JP2013531031A5 - - Google Patents

Download PDF

Info

Publication number
JP2013531031A5
JP2013531031A5 JP2013519189A JP2013519189A JP2013531031A5 JP 2013531031 A5 JP2013531031 A5 JP 2013531031A5 JP 2013519189 A JP2013519189 A JP 2013519189A JP 2013519189 A JP2013519189 A JP 2013519189A JP 2013531031 A5 JP2013531031 A5 JP 2013531031A5
Authority
JP
Japan
Prior art keywords
linked
optionally substituted
pharmaceutically acceptable
heteroaryl
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013519189A
Other languages
English (en)
Japanese (ja)
Other versions
JP5830534B2 (ja
JP2013531031A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2011/052974 external-priority patent/WO2012004743A1/en
Publication of JP2013531031A publication Critical patent/JP2013531031A/ja
Publication of JP2013531031A5 publication Critical patent/JP2013531031A5/ja
Application granted granted Critical
Publication of JP5830534B2 publication Critical patent/JP5830534B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013519189A 2010-07-09 2011-07-05 化合物 Expired - Fee Related JP5830534B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36292710P 2010-07-09 2010-07-09
US61/362,927 2010-07-09
US201161492525P 2011-06-02 2011-06-02
US61/492,525 2011-06-02
PCT/IB2011/052974 WO2012004743A1 (en) 2010-07-09 2011-07-05 Benzenesulfonamides useful as sodium channel inhibitors

Publications (3)

Publication Number Publication Date
JP2013531031A JP2013531031A (ja) 2013-08-01
JP2013531031A5 true JP2013531031A5 (enExample) 2014-07-31
JP5830534B2 JP5830534B2 (ja) 2015-12-09

Family

ID=45439019

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013519189A Expired - Fee Related JP5830534B2 (ja) 2010-07-09 2011-07-05 化合物

Country Status (8)

