MX2017005282A - Nuevos compuestos como inhibidores de la cinasa inductora de nf-kb (nik). - Google Patents

Nuevos compuestos como inhibidores de la cinasa inductora de nf-kb (nik).

Info

Publication number
MX2017005282A
MX2017005282A MX2017005282A MX2017005282A MX2017005282A MX 2017005282 A MX2017005282 A MX 2017005282A MX 2017005282 A MX2017005282 A MX 2017005282A MX 2017005282 A MX2017005282 A MX 2017005282A MX 2017005282 A MX2017005282 A MX 2017005282A
Authority
MX
Mexico
Prior art keywords
disorders
compounds
new compounds
cancer
nik
Prior art date
Application number
MX2017005282A
Other languages
English (en)
Other versions
MX371153B (es
Inventor
John Gary Montana
Calum Macleod
Janusz Jozef Kulagowski
George Hynd
Samuel Edward Mann
Patrizia Tisselli
Colin Price Stephen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2017005282A publication Critical patent/MX2017005282A/es
Publication of MX371153B publication Critical patent/MX371153B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, y en particular a inhibidores de la cinasa inductora de NF-KB (NIK - también conocida como MAP3K14) útiles para tratar enfermedades tales como el cáncer, trastornos inflamatorios, trastornos metabólicos y trastornos autoinmunitarios; la invención también se refiere a composiciones farmacéuticas que comprenden tales compuestos, a procesos para preparar tales compuestos y composiciones, y al uso de tales compuestos o composiciones farmacéuticas para prevenir o tratar enfermedades tales como el cáncer, trastornos inflamatorios, trastornos metabólicos, incluidas la obesidad y la diabetes, y trastornos autoinmunitarios.
MX2017005282A 2014-10-23 2015-10-22 Nuevos compuestos como inhibidores de la cinasa inductora de nf-kb (nik). MX371153B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14190068 2014-10-23
PCT/EP2015/074437 WO2016062792A1 (en) 2014-10-23 2015-10-22 New compounds as nik inhibitors

Publications (2)

Publication Number Publication Date
MX2017005282A true MX2017005282A (es) 2017-08-15
MX371153B MX371153B (es) 2020-01-20

Family

ID=51868764

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005282A MX371153B (es) 2014-10-23 2015-10-22 Nuevos compuestos como inhibidores de la cinasa inductora de nf-kb (nik).

Country Status (13)

Country Link
US (1) US10005776B2 (es)
EP (1) EP3209662B1 (es)
JP (1) JP6676048B2 (es)
KR (1) KR102500071B1 (es)
CN (1) CN107074855B (es)
AU (1) AU2015334917B2 (es)
BR (1) BR112017008045A2 (es)
CA (1) CA2960336C (es)
EA (1) EA030908B1 (es)
ES (1) ES2718557T3 (es)
IL (1) IL251780B (es)
MX (1) MX371153B (es)
WO (1) WO2016062792A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI663166B (zh) 2013-04-24 2019-06-21 健生藥品公司 新化合物
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
AU2015334917B2 (en) 2014-10-23 2019-08-29 Janssen Pharmaceutica Nv New compounds as NIK inhibitors
JP6603713B2 (ja) 2014-10-23 2019-11-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のチエノピリミジン誘導体
CA2960574C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Pyrazolopyrimidine derivatives as nik inhibitors
CN107074818B (zh) 2014-10-23 2020-04-17 詹森药业有限公司 作为nik抑制剂的吡唑衍生物
CN107921094B (zh) 2015-06-04 2022-03-01 圣拉斐尔医院有限公司 Igfbp3及其用途
EA033821B1 (ru) 2015-06-04 2019-11-29 Ospedale San Raffaele Srl Применение ингибитора оси igfbp3/tmem219 для лечения диабета
WO2019236884A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
EP3632929A1 (en) 2018-10-02 2020-04-08 Ospedale San Raffaele S.r.l. Antibodies and uses thereof
EP3656762A1 (en) 2018-11-26 2020-05-27 Instituto Biomar S.A. Compounds for the treatment of nf-kb-related diseases or disorders
CA3123215C (en) 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
LT3976597T (lt) 2019-05-31 2024-10-10 Janssen Pharmaceutica Nv Nf-κb indukuojančios kinazės mažos molekulės inhibitoriai

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06012449A (es) * 2004-04-26 2007-01-17 Pfizer Inhibidores de la enzima integrasa de vih.
TW200736260A (en) 2005-11-10 2007-10-01 Smithkline Beecham Corp Inhibitors of Akt activity
DE102008005493A1 (de) 2008-01-22 2009-07-23 Merck Patent Gmbh 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
JP2011525915A (ja) 2008-06-26 2011-09-29 アムジエン・インコーポレーテツド キナーゼ阻害薬としてのアルキニルアルコール類
AU2009266806A1 (en) 2008-07-03 2010-01-07 Exelixis Inc. CDK modulators
WO2010042337A1 (en) 2008-10-07 2010-04-15 Merck Sharp & Dohme Corp. Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
CN101723936B (zh) * 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
WO2011050245A1 (en) 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
US8901313B2 (en) * 2011-03-16 2014-12-02 Genentech, Inc. 6,5-heterocyclic propargylic alcohol compounds and uses therefor
WO2012126181A1 (en) * 2011-03-24 2012-09-27 Ying Luo Use of kinase inhibitors in preventing and treating inflammatory disorder
TWI663166B (zh) * 2013-04-24 2019-06-21 健生藥品公司 新化合物
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
AU2015334917B2 (en) 2014-10-23 2019-08-29 Janssen Pharmaceutica Nv New compounds as NIK inhibitors
JP6603713B2 (ja) 2014-10-23 2019-11-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としての新規のチエノピリミジン誘導体
CN107074818B (zh) 2014-10-23 2020-04-17 詹森药业有限公司 作为nik抑制剂的吡唑衍生物
CA2960574C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Pyrazolopyrimidine derivatives as nik inhibitors

Also Published As

Publication number Publication date
JP6676048B2 (ja) 2020-04-08
US10005776B2 (en) 2018-06-26
AU2015334917A1 (en) 2017-03-23
IL251780A0 (en) 2017-06-29
CA2960336A1 (en) 2016-04-28
CN107074855B (zh) 2019-11-05
EA201790688A1 (ru) 2017-08-31
EA030908B1 (ru) 2018-10-31
EP3209662B1 (en) 2019-01-09
EP3209662A1 (en) 2017-08-30
BR112017008045A2 (pt) 2017-12-19
IL251780B (en) 2020-08-31
WO2016062792A1 (en) 2016-04-28
JP2017531681A (ja) 2017-10-26
CA2960336C (en) 2023-03-07
CN107074855A (zh) 2017-08-18
US20170334906A1 (en) 2017-11-23
AU2015334917B2 (en) 2019-08-29
ES2718557T3 (es) 2019-07-02
MX371153B (es) 2020-01-20
KR102500071B1 (ko) 2023-02-14
KR20170066473A (ko) 2017-06-14

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