JP2013533883A5 - - Google Patents
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- Publication number
- JP2013533883A5 JP2013533883A5 JP2013518684A JP2013518684A JP2013533883A5 JP 2013533883 A5 JP2013533883 A5 JP 2013533883A5 JP 2013518684 A JP2013518684 A JP 2013518684A JP 2013518684 A JP2013518684 A JP 2013518684A JP 2013533883 A5 JP2013533883 A5 JP 2013533883A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- halo
- substituted
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36000110P | 2010-06-30 | 2010-06-30 | |
| US61/360,001 | 2010-06-30 | ||
| PCT/US2011/042506 WO2012003264A1 (en) | 2010-06-30 | 2011-06-30 | Nitrogen containing heterocyclic compounds as pik3 -delta inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533883A JP2013533883A (ja) | 2013-08-29 |
| JP2013533883A5 true JP2013533883A5 (enExample) | 2014-08-14 |
Family
ID=44454536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518684A Withdrawn JP2013533883A (ja) | 2010-06-30 | 2011-06-30 | ＰＩ３Ｋδ阻害剤としての含窒素複素環化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130079342A1 (enExample) |
| EP (1) | EP2588473A1 (enExample) |
| JP (1) | JP2013533883A (enExample) |
| AU (1) | AU2011271462A1 (enExample) |
| CA (1) | CA2803620A1 (enExample) |
| MX (1) | MX2012015143A (enExample) |
| WO (1) | WO2012003264A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2916868B1 (en) | 2012-11-08 | 2022-05-11 | Rhizen Pharmaceuticals S.A. | Pharmaceutical compositions containing a pde4 inhibitor and a pi3 delta or dual pi3 delta-gamma kinase inhibitor |
| BR112015011148A8 (pt) * | 2012-11-16 | 2019-10-01 | Merck Sharp & Dohme | composto, composição farmacêutica, e combinação |
| JP6322200B2 (ja) * | 2012-11-16 | 2018-05-09 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ヒトホスファチジルイノシトール３−キナーゼデルタのプリン阻害剤 |
| CU24428B1 (es) | 2014-07-04 | 2019-06-04 | Lupin Ltd | Derivados de quinolizinona como inhibidores de pi3k |
| MA40957A (fr) * | 2014-10-09 | 2017-09-19 | Biomarin Pharm Inc | Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies |
| CN108473435A (zh) | 2015-10-05 | 2018-08-31 | 纽约市哥伦比亚大学理事会 | 自噬潮和磷脂酶d的活化剂以及包括tau的蛋白聚集体的清除和蛋白质病的治疗 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| CN114793434A (zh) | 2019-10-18 | 2022-07-26 | 加利福尼亚大学董事会 | 作为用于治疗病原性血管病症的药剂的3-苯基磺酰基-喹啉衍生物 |
| CA3162386A1 (en) | 2019-12-18 | 2021-06-24 | Glen N. Barber | Substituted 1,2, 4-triazoles and methods of use |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11897888B1 (en) | 2020-04-30 | 2024-02-13 | Stinginn Llc | Small molecular inhibitors of sting signaling compositions and methods of use |
| TW202204350A (zh) | 2020-05-06 | 2022-02-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| DE3020458C2 (de) | 1980-05-29 | 1986-07-31 | Herzog, Thomas, Prof. Dr., 3500 Kassel | Vorgehängte Fassaden-, Bau- oder Dekorationsplatte |
| EP0533882B1 (en) * | 1991-04-03 | 2001-02-07 | Korea Research Institute Of Chemical Technology | 2-quinolinone derivatives, methods for preparing the same and fungicides and insecticides including them |
| US6043062A (en) | 1995-02-17 | 2000-03-28 | The Regents Of The University Of California | Constitutively active phosphatidylinositol 3-kinase and uses thereof |
| GB9611460D0 (en) | 1996-06-01 | 1996-08-07 | Ludwig Inst Cancer Res | Novel lipid kinase |
| US5858753A (en) | 1996-11-25 | 1999-01-12 | Icos Corporation | Lipid kinase |
| US5822910A (en) | 1997-10-02 | 1998-10-20 | Shewmake; I. W. | Fishing line tensioning device |
| WO2004108704A1 (en) * | 2003-06-05 | 2004-12-16 | Astrazeneca Ab | Pyrimidin-4-yl 3-cyanoquinoline derivatives for use in the treatment of tumours |
| WO2004108703A1 (en) * | 2003-06-05 | 2004-12-16 | Astrazeneca Ab | Pyrazinyl 3-cyanoquinoline derivatives for use in the treatment of tumours |
| TW200529846A (en) * | 2004-02-20 | 2005-09-16 | Wyeth Corp | 3-quinolinecarbonitrile protein kinase inhibitors |
| PL2137186T3 (pl) * | 2007-03-23 | 2016-09-30 | Związki heterocykliczne i ich zastosowania | |
| DK2139882T3 (en) * | 2007-03-23 | 2014-03-10 | Amgen Inc | 3-substituted quinoline or quinoxaline derivatives and their use as inhibitors of phosphatidylinositol 3-kinase (PI3K) |
| US8399483B2 (en) * | 2007-12-21 | 2013-03-19 | Ucb Pharma S.A. | Quinoxaline and quinoline derivatives as kinase inhibitors |
| SG176978A1 (en) * | 2009-06-25 | 2012-02-28 | Amgen Inc | Heterocyclic compounds and their uses |
| AR077267A1 (es) * | 2009-06-25 | 2011-08-17 | Amgen Inc | Derivados nitrogenados heterociclicos inhibidores selectivos de pi3k, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias y/o autoinmunes. |
| ES2534096T3 (es) * | 2009-11-12 | 2015-04-17 | Ucb Pharma, S.A. | Derivados de piridina y pirazina bicíclicos condensados como inhibidores de quinasa |
| US8623889B2 (en) * | 2010-12-17 | 2014-01-07 | Genentech, Inc. | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof |
-
2011
- 2011-06-30 AU AU2011271462A patent/AU2011271462A1/en not_active Abandoned
- 2011-06-30 MX MX2012015143A patent/MX2012015143A/es unknown
- 2011-06-30 US US13/701,912 patent/US20130079342A1/en not_active Abandoned
- 2011-06-30 CA CA2803620A patent/CA2803620A1/en not_active Abandoned
- 2011-06-30 WO PCT/US2011/042506 patent/WO2012003264A1/en not_active Ceased
- 2011-06-30 EP EP11738520.3A patent/EP2588473A1/en not_active Withdrawn
- 2011-06-30 JP JP2013518684A patent/JP2013533883A/ja not_active Withdrawn
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