Country Link
US (1) US8772293B2 (enExample)
EP (1) EP2590951B1 (enExample)
JP (1) JP5830534B2 (enExample)
AR (1) AR082201A1 (enExample)
CA (1) CA2804593C (enExample)
ES (1) ES2533065T3 (enExample)
UY (1) UY33491A (enExample)
WO (1) WO2012004743A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5872552B2 (ja) 2010-07-09 2016-03-01 ファイザー・リミテッドPfizer Limited 化学化合物
ES2526675T3 (es) 2010-07-09 2015-01-14 Pfizer Limited N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
JP2013532185A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 化合物
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なn−スルホニルベンズアミド誘導体
JP2013531030A (ja) 2010-07-12 2013-08-01 ファイザー・リミテッド 電位開口型ナトリウムチャネルの阻害剤としてのn−スルホニルベンズアミド
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
JP2013536165A (ja) 2010-07-12 2013-09-19 ファイザー・リミテッド 痛みの処置のためのnav1.7阻害薬としてのスルホンアミド誘導体
JP6014155B2 (ja) * 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
US9630929B2 (en) 2011-10-31 2017-04-25 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
US8889741B2 (en) * 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
JPWO2013137371A1 (ja) * 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
WO2013161928A1 (ja) * 2012-04-26 2013-10-31 塩野義製薬株式会社 オキサゾロトリアゾール誘導体およびそれらを含有する医薬組成物
SG11201408284VA (en) 2012-05-22 2015-02-27 Xenon Pharmaceuticals Inc N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en) 2012-07-06 2018-09-11 Genentech, Inc. N-substituted benzamides and methods of use thereof
ES2798138T3 (es) 2012-10-15 2020-12-09 Dae Woong Pharma Bloqueadores de los canales de sodio, método de preparación de los mismos y uso de los mismos
US9388179B2 (en) 2012-10-26 2016-07-12 Merck Sharp & Dohme Corp. N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
US9550775B2 (en) 2013-03-14 2017-01-24 Genentech, Inc. Substituted triazolopyridines and methods of use thereof
MX2015010775A (es) 2013-03-15 2016-04-25 Genentech Inc Benzoxazoles sustituidos y metodos para usarlos.
ES2687481T3 (es) * 2013-03-15 2018-10-25 Chromocell Corporation Moduladores del canal de sodio para el tratamiento del dolor
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
TW201443025A (zh) 2013-04-19 2014-11-16 Pfizer Ltd 化學化合物
AU2014318979B2 (en) * 2013-09-10 2019-03-28 Chromocell Corporation Sodium channel modulators for the treatment of pain and diabetes
CR20160296A (es) 2013-11-27 2016-09-20 Genentech Inc Benzamidas sustituidas y métodos para usarlas
US10468036B2 (en) * 2014-04-30 2019-11-05 Accusonus, Inc. Methods and systems for processing and mixing signals using signal decomposition
CA2950393A1 (en) 2014-05-30 2015-12-03 Pfizer Inc. Benzenesulfonamides useful as sodium channel inhibitors
CN106715418A (zh) 2014-07-07 2017-05-24 基因泰克公司 治疗化合物及其使用方法
WO2016034971A1 (en) 2014-09-04 2016-03-10 Pfizer Limited Sulfonamides derivatives as urat1 inhibitors
JP2018520107A (ja) 2015-05-22 2018-07-26 ジェネンテック, インコーポレイテッド 置換ベンズアミド及びその使用方法
EP3341353A1 (en) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutic compounds and methods of use thereof
CN108290881B (zh) 2015-09-28 2021-12-07 健泰科生物技术公司 治疗性化合物和其使用方法
US10316026B2 (en) 2015-11-06 2019-06-11 Daiichi Sankyo Company, Limited Method for removing dimethoxybenzyl group
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3390374B1 (en) 2015-12-18 2020-08-26 Merck Sharp & Dohme Corp. Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
HRP20250505T1 (hr) 2016-05-20 2025-06-20 Xenon Pharmaceuticals Inc. Spojevi benzensulfonamida i njihova uporaba za terapijska sredstva
AU2017347549A1 (en) 2016-10-17 2019-05-02 Genentech, Inc. Therapeutic compounds and methods of use thereof
ES2967410T3 (es) 2016-12-09 2024-04-30 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y sus usos en forma de agentes terapéuticos
JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック, インコーポレイテッド ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体
AR114263A1 (es) 2018-02-26 2020-08-12 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
CN112262142B (zh) 2018-06-13 2023-11-14 泽农医药公司 苯磺酰胺化合物及其作为治疗剂的用途
MX2021001380A (es) 2018-08-31 2021-05-27 Xenon Pharmaceuticals Inc Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos.
MA53488A (fr) 2018-08-31 2021-12-08 Xenon Pharmaceuticals Inc Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
EP3891157A4 (en) 2018-12-05 2022-08-31 Merck Sharp & Dohme Corp. 4-AMINO- OR 4-ALKOXY-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATE SODIUM CHANNELS
TW202216671A (zh) * 2020-06-25 2022-05-01 瑞士商諾華公司 1,4—二取代的嗒𠯤化合物之製造方法
CN119013013A (zh) * 2021-12-23 2024-11-22 维拉洛斯治疗公司 用于治疗12-脂加氧酶(12-lox)介导的疾病的组合物和使用方法
WO2025160284A1 (en) * 2024-01-23 2025-07-31 The Board Of Trustees Of The University Of Illinois Algorithm for computer-assisted molecular modularization

