JP2019537588A5 - - Google Patents
Info
- Publication number
- JP2019537588A5 JP2019537588A5 JP2019522962A JP2019522962A JP2019537588A5 JP 2019537588 A5 JP2019537588 A5 JP 2019537588A5 JP 2019522962 A JP2019522962 A JP 2019522962A JP 2019522962 A JP2019522962 A JP 2019522962A JP 2019537588 A5 JP2019537588 A5 JP 2019537588A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently selected
- phenyl
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610970314.3 | 2016-10-28 | ||
| CN201610970314 | 2016-10-28 | ||
| CN201710044000 | 2017-01-21 | ||
| CN201710044000.5 | 2017-01-21 | ||
| PCT/CN2017/108100 WO2018077246A1 (zh) | 2016-10-28 | 2017-10-27 | 用作神经营养因子酪氨酸激酶受体抑制剂的氨基吡唑并嘧啶化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537588A JP2019537588A (ja) | 2019-12-26 |
| JP2019537588A5 true JP2019537588A5 (enExample) | 2022-01-21 |
| JP7046940B2 JP7046940B2 (ja) | 2022-04-04 |
Family
ID=62024344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522962A Active JP7046940B2 (ja) | 2016-10-28 | 2017-10-27 | 神経栄養因子チロシンキナーゼ受容体阻害剤として用いられるアミノピラゾロピリミジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10829492B2 (enExample) |
| EP (1) | EP3533796B1 (enExample) |
| JP (1) | JP7046940B2 (enExample) |
| KR (1) | KR102616249B1 (enExample) |
| CN (1) | CN109890820B (enExample) |
| AU (1) | AU2017348826B2 (enExample) |
| CA (1) | CA3041942C (enExample) |
| DK (1) | DK3533796T3 (enExample) |
| ES (1) | ES2896943T3 (enExample) |
| HU (1) | HUE057733T2 (enExample) |
| MX (1) | MX380283B (enExample) |
| PL (1) | PL3533796T3 (enExample) |
| PT (1) | PT3533796T (enExample) |
| RU (1) | RU2764523C2 (enExample) |
| WO (1) | WO2018077246A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3658148T (pt) * | 2017-07-28 | 2024-08-26 | Turning Point Therapeutics Inc | Compostos macrocíclicos e utilizações dos mesmos |
| KR102619444B1 (ko) | 2017-08-23 | 2023-12-29 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 아미노피라졸 및 피리미딘을 함유하는 마크로사이클 및 그의 약학적 조성물 및 용도 |
| CN108794370A (zh) * | 2018-07-31 | 2018-11-13 | 上海弈柯莱生物医药科技有限公司 | 一种拉罗替尼中间体的制备方法 |
| TW202033526A (zh) * | 2018-12-07 | 2020-09-16 | 大陸商貝達藥業股份有限公司 | 用作酪胺酸激酶抑制劑的化合物、包含其的藥物組合物及其用途 |
| WO2020187291A1 (zh) | 2019-03-19 | 2020-09-24 | 华中师范大学 | 吡唑并嘧啶化合物和药物组合物及其应用 |
| CN112979654B (zh) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | 杂芳基稠环化合物、其制备方法及应用 |
| WO2021249450A1 (zh) * | 2020-06-11 | 2021-12-16 | 贝达药业股份有限公司 | 酪氨酸激酶抑制剂的盐型、晶型、药物组合物及其用途 |
| CN111620881B (zh) * | 2020-07-08 | 2023-03-31 | 浙江合聚生物医药有限公司 | 拉罗替尼衍生物及其制备方法和应用 |
| CN113563343B (zh) * | 2020-07-27 | 2022-05-24 | 杭州邦顺制药有限公司 | 取代的吡唑并[1,5-a]嘧啶化合物及其用途 |
| CN112010860B (zh) * | 2020-08-05 | 2023-03-10 | 南京纳丁菲医药科技有限公司 | 苄氧基吡唑并嘧啶化合物和药物组合物及其应用 |
| CN114437075B (zh) * | 2020-11-03 | 2026-01-30 | 上海瑶琪生物科技有限公司 | 用作ntrk激酶抑制剂的化合物及其应用 |
| CN113200963A (zh) * | 2021-03-31 | 2021-08-03 | 广东石油化工学院 | N-(吡咯基)-3-吡唑基胺及其制备方法 |
