulations
WO2021253380A1 (en) * 2020-06-19 2021-12-23 InventisBio Co., Ltd. Oral formulations and uses thereof
JP2023538517A (ja) 2020-08-05 2023-09-08 シーフォー セラピューティクス, インコーポレイテッド Retの標的分解のための化合物
EP4192439A1 (en) * 2020-08-05 2023-06-14 Aizant Drug Research Solutions Private Limited Solid dosage forms of palbociclib
US20240002950A1 (en) 2020-11-23 2024-01-04 Sanofi Panel of ER Regulated Genes for Use in Monitoring Endocrine Therapy in Breast Cancer
JP2024502270A (ja) 2020-12-23 2024-01-18 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー エストロゲン受容体調節薬
WO2022204184A1 (en) 2021-03-23 2022-09-29 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
JP2024523839A (ja) 2021-06-08 2024-07-02 シーフォー セラピューティクス, インコーポレイテッド 突然変異体brafを分解する療法薬
US20250049768A1 (en) * 2021-07-08 2025-02-13 Olema Pharmaceuticals, Inc. Methods of treating estrogen receptor-associated diseases
AU2022307207A1 (en) 2021-07-09 2024-02-15 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Salt types of tricyclic tetrahydro isoquinoline derivative
WO2023221123A1 (en) * 2022-05-20 2023-11-23 Olema Pharmaceuticals, Inc. Crystalline forms of an estrogen receptor antagonist
EP4565585A1 (en) 2022-08-03 2025-06-11 Bristol-Myers Squibb Company Compounds for modulating ret protein
JP2025540906A (ja) 2022-11-04 2025-12-17 ブリストル-マイヤーズ スクイブ カンパニー Ret-lddタンパク質阻害剤
CN120569388A (zh) 2022-11-04 2025-08-29 百时美施贵宝公司 Ret-ldd蛋白降解剂
WO2024242504A1 (ko) * 2023-05-25 2024-11-28 주식회사 삼양홀딩스 팔보시클립의 경구용 조성물
WO2025006753A2 (en) 2023-06-30 2025-01-02 Merck Patent Gmbh Heterobifunctional compounds for the degradation of kras protein

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
AU2381497A (en) 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
FR2778404B1 (fr) * 1998-05-06 2000-06-30 Hoechst Marion Roussel Inc Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
CZ20013833A3 (cs) 1999-04-28 2002-02-13 Aventis Pharma Deutschland Gmbh Deriváty kyselin se dvěma arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují
FR2796644B1 (fr) * 1999-07-23 2001-09-07 Adir Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR100826817B1 (ko) * 2000-03-15 2008-05-02 사노피-아벤티스 도이칠란트 게엠베하 치환된 베타-카볼린
US6720331B2 (en) 2001-04-03 2004-04-13 National Sun Yat-Sen University 1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents
US20050239899A1 (en) 2002-01-18 2005-10-27 Wolfgang Fecke Beta-secretase inhibitors
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US20050004164A1 (en) 2003-04-30 2005-01-06 Caggiano Thomas J. 2-Cyanopropanoic acid amide and ester derivatives and methods of their use
JP4671123B2 (ja) 2003-06-23 2011-04-13 小野薬品工業株式会社 新規三環性複素環化合物
RU2345981C2 (ru) * 2003-07-28 2009-02-10 Смитклайн Бичем Корпорейшн ЦИКЛОАЛКИЛИДЕНОВЫЕ СОЕДИНЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ИХ ПРИМЕНЕНИЕ И СПОСОБ СЕЛЕКТИВНОГО СВЯЗЫВАНИЯ ERα- И ERβ-ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ
DE10335725A1 (de) 2003-08-05 2005-03-03 Bayer Cropscience Gmbh Safener auf Basis aromatisch-aliphatischer Carbonsäuredarivate
CA2554150A1 (en) * 2004-01-23 2005-08-04 Chiron Corporation Tetrahydrocarboline compounds as anticancer agents
ES2304010T3 (es) * 2004-03-11 2008-09-01 Actelion Pharmaceuticals Ltd. Derivados de tetrahidropiridoindol.
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
GB0422057D0 (en) 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
TW200631949A (en) 2004-10-28 2006-09-16 Inst For Pharm Discovery Inc Substituted carboxylic acids
AU2005307818A1 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocyclylbiphenyl derivates as protein Tyrosine phosphatase inhibitors
US7772245B2 (en) 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
CN102030750A (zh) * 2005-03-22 2011-04-27 阿斯利康(瑞典)有限公司 用作CB1受体配体的新四氢-1H-吡啶并[4,3-b]吲哚衍生物
US20070032385A1 (en) 2005-06-20 2007-02-08 Dunetz Joshua R Sustainable chemical processes
CA2652235A1 (en) 2006-05-09 2007-11-22 Hemaquest Pharmaceuticals, Inc. Methods for treating blood disorders
ES2648388T3 (es) 2006-08-23 2018-01-02 Kudos Pharmaceuticals Limited Derivados de 2-metilmorfolin pirido-, pirazo- y pirimido-pirimidina como inhibidores de mTOR
WO2008025965A2 (en) 2006-08-29 2008-03-06 Reinnervate Limited Retinoid compounds and their use
WO2008124838A1 (en) 2007-04-10 2008-10-16 University Of Maryland, Baltimore Compounds that inhibit human dna ligases and methods of treating cancer
WO2008124836A2 (en) 2007-04-10 2008-10-16 Uwm Research Foundation, Inc. Methods of reducing virulence in bacteria
AU2008239598A1 (en) 2007-04-13 2008-10-23 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
AU2008276568A1 (en) 2007-07-19 2009-01-22 Merck & Co., Inc. Beta carboline derivatives as antidiabetic compounds
CA2728301A1 (en) * 2008-07-03 2010-01-07 Osteogenex Inc. Vinpocetine and eburnamonine derivatives for promoting bone growth
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
US20120135089A1 (en) 2009-03-17 2012-05-31 Stockwell Brent R E3 ligase inhibitors
WO2010138706A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating breast cancer
PL2434891T3 (pl) * 2009-05-27 2020-12-28 Ptc Therapeutics, Inc. Sposoby leczenia nowotworu złośliwego i stanów nienowotworowych
WO2012112965A1 (en) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Compounds and methods of treating diabetes
WO2013022740A2 (en) 2011-08-05 2013-02-14 Corning Incorporated Gpr35 ligands and the uses thereof

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