JP2014505037A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014505037A5 JP2014505037A5 JP2013543883A JP2013543883A JP2014505037A5 JP 2014505037 A5 JP2014505037 A5 JP 2014505037A5 JP 2013543883 A JP2013543883 A JP 2013543883A JP 2013543883 A JP2013543883 A JP 2013543883A JP 2014505037 A5 JP2014505037 A5 JP 2014505037A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- pyrrolo
- pyrimidin
- methyl
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42386510P | 2010-12-16 | 2010-12-16 | |
| US61/423,865 | 2010-12-16 | ||
| PCT/GB2011/052484 WO2012080735A1 (en) | 2010-12-16 | 2011-12-15 | Ask1 inhibiting pyrrolopyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505037A JP2014505037A (ja) | 2014-02-27 |
| JP2014505037A5 true JP2014505037A5 (enExample) | 2016-01-07 |
| JP5927201B2 JP5927201B2 (ja) | 2016-06-01 |
Family
ID=45444639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543883A Expired - Fee Related JP5927201B2 (ja) | 2010-12-16 | 2011-12-15 | Ａｓｋ１阻害ピロロピリミジン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9045485B2 (enExample) |
| EP (1) | EP2651417B1 (enExample) |
| JP (1) | JP5927201B2 (enExample) |
| ES (1) | ES2617339T3 (enExample) |
| PL (1) | PL2651417T3 (enExample) |
| WO (1) | WO2012080735A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| PL2651417T3 (pl) * | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
| CN104119342A (zh) * | 2013-04-25 | 2014-10-29 | 苏州科捷生物医药有限公司 | 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法 |
| WO2015187499A1 (en) * | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| BR112017004589A2 (pt) * | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| NZ729678A (en) | 2014-09-24 | 2018-07-27 | Gilead Sciences Inc | Methods of treating non-alcoholic steatohepatitis using ask1 inhibitor in combination with a fxr agonist |
| TWI749934B (zh) | 2014-12-23 | 2021-12-11 | 美商基利科學股份有限公司 | 製備2-氟-4-甲基-5-(4-環丙基-1h-咪唑-1-基)苯甲酸之方法 |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| MX377489B (es) | 2016-08-31 | 2025-03-10 | Eisai R&D Man Co Ltd | Compuesto de pirazolo[1,5-a]pirimidina. |
| JOP20190221A1 (ar) | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
| EP3621615B1 (en) | 2017-05-12 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10246439B2 (en) | 2017-05-25 | 2019-04-02 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2018218042A1 (en) | 2017-05-25 | 2018-11-29 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10450301B2 (en) | 2017-05-25 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| GB201711234D0 (en) * | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
| CN107556318B (zh) * | 2017-08-22 | 2020-08-11 | 山东大学 | 一种含哌啶的吡咯并嘧啶类化合物及其制备方法与应用 |
| WO2019046186A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF |
| EP3735404B1 (en) | 2018-01-02 | 2023-11-29 | Seal Rock Therapeutics, Inc. | Ask1 inhibitor compounds and uses thereof |
| WO2019163956A1 (ja) | 2018-02-26 | 2019-08-29 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロ［１，５－ａ］ピリミジン化合物の塩およびその結晶 |
| MX2020011225A (es) | 2018-05-02 | 2021-01-20 | Enanta Pharm Inc | Tetrazol que contiene inhibidores de la cinasa 1 reguladora de la señal de apoptosis y métodos de uso de los mismos. |
| WO2019213239A1 (en) | 2018-05-02 | 2019-11-07 | Enanta Pharmaceuticals Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| JPWO2020017569A1 (ja) * | 2018-07-17 | 2021-12-02 | 日本ケミファ株式会社 | Ｔ型カルシウムチャネル阻害剤 |
| US10968199B2 (en) | 2018-08-22 | 2021-04-06 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11345699B2 (en) | 2018-11-19 | 2022-05-31 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CA3135344A1 (en) * | 2019-03-29 | 2020-10-08 | Nippon Chemiphar Co., Ltd. | Use of t-type calcium channel blocker for treating pruritus |
| JP2022081710A (ja) * | 2019-03-29 | 2022-06-01 | ユーティアイ リミテッド パートナーシップ | 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用 |