| EP4335441B1 (en) * | 2021-05-03 | 2025-05-28 | JBKLAB Co., Ltd. | Pharmaceutical composition for preventing, alleviating, or treating cancer, containing 2,6-dichloro-4-(4-(4-hydroxycyclohexylamino)-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenol as active ingredient |
| CN117751121A (zh) * | 2021-07-30 | 2024-03-22 | 正大天晴药业集团股份有限公司 | 氨基吡唑并嘧啶化合物的晶体 |
| WO2023011616A1 (zh) * | 2021-08-06 | 2023-02-09 | 正大天晴药业集团股份有限公司 | 氨基吡唑并嘧啶化合物在治疗trk激酶介导的肿瘤中的用途 |
| CN117088800B (zh) * | 2023-08-18 | 2024-05-28 | 龙曦宁（上海）医药科技有限公司 | 一种5-甲基吡咯烷-3-醇盐酸盐的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10356579A1 (de) * | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| CA2722418C (en) | 2008-05-13 | 2013-09-17 | Irm Llc | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| CA2727250A1 (en) | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| CN102264736B (zh) * | 2008-10-22 | 2013-08-14 | 阵列生物制药公司 | 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| WO2012034095A1 (en) * | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| BR112013021638A2 (pt) | 2011-02-25 | 2016-08-02 | Irm Llc | "compostos inibidores de trk, seu uso e composições que os compreendem" |
| WO2013028263A1 (en) * | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as pi3 kinase inhibitors |
| KR20140105508A (ko) | 2011-12-12 | 2014-09-01 | 닥터 레디스 레보러터리즈 리미티드 | 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘 |
| MX362181B (es) | 2013-02-19 | 2019-01-08 | Ono Pharmaceutical Co | Compuesto inhibidor de cinasa del receptor de tropomiosina (trk). |
| EP2970288A1 (en) * | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN104650092B (zh) | 2013-11-16 | 2017-11-10 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| HUE046727T2 (hu) * | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
| HUE067779T2 (hu) * | 2014-12-15 | 2024-11-28 | Cmg Pharmaceutical Co Ltd | Kondenzált gyûrûs heteroaril vegyületek és azok felhasználása TRK inhibitorokként |
-
2017
- 2017-10-27 AU AU2017348826A patent/AU2017348826B2/en active Active
- 2017-10-27 ES ES17863410T patent/ES2896943T3/es active Active
- 2017-10-27 PL PL17863410T patent/PL3533796T3/pl unknown
- 2017-10-27 DK DK17863410.1T patent/DK3533796T3/da active
- 2017-10-27 WO PCT/CN2017/108100 patent/WO2018077246A1/zh not_active Ceased
- 2017-10-27 US US16/345,679 patent/US10829492B2/en active Active
- 2017-10-27 HU HUE17863410A patent/HUE057733T2/hu unknown
- 2017-10-27 RU RU2019114600A patent/RU2764523C2/ru active
- 2017-10-27 EP EP17863410.1A patent/EP3533796B1/en active Active
- 2017-10-27 MX MX2019004847A patent/MX380283B/es unknown
- 2017-10-27 JP JP2019522962A patent/JP7046940B2/ja active Active
- 2017-10-27 CA CA3041942A patent/CA3041942C/en active Active
- 2017-10-27 PT PT178634101T patent/PT3533796T/pt unknown
- 2017-10-27 KR KR1020197015241A patent/KR102616249B1/ko active Active
- 2017-10-27 CN CN201780064022.6A patent/CN109890820B/zh active Active
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