CR20210587A - Inhibidores de molécula pequeña de quinasa inductora de nf-kb - Google Patents
Inhibidores de molécula pequeña de quinasa inductora de nf-kbInfo
- Publication number
- CR20210587A CR20210587A CR20210587A CR20210587A CR20210587A CR 20210587 A CR20210587 A CR 20210587A CR 20210587 A CR20210587 A CR 20210587A CR 20210587 A CR20210587 A CR 20210587A CR 20210587 A CR20210587 A CR 20210587A
- Authority
- CR
- Costa Rica
- Prior art keywords
- disorders
- compounds
- small molecule
- molecule inhibitors
- inducing kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se relaciona con compuestos que inhiben el NIK y composiciones farmacéuticas que comprenden tales compuestos y métodos para el uso de estos. Se prevé que estos compuestos y composiciones farmacéuticas son útiles para prevenir o tratar enfermedades tales como cáncer (tal como neoplasias de células B que incluyen leucemias, linfomas y mieloma), trastornos inflamatorios, trastornos autoinmunes, trastornos inmunodermatológicos tales como pustulosis palmoplantar e hidradenitis supurativa, y trastornos metabólicos tales como obesidad y diabetes
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855144P | 2019-05-31 | 2019-05-31 | |
| US201962907833P | 2019-09-30 | 2019-09-30 | |
| PCT/EP2020/065024 WO2020239999A1 (en) | 2019-05-31 | 2020-05-29 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210587A true CR20210587A (es) | 2022-02-11 |
Family
ID=71108552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210587A CR20210587A (es) | 2019-05-31 | 2020-05-29 | Inhibidores de molécula pequeña de quinasa inductora de nf-kb |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11254673B2 (es) |
| EP (1) | EP3976597A1 (es) |
| JP (1) | JP2022534302A (es) |
| KR (1) | KR20220027871A (es) |
| CN (1) | CN114222737A (es) |
| AU (1) | AU2020282005A1 (es) |
| BR (1) | BR112021023796A2 (es) |
| CA (1) | CA3143350A1 (es) |
| CL (1) | CL2021003142A1 (es) |
| CO (1) | CO2021017838A2 (es) |
| CR (1) | CR20210587A (es) |
| DO (1) | DOP2021000244A (es) |
| EC (1) | ECSP21093623A (es) |
| IL (1) | IL288387A (es) |
| JO (1) | JOP20210318A1 (es) |
| MA (1) | MA56038A (es) |
| MX (1) | MX2021014679A (es) |
| PE (1) | PE20220768A1 (es) |
| SG (1) | SG11202112994WA (es) |
| TW (1) | TW202110842A (es) |
| UY (1) | UY38721A (es) |
| WO (1) | WO2020239999A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20210318A1 (ar) * | 2019-05-31 | 2023-01-30 | Janssen Pharmaceutica Nv | مثبطات جزيئية صغيرة لكيناز تحفيز nf-?b |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| WO2023217906A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidinone derivatives as inhibitors of nf kappa b inducing kinase |
| WO2023217879A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidione derivatives as inhibitors of nf kappa b inducing kinase |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| CN101213194A (zh) * | 2004-08-03 | 2008-07-02 | 惠氏公司 | 可用于治疗心血管疾病的吲唑化合物 |
| KR101227228B1 (ko) | 2004-11-12 | 2013-01-28 | 스태츠 칩팩, 엘티디. | 와이어 본드 배선 |
| US20110086834A1 (en) | 2008-06-26 | 2011-04-14 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| WO2010042337A1 (en) | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| JP2014508183A (ja) * | 2011-03-16 | 2014-04-03 | エフ．ホフマン−ラ ロシュ アーゲー | ６，５−複素環式プロパルギルアルコール化合物及びこれらの使用 |
| KR20140131359A (ko) | 2012-02-17 | 2014-11-12 | 에프. 호프만-라 로슈 아게 | 트라이사이클릭 화합물 및 이의 사용 방법 |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| MX2016002238A (es) * | 2013-08-22 | 2016-05-31 | Hoffmann La Roche | Alcoholes de alquilino y metodos de uso. |
| RU2016110021A (ru) * | 2013-08-22 | 2017-09-27 | Ф. Хоффманн-Ля Рош Аг | Алкиниловые спирты и способы их применения |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| ES2718557T3 (es) | 2014-10-23 | 2019-07-02 | Janssen Pharmaceutica Nv | Nuevos compuestos como inhibidores de nik |
| WO2016062790A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New pyrazolopyrimidine derivatives as nik inhibitors |
| BR112017008039B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V. | Derivados de pirazol como inibidores de nik, seu uso no tratamento ou prevenção de câncer e composição farmacêutica que os compreende |
