ES2606839T3 - Tetraaza-ciclopenta[a]indenilo y su uso como moduladores alostéricos positivos - Google Patents
Tetraaza-ciclopenta[a]indenilo y su uso como moduladores alostéricos positivos Download PDFInfo
- Publication number
- ES2606839T3 ES2606839T3 ES12798612.3T ES12798612T ES2606839T3 ES 2606839 T3 ES2606839 T3 ES 2606839T3 ES 12798612 T ES12798612 T ES 12798612T ES 2606839 T3 ES2606839 T3 ES 2606839T3
- Authority
- ES
- Spain
- Prior art keywords
- hal
- independently selected
- denotes
- cyc
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578931P | 2011-12-22 | 2011-12-22 | |
| EP11195214.9A EP2607364A1 (en) | 2011-12-22 | 2011-12-22 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| EP11195214 | 2011-12-22 | ||
| US201161578931P | 2011-12-22 | ||
| US201261657978P | 2012-06-11 | 2012-06-11 | |
| EP12171415.8A EP2674434A1 (en) | 2012-06-11 | 2012-06-11 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
| EP12171415 | 2012-06-11 | ||
| US201261657978P | 2012-06-11 | ||
| PCT/EP2012/004968 WO2013091773A1 (en) | 2011-12-22 | 2012-11-30 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2606839T3 true ES2606839T3 (es) | 2017-03-28 |
Family
ID=48667735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12798612.3T Active ES2606839T3 (es) | 2011-12-22 | 2012-11-30 | Tetraaza-ciclopenta[a]indenilo y su uso como moduladores alostéricos positivos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9403835B2 (enExample) |
| EP (1) | EP2794608B1 (enExample) |
| JP (1) | JP6112316B2 (enExample) |
| CN (1) | CN104039789B (enExample) |
| AU (1) | AU2012357169B2 (enExample) |
| CA (1) | CA2860008C (enExample) |
| ES (1) | ES2606839T3 (enExample) |
| WO (1) | WO2013091773A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| RU2702106C2 (ru) * | 2014-08-26 | 2019-10-04 | Астеллас Фарма Инк. | Производное 2-аминотиазола или его соль |
| DK3256476T3 (en) * | 2015-02-11 | 2019-03-11 | Sunovion Pharmaceuticals Inc | CONDENSED DIHYDRO-4H-PYRAZOLO [5,1-C] [1,4] OXAZINYL COMPOUNDS AND ANALOGS FOR TREATMENT OF CNS DISORDERS |
| US10822357B2 (en) * | 2015-08-28 | 2020-11-03 | Sekisui Medical Co., Ltd. | Benzyl compound |
| EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | COMPOUNDS AND COMPOSITIONS, AND USES THEREOF |
| CA3070993C (en) | 2017-08-02 | 2025-05-20 | Sunovion Pharmaceuticals Inc. | ISOCHROMANE COMPOUNDS AND THEIR USES |
| FI3728207T3 (fi) | 2017-12-21 | 2023-04-24 | Ribon Therapeutics Inc | Kinatsolinoneja parp14:n inhibiittoreina |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525937A (ja) * | 2001-03-27 | 2004-08-26 | ニューロジェン コーポレイション | （オキソ−ピラゾロ［１，５ａ］ピリミジン−２−イル）アルキル−カルボキサミド |
| AU2005315914B2 (en) * | 2004-12-15 | 2011-03-03 | F. Hoffmann-La Roche Ag | Bi- and tricyclic substituted phenyl methanones as glycine transporter I (GlyT-1) inhibitors for the treatment of Alzheimer's disease |
| WO2008060488A1 (en) | 2006-11-14 | 2008-05-22 | Merck & Co., Inc. | Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| EP2563126B1 (en) * | 2010-04-30 | 2016-05-11 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived m1 receptor positive allosteric modulators |
| EP2813505A1 (en) * | 2013-06-14 | 2014-12-17 | Asceneuron SA | Tetraaza-cyclopenta[a]indenyl derivatives |
-
2012
- 2012-11-30 WO PCT/EP2012/004968 patent/WO2013091773A1/en not_active Ceased
- 2012-11-30 AU AU2012357169A patent/AU2012357169B2/en active Active
- 2012-11-30 EP EP12798612.3A patent/EP2794608B1/en active Active