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71915B (enExample) 1979-11-27 1983-08-16 Pfizer
EP0194599A3 (en) 1985-03-14 1988-01-20 Nissan Chemical Industries Ltd. Benzamide derivatives, process for producing the same, and soil fungicides containing the same
HUT48799A (en) 1986-08-20 1989-07-28 Fmc Corp Herbicides containing as active substance derivatives of triazolinon and process for production of the active substances
US5084085A (en) 1986-08-20 1992-01-28 Fmc Corporation Herbicidal aryloxyphenyltriazolinones and related compounds
US4845264A (en) 1987-03-05 1989-07-04 Teijin Limited Phenoxycarboxylic acid and herbicide comprising it as active ingredient
US4920133A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920130A (en) 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
DE68909958D1 (de) 1988-01-19 1993-11-25 Tanabe Seiyaku Co Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung.
GB8911854D0 (en) 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
EP0412848B1 (en) 1989-08-11 1995-01-18 Zeneca Limited Quinoline derivatives, process for their preparation and their use as medicaments
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB2244054B (en) 1990-04-19 1994-04-06 Ici Plc Pyridine derivatives
WO1993000332A1 (en) 1991-06-25 1993-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
GB2266527A (en) 1992-03-17 1993-11-03 Merck & Co Inc Substituted azetidinones useful in the treatment of leukemia
JPH05289262A (ja) 1992-04-10 1993-11-05 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JPH05307242A (ja) 1992-04-28 1993-11-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JP3101848B2 (ja) 1992-05-15 2000-10-23 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
FR2694295B1 (fr) 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
AU5802894A (en) 1992-12-17 1994-07-04 Merck & Co., Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents
PT617001E (pt) 1993-03-19 2000-06-30 Merck & Co Inc Derivados do acido fenoxifenilacetico
WO1996004905A1 (en) 1994-08-08 1996-02-22 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
JPH06347968A (ja) 1993-04-14 1994-12-22 Fuji Photo Film Co Ltd ハロゲン化銀感光材料
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
JP3503839B2 (ja) 1994-05-25 2004-03-08 富士写真フイルム株式会社 ポジ型感光性組成物
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
GB9514031D0 (en) 1995-07-10 1995-09-06 Zeneca Ltd Chemical process
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
JP3519218B2 (ja) 1996-08-14 2004-04-12 富士写真フイルム株式会社 ハロゲン化銀写真感光材料および画像形成方法
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
AU745081B2 (en) 1997-06-27 2002-03-14 Fujisawa Pharmaceutical Co., Ltd. Sulfonamide compounds and medicinal use thereof
US6555584B1 (en) 2000-06-29 2003-04-29 Ajinomoto Co., Inc. Acylsulfonamide derivative
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
AU9696198A (en) 1997-10-17 1999-05-10 Aventis Pharmaceuticals Products Inc. Therapeutic uses of quinoline derivatives
JP2001526255A (ja) 1997-12-23 2001-12-18 ワーナー−ランバート・カンパニー 炎症性疾患およびアテローム性動脈硬化症を治療または予防するチオ尿素およびベンズアミド化合物、組成物並びに方法
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GT199900044A (es) 1998-04-10 2000-09-14 Procedimientos para preparar haluros de fenoxifenilsulfonilo.
DE19851184A1 (de) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-Arylsulfonyl-aminosäure-omega-amide
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
PL351470A1 (en) 1999-04-28 2003-04-22 Aventis Pharma Gmbh Tri-aryl acid derivatives as ppar receptor ligands
CA2372079A1 (en) 1999-05-05 2000-11-09 Aaron H. Leeman Novel catechols as antimicrobial agents
JP2003500382A (ja) 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Xa因子の阻害剤
CA2374947A1 (en) 1999-05-24 2000-11-30 Robert M. Scarborough Inhibitors of factor xa
AU5283700A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
JP2001075213A (ja) 1999-09-07 2001-03-23 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤、その製造方法及びこれを用いたハロゲン化銀写真感光材料
AU7404700A (en) 1999-09-29 2001-04-30 Novo Nordisk A/S Novel aromatic compounds
WO2001027068A1 (en) 1999-10-13 2001-04-19 Pfizer Products Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
GB9927056D0 (en) 1999-11-17 2000-01-12 Karobio Ab Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders
IL151517A0 (en) 2000-03-09 2003-04-10 Aventis Pharma Gmbh Therapeutic uses of ppar mediators
AR031130A1 (es) 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
EP1260221A3 (en) 2001-05-23 2002-12-18 Pfizer Products Inc. Combination treatment for depression and anxiety
SE0101978D0 (sv) 2001-06-01 2001-06-01 Astrazeneca Ab New compounds
