JP2014505037A5 - - Google Patents
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- Publication number
- JP2014505037A5 JP2014505037A5 JP2013543883A JP2013543883A JP2014505037A5 JP 2014505037 A5 JP2014505037 A5 JP 2014505037A5 JP 2013543883 A JP2013543883 A JP 2013543883A JP 2013543883 A JP2013543883 A JP 2013543883A JP 2014505037 A5 JP2014505037 A5 JP 2014505037A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- pyrrolo
- pyrimidin
- methyl
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42386510P | 2010-12-16 | 2010-12-16 | |
| US61/423,865 | 2010-12-16 | ||
| PCT/GB2011/052484 WO2012080735A1 (en) | 2010-12-16 | 2011-12-15 | Ask1 inhibiting pyrrolopyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505037A JP2014505037A (ja) | 2014-02-27 |
| JP2014505037A5 true JP2014505037A5 (enExample) | 2016-01-07 |
| JP5927201B2 JP5927201B2 (ja) | 2016-06-01 |
Family
ID=45444639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543883A Expired - Fee Related JP5927201B2 (ja) | 2010-12-16 | 2011-12-15 | Ａｓｋ１阻害ピロロピリミジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9045485B2 (enExample) |
| EP (1) | EP2651417B1 (enExample) |
| JP (1) | JP5927201B2 (enExample) |
| ES (1) | ES2617339T3 (enExample) |
| PL (1) | PL2651417T3 (enExample) |
| WO (1) | WO2012080735A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| JP5927201B2 (ja) | 2010-12-16 | 2016-06-01 | カルチャン リミテッド | Ａｓｋ１阻害ピロロピリミジン誘導体 |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| CN104981247A (zh) * | 2012-09-06 | 2015-10-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| CN104119342A (zh) * | 2013-04-25 | 2014-10-29 | 苏州科捷生物医药有限公司 | 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法 |
| WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| JP2017528464A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム，インコーポレイティド | 置換ピペリジン化合物 |
| SG11201701723XA (en) | 2014-09-24 | 2017-04-27 | Gilead Sciences Inc | Methods of treating liver disease |
| WO2016106384A1 (en) | 2014-12-23 | 2016-06-30 | Gilead Sciences, Inc. | Processes for preparing ask1 inhibitors |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| AU2017319080B2 (en) | 2016-08-31 | 2020-12-17 | Eisai R&D Management Co., Ltd. | Pyrazolo[1,5-a]pyrimidine compound |
| JOP20190221A1 (ar) * | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
| ES2971098T3 (es) | 2017-05-12 | 2024-06-03 | Enanta Pharm Inc | Inhibidores de la quinasa 1 que regula la señal de apoptosis y métodos de uso de los mismos |
| WO2018218051A1 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10246439B2 (en) | 2017-05-25 | 2019-04-02 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10253018B2 (en) | 2017-05-25 | 2019-04-09 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| GB201711234D0 (en) * | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
| CN107556318B (zh) * | 2017-08-22 | 2020-08-11 | 山东大学 | 一种含哌啶的吡咯并嘧啶类化合物及其制备方法与应用 |
| US10597382B2 (en) | 2017-08-28 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CN111801314B (zh) | 2018-01-02 | 2023-10-31 | 西尔洛克治疗公司 | Ask1抑制剂化合物及其用途 |
| WO2019163956A1 (ja) | 2018-02-26 | 2019-08-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロ［１，５－ａ］ピリミジン化合物の塩およびその結晶 |
| EP3787621B1 (en) | 2018-05-02 | 2024-12-18 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CA3106470A1 (en) * | 2018-07-17 | 2020-01-23 | Nippon Chemiphar Co., Ltd. | T-type calcium channel blocker |
| US10968199B2 (en) | 2018-08-22 | 2021-04-06 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11345699B2 (en) | 2018-11-19 | 2022-05-31 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| JP2022081710A (ja) * | 2019-03-29 | 2022-06-01 | ユーティアイ リミテッド パートナーシップ | 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用 |
| EP3950059A4 (en) * | 2019-03-29 | 2023-01-11 | Nippon Chemiphar Co., Ltd. | USE OF A T-TYPE CALCIUM CHANNEL BLOCKER TO TREAT PRURITUS |
| CN111303155A (zh) * | 2020-03-13 | 2020-06-19 | 深圳大学 | 靶向pak1抑制剂及其在抗肿瘤治疗药物中的应用 |
| CN117285520A (zh) * | 2022-06-24 | 2023-12-26 | 上海科技大学 | 甲酰胺类衍生物的医药用途、甲酰胺类衍生物、包含其的药物组合物 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970009225B1 (ko) | 1989-09-19 | 1997-06-09 | 데이진 가부시끼가이샤 | 피롤로[2,3-디] 피리미딘 유도체, 그의 제조방법 및 그것을 유효성분으로 하는 의약제제 |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| IL139787A0 (en) | 1998-06-02 | 2002-02-10 | Osi Pharm Inc | PYRROLO [2, 3d] PYRIMIDINE COMPOSITIONS AND THEIR USE |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| HUP0203487A2 (hu) * | 1999-10-25 | 2003-02-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahidrotiopirán-ftalazinon-származékok, mint PDE4-inhibitorok és ezeket tartalmazó gyógyszerkészítmények |
| WO2001039777A1 (en) | 1999-12-02 | 2001-06-07 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine a1 a2a, and a3 receptors and uses thereof |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| CA2464934A1 (en) | 2001-10-31 | 2003-05-08 | Bayer Healthcare Ag | Pyrimido [4,5-b] indole derivatives |