| CN111303155A (zh) * | 2020-03-13 | 2020-06-19 | 深圳大学 | 靶向pak1抑制剂及其在抗肿瘤治疗药物中的应用 |
| CN117285520A (zh) * | 2022-06-24 | 2023-12-26 | 上海科技大学 | 甲酰胺类衍生物的医药用途、甲酰胺类衍生物、包含其的药物组合物 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970009225B1 (ko) | 1989-09-19 | 1997-06-09 | 데이진 가부시끼가이샤 | 피롤로[2,3-디] 피리미딘 유도체, 그의 제조방법 및 그것을 유효성분으로 하는 의약제제 |
| DZ2805A1 (fr) | 1998-06-02 | 2005-01-30 | Cadus Pharmaceutical Corp | Composition à pyrroloÄ2,,3dÜ pyrimidine et leurs usages. |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| JP2003512466A (ja) * | 1999-10-25 | 2003-04-02 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのテトラヒドロチオピランフタラジノン誘導体 |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| AU784878B2 (en) | 1999-12-02 | 2006-07-13 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 A2A and A3 receptors and uses thereof |
| JP2005515173A (ja) | 2001-10-31 | 2005-05-26 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ピリミド［４，５−ｂ］インドール誘導体 |
| US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
| EP1582586A4 (en) | 2002-11-22 | 2007-03-14 | Takeda Pharmaceutical | APOPTOSIS ASSOCIATED PROTEIN AND ITS USE |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| DK3719018T3 (da) * | 2006-04-25 | 2025-09-29 | Astex Therapeutics Ltd | Purin og deazapurinderivater som farmaceutiske forbindelser |
| EP2037931A2 (en) | 2006-04-25 | 2009-03-25 | Astex Therapeutics Limited | Pharmaceutical combinations of pk inhibitors and other active agents |
| US20100016340A1 (en) | 2006-04-25 | 2010-01-21 | Astex Therapeutics Limited | Pharmaceutical compounds |
| WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| WO2008016131A1 (en) | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| EP2129660A2 (en) * | 2006-12-19 | 2009-12-09 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| AR064416A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| AR064415A1 (es) | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de pirrolo-piperidinas y purinas,composiciones farmaceuticas que los contienen y usos en trastornos y/o enfermedades mediadas por pka y pkb. |
| EP2132196A1 (en) * | 2007-02-26 | 2009-12-16 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| WO2008117796A1 (ja) | 2007-03-28 | 2008-10-02 | Dainippon Sumitomo Pharma Co., Ltd. | 新規ムチリン誘導体 |
| AU2008291075A1 (en) | 2007-08-31 | 2009-03-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
| BRPI0818533B8 (pt) | 2007-10-11 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
| JP5432982B2 (ja) | 2008-03-31 | 2014-03-05 | 武田薬品工業株式会社 | アポトーシスシグナル調節キナーゼ１阻害剤 |
| WO2009131940A1 (en) | 2008-04-21 | 2009-10-29 | Lexicon Pharmaceuticals, Inc. | Limk2 inhibitors, compositions comprising them, and methods of their use |
| WO2010008843A1 (en) | 2008-06-24 | 2010-01-21 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| CN102143746A (zh) | 2008-07-03 | 2011-08-03 | 埃克塞利希斯股份有限公司 | Cdk 调节剂 |
| CA2734305A1 (en) | 2008-08-15 | 2010-02-18 | Board Of Regents, The University Of Texas System | 1,4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions |
| BRPI1004899B8 (pt) | 2009-01-08 | 2021-05-25 | Curis Inc | composto inibidor de fosfoinositida 3-quinase, composição farmacêutica e uso de um composto |
| WO2010121243A1 (en) | 2009-04-17 | 2010-10-21 | University Of Arizona | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles |
| US9346809B2 (en) | 2009-07-08 | 2016-05-24 | Leo Pharma A/S | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors |
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| WO2011029043A1 (en) | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
| HRP20140114T1 (hr) | 2010-02-03 | 2014-03-14 | Takeda Pharmaceutical Company Limited | Inhibitori kinaze 1 koji reguliraju signal apoptoze |
| US9260417B2 (en) | 2010-02-08 | 2016-02-16 | Amitech Therapeutic Solutions, Inc. | Therapeutic methods and compositions involving allosteric kinase inhibition |