RO123430B1 (ro) 2001-11-16 2012-04-30 Toyama Chemical Co., Ltd. Derivaţi noi de benzofenonă sau sărurile acestora
AU2003262805A1 (en) 2002-08-26 2004-03-11 Merck & Co., Inc. Acetophenone potentiators of metabotropic glutamate receptors
EP1558245A2 (en) 2002-10-28 2005-08-03 Novo Nordisk A/S Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
EP1601348A4 (en) 2003-02-28 2008-12-10 Oxigene Inc Compositions and methods with improved therapeutic activity
EP1673357A2 (en) 2003-08-08 2006-06-28 Vertex Pharmaceuticals Incorporated Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
CA2551909C (en) 2004-02-12 2011-10-11 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
GB0405033D0 (en) 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
CA2564355C (en) 2004-05-07 2012-07-03 Amgen Inc. Protein kinase modulators and method of use
US20080312286A1 (en) 2004-07-30 2008-12-18 Pinkerton Anthony B Indanone Potentiators of Metabotropic Glutamate Receptors
ZA200703912B (en) 2004-10-20 2008-09-25 Serono Lab 3-arylamino pyridine derivatives
JP2008189549A (ja) 2005-05-12 2008-08-21 Astellas Pharma Inc カルボン酸誘導体またはその塩
TW200732296A (en) 2005-12-15 2007-09-01 Astrazeneca Ab Novel compounds
JP2009057282A (ja) 2005-12-19 2009-03-19 Astellas Pharma Inc カルボン酸誘導体又はその塩
CA2652307A1 (en) 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
DE602007011793D1 (de) 2006-10-18 2011-02-17 Pfizer Prod Inc Biaryl-ether-harnstoffverbindungen
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
EP1995241B1 (en) 2007-03-23 2010-03-17 ICAgen, Inc. Inhibitors of ion channels
CA2684105C (en) 2007-05-03 2011-09-06 Pfizer Limited Pyridine derivatives
US20100179137A1 (en) 2007-06-07 2010-07-15 Takashi Kamikubo Pyridone compound
US8124610B2 (en) * 2007-07-13 2012-02-28 Icagen Inc. Sodium channel inhibitors
WO2009049181A1 (en) 2007-10-11 2009-04-16 Vertex Pharmaceuticals Incorporated Amides useful as inhibitors of voltage-gated sodium channels
TW200930368A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
TW200930369A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
US20090291921A1 (en) 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
JP2011504505A (ja) 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールpde4抑制剤
GB0725214D0 (en) 2007-12-24 2008-02-06 Karobio Ab Pharmaceutical compounds
WO2009101082A1 (en) 2008-02-15 2009-08-20 Basf Se Substituted sulfonic acid amide compounds
EP2119690A1 (en) 2008-05-14 2009-11-18 Academisch Medisch Centrum bij de Universiteit van Amsterdam Radiolabelled MMP selective compounds
BRPI0912109A2 (pt) 2008-05-28 2015-07-28 Basf Se Composto, processo para preparar os mesmos, composições agroquímicas, método para combater fungos nocivos fitopatogênicos, uso dos compostos, e, semente
JP5304785B2 (ja) 2008-06-23 2013-10-02 アステラス製薬株式会社 スルホンアミド化合物又はその塩
US8107894B2 (en) 2008-08-12 2012-01-31 Raytheon Company Modular solid-state millimeter wave (MMW) RF power source
PE20120008A1 (es) 2009-01-12 2012-01-24 Icagen Inc Derivados de fenoxi bencenosulfonamida
JP5289262B2 (ja) 2009-09-30 2013-09-11 京セラドキュメントソリューションズ株式会社 シート搬送装置とこれを備えた画像読取装置及び画像形成装置
JP5872552B2 (ja) * 2010-07-09 2016-03-01 ファイザー・リミテッドPfizer Limited 化学化合物
ES2526675T3 (es) * 2010-07-09 2015-01-14 Pfizer Limited N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なn−スルホニルベンズアミド誘導体
JP2013531030A (ja) 2010-07-12 2013-08-01 ファイザー・リミテッド 電位開口型ナトリウムチャネルの阻害剤としてのn−スルホニルベンズアミド
JP2013536165A (ja) 2010-07-12 2013-09-19 ファイザー・リミテッド 痛みの処置のためのnav1.7阻害薬としてのスルホンアミド誘導体
JP2013532185A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 化合物
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds

Similar Documents

Publication Publication Date Title
JP2013531031A5 (enExample)
JP2013531029A5 (enExample)
JP2015504067A5 (enExample)
JP2016040288A5 (enExample)
JP2016506960A5 (enExample)
RU2015143843A (ru) Ингибиторы гистондеацетилазы
JP2016528301A5 (enExample)
RU2016105581A (ru) Способ лечения острого, хронического и подострого кашля и непреодолимого желания откашляться
JP2015535277A5 (enExample)
JP2019509276A5 (enExample)
JP2013537203A5 (enExample)
TN2012000608A1 (en) Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
JP2016536364A5 (enExample)
JP2006524660A5 (enExample)
TN2012000609A1 (en) Indolizine derivatives, process for the preparation thereof and therapeutic use thereof
RU2015120216A (ru) Ингибиторы тирозинкиназы брутона
JP2016536363A5 (enExample)
JP2011521911A5 (enExample)
JP2016518437A5 (enExample)
JP2013542261A5 (enExample)
NZ588830A (en) Inhibitors of protein kinases
JP2016506962A5 (enExample)
GB201201744D0 (en) Novel compounds
JP2015504081A5 (enExample)
JP2013533883A5 (enExample)