| US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
| EP1582586A4 (en) | 2002-11-22 | 2007-03-14 | Takeda Pharmaceutical | APOPTOSIS ASSOCIATED PROTEIN AND ITS USE |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP5606734B2 (ja) * | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| US20090082370A1 (en) | 2006-04-25 | 2009-03-26 | Neil Thomas Thompson | Pharmaceutical Combinations of PK Inhibitors and Other Active Agents |
| US20100016340A1 (en) | 2006-04-25 | 2010-01-21 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| US20100029619A1 (en) | 2006-08-04 | 2010-02-04 | Takeda Pharmaceutical Company Limted | Fused heterocyclic compound |
| JP2010513458A (ja) * | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| AR064416A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| AR064415A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de pirrolo-piperidinas y purinas,composiciones farmaceuticas que los contienen y usos en trastornos y/o enfermedades mediadas por pka y pkb. |
| CA2679198C (en) * | 2007-02-26 | 2011-07-12 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| WO2008117796A1 (ja) | 2007-03-28 | 2008-10-02 | Dainippon Sumitomo Pharma Co., Ltd. | 新規ムチリン誘導体 |
| MX2010002312A (es) | 2007-08-31 | 2010-03-18 | Merck Serono Sa | Compuestos de triazolopiridina y su uso como inhibidores de cinasa reguladora de señal de apoptosis. |
| BRPI0818533B8 (pt) | 2007-10-11 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
| EP2271646A1 (en) | 2008-03-31 | 2011-01-12 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| EP2297153B1 (en) | 2008-04-21 | 2015-05-27 | Lexicon Pharmaceuticals, Inc. | Limk2 inhibitors, compositions comprising them, and methods of their use |
| US8178555B2 (en) | 2008-06-24 | 2012-05-15 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| CA2728559A1 (en) | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| BRPI0917412A2 (pt) | 2008-08-15 | 2015-12-01 | Agents The University Of Texas System Board Of | composto e uso de um composto |
| EP2385832B1 (en) | 2009-01-08 | 2015-07-15 | Curis, Inc. | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety |
| WO2010121243A1 (en) | 2009-04-17 | 2010-10-21 | University Of Arizona | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles |
| BR112012000422A2 (pt) | 2009-07-08 | 2017-05-09 | Leo Pharma As | composto, composição farmacêutica, uso de um composto, e, método para a prevenir tratar ou melhorar doenças do sistema imune |
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| WO2011029043A1 (en) | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| WO2011097079A1 (en) | 2010-02-03 | 2011-08-11 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| JP2013518909A (ja) | 2010-02-08 | 2013-05-23 | キナゲン，インク． | アロステリックキナーゼ阻害が関係する治療方法および組成物 |
| MX339192B (es) | 2010-03-24 | 2016-05-13 | Amitech Therapeutic Solutions Inc | Compuestos heterociclicos utiles para inhibicion de cinasa. |
| AU2011272782B2 (en) | 2010-07-02 | 2014-11-27 | Gilead Sciences, Inc. | Apoptosis signal-regulating kinase inhibitors |
| WO2012011548A1 (ja) | 2010-07-23 | 2012-01-26 | 国立大学法人 東京大学 | 含窒素複素環誘導体 |
| JP5749341B2 (ja) | 2010-08-20 | 2015-07-15 | ハチソン メディファーマ リミテッド | ピロロピリミジン化合物およびその使用 |
| CN102372717B (zh) | 2010-08-20 | 2014-06-18 | 和记黄埔医药（上海）有限公司 | 吡咯并嘧啶类化合物及其用途 |
| WO2012022045A1 (en) | 2010-08-20 | 2012-02-23 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| US8937077B2 (en) | 2010-10-22 | 2015-01-20 | Merck Sharp & Dohme Corp. | Bicyclic diamines as janus kinase inhibitors |
| WO2012058645A1 (en) | 2010-10-29 | 2012-05-03 | Biogen Idec Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| JP5927201B2 (ja) * | 2010-12-16 | 2016-06-01 | カルチャン リミテッド | Ａｓｋ１阻害ピロロピリミジン誘導体 |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| MD20140130A2 (ro) | 2012-06-29 | 2015-04-30 | Pfizer Inc. | 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2 |
| CN104981247A (zh) | 2012-09-06 | 2015-10-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| WO2014043272A1 (en) | 2012-09-12 | 2014-03-20 | Trius Therapeutics Inc. | Tricyclic gyrase inhibitors for use as antibacterial agents |
| UY35212A (es) | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
-
2011
- 2011-12-15 JP JP2013543883A patent/JP5927201B2/ja not_active Expired - Fee Related
- 2011-12-15 US US13/994,691 patent/US9045485B2/en active Active
- 2011-12-15 EP EP11804756.2A patent/EP2651417B1/en active Active
- 2011-12-15 ES ES11804756.2T patent/ES2617339T3/es active Active
- 2011-12-15 PL PL11804756T patent/PL2651417T3/pl unknown
- 2011-12-15 WO PCT/GB2011/052484 patent/WO2012080735A1/en not_active Ceased
-
2015
- 2015-04-28 US US14/698,489 patent/US9585886B2/en not_active Expired - Fee Related
-
2017
- 2017-01-30 US US15/420,000 patent/US20170210748A1/en not_active Abandoned
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