JP2013531031A5 - - Google Patents

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Publication number
JP2013531031A5
JP2013531031A5 JP2013519189A JP2013519189A JP2013531031A5 JP 2013531031 A5 JP2013531031 A5 JP 2013531031A5 JP 2013519189 A JP2013519189 A JP 2013519189A JP 2013519189 A JP2013519189 A JP 2013519189A JP 2013531031 A5 JP2013531031 A5 JP 2013531031A5
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JP
Japan
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linked
optionally substituted
pharmaceutically acceptable
heteroaryl
acceptable salt
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JP2013519189A
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English (en)
Japanese (ja)
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JP5830534B2 (ja
JP2013531031A (ja
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Priority claimed from PCT/IB2011/052974 external-priority patent/WO2012004743A1/en
Publication of JP2013531031A publication Critical patent/JP2013531031A/ja
Publication of JP2013531031A5 publication Critical patent/JP2013531031A5/ja
Application granted granted Critical
Publication of JP5830534B2 publication Critical patent/JP5830534B2/ja
Expired - Fee Related legal-status Critical Current
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JP2013519189A 2010-07-09 2011-07-05 化合物 Expired - Fee Related JP5830534B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36292710P 2010-07-09 2010-07-09
US61/362,927 2010-07-09
US201161492525P 2011-06-02 2011-06-02
US61/492,525 2011-06-02
PCT/IB2011/052974 WO2012004743A1 (en) 2010-07-09 2011-07-05 Benzenesulfonamides useful as sodium channel inhibitors

Publications (3)

Publication Number Publication Date
JP2013531031A JP2013531031A (ja) 2013-08-01
JP2013531031A5 true JP2013531031A5 (enExample) 2014-07-31
JP5830534B2 JP5830534B2 (ja) 2015-12-09

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JP2013519189A Expired - Fee Related JP5830534B2 (ja) 2010-07-09 2011-07-05 化合物