| CN107074881B (zh) | 2014-10-23 | 2019-07-30 | 詹森药业有限公司 | 作为nik抑制剂的新的噻吩并嘧啶衍生物 |
| CN107406427A (zh) | 2015-02-25 | 2017-11-28 | 豪夫迈·罗氏有限公司 | 炔基醇及其使用方法 |
| JP6916796B2 (ja) | 2016-01-22 | 2021-08-11 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな６員のヘテロ芳香族置換シアノインドリン誘導体 |
| BR112018014675B1 (pt) | 2016-01-22 | 2023-12-19 | Janssen Pharmaceutica Nv | Derivados de cianoindolina substituída como inibidores de nik e composição farmacêutica que os compreende |
| AU2017289317B2 (en) | 2016-06-30 | 2021-04-01 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as NIK inhibitors |
| CN109641882B (zh) | 2016-06-30 | 2022-10-28 | 杨森制药有限公司 | 作为nik抑制剂的杂芳族衍生物 |
| CN109863142B (zh) | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| JP7140751B2 (ja) | 2016-08-24 | 2022-09-21 | エフ．ホフマン－ラ ロシュ アーゲー | ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法 |
| KR102662373B1 (ko) | 2017-07-06 | 2024-04-29 | 얀센 파마슈티카 엔브이 | Nik 억제제로서의 신규 치환 아자인돌린 유도체 |
| CN109810110B (zh) * | 2017-11-22 | 2023-01-24 | 中国科学院上海药物研究所 | 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| TW202108571A (zh) | 2019-05-31 | 2021-03-01 | 美商醫肯納腫瘤學公司 | Tead抑制劑及其用途 |
| CN113891745B (zh) | 2019-05-31 | 2024-05-07 | 奇斯药制品公司 | 作为p2x3抑制剂的氨基喹唑啉衍生物 |
| BR112021024033A2 (pt) | 2019-05-31 | 2022-02-08 | Sage Therapeutics Inc | Esteroides neuroativos e suas composições |
| JOP20210318A1 (ar) * | 2019-05-31 | 2023-01-30 | Janssen Pharmaceutica Nv | مثبطات جزيئية صغيرة لكيناز تحفيز nf-?b |
| TW202126652A (zh) | 2019-09-30 | 2021-07-16 | 美商英塞特公司 | 作為免疫調節劑之吡啶并［３，２—ｄ］嘧啶化合物 |
-
2020
- 2020-05-29 JO JOP/2021/0318A patent/JOP20210318A1/ar unknown
- 2020-05-29 PE PE2021001987A patent/PE20220768A1/es unknown
- 2020-05-29 TW TW109118004A patent/TW202110842A/zh unknown
- 2020-05-29 CN CN202080057418.XA patent/CN114222737A/zh active Pending
- 2020-05-29 MX MX2021014679A patent/MX2021014679A/es unknown
- 2020-05-29 CR CR20210587A patent/CR20210587A/es unknown
- 2020-05-29 CA CA3143350A patent/CA3143350A1/en active Pending
- 2020-05-29 WO PCT/EP2020/065024 patent/WO2020239999A1/en active Application Filing
- 2020-05-29 EP EP20733688.4A patent/EP3976597A1/en active Pending
- 2020-05-29 SG SG11202112994WA patent/SG11202112994WA/en unknown
- 2020-05-29 JP JP2021570919A patent/JP2022534302A/ja active Pending
- 2020-05-29 AU AU2020282005A patent/AU2020282005A1/en active Pending
- 2020-05-29 MA MA056038A patent/MA56038A/fr unknown
- 2020-05-29 UY UY0001038721A patent/UY38721A/es unknown
- 2020-05-29 US US16/887,889 patent/US11254673B2/en active Active
- 2020-05-29 KR KR1020217042635A patent/KR20220027871A/ko unknown
- 2020-05-29 BR BR112021023796A patent/BR112021023796A2/pt unknown
-
2021
- 2021-11-25 CL CL2021003142A patent/CL2021003142A1/es unknown
- 2021-11-25 IL IL288387A patent/IL288387A/en unknown
- 2021-11-26 DO DO2021000244A patent/DOP2021000244A/es unknown
- 2021-12-13 US US17/549,057 patent/US11827634B2/en active Active
- 2021-12-27 CO CONC2021/0017838A patent/CO2021017838A2/es unknown
- 2021-12-28 EC ECSENADI202193623A patent/ECSP21093623A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11254673B2 (en) | 2022-02-22 |
| JP2022534302A (ja) | 2022-07-28 |
| WO2020239999A1 (en) | 2020-12-03 |
| CL2021003142A1 (es) | 2022-08-19 |
| AU2020282005A1 (en) | 2021-12-23 |
| CN114222737A (zh) | 2022-03-22 |
| MA56038A (fr) | 2022-04-06 |
| CA3143350A1 (en) | 2020-12-03 |
| TW202110842A (zh) | 2021-03-16 |
| MX2021014679A (es) | 2022-04-06 |
| UY38721A (es) | 2020-11-30 |
| US20210300918A1 (en) | 2021-09-30 |
| KR20220027871A (ko) | 2022-03-08 |
| IL288387A (en) | 2022-01-01 |
| BR112021023796A2 (pt) | 2022-02-08 |
| PE20220768A1 (es) | 2022-05-16 |
| JOP20210318A1 (ar) | 2023-01-30 |
| DOP2021000244A (es) | 2022-04-18 |
| SG11202112994WA (en) | 2021-12-30 |
| US11827634B2 (en) | 2023-11-28 |
| CO2021017838A2 (es) | 2022-01-17 |
| EP3976597A1 (en) | 2022-04-06 |
| ECSP21093623A (es) | 2022-01-31 |
| US20230080834A1 (en) | 2023-03-16 |
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