BR112016006232B1 - Derivados de 3-(1h-pirazol-4-il)-1h-pirrolo[2,3-c]piridina como inibidores de nik e composição farmacêutica que os compreende - Google Patents

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Publication number

BR112016006232B1

BR112016006232B1 BR112016006232-9A BR112016006232A BR112016006232B1 BR 112016006232 B1 BR112016006232 B1 BR 112016006232B1 BR 112016006232 A BR112016006232 A BR 112016006232A BR 112016006232 B1 BR112016006232 B1 BR 112016006232B1

Authority

BR

Brazil

Prior art keywords

alkyl

group

hydrogen

substituted

substituents

Prior art date

2013-09-26

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• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 20
• 239000003112 inhibitor Substances 0.000 title abstract description 14
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 227
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 334
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 237
• 125000000217 alkyl group Chemical group 0.000 claims description 172
• 239000001257 hydrogen Substances 0.000 claims description 164
• 229910052739 hydrogen Inorganic materials 0.000 claims description 164
• 125000001153 fluoro group Chemical group F* 0.000 claims description 141
• 125000001424 substituent group Chemical group 0.000 claims description 123
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 121
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 112
• 150000003839 salts Chemical class 0.000 claims description 112
• 229910052736 halogen Inorganic materials 0.000 claims description 77
• 150000002367 halogens Chemical class 0.000 claims description 77
• 125000004432 carbon atom Chemical group C* 0.000 claims description 76
• 229910052799 carbon Inorganic materials 0.000 claims description 70
• 125000000623 heterocyclic group Chemical group 0.000 claims description 60
• 229910052731 fluorine Inorganic materials 0.000 claims description 51
• 239000011737 fluorine Substances 0.000 claims description 51
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 51
• 125000003386 piperidinyl group Chemical group 0.000 claims description 51
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 43
• 125000002393 azetidinyl group Chemical group 0.000 claims description 41
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 40
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 40
• 125000003566 oxetanyl group Chemical group 0.000 claims description 38
• 125000000335 thiazolyl group Chemical group 0.000 claims description 34
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 30
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 22
• 125000001072 heteroaryl group Chemical group 0.000 claims description 18
• 125000002883 imidazolyl group Chemical group 0.000 claims description 16
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 16
• 125000002757 morpholinyl group Chemical group 0.000 claims description 15
• 125000004193 piperazinyl group Chemical group 0.000 claims description 15
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 14
• 125000001786 isothiazolyl group Chemical group 0.000 claims description 13
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• 125000002098 pyridazinyl group Chemical group 0.000 claims description 5
• 125000004076 pyridyl group Chemical group 0.000 claims description 5
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
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• 235000011152 sodium sulphate Nutrition 0.000 description 17
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