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US (1) US8772293B2 (enExample)
EP (1) EP2590951B1 (enExample)
JP (1) JP5830534B2 (enExample)
AR (1) AR082201A1 (enExample)
CA (1) CA2804593C (enExample)
ES (1) ES2533065T3 (enExample)
UY (1) UY33491A (enExample)
WO (1) WO2012004743A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2526675T3 (es) 2010-07-09 2015-01-14 Pfizer Limited N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
JP5872552B2 (ja) 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化学化合物
EP2593428B1 (en) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
EP2593427B1 (en) 2010-07-12 2014-12-24 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なｎ−スルホニルベンズアミド誘導体
EP2593431B1 (en) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
MX2014005304A (es) 2011-10-31 2015-03-20 Xenon Pharmaceuticals Inc Biaril eter sulfonamidas y su uso como agentes terapeuticos.
ES2586213T3 (es) * 2011-10-31 2016-10-13 Xenon Pharmaceuticals Inc. Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
US8889741B2 (en) * 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
WO2013137371A1 (ja) * 2012-03-15 2013-09-19 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
WO2013161928A1 (ja) * 2012-04-26 2013-10-31 塩野義製薬株式会社 オキサゾロトリアゾール誘導体およびそれらを含有する医薬組成物
CA2874621A1 (en) 2012-05-22 2013-11-28 Genentech, Inc. N-substituted benzamides and their use in the treatment of pain
US10071957B2 (en) 2012-07-06 2018-09-11 Genentech, Inc. N-substituted benzamides and methods of use thereof
US9376429B2 (en) * 2012-10-15 2016-06-28 Daewoong Pharmaceutical Co., Ltd. Sodium channel blockers, preparation method thereof and use thereof
AU2013334664A1 (en) 2012-10-26 2015-05-07 Merck Sharp & Dohme Corp. N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels
CN105263490B (zh) 2013-03-14 2018-05-22 基因泰克公司 取代的三唑并吡啶及其使用方法
CA2898680A1 (en) 2013-03-15 2014-09-18 Genentech,Inc. Substituted benzoxazoles and methods of use thereof
US10179781B2 (en) * 2013-03-15 2019-01-15 Chromocell Corporation Sodium channel modulators for the treatment of pain
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
TW201443025A (zh) 2013-04-19 2014-11-16 Pfizer Ltd 化學化合物
CN105611923B (zh) * 2013-09-10 2019-08-23 卓莫赛尔公司 用于治疗疼痛和糖尿病的钠通道调节剂
JP6383418B2 (ja) 2013-11-27 2018-08-29 ジェネンテック， インコーポレイテッド 置換ベンズアミド及びその使用方法
US10468036B2 (en) * 2014-04-30 2019-11-05 Accusonus, Inc. Methods and systems for processing and mixing signals using signal decomposition
EP3148992A1 (en) 2014-05-30 2017-04-05 Pfizer Inc. Benzenesulfonamides useful as sodium channel inhibitors
CN106715418A (zh) 2014-07-07 2017-05-24 基因泰克公司 治疗化合物及其使用方法
WO2016034971A1 (en) 2014-09-04 2016-03-10 Pfizer Limited Sulfonamides derivatives as urat1 inhibitors
MA42118A (fr) 2015-05-22 2018-03-28 Genentech Inc Benzamides substitués et leurs méthodes d'utilisation
WO2017035271A1 (en) 2015-08-27 2017-03-02 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP6987746B2 (ja) 2015-09-28 2022-01-05 ジェネンテック， インコーポレイテッド 治療用化合物及びその使用方法
CN108349894A (zh) * 2015-11-06 2018-07-31 第三共株式会社 除去二甲氧基苄基的方法
US10899732B2 (en) 2015-11-25 2021-01-26 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
CN108699015A (zh) 2015-12-18 2018-10-23 默沙东公司 对电压门控性钠通道具有选择性活性的羟基烷基胺-和羟基环烷基胺-取代的二胺-芳基磺胺化合物
US10766858B2 (en) 2016-03-30 2020-09-08 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2017201468A1 (en) 2016-05-20 2017-11-23 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
BR112019007763A2 (pt) 2016-10-17 2019-07-02 Genentech Inc composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção
EP3551626B1 (en) 2016-12-09 2023-10-25 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
EP3601273B1 (en) 2017-03-24 2021-12-01 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
AR114263A1 (es) 2018-02-26 2020-08-12 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
WO2019191702A1 (en) 2018-03-30 2019-10-03 F. Hoffmann-La Roche Ag Substituted hydro-pyrido-azines as sodium channel inhibitors
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
AU2019285184B2 (en) 2018-06-13 2023-11-16 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
US10981905B2 (en) 2018-08-31 2021-04-20 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
MA53488A (fr) 2018-08-31 2021-12-08 Xenon Pharmaceuticals Inc Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
WO2020117626A1 (en) 2018-12-05 2020-06-11 Merck Sharp & Dohme Corp. 4-amino or 4-alkoxy-substituted aryl sulfonamide compounds with selective activity in voltage-gated sodium channels
TW202216671A (zh) * 2020-06-25 2022-05-01 瑞士商諾華公司 １，４—二取代的嗒𠯤化合物之製造方法
CA3242011A1 (en) * 2021-12-23 2023-06-29 David Maloney Compositions and methods of use to treat 12-lipoxygenase (12-lox) mediated diseases
WO2025160284A1 (en) * 2024-01-23 2025-07-31 The Board Of Trustees Of The University Of Illinois Algorithm for computer-assisted molecular modularization

