JP2017531677A5 - - Google Patents
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- JP2017531677A5 JP2017531677A5 JP2017522072A JP2017522072A JP2017531677A5 JP 2017531677 A5 JP2017531677 A5 JP 2017531677A5 JP 2017522072 A JP2017522072 A JP 2017522072A JP 2017522072 A JP2017522072 A JP 2017522072A JP 2017531677 A5 JP2017531677 A5 JP 2017531677A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- het
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14190072 | 2014-10-23 | ||
| EP14190072.0 | 2014-10-23 | ||
| PCT/EP2015/074433 WO2016062791A1 (en) | 2014-10-23 | 2015-10-22 | New pyrazole derivatives as nik inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531677A JP2017531677A (ja) | 2017-10-26 |
| JP2017531677A5 true JP2017531677A5 (enExample) | 2019-11-21 |
| JP6616411B2 JP6616411B2 (ja) | 2019-12-04 |
Family
ID=51865980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522072A Expired - Fee Related JP6616411B2 (ja) | 2014-10-23 | 2015-10-22 | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9981962B2 (enExample) |
| EP (1) | EP3209654B1 (enExample) |
| JP (1) | JP6616411B2 (enExample) |
| KR (1) | KR102499862B1 (enExample) |
| CN (1) | CN107074818B (enExample) |
| AU (1) | AU2015334916B2 (enExample) |
| BR (1) | BR112017008039B1 (enExample) |
| CA (1) | CA2960335C (enExample) |
| EA (1) | EA033236B1 (enExample) |
| ES (1) | ES2704749T3 (enExample) |
| IL (1) | IL251777B (enExample) |
| MX (1) | MX371150B (enExample) |
| WO (1) | WO2016062791A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| US9981962B2 (en) | 2014-10-23 | 2018-05-29 | Janssen Pharmaceutica Nv | Pyrazole derivatives as NIK inhibitors |
| MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
| BR112017007704B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V | Derivados de pirazolopirimidina como inibidores de nik, seu uso e composição farmacêutica que os compreende |
| ES2718557T3 (es) | 2014-10-23 | 2019-07-02 | Janssen Pharmaceutica Nv | Nuevos compuestos como inhibidores de nik |
| EP4455145A3 (en) * | 2015-12-02 | 2025-03-12 | Astraea Therapeutics, LLC | Piperidinyl nociceptin receptor compounds |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| US11001569B2 (en) * | 2016-01-22 | 2021-05-11 | Janssen Pharmaceutica Nv | 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors |
| ES2989387T3 (es) | 2019-05-31 | 2024-11-26 | Janssen Pharmaceutica Nv | Pequeñas moléculas inhibidoras de la quinasa inductora de nf-kb |
| TW202402269A (zh) * | 2022-05-26 | 2024-01-16 | 大陸商迪哲（江蘇）醫藥股份有限公司 | ＲＯＣＫ（Ｒｈｏ相關激酶）抑制劑及其用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06012449A (es) | 2004-04-26 | 2007-01-17 | Pfizer | Inhibidores de la enzima integrasa de vih. |
| TW200736260A (en) | 2005-11-10 | 2007-10-01 | Smithkline Beecham Corp | Inhibitors of Akt activity |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| US20110086834A1 (en) | 2008-06-26 | 2011-04-14 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| CA2728559A1 (en) | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| US20110183975A1 (en) | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| KR20130133051A (ko) * | 2011-03-16 | 2013-12-05 | 에프. 호프만-라 로슈 아게 | 6,5-헤테로사이클릭 프로파길릭 알콜 화합물 및 이의 용도 |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| BR112017007704B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V | Derivados de pirazolopirimidina como inibidores de nik, seu uso e composição farmacêutica que os compreende |
| ES2718557T3 (es) | 2014-10-23 | 2019-07-02 | Janssen Pharmaceutica Nv | Nuevos compuestos como inhibidores de nik |
| MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
| US9981962B2 (en) | 2014-10-23 | 2018-05-29 | Janssen Pharmaceutica Nv | Pyrazole derivatives as NIK inhibitors |
-
2015
- 2015-10-22 US US15/520,342 patent/US9981962B2/en active Active
- 2015-10-22 JP JP2017522072A patent/JP6616411B2/ja not_active Expired - Fee Related
- 2015-10-22 WO PCT/EP2015/074433 patent/WO2016062791A1/en not_active Ceased
- 2015-10-22 MX MX2017005283A patent/MX371150B/es active IP Right Grant
- 2015-10-22 CA CA2960335A patent/CA2960335C/en active Active
- 2015-10-22 EP EP15784360.8A patent/EP3209654B1/en active Active
- 2015-10-22 BR BR112017008039-7A patent/BR112017008039B1/pt not_active IP Right Cessation
- 2015-10-22 ES ES15784360T patent/ES2704749T3/es active Active
- 2015-10-22 AU AU2015334916A patent/AU2015334916B2/en not_active Ceased
- 2015-10-22 CN CN201580057462.XA patent/CN107074818B/zh not_active Expired - Fee Related
- 2015-10-22 EA EA201790904A patent/EA033236B1/ru not_active IP Right Cessation
- 2015-10-22 KR KR1020177010800A patent/KR102499862B1/ko active Active
-
2017
- 2017-04-19 IL IL251777A patent/IL251777B/en unknown