CA2941870C - Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use - Google Patents

Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use Download PDF

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Publication number
CA2941870C
CA2941870C CA2941870A CA2941870A CA2941870C CA 2941870 C CA2941870 C CA 2941870C CA 2941870 A CA2941870 A CA 2941870A CA 2941870 A CA2941870 A CA 2941870A CA 2941870 C CA2941870 C CA 2941870C
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CA
Canada
Prior art keywords
compound
aak1
disease
mice
pain
Prior art date
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Active
Application number
CA2941870A
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English (en)
French (fr)
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CA2941870A1 (en
Inventor
Yingzhi Bi
Godwin KUMI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
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Lexicon Pharmaceuticals Inc
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Publication of CA2941870A1 publication Critical patent/CA2941870A1/en
Application granted granted Critical
Publication of CA2941870C publication Critical patent/CA2941870C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2941870A 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use Active CA2941870C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953976P 2014-03-17 2014-03-17
US61/953,976 2014-03-17
PCT/US2015/020696 WO2015142714A1 (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

Publications (2)

Publication Number Publication Date
CA2941870A1 CA2941870A1 (en) 2015-09-24
CA2941870C true CA2941870C (en) 2022-07-19

Family

ID=52727478

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2941870A Active CA2941870C (en) 2014-03-17 2015-03-16 Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use

Country Status (14)

Country Link
US (1) US9682982B2 (enExample)
EP (2) EP3119783B1 (enExample)
JP (1) JP6553081B2 (enExample)
CN (1) CN106103447B (enExample)
AR (1) AR099766A1 (enExample)
AU (1) AU2015231672B2 (enExample)
CA (1) CA2941870C (enExample)
DK (2) DK3119783T3 (enExample)
ES (2) ES2911388T3 (enExample)
HU (1) HUE050975T2 (enExample)
PL (2) PL3119783T3 (enExample)
PT (2) PT3719021T (enExample)
TW (1) TW201620911A (enExample)
WO (1) WO2015142714A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302649B (zh) * 2012-03-09 2017-06-23 莱西肯医药有限公司 基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
JP6473146B2 (ja) 2013-10-11 2019-02-20 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ピロロトリアジンキナーゼ阻害剤
CN109369576B (zh) * 2018-09-19 2020-11-27 上海凌凯医药科技有限公司 一种合成3-甲基氧杂环丁烷-3-(4-硝基苯基)碳酸酯的方法
US11730723B2 (en) 2020-04-21 2023-08-22 Lexicon Pharmaceuticals, Inc. Compounds and methods for treating viral infections
CN115427045A (zh) * 2020-04-21 2022-12-02 莱西肯医药有限公司 用于治疗cov-229e或cov-oc43冠状病毒感染的4-(3-(吡啶-3-基)吡唑并[1，5-a]嘧啶-5-基)哌嗪
WO2023196584A2 (en) * 2022-04-08 2023-10-12 New York University Endocytosis inhibitors and their use for pain treatment

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
WO2010118207A1 (en) * 2009-04-09 2010-10-14 Schering Corporation Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators
WO2011087999A1 (en) * 2010-01-14 2011-07-21 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
HUE036040T2 (hu) * 2012-03-09 2018-06-28 Lexicon Pharmaceuticals Inc Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére
CN104302649B (zh) 2012-03-09 2017-06-23 莱西肯医药有限公司 基于吡唑并[1,5‑a]嘧啶的化合物、包含它们的组合物及其使用方法
US8969565B2 (en) * 2012-03-09 2015-03-03 Lexicon Pharmaceuticals, Inc. Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use

Also Published As

Publication number Publication date
CN106103447B (zh) 2019-07-16
EP3119783B1 (en) 2020-06-24
JP6553081B2 (ja) 2019-07-31
AU2015231672A1 (en) 2016-09-15
EP3719021B1 (en) 2022-03-09
DK3719021T3 (da) 2022-06-13
HUE050975T2 (hu) 2021-01-28
HK1226065A1 (zh) 2017-09-22
PT3119783T (pt) 2020-09-24
PL3119783T3 (pl) 2021-01-11
EP3719021A1 (en) 2020-10-07
ES2821441T3 (es) 2021-04-26
PT3719021T (pt) 2022-04-08
US9682982B2 (en) 2017-06-20
US20160039824A1 (en) 2016-02-11
CA2941870A1 (en) 2015-09-24
TW201620911A (zh) 2016-06-16
DK3119783T3 (da) 2020-09-28
JP2017507980A (ja) 2017-03-23
CN106103447A (zh) 2016-11-09
EP3119783A1 (en) 2017-01-25
AU2015231672B2 (en) 2019-06-20
ES2911388T3 (es) 2022-05-19
WO2015142714A1 (en) 2015-09-24
PL3719021T3 (pl) 2022-06-20
AR099766A1 (es) 2016-08-17

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