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71915B (enExample) 1979-11-27 1983-08-16 Pfizer
EP0194599A3 (en) 1985-03-14 1988-01-20 Nissan Chemical Industries Ltd. Benzamide derivatives, process for producing the same, and soil fungicides containing the same
US5084085A (en) 1986-08-20 1992-01-28 Fmc Corporation Herbicidal aryloxyphenyltriazolinones and related compounds
HUT48799A (en) 1986-08-20 1989-07-28 Fmc Corp Herbicides containing as active substance derivatives of triazolinon and process for production of the active substances
US4845264A (en) 1987-03-05 1989-07-04 Teijin Limited Phenoxycarboxylic acid and herbicide comprising it as active ingredient
US4920130A (en) 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920133A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
DE68909958D1 (de) 1988-01-19 1993-11-25 Tanabe Seiyaku Co Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung.
GB8911854D0 (en) 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
ATE117294T1 (de) 1989-08-11 1995-02-15 Ici Plc Chinolin-derivate, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB2244054B (en) 1990-04-19 1994-04-06 Ici Plc Pyridine derivatives
WO1993000332A1 (en) 1991-06-25 1993-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
GB2266527A (en) 1992-03-17 1993-11-03 Merck & Co Inc Substituted azetidinones useful in the treatment of leukemia
JPH05289262A (ja) 1992-04-10 1993-11-05 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JPH05307242A (ja) 1992-04-28 1993-11-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
JP3101848B2 (ja) 1992-05-15 2000-10-23 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
FR2694295B1 (fr) 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
AU5802894A (en) 1992-12-17 1994-07-04 Merck & Co., Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents
ES2141197T3 (es) 1993-03-19 2000-03-16 Merck & Co Inc Derivados del acido fenoxifenilacetico.
JPH06347968A (ja) 1993-04-14 1994-12-22 Fuji Photo Film Co Ltd ハロゲン化銀感光材料
DK77393D0 (da) 1993-06-29 1993-06-29 Novo Nordisk As Aktivering af enzymer
JP3503839B2 (ja) 1994-05-25 2004-03-08 富士写真フイルム株式会社 ポジ型感光性組成物
EP0774965A4 (en) 1994-08-08 1997-10-29 Merck & Co Inc PHENOXYPHENYLACETIC ACID DERIVATIVES
WO1996009818A1 (en) 1994-09-27 1996-04-04 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
GB9514031D0 (en) 1995-07-10 1995-09-06 Zeneca Ltd Chemical process
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
JP3519218B2 (ja) 1996-08-14 2004-04-12 富士写真フイルム株式会社 ハロゲン化銀写真感光材料および画像形成方法
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO1999000372A1 (fr) 1997-06-27 1999-01-07 Fujisawa Pharmaceutical Co., Ltd. Sulfamides et leur utilisation medicale
US6555584B1 (en) 2000-06-29 2003-04-29 Ajinomoto Co., Inc. Acylsulfonamide derivative
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
AU9696198A (en) 1997-10-17 1999-05-10 Aventis Pharmaceuticals Products Inc. Therapeutic uses of quinoline derivatives
US6268387B1 (en) 1997-12-23 2001-07-31 Warner-Lambert Company Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GT199900044A (es) 1998-04-10 2000-09-14 Procedimientos para preparar haluros de fenoxifenilsulfonilo.
DE19851184A1 (de) 1998-11-06 2000-05-11 Aventis Pharma Gmbh N-Arylsulfonyl-aminosäure-omega-amide
GB9828442D0 (en) 1998-12-24 1999-02-17 Karobio Ab Novel thyroid receptor ligands and method II
NZ515087A (en) 1999-04-28 2003-11-28 Aventis Pharma Gmbh Tri-aryl acid derivatives as PPAR receptor ligands
US6348482B1 (en) 1999-05-05 2002-02-19 Merck & Co., Inc. Catechols as antimicrobial agents
AU5158100A (en) 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
US6545055B1 (en) 1999-05-24 2003-04-08 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
WO2000071511A2 (en) 1999-05-24 2000-11-30 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
JP2001075213A (ja) 1999-09-07 2001-03-23 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤、その製造方法及びこれを用いたハロゲン化銀写真感光材料
JP2003510304A (ja) 1999-09-29 2003-03-18 ノボ ノルディスク アクティーゼルスカブ 新規芳香族化合物