| CA2794086A1 (en) | 2010-03-24 | 2011-09-29 | Amitech Therapeutic Solutions, Inc. | Heterocyclic compounds useful for kinase inhibition |
| KR101759759B1 (ko) | 2010-07-02 | 2017-07-19 | 길리애드 사이언시즈, 인코포레이티드 | 세포자멸사 신호-조절 키나아제 저해제 |
| JP5525612B2 (ja) | 2010-07-23 | 2014-06-18 | 国立大学法人 東京大学 | 含窒素複素環誘導体 |
| WO2012022045A1 (en) | 2010-08-20 | 2012-02-23 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| US9346810B2 (en) | 2010-08-20 | 2016-05-24 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| CN102372717B (zh) | 2010-08-20 | 2014-06-18 | 和记黄埔医药（上海）有限公司 | 吡咯并嘧啶类化合物及其用途 |
| EP2629777B1 (en) | 2010-10-22 | 2018-12-19 | Merck Sharp & Dohme Corp. | Bicyclic diamines as janus kinase inhibitors |
| WO2012058645A1 (en) | 2010-10-29 | 2012-05-03 | Biogen Idec Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| PL2651417T3 (pl) * | 2010-12-16 | 2017-08-31 | Calchan Limited | Pochodne pirolopirymidyny hamujące ASK1 |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| JP6189948B2 (ja) | 2012-06-29 | 2017-08-30 | ファイザー・インク | ＬＲＲＫ２阻害薬としての新規な４−（置換アミノ）−７Ｈ−ピロロ［２，３−ｄ］ピリミジン |
| ES2889757T3 (es) | 2012-09-06 | 2022-01-13 | Plexxikon Inc | Compuestos y procedimientos para la modulación de quinasas e indicaciones para estos |
| US10865216B2 (en) | 2012-09-12 | 2020-12-15 | Merck Sharp & Dohme Corp. | Tricyclic Gyrase inhibitors |
| UY35212A (es) | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
-
2011
- 2011-12-15 PL PL11804756T patent/PL2651417T3/pl unknown
- 2011-12-15 EP EP11804756.2A patent/EP2651417B1/en active Active
- 2011-12-15 ES ES11804756.2T patent/ES2617339T3/es active Active
- 2011-12-15 US US13/994,691 patent/US9045485B2/en active Active
- 2011-12-15 WO PCT/GB2011/052484 patent/WO2012080735A1/en not_active Ceased
- 2011-12-15 JP JP2013543883A patent/JP5927201B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-28 US US14/698,489 patent/US9585886B2/en not_active Expired - Fee Related
-
2017
- 2017-01-30 US US15/420,000 patent/US20170210748A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014505037A5 (enExample) | ||
| JP6318238B2 (ja) | スルファモイルピロールアミド誘導体およびｂ型肝炎を処置するための医薬品としてのその使用 | |
| HRP20192336T1 (hr) | Derivati imidazotiadiazola i imidazopirazina kao inhibitori proteazom aktiviranog receptora 4 (par4) za liječenje agregacije trombocita | |
| JP2018522823A5 (enExample) | ||
| EP2533783A1 (en) | Compounds and methods | |
| CA2672373A1 (en) | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases | |
| RU2017145650A (ru) | Ингибиторы тирозинкиназы брутона | |
| RU2019114600A (ru) | Соединение аминопиразолопиримидина, используемое в качестве ингибитора тирозинкиназного рецептора нейротрофического фактора | |
| JP2014523851A5 (enExample) | ||
| AR038420A1 (es) | Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende | |
| HRP20191140T1 (hr) | Spojevi i pripravci kao inhibitori c-kit kinaze | |
| HRP20170363T1 (hr) | Derivati piridina kao inhibitori kinaze pregrađene prilikom transfekcije (ret) | |
| JP2014506599A5 (enExample) | ||
| HRP20161558T1 (hr) | Novi biciklički piridinoni | |
| JP2009536918A5 (enExample) | ||
| JP2013528204A5 (enExample) | ||
| TW201204346A (en) | Novel hydroxamic acid derivative | |
| JP2009534403A5 (enExample) | ||
| RU2014103587A (ru) | Производные циклических аминов в качестве антагонистов рецептора ер4 | |
| RU2015143000A (ru) | N-(4-(азаиндазол-6-ил)-фенил)-сульфонамиды и их применение в качестве лекарственных средств | |
| ME02672B (me) | Fenil-3-aza-bicikl0[3.1.0]heks-3-il-metanoni i njihova primena kao medikament | |
| JP2012530765A5 (enExample) | ||
| CA2647036A1 (en) | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | |
| ES2548258T3 (es) | Compuestos de oxadiazol sustituidos y su uso como agonistas de S1P1 | |
| FI3792260T3 (fi) | Atsabentsimidatsoliyhdisteitä ja lääkkeitä |