|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
HU196714B
(en)
|
1984-10-04 |
1989-01-30 |
Monsanto Co |
Process for producing non-aqueous composition comprising somatotropin
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US5612059A
(en)
|
1988-08-30 |
1997-03-18 |
Pfizer Inc. |
Use of asymmetric membranes in delivery devices
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
EP0711804A3
(de)
|
1994-11-14 |
1999-09-22 |
Ciba SC Holding AG |
Kryptolichtschutzmittel
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
US5798119A
(en)
|
1995-06-13 |
1998-08-25 |
S. C. Johnson & Son, Inc. |
Osmotic-delivery devices having vapor-permeable coatings
|
|
EP0835101B1
(en)
|
1995-06-27 |
2004-06-09 |
Takeda Chemical Industries, Ltd. |
Method of producing sustained-release preparation
|
|
JP3512911B2
(ja)
|
1995-07-11 |
2004-03-31 |
富士写真フイルム株式会社 |
紫外線吸収剤前駆体化合物、それを含有する感光性樹脂組成物及び画像形成方法
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
NZ334914A
(en)
|
1996-10-01 |
2000-09-29 |
Stanford Res Inst Int |
Taste-masked microcapsule compositions and methods of manufacture using a phase seperation-coacervation technique
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
DE69730093T2
(de)
|
1996-10-31 |
2006-07-20 |
Takeda Pharmaceutical Co. Ltd. |
Zubereitung mit verzögerter Freisetzung
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
CA2275422A1
(en)
|
1996-12-20 |
1998-07-02 |
Takeda Chemical Industries, Ltd. |
Method of producing a sustained-release preparation
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
US6251900B1
(en)
|
1997-07-24 |
2001-06-26 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compounds and antitumor agent containing the same as active ingredient
|
|
JPH11174638A
(ja)
|
1997-12-08 |
1999-07-02 |
Konica Corp |
ハロゲン化銀カラー写真感光材料
|
|
US6350458B1
(en)
|
1998-02-10 |
2002-02-26 |
Generex Pharmaceuticals Incorporated |
Mixed micellar drug deliver system and method of preparation
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
JP2003523942A
(ja)
*
|
1999-06-30 |
2003-08-12 |
メルク エンド カムパニー インコーポレーテッド |
Srcキナーゼ阻害剤化合物
|
|
EP1246823A1
(en)
*
|
1999-12-28 |
2002-10-09 |
Pharmacopeia, Inc. |
Pyrimidine and triazine kinase inhibitors
|
|
RS51458B
(sr)
|
2000-04-25 |
2011-04-30 |
Icos Corporation |
Inhibitori humane fosfatidil-inozitol 3-kinaze delta
|
|
AU6513701A
(en)
|
2000-05-30 |
2001-12-11 |
Advanced Res & Tech Inst |
Compositions and methods for identifying agents which modulate pten function andpi-3 kinase pathways
|
|
AP2001002264A0
(en)
|
2000-08-30 |
2001-09-30 |
Pfizer Prod Inc |
Sustained release formulations for growth hormone secretagogues.
