JP2017507980A5 - - Google Patents
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- JP2017507980A5 JP2017507980A5 JP2016557251A JP2016557251A JP2017507980A5 JP 2017507980 A5 JP2017507980 A5 JP 2017507980A5 JP 2016557251 A JP2016557251 A JP 2016557251A JP 2016557251 A JP2016557251 A JP 2016557251A JP 2017507980 A5 JP2017507980 A5 JP 2017507980A5
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- JP
- Japan
- Prior art keywords
- degrees
- pharmaceutical composition
- disease
- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102100038079 AP2-associated protein kinase 1 Human genes 0.000 claims 2
- 101000742699 Homo sapiens AP2-associated protein kinase 1 Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461953976P | 2014-03-17 | 2014-03-17 | |
| US61/953,976 | 2014-03-17 | ||
| PCT/US2015/020696 WO2015142714A1 (en) | 2014-03-17 | 2015-03-16 | Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507980A JP2017507980A (ja) | 2017-03-23 |
| JP2017507980A5 true JP2017507980A5 (enExample) | 2018-04-12 |
| JP6553081B2 JP6553081B2 (ja) | 2019-07-31 |
Family
ID=52727478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557251A Active JP6553081B2 (ja) | 2014-03-17 | 2015-03-16 | アダプター関連キナーゼ１の阻害剤、それを含む組成物、及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9682982B2 (enExample) |
| EP (2) | EP3119783B1 (enExample) |
| JP (1) | JP6553081B2 (enExample) |
| CN (1) | CN106103447B (enExample) |
| AR (1) | AR099766A1 (enExample) |
| AU (1) | AU2015231672B2 (enExample) |
| CA (1) | CA2941870C (enExample) |
| DK (2) | DK3719021T3 (enExample) |
| ES (2) | ES2821441T3 (enExample) |
| HU (1) | HUE050975T2 (enExample) |
| PL (2) | PL3119783T3 (enExample) |
| PT (2) | PT3119783T (enExample) |
| TW (1) | TW201620911A (enExample) |
| WO (1) | WO2015142714A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2834243T3 (pl) * | 2012-03-09 | 2018-09-28 | Lexicon Pharmaceuticals, Inc. | Związki na bazie pirazolo[1,5-a]pirymidyny, zawierające je kompozycje i sposoby ich zastosowania |
| ES2678877T3 (es) | 2013-10-11 | 2018-08-20 | Bristol-Myers Squibb Company | Inhibidores de pirrolotriazina quinasa |
| CN109369576B (zh) * | 2018-09-19 | 2020-11-27 | 上海凌凯医药科技有限公司 | 一种合成3-甲基氧杂环丁烷-3-(4-硝基苯基)碳酸酯的方法 |
| CA3175973A1 (en) * | 2020-04-21 | 2021-10-28 | Lexicon Pharmaceuticals, Inc. | 4-(3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine for use in the the treatment of cov-229e or cov-oc43 coronaviruses infections |
| US11730723B2 (en) | 2020-04-21 | 2023-08-22 | Lexicon Pharmaceuticals, Inc. | Compounds and methods for treating viral infections |
| WO2023196584A2 (en) * | 2022-04-08 | 2023-10-12 | New York University | Endocytosis inhibitors and their use for pain treatment |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US6194410B1 (en) * | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| EP1873157A1 (en) * | 2006-06-21 | 2008-01-02 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| WO2010118207A1 (en) * | 2009-04-09 | 2010-10-14 | Schering Corporation | Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors |
| UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| WO2011030139A1 (en) * | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
| EP2523552B1 (en) * | 2010-01-14 | 2015-05-13 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidines as mark inhibitors |
| WO2012034095A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| HUE036040T2 (hu) * | 2012-03-09 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére |
| PL2834243T3 (pl) * | 2012-03-09 | 2018-09-28 | Lexicon Pharmaceuticals, Inc. | Związki na bazie pirazolo[1,5-a]pirymidyny, zawierające je kompozycje i sposoby ich zastosowania |
| WO2013134219A1 (en) * | 2012-03-09 | 2013-09-12 | Lexicon Pharmaceuticals, Inc. | Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof |
-
2015
- 2015-03-04 TW TW104106872A patent/TW201620911A/zh unknown
- 2015-03-16 AU AU2015231672A patent/AU2015231672B2/en active Active
- 2015-03-16 PL PL15712026T patent/PL3119783T3/pl unknown
- 2015-03-16 PT PT157120262T patent/PT3119783T/pt unknown
- 2015-03-16 US US14/658,653 patent/US9682982B2/en active Active
- 2015-03-16 JP JP2016557251A patent/JP6553081B2/ja active Active
- 2015-03-16 CN CN201580014255.6A patent/CN106103447B/zh active Active
- 2015-03-16 HU HUE15712026A patent/HUE050975T2/hu unknown
- 2015-03-16 AR ARP150100787A patent/AR099766A1/es unknown
- 2015-03-16 EP EP15712026.2A patent/EP3119783B1/en active Active
- 2015-03-16 WO PCT/US2015/020696 patent/WO2015142714A1/en not_active Ceased
- 2015-03-16 ES ES15712026T patent/ES2821441T3/es active Active
- 2015-03-16 PL PL20177604T patent/PL3719021T3/pl unknown
- 2015-03-16 PT PT201776044T patent/PT3719021T/pt unknown
- 2015-03-16 DK DK20177604.4T patent/DK3719021T3/da active
- 2015-03-16 EP EP20177604.4A patent/EP3719021B1/en active Active
- 2015-03-16 ES ES20177604T patent/ES2911388T3/es active Active
- 2015-03-16 CA CA2941870A patent/CA2941870C/en active Active
- 2015-03-16 DK DK15712026.2T patent/DK3119783T3/da active
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