SK4732002A3 (en) 1999-10-13 2002-12-03 Pfizer Prod Inc Biaryl ether derivatives useful as monoamine reuptake inhibitors
GB9927056D0 (en) 1999-11-17 2000-01-12 Karobio Ab Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders
MXPA02007603A (es) 2000-03-09 2003-02-24 Aventis Pharma Gmbh Usos terapeuticos de mediadores ppar.
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
UY26942A1 (es) 2000-09-20 2002-04-26 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
EP1260221A3 (en) 2001-05-23 2002-12-18 Pfizer Products Inc. Combination treatment for depression and anxiety
SE0101978D0 (sv) 2001-06-01 2001-06-01 Astrazeneca Ab New compounds
DK1445249T3 (da) 2001-11-16 2012-12-17 Toyama Chemical Co Ltd Nye bensophenon-derivater eller salte deraf
JP2006502143A (ja) 2002-08-26 2006-01-19 メルク　エンド　カムパニー　インコーポレーテッド 向代謝型グルタミン酸受容体のアセトフェノン増強因子
JP2006507359A (ja) 2002-10-28 2006-03-02 ノボ・ノルデイスク・エー／エス 心循環器疾患の治療のためのグリコーゲンホスホリラーゼ阻害剤の使用
US8198302B2 (en) 2003-02-28 2012-06-12 Oxigene, Inc. Compositions and methods with enhanced therapeutic activity
KR20060073930A (ko) 2003-08-08 2006-06-29 버텍스 파마슈티칼스 인코포레이티드 통증 치료시 나트륨 또는 칼슘 채널 차단제로서 유용한헤테로아릴아미노설포닐페닐 유도체
WO2005080346A1 (en) 2004-02-12 2005-09-01 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
GB0405033D0 (en) 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
EP1751136B1 (en) 2004-05-07 2014-07-02 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
CA2574971A1 (en) 2004-07-30 2006-02-09 Merck & Co., Inc. Indanone potentiators of metabotropic glutamate receptors
ES2444866T3 (es) 2004-10-20 2014-02-27 Merck Serono Sa Derivados de 3-arilamino piridina
JP2008189549A (ja) 2005-05-12 2008-08-21 Astellas Pharma Inc カルボン酸誘導体またはその塩
ES2380683T3 (es) 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
JP2009057282A (ja) 2005-12-19 2009-03-19 Astellas Pharma Inc カルボン酸誘導体又はその塩
CA2652307A1 (en) 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
CL2008000835A1 (es) 2007-03-23 2008-10-03 Icagen Inc Pfizer Ltd Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm
EA015952B1 (ru) 2007-05-03 2011-12-30 Пфайзер Лимитед 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов
WO2008149965A1 (ja) 2007-06-07 2008-12-11 Astellas Pharma Inc. ピリドン化合物
JP5460589B2 (ja) 2007-07-13 2014-04-02 アイカジェン， インコーポレイテッド ナトリウムチャネル阻害物質
MX2010003864A (es) 2007-10-11 2010-06-01 Vertex Pharma Amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
UY31468A1 (es) 2007-11-15 2009-07-17 Derivados bis-(sulfonilamino) en terapia 065
TW200930369A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
US20090291921A1 (en) 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
CN103351390A (zh) 2007-11-21 2013-10-16 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4 抑制剂
GB0725214D0 (en) 2007-12-24 2008-02-06 Karobio Ab Pharmaceutical compounds
WO2009101082A1 (en) 2008-02-15 2009-08-20 Basf Se Substituted sulfonic acid amide compounds
EP2119690A1 (en) 2008-05-14 2009-11-18 Academisch Medisch Centrum bij de Universiteit van Amsterdam Radiolabelled MMP selective compounds
EP2300471A1 (en) 2008-05-28 2011-03-30 Basf Se Substituted pyridin-4-yl-methyl sulfonamidesas fungicides
CN102076660B (zh) 2008-06-23 2014-01-08 安斯泰来制药有限公司 磺胺化合物或其盐
US8107894B2 (en) 2008-08-12 2012-01-31 Raytheon Company Modular solid-state millimeter wave (MMW) RF power source
CA2747419C (en) 2009-01-12 2014-07-08 Icagen, Inc. Sulfonamide derivatives
JP5289262B2 (ja) 2009-09-30 2013-09-11 京セラドキュメントソリューションズ株式会社 シート搬送装置とこれを備えた画像読取装置及び画像形成装置
JP5872552B2 (ja) * 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化学化合物
ES2526675T3 (es) * 2010-07-09 2015-01-14 Pfizer Limited N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje
EP2593427B1 (en) 2010-07-12 2014-12-24 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
EP2593428B1 (en) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
EP2593431B1 (en) 2010-07-12 2014-11-19 Pfizer Limited N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
JP2013532184A (ja) 2010-07-12 2013-08-15 ファイザー・リミテッド 電位開口型ナトリウムチャネル阻害剤として有用なｎ−スルホニルベンズアミド誘導体

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