|
|
AU2002253619B2
(en)
|
2001-04-27 |
2007-05-17 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compound and antitumor agent containing the same active ingredients
|
|
DE10207037A1
(de)
|
2002-02-20 |
2003-08-28 |
Bayer Cropscience Gmbh |
2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
|
|
AU2003220300A1
(en)
|
2002-03-15 |
2003-09-29 |
Binch, Hayley |
Compositions useful as inhibitors of protein kinases
|
|
ATE433973T1
(de)
|
2002-03-15 |
2009-07-15 |
Vertex Pharma |
Azolylaminoazine als inhibitoren von proteinkinasen
|
|
EP1485100B1
(en)
|
2002-03-15 |
2010-05-05 |
Vertex Pharmaceuticals Incorporated |
Azinylaminoazoles as inhibitors of protein kinases
|
|
US20040009981A1
(en)
|
2002-03-15 |
2004-01-15 |
David Bebbington |
Compositions useful as inhibitors of protein kinases
|
|
CN1668759A
(zh)
|
2002-05-17 |
2005-09-14 |
协和发酵工业株式会社 |
具有抗糖尿病作用的物质的探索方法
|
|
ES2389253T3
(es)
|
2002-10-25 |
2012-10-24 |
Zenyaku Kogyo Kabushiki Kaisha |
Compuestos heterocíclicos y agentes antitumorales que comprenden los mismos como ingrediente activo
|
|
CA2507100C
(en)
*
|
2002-11-21 |
2012-10-09 |
Chiron Corporation |
2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer
|
|
US7223759B2
(en)
|
2003-09-15 |
2007-05-29 |
Anadys Pharmaceuticals, Inc. |
Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
|
|
ES2389203T3
(es)
|
2004-01-12 |
2012-10-24 |
Ym Biosciences Australia Pty Ltd |
Inhibidores de quinasa selectivos
|
|
WO2005095389A1
(ja)
|
2004-03-31 |
2005-10-13 |
Zenyaku Kogyo Kabushiki Kaisha |
複素環式化合物及びそれを有効成分とする抗悪性腫瘍剤
|
|
ES2355923T3
(es)
|
2004-08-26 |
2011-04-01 |
Pfizer, Inc. |
Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa.
|
|
AU2005304393B2
(en)
|
2004-11-10 |
2012-09-27 |
Synta Pharmaceuticals Corp. |
IL-12 modulatory compounds
|
|
WO2006053109A1
(en)
|
2004-11-10 |
2006-05-18 |
Synta Pharmaceuticals Corp. |
Heteroaryl compounds
|
|
ES2395196T3
(es)
|
2005-03-11 |
2013-02-11 |
Zenyaku Kogyo Kabushikikaisha |
Agente inmunosupresor que comprende un compuesto heterocíclico como ingrediente activo
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
GB0525080D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
GB0525081D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US20070244110A1
(en)
|
2006-04-14 |
2007-10-18 |
Zenyaku Kogyo Kabushiki Kaisha |
Treatment of prostate cancer, melanoma or hepatic cancer
|
|
CN101511840A
(zh)
|
2006-04-26 |
2009-08-19 |
吉宁特有限公司 |
磷酸肌醇3-激酶抑制剂化合物及其使用方法
|
|
JP5546240B2
(ja)
*
|
2006-04-26 |
2014-07-09 |
ジェネンテック, インコーポレイテッド |
医薬化合物
|
|
AU2007282535B9
(en)
|
2006-08-08 |
2013-06-20 |
Chugai Seiyaku Kabushiki Kaisha |
Pyrimidine derivative as PI3K inhibitor and use thereof
|
|
WO2008032033A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
CN101595103A
(zh)
|
2006-09-14 |
2009-12-02 |
阿斯利康(瑞典)有限公司 |
嘧啶衍生物
|
|
WO2008032089A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032077A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2008032036A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032060A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032027A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
EP2064203A1
(en)
|
2006-09-14 |
2009-06-03 |
AstraZeneca AB |
2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032091A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
US20090325954A1
(en)
|
2006-09-14 |
2009-12-31 |
Sam Butterworth |
2-benzimidazolyl-6-morpholino-4-phenylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032041A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives having inhibitory activity against pi3k enzymes
|
|
WO2008032028A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
2 -benzimidazolyl- 6 -morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
EA200901065A1
(ru)
|
2007-02-06 |
2010-02-26 |
Новартис Аг |
Ингибиторы pi 3-киназы и способы их применения
|
|
US20080221103A1
(en)
|
2007-03-09 |
2008-09-11 |
Orchid Research Laboratories Ltd. |
New heterocyclic compounds
|
|
US20080233127A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
|
|
EP2125819B1
(en)
*
|
2007-03-21 |
2014-10-22 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases
|
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
|
US20090029992A1
(en)
|
2007-06-11 |
2009-01-29 |
Agoston Gregory E |
Substituted pyrazole compounds
|
|
WO2009007751A2
(en)
|
2007-07-09 |
2009-01-15 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
RU2518098C2
(ru)
|
2007-10-05 |
2014-06-10 |
Верастэм,Инк. |
Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ и способ лечения пролиферативных заболеваний
|
|
US20110009403A1
(en)
|
2007-10-05 |
2011-01-13 |
S*Bio Pte Ltd. |
2-morpholinylpurines as inhibitors of pi3k
|
|
WO2009066775A1
(ja)
|
2007-11-22 |
2009-05-28 |
Zenyaku Kogyo Kabushikikaisha |
複素環式化合物の非晶質体、それを含む固体分散体、薬剤、およびその製造法
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
MX2010007746A
(es)
|
2008-01-15 |
2010-08-18 |
Wyeth Llc |
Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de diana de rapamicina de mamifero quinasa y fosfatidilinositol quinasa y su sintesis.
