JP2018513832A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018513832A5 JP2018513832A5 JP2017541855A JP2017541855A JP2018513832A5 JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5 JP 2017541855 A JP2017541855 A JP 2017541855A JP 2017541855 A JP2017541855 A JP 2017541855A JP 2018513832 A5 JP2018513832 A5 JP 2018513832A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound according
- hydrogen
- pharmaceutically acceptable
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C Chemical compound C*(C)N(C1C(*)C1)C(N=C(C1)C1*=C)=C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510157772 | 2015-04-03 | ||
| CN201510157772.0 | 2015-04-03 | ||
| PCT/CN2016/077519 WO2016155593A1 (zh) | 2015-04-03 | 2016-03-28 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513832A JP2018513832A (ja) | 2018-05-31 |
| JP2018513832A5 true JP2018513832A5 (enExample) | 2019-03-28 |
| JP6769000B2 JP6769000B2 (ja) | 2020-10-14 |
Family
ID=57004251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541855A Expired - Fee Related JP6769000B2 (ja) | 2015-04-03 | 2016-03-28 | ４’−チオヌクレオシドの新規な化合物、並びにその調製方法、その医薬組成物及びその用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10662214B2 (enExample) |
| EP (1) | EP3279207B1 (enExample) |
| JP (1) | JP6769000B2 (enExample) |
| CN (2) | CN106661077B (enExample) |
| AU (1) | AU2016240117C1 (enExample) |
| CA (1) | CA2975990A1 (enExample) |
| EA (1) | EA034375B1 (enExample) |
| WO (1) | WO2016155593A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201406080VA (en) | 2012-03-28 | 2014-11-27 | Fujifilm Corp | SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE |
| CA2880794C (en) | 2012-08-13 | 2018-08-28 | Fujifilm Corporation | Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-.beta.-d-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and methods for producing the same |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| US10662214B2 (en) * | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
| RU2752172C2 (ru) | 2016-08-31 | 2021-07-23 | Фуджифилм Корпорэйшн | Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор |
| US10787477B2 (en) | 2016-12-22 | 2020-09-29 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Solid form of 4′-thio-2′-fluoronucleoside phosphamide compound and preparation method therefor and use thereof |
| WO2019001292A1 (zh) * | 2017-06-29 | 2019-01-03 | 四川科伦博泰生物医药股份有限公司 | 4'-硫代核苷的新型化合物的制备方法和此制备方法中的中间体 |
| WO2019042226A1 (zh) | 2017-09-01 | 2019-03-07 | 四川科伦博泰生物医药股份有限公司 | 用于肿瘤治疗或预防的药物组合物、方法及其用途 |
| CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| EP4209498A1 (en) * | 2018-04-19 | 2023-07-12 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| WO2020108343A1 (zh) * | 2018-11-28 | 2020-06-04 | 四川科伦博泰生物医药股份有限公司 | 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途 |
| US20220281910A1 (en) * | 2019-07-30 | 2022-09-08 | Pinotbio, Inc. | Dinucleotide compounds for treating cancers and medical uses thereof |
| CN115768432A (zh) | 2020-04-23 | 2023-03-07 | 南方研究院 | 使用4’-硫代-5-氮杂-2’-脱氧胞苷来治疗血癌的组合物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128458A (en) | 1990-04-20 | 1992-07-07 | Southern Research Institute | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents |
| US6147058A (en) | 1996-04-09 | 2000-11-14 | Yamasa Corporation | 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine |
| JPH1087687A (ja) | 1996-04-09 | 1998-04-07 | Yamasa Shoyu Co Ltd | ５−置換−１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）ウラシル |
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| JP5379347B2 (ja) | 2003-09-18 | 2013-12-25 | アイシス ファーマシューティカルズ， インコーポレーテッド | ４’−チオヌクレオシドおよびオリゴマー化合物 |
| US7888330B2 (en) * | 2005-11-09 | 2011-02-15 | Wayne State University | Phosphoramidate derivatives of FAU |
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| EP2734535A4 (en) * | 2011-07-19 | 2014-10-22 | Nanjing Molecular Res Inc | 2 ', 3'-DIDEOXY-2'-ALPHA-FLUOR-2'-BETA-C-METHYL NUCLEOSIDE AND PRODRUGS THEREOF |
| WO2014124430A1 (en) * | 2013-02-11 | 2014-08-14 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| WO2014197578A1 (en) * | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| US10662214B2 (en) * | 2015-04-03 | 2020-05-26 | Sichuan Keiun-Biotech Biopharmaceutical Co., Ltd. | Compound of 4′-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
-
2016
- 2016-03-28 US US15/558,620 patent/US10662214B2/en active Active
- 2016-03-28 AU AU2016240117A patent/AU2016240117C1/en not_active Ceased
- 2016-03-28 JP JP2017541855A patent/JP6769000B2/ja not_active Expired - Fee Related
- 2016-03-28 EA EA201791535A patent/EA034375B1/ru unknown
- 2016-03-28 WO PCT/CN2016/077519 patent/WO2016155593A1/zh not_active Ceased
- 2016-03-28 CN CN201680001812.5A patent/CN106661077B/zh active Active
- 2016-03-28 CA CA2975990A patent/CA2975990A1/en not_active Abandoned
- 2016-03-28 CN CN201811577363.6A patent/CN109553651B/zh active Active
- 2016-03-28 EP EP16771348.6A patent/EP3279207B1/en active Active
-
2020
- 2020-04-17 US US16/851,217 patent/US20200262860A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018513832A5 (enExample) | ||
| ES2925564T3 (es) | Derivados de azetidina tal como moduladores de receptores de quimiocinas y usos de los mismos | |
| JP5271913B2 (ja) | 化合物 | |
| KR101612642B1 (ko) | 테노포비어 알라펜아미드 헤미푸마레이트 | |
| ES2654161T3 (es) | Compuestos químicos | |
| JP2020515610A5 (enExample) | ||
| RU2007124329A (ru) | ПРОИЗВОДНЫЕ 5-ГИДРОКСИБЕНЗОТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ β2 АДРЕНОРЕЦЕПТОРОВ | |
| CA2938280A1 (en) | 4-amino-imidazoquinoline compounds | |
| JP2013010792A5 (enExample) | ||
| RU2005107314A (ru) | Пиримидопроизводные, характеризующиеся антипролиферативной активностью | |
| KR101986272B1 (ko) | 삼환식 화합물, 이를 포함하는 조성물 및 그의 용도 | |
| JP2013056886A5 (enExample) | ||
| KR20150046315A (ko) | 테노포비르 전구약물 및 그의 약학적 용도 | |
| ES2714100T3 (es) | Compuestos de quinolina fusionados como inhibidores de mTor, pi3k | |
| JP2015508092A5 (enExample) | ||
| JP2017534657A (ja) | 新型シチジン誘導体およびその適用 | |
| JP2020516616A5 (enExample) | ||
| JP2015502371A5 (enExample) | ||
| WO2015197006A1 (zh) | 一种取代的氨基酸硫酯类化合物、其组合物及应用 | |
| JP6872179B2 (ja) | テノホビルプロドラッグの新規な多結晶形並びにその製造方法及び用途 | |
| TWI638825B (zh) | 抑制癌症及病毒之化合物 | |
| CA2552855A1 (en) | Azabicyclooctan-3-one derivatives and use thereof | |
| RU2008112181A (ru) | Применение конденсированных производных имидазола для лечения заболеваний, опосредованных рецептором ccr3 | |
| JP2013525290A5 (enExample) | ||
| JP2006500372A5 (enExample) |