ZA201307224B - (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 triazinyl bemzimidazoles, pahrmaceutical compositions containing them, and these compounds for use in treating proliferative deseases - Google Patents

(alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 triazinyl bemzimidazoles, pahrmaceutical compositions containing them, and these compounds for use in treating proliferative deseases

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Publication number
ZA201307224B
ZA201307224B ZA2013/07224A ZA201307224A ZA201307224B ZA 201307224 B ZA201307224 B ZA 201307224B ZA 2013/07224 A ZA2013/07224 A ZA 2013/07224A ZA 201307224 A ZA201307224 A ZA 201307224A ZA 201307224 B ZA201307224 B ZA 201307224B
Authority
ZA
South Africa
Prior art keywords
bemzimidazoles
pahrmaceutical
deseases
heteroarylalkylamino
triazinyl
Prior art date
Application number
ZA2013/07224A
Other languages
English (en)
Inventor
S David Brown
David J Matthews
Original Assignee
Mei Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mei Pharma Inc filed Critical Mei Pharma Inc
Publication of ZA201307224B publication Critical patent/ZA201307224B/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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ZA2013/07224A 2011-03-28 2013-09-26 (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 triazinyl bemzimidazoles, pahrmaceutical compositions containing them, and these compounds for use in treating proliferative deseases ZA201307224B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161468502P 2011-03-28 2011-03-28
US201161530859P 2011-09-02 2011-09-02
US201161560699P 2011-11-16 2011-11-16
PCT/US2012/030640 WO2012135160A1 (en) 2011-03-28 2012-03-27 (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases

Publications (1)

Publication Number Publication Date
ZA201307224B true ZA201307224B (en) 2014-12-23

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ZA2013/07224A ZA201307224B (en) 2011-03-28 2013-09-26 (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 triazinyl bemzimidazoles, pahrmaceutical compositions containing them, and these compounds for use in treating proliferative deseases

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US (6) US9056852B2 (enExample)
EP (1) EP2691384B1 (enExample)
JP (1) JP6042406B2 (enExample)
KR (1) KR101940831B1 (enExample)
CN (2) CN107501241B (enExample)
AU (2) AU2012236834B2 (enExample)
BR (1) BR112013024907A2 (enExample)
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TW (1) TWI572599B (enExample)
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AU2012236834B2 (en) 2011-03-28 2015-12-10 Mei Pharma, Inc (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases
BR112013024909A2 (pt) * 2011-03-28 2019-09-24 Mei Pharma Inc composto, composição farmacêutica, método para o tratamento, prevenção ou melhoria de um ou mais sintomas de desordem, doença, ou condição mediada por pi3k, e método para modular a atividade enzimática de pi3k
JP6434416B2 (ja) 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
JP6423372B2 (ja) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体
EP3053926B1 (en) 2013-09-30 2018-08-08 Shanghai Yingli Pharmaceutical Co. Ltd. Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
JP6139789B2 (ja) 2013-10-16 2017-05-31 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合複素環化合物、その調製方法、医薬組成物及びその使用
CN103992228A (zh) * 2014-05-26 2014-08-20 南京工业大学 一种盐酸芬特明的合成方法
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US20220323449A1 (en) 2022-10-13
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CN107501241A (zh) 2017-12-22
US20150265625A1 (en) 2015-09-24
US10064868B2 (en) 2018-09-04
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