JP2015502371A5 - - Google Patents
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- Publication number
- JP2015502371A5 JP2015502371A5 JP2014547736A JP2014547736A JP2015502371A5 JP 2015502371 A5 JP2015502371 A5 JP 2015502371A5 JP 2014547736 A JP2014547736 A JP 2014547736A JP 2014547736 A JP2014547736 A JP 2014547736A JP 2015502371 A5 JP2015502371 A5 JP 2015502371A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- hal
- compound
- independently selected
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 239000007821 HATU Substances 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578931P | 2011-12-22 | 2011-12-22 | |
| EP11195214.9 | 2011-12-22 | ||
| EP11195214.9A EP2607364A1 (en) | 2011-12-22 | 2011-12-22 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| US61/578,931 | 2011-12-22 | ||
| US201261657978P | 2012-06-11 | 2012-06-11 | |
| EP12171415.8A EP2674434A1 (en) | 2012-06-11 | 2012-06-11 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| EP12171415.8 | 2012-06-11 | ||
| US61/657,978 | 2012-06-11 | ||
| PCT/EP2012/004968 WO2013091773A1 (en) | 2011-12-22 | 2012-11-30 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502371A JP2015502371A (ja) | 2015-01-22 |
| JP2015502371A5 true JP2015502371A5 (enExample) | 2016-08-04 |
| JP6112316B2 JP6112316B2 (ja) | 2017-04-12 |
Family
ID=48667735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547736A Active JP6112316B2 (ja) | 2011-12-22 | 2012-11-30 | テトラアザ−シクロペンタ［ａ］インデニル及びポジティブアロステリックモジュレーターとしてのそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9403835B2 (enExample) |
| EP (1) | EP2794608B1 (enExample) |
| JP (1) | JP6112316B2 (enExample) |
| CN (1) | CN104039789B (enExample) |
| AU (1) | AU2012357169B2 (enExample) |
| CA (1) | CA2860008C (enExample) |
| ES (1) | ES2606839T3 (enExample) |
| WO (1) | WO2013091773A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| RU2702106C2 (ru) * | 2014-08-26 | 2019-10-04 | Астеллас Фарма Инк. | Производное 2-аминотиазола или его соль |
| DK3256476T3 (en) * | 2015-02-11 | 2019-03-11 | Sunovion Pharmaceuticals Inc | CONDENSED DIHYDRO-4H-PYRAZOLO [5,1-C] [1,4] OXAZINYL COMPOUNDS AND ANALOGS FOR TREATMENT OF CNS DISORDERS |
| US10822357B2 (en) * | 2015-08-28 | 2020-11-03 | Sekisui Medical Co., Ltd. | Benzyl compound |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| CA3070993C (en) | 2017-08-02 | 2025-05-20 | Sunovion Pharmaceuticals Inc. | ISOCHROMANE COMPOUNDS AND THEIR USES |
| FI3728207T3 (fi) | 2017-12-21 | 2023-04-24 | Ribon Therapeutics Inc | Kinatsolinoneja parp14:n inhibiittoreina |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525937A (ja) * | 2001-03-27 | 2004-08-26 | ニューロジェン コーポレイション | （オキソ−ピラゾロ［１，５ａ］ピリミジン−２−イル）アルキル−カルボキサミド |
| AU2005315914B2 (en) * | 2004-12-15 | 2011-03-03 | F. Hoffmann-La Roche Ag | Bi- and tricyclic substituted phenyl methanones as glycine transporter I (GlyT-1) inhibitors for the treatment of Alzheimer's disease |
| WO2008060488A1 (en) | 2006-11-14 | 2008-05-22 | Merck & Co., Inc. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| EP2563126B1 (en) * | 2010-04-30 | 2016-05-11 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived m1 receptor positive allosteric modulators |
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
-
2012
- 2012-11-30 WO PCT/EP2012/004968 patent/WO2013091773A1/en not_active Ceased
- 2012-11-30 AU AU2012357169A patent/AU2012357169B2/en active Active
- 2012-11-30 EP EP12798612.3A patent/EP2794608B1/en active Active
- 2012-11-30 ES ES12798612.3T patent/ES2606839T3/es active Active
- 2012-11-30 CN CN201280062522.3A patent/CN104039789B/zh active Active
- 2012-11-30 CA CA2860008A patent/CA2860008C/en active Active
- 2012-11-30 JP JP2014547736A patent/JP6112316B2/ja active Active
- 2012-11-30 US US14/366,901 patent/US9403835B2/en active Active