RU2608742C2 - (альфа-замещенные аралкиламино- и гетероарилалкиламино)пиримидинил- и 1, 3, 5-триазинилбензимидазолы, их фармацевтические композиции и их применение в лечении пролиферативных заболеваний - Google Patents

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Publication number

RU2608742C2

RU2608742C2 RU2013147823A RU2013147823A RU2608742C2 RU 2608742 C2 RU2608742 C2 RU 2608742C2 RU 2013147823 A RU2013147823 A RU 2013147823A RU 2013147823 A RU2013147823 A RU 2013147823A RU 2608742 C2 RU2608742 C2 RU 2608742C2

Authority

RU

Russia

Prior art keywords

substituents

optionally substituted

hydrogen

alkyl

formula

Prior art date

2011-03-28

Links

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• 201000010099 disease Diseases 0.000 title claims description 31
• 230000002062 proliferating effect Effects 0.000 title description 3
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• 150000001875 compounds Chemical class 0.000 claims abstract description 157
• 108091007960 PI3Ks Proteins 0.000 claims abstract description 51
• 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims abstract 11
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 383
• 125000000217 alkyl group Chemical group 0.000 claims description 290
• 125000000623 heterocyclic group Chemical group 0.000 claims description 256
• 125000003118 aryl group Chemical group 0.000 claims description 223
• 125000001072 heteroaryl group Chemical group 0.000 claims description 213
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 151
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• 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 101
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• 150000003839 salts Chemical class 0.000 claims description 80
• 229910052799 carbon Inorganic materials 0.000 claims description 64
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 60
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 47
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 46
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