|
|
WO2009093981A1
(en)
|
2008-01-23 |
2009-07-30 |
S Bio Pte Ltd |
Triazine compounds as kinase inhibitors
|
|
US20090192176A1
(en)
|
2008-01-30 |
2009-07-30 |
Wyeth |
1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
|
|
TW200938201A
(en)
|
2008-02-07 |
2009-09-16 |
Chugai Pharmaceutical Co Ltd |
Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof
|
|
WO2009120094A2
(en)
|
2008-03-27 |
2009-10-01 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
AP2775A
(en)
|
2008-05-23 |
2013-09-30 |
Wyeth Llc |
Triazine compounds as P13 kinase and MTOR inhibitors
|
|
US20110105500A1
(en)
|
2008-06-27 |
2011-05-05 |
S*Bio Pte Ltd. |
Pyrazine substituted purines
|
|
EP2307414A4
(en)
|
2008-07-07 |
2011-10-26 |
Xcovery Holding Co Llc |
SELECTIVE INHIBITORS OF PI3 KINASE ISOFORMS
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
EP2355828B1
(en)
|
2008-11-13 |
2018-05-30 |
Gilead Calistoga LLC |
Therapies for hematologic malignancies
|
|
MX2011008444A
(es)
*
|
2009-02-12 |
2011-09-06 |
Astellas Pharma Inc |
Derivado de heteroanillo.
|
|
SG174527A1
(en)
*
|
2009-03-27 |
2011-11-28 |
Pathway Therapeutics Inc |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
WO2010110686A1
(en)
|
2009-03-27 |
2010-09-30 |
Pathway Therapeutics Limited |
Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
|
|
KR20130026364A
(ko)
|
2009-05-27 |
2013-03-13 |
제넨테크, 인크. |
P110 델타에 대해 선택적인 비시클릭 피리미딘 pi3k 억제제 화합물 및 사용 방법
|
|
US8158625B2
(en)
|
2009-05-27 |
2012-04-17 |
Genentech, Inc. |
Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
|
|
UY32742A
(es)
|
2009-06-25 |
2010-12-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
AU2010266064A1
(en)
|
2009-06-25 |
2012-01-19 |
Amgen Inc. |
4H - pyrido [1, 2 - a] pyrimidin - 4 - one derivatives as PI3 K inhibitors
|
|
US8765940B2
(en)
|
2009-06-25 |
2014-07-01 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
MX2011013510A
(es)
|
2009-06-25 |
2012-03-07 |
Amgen Inc |
Compuestos heterociclicos y sus usos.
