JP2016531858A5 - - Google Patents
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- JP2016531858A5 JP2016531858A5 JP2016516870A JP2016516870A JP2016531858A5 JP 2016531858 A5 JP2016531858 A5 JP 2016531858A5 JP 2016516870 A JP2016516870 A JP 2016516870A JP 2016516870 A JP2016516870 A JP 2016516870A JP 2016531858 A5 JP2016531858 A5 JP 2016531858A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- hydrogen atom
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13186148 | 2013-09-26 | ||
| EP13186148.6 | 2013-09-26 | ||
| EP14176125 | 2014-07-08 | ||
| EP14176125.4 | 2014-07-08 | ||
| PCT/EP2014/070489 WO2015044269A1 (en) | 2013-09-26 | 2014-09-25 | NEW 3-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531858A JP2016531858A (ja) | 2016-10-13 |
| JP2016531858A5 true JP2016531858A5 (enExample) | 2017-11-02 |
| JP6404332B2 JP6404332B2 (ja) | 2018-10-10 |
Family
ID=51626028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516870A Expired - Fee Related JP6404332B2 (ja) | 2013-09-26 | 2014-09-25 | 新規な、ＮＩＫ阻害剤としての３−（１Ｈ−ピラゾール−４−イル）−１Ｈ−ピロロ［２，３−ｃ］ピリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9981963B2 (enExample) |
| EP (1) | EP3049412B1 (enExample) |
| JP (1) | JP6404332B2 (enExample) |
| KR (1) | KR102317335B1 (enExample) |
| CN (1) | CN105579452B (enExample) |
| AU (1) | AU2014327235B2 (enExample) |
| BR (1) | BR112016006232B1 (enExample) |
| CA (1) | CA2922633C (enExample) |
| EA (1) | EA028101B1 (enExample) |
| ES (1) | ES2643070T3 (enExample) |
| IL (1) | IL244702B (enExample) |
| MX (1) | MX365739B (enExample) |
| TW (1) | TWI627173B (enExample) |
| WO (1) | WO2015044269A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
| AU2015334914B2 (en) | 2014-10-23 | 2019-09-19 | Janssen Pharmaceutica Nv | New thienopyrimidine derivatives as NIK inhibitors |
| EA033237B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее |
| JP6616411B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| CN122562777A (zh) * | 2015-12-02 | 2026-08-14 | 阿斯特来亚治疗有限责任公司 | 哌啶基痛敏肽受体化合物 |
| HRP20200133T1 (hr) | 2016-01-22 | 2020-05-15 | Janssen Pharmaceutica Nv | Novi supstituirani derivati cijanoindolina kao inhibitori nik |
| EP3405464B1 (en) | 2016-01-22 | 2019-12-04 | Janssen Pharmaceutica NV | New 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| EP3478675B1 (en) | 2016-06-30 | 2020-04-22 | Janssen Pharmaceutica NV | Heteroaromatic derivatives as nik inhibitors |
| JP7549345B2 (ja) * | 2019-02-08 | 2024-09-11 | 学校法人近畿大学 | 悪性腫瘍疾患の改善用組成物 |
| CR20210587A (es) | 2019-05-31 | 2022-02-11 | Janssen Pharmaceutica Nv | Inhibidores de molécula pequeña de quinasa inductora de nf-kb |
| CN110156766A (zh) * | 2019-06-04 | 2019-08-23 | 南京工业大学 | 一种银催化的氘代五元芳香杂环化合物的制备方法 |
| US20240124430A1 (en) | 2020-12-22 | 2024-04-18 | Kinki University | Pharmaceutical composition for ameliorating malignant diseases |
| TW202402269A (zh) * | 2022-05-26 | 2024-01-16 | 大陸商迪哲（江蘇）醫藥股份有限公司 | ＲＯＣＫ（Ｒｈｏ相關激酶）抑制劑及其用途 |
| JPWO2024029528A1 (enExample) | 2022-08-02 | 2024-02-08 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンａ２受容体拮抗剤 |
| DE19948417A1 (de) * | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
| BRPI0510319A (pt) | 2004-04-26 | 2007-10-16 | Pfizer | inibidores da enzima integrase de hiv |
| TW200736260A (en) * | 2005-11-10 | 2007-10-01 | Smithkline Beecham Corp | Inhibitors of Akt activity |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| AU2009263037B2 (en) | 2008-06-26 | 2011-10-06 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| CA2728559A1 (en) | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| WO2010042337A1 (en) * | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| AR085908A1 (es) | 2011-03-16 | 2013-11-06 | Hoffmann La Roche | DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK) |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) * | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| AU2015334914B2 (en) | 2014-10-23 | 2019-09-19 | Janssen Pharmaceutica Nv | New thienopyrimidine derivatives as NIK inhibitors |
| JP6616411B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
| WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
| EA033237B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее |
-
2014
- 2014-09-24 TW TW103132895A patent/TWI627173B/zh not_active IP Right Cessation
- 2014-09-25 EA EA201690657A patent/EA028101B1/ru not_active IP Right Cessation
- 2014-09-25 WO PCT/EP2014/070489 patent/WO2015044269A1/en not_active Ceased
- 2014-09-25 JP JP2016516870A patent/JP6404332B2/ja not_active Expired - Fee Related
- 2014-09-25 ES ES14776635.6T patent/ES2643070T3/es active Active
- 2014-09-25 CA CA2922633A patent/CA2922633C/en active Active
- 2014-09-25 BR BR112016006232-9A patent/BR112016006232B1/pt not_active IP Right Cessation
- 2014-09-25 EP EP14776635.6A patent/EP3049412B1/en active Active
- 2014-09-25 AU AU2014327235A patent/AU2014327235B2/en not_active Ceased
- 2014-09-25 CN CN201480052798.2A patent/CN105579452B/zh not_active Expired - Fee Related
- 2014-09-25 KR KR1020167007902A patent/KR102317335B1/ko not_active Expired - Fee Related
- 2014-09-25 US US15/024,724 patent/US9981963B2/en not_active Expired - Fee Related
- 2014-09-25 MX MX2016003863A patent/MX365739B/es active IP Right Grant
-
2016
- 2016-03-22 IL IL244702A patent/IL244702B/en active IP Right Grant
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