- 2012-11-30 ES ES12798612.3T patent/ES2606839T3/es active Active
- 2012-11-30 CN CN201280062522.3A patent/CN104039789B/zh active Active
- 2012-11-30 CA CA2860008A patent/CA2860008C/en active Active
- 2012-11-30 JP JP2014547736A patent/JP6112316B2/ja active Active
- 2012-11-30 US US14/366,901 patent/US9403835B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015502371A (ja) | 2015-01-22 |
| CA2860008A1 (en) | 2013-06-27 |
| US9403835B2 (en) | 2016-08-02 |
| AU2012357169A1 (en) | 2014-08-07 |
| AU2012357169B2 (en) | 2017-03-30 |
| JP6112316B2 (ja) | 2017-04-12 |
| WO2013091773A1 (en) | 2013-06-27 |
| US20150018343A1 (en) | 2015-01-15 |
| EP2794608A1 (en) | 2014-10-29 |
| CN104039789B (zh) | 2016-09-07 |
| CA2860008C (en) | 2020-11-10 |
| CN104039789A (zh) | 2014-09-10 |
| EP2794608B1 (en) | 2016-09-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2606839T3 (es) | Tetraaza-ciclopenta[a]indenilo y su uso como moduladores alostéricos positivos | |
| AR088226A1 (es) | Derivados piperidinicos heterociclicos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades neurodegenerativas | |
| ECSP099638A (es) | Nuevo compuesto de adenina | |
| AR049291A1 (es) | Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso | |
| AR076900A1 (es) | Derivados heterociclicos nitrogenados utiles como agentes antivirales, composiciones farmaceuticas que los contienen y uso de los mismos como inhibidores del vhc | |
| AR078278A1 (es) | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. | |
| AR084507A1 (es) | Derivados de indazoliltriazol | |
| CL2012000999A1 (es) | Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina. | |
| CU20090048A7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR061134A1 (es) | Derivados de tioxantina | |
| CO5611131A2 (es) | Derivados de 5-feniltiazol y su uso como inhibidores de pi3 cinasa | |
| ES2607952T3 (es) | Derivados tricíclicos de Pirazol Amina | |
| AR073136A1 (es) | Compuestos de pirrol | |
| UY31940A (es) | Derivados sustituido del 4,5-(sustituido-piridin-3-il)-1-metil-1h-indol, sus sales farmacéuticamente aceptables, polimorfos, rotámeros, pro-fármacos, anantiómeros, hidratos, solvatos del mismo, composiciones conteniéndolos y aplicaciones | |
| AR084011A1 (es) | Compuestos nitrogenados heterociclicos utiles para el tratamiento de infecciones por el virus sincitial respiratorio (rsv), proceso para prepararlos y composiciones farmaceuticas que los contienen | |
| ECSP099335A (es) | Compuestos heterocíclicos que contienen nitrógeno y métodos de uso de los mismos | |
| UY31014A1 (es) | Derivados de ftalazinona | |
| AR085920A1 (es) | Derivados benzimidazolicos utiles como agentes antitumorales y composiciones farmaceuticas que los contienen | |
| BR112013031405A2 (pt) | piridopirazinas substituídas como novos inibidores de syk | |
| UY30104A1 (es) | Derivados nuevos de urea ciclica, su preparacinn y su utilizacinn farmacéutica como inhibidores de cinasas | |
| AR081819A1 (es) | Derivados de pirimidil-piperidinil-oxipiridinona, composiciones farmaceuticas que los contienen y uso de los mismos para tratar diabetes, dislipemias, obesidad y otras enfermedades | |
| NI201000011A (es) | Derivados de pirimidina 934. | |
| ECSP088805A (es) | 2-(piridin-2-il)-pirimidinas como fungicidas | |
| AR079448A1 (es) | Inhibidores de la esfingosina quinasa | |
| AR091687A1 (es) | Formas solidas de inhibidores de fosfodiesterasa tipo 5 |