|
|
US8486939B2
(en)
*
|
2009-07-07 |
2013-07-16 |
Pathway Therapeutics Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
PL2604601T3
(pl)
*
|
2010-08-10 |
2016-09-30 |
|
Związek heteropierścieniowy
|
|
JP2014500275A
(ja)
|
2010-12-06 |
2014-01-09 |
フォリカ,インコーポレイテッド |
禿頭症を治療するため、および毛髪の成長を促進するための方法
|
|
US9464065B2
(en)
|
2011-03-24 |
2016-10-11 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
SG193982A1
(en)
|
2011-03-28 |
2013-11-29 |
Mei Pharma Inc |
(alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases
|
|
BR112013024909A2
(pt)
*
|
2011-03-28 |
2019-09-24 |
Mei Pharma Inc |
composto, composição farmacêutica, método para o tratamento, prevenção ou melhoria de um ou mais sintomas de desordem, doença, ou condição mediada por pi3k, e método para modular a atividade enzimática de pi3k
|
|
US20140088103A1
(en)
|
2011-03-28 |
2014-03-27 |
Mei Pharma, Inc. |
(fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
EP2723746A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013006408A1
(en)
|
2011-07-01 |
2013-01-10 |
Tempero Pharmaceuticals, Inc. |
Compounds and methods
|
|
US9499474B2
(en)
|
2011-11-11 |
2016-11-22 |
Merck Patent Gmbh |
Process for producing arylamines
|
|
PL2882442T3
(pl)
|
2012-08-09 |
2021-12-13 |
Celgene Corporation |
Sposoby leczenia nowotworów z wykorzystaniem 3-(4-((4-(morfolinometylo)benzylo)oksy)-1-oksoizoindolin-2-ylo)piperydyno-2,6-dionu
|
|
WO2014055647A1
(en)
|
2012-10-03 |
2014-04-10 |
Mei Pharma, Inc. |
(sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
|
EA201691169A1
(ru)
|
2013-12-05 |
2016-09-30 |
Асерта Фарма Б.В. |
Терапевтическая комбинация ингибитора pi3k и ингибитора btk
|
|
AU2015220427B2
(en)
|
2014-02-19 |
2017-09-21 |
Piramal Enterprises Limited |
Compounds for use as GPR120 agonists
|
|
TW201613644A
(en)
|
2014-06-17 |
2016-04-16 |
Acerta Pharma Bv |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, and/or a JAK-2 inhibitor
|
|
AU2015289922A1
(en)
|
2014-07-15 |
2017-02-16 |
The Johns Hopkins University |
Suppression of myeloid derived suppressor cells and immune checkpoint blockade
|
|
TW201618774A
(zh)
|
2014-08-11 |
2016-06-01 |
艾森塔製藥公司 |
使用btk抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法
|
|
SMT202200285T1
(it)
|
2014-08-11 |
2022-09-14 |
Acerta Pharma Bv |
Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1
|
|
US20160082120A1
(en)
|
2014-09-23 |
2016-03-24 |
Genentech, Inc. |
METHODS OF USING ANTI-CD79b IMMUNOCONJUGATES
|
|
PH12017501029B1
(en)
|
2014-12-24 |
2022-04-27 |
Lg Chemical Ltd |
Biaryl derivative as gpr120 agonist
|
|
RU2748884C2
(ru)
|
2015-07-20 |
2021-06-01 |
Джензим Корпорейшн |
Ингибиторы рецептора колониестимулирующего фактора-1 (csf-1r)
|
|
EA201890567A1
(ru)
|
2015-08-24 |
2018-08-31 |
Эпизайм, Инк. |
Способ лечения рака
|
|
WO2017059224A2
(en)
|
2015-10-01 |
2017-04-06 |
Gilead Sciences, Inc. |
Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
|
|
WO2017066705A1
(en)
|
2015-10-14 |
2017-04-20 |
Aquinnah Pharmaceuticals, Inc. |
Compounds, compositions and methods of use against stress granules
|
|
CA3031542A1
(en)
|
2016-07-20 |
2018-01-25 |
University Of Utah Research Foundation |
Cd229 car t cells and methods of use thereof
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
AU2018271862B2
(en)
|
2017-05-23 |
2022-12-15 |
Mei Pharma, Inc. |
Combination therapy
|
|
KR20200041358A
(ko)
|
2017-08-14 |
2020-04-21 |
메이 파마, 아이엔씨. |
병용 요법
|
|
EA202092154A1
(ru)
|
2018-03-21 |
2021-03-22 |
Мей Фарма, Инк. |
Комбинированная терапия
|
|
JP2021534116A
(ja)
|
2018-08-14 |
2021-12-09 |
エムイーアイ ファーマ,インク. |
再発性の濾胞性リンパ腫の処置
|
|
KR20210043635A
(ko)
|
2018-08-14 |
2021-04-21 |
메이 파마, 아이엔씨. |
B 세포 악성 종양의 치료
|
|
WO2020132563A1
(en)
|
2018-12-21 |
2020-06-25 |
Mei Pharma, Inc. |
Combination therapy
|