JP5927201B2 - Ａｓｋ１阻害ピロロピリミジン誘導体 - Google Patents

Ａｓｋ１阻害ピロロピリミジン誘導体 Download PDF

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JP5927201B2
JP5927201B2 JP2013543883A JP2013543883A JP5927201B2 JP 5927201 B2 JP5927201 B2 JP 5927201B2 JP 2013543883 A JP2013543883 A JP 2013543883A JP 2013543883 A JP2013543883 A JP 2013543883A JP 5927201 B2 JP5927201 B2 JP 5927201B2
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pyrrolo
pyrimidin
piperidinyl
methyl
benzamide
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JP2014505037A5 (enExample
JP2014505037A (ja
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アール．ウイトトイ ダビド
アール．ウイトトイ ダビド
ノルトン ダビド
ノルトン ダビド
パウル トイエルネイ ジャソン
パウル トイエルネイ ジャソン
ロルトヒオイル グヒスライネ
ロルトヒオイル グヒスライネ
シメ マイリ
シメ マイリ
ロウイセ プヒルポトト カレン
ロウイセ プヒルポトト カレン
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カルチャン リミテッド
カルチャン リミテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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JP2013543883A 2010-12-16 2011-12-15 Ａｓｋ１阻害ピロロピリミジン誘導体 Expired - Fee Related JP5927201B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42386510P 2010-12-16 2010-12-16
US61/423,865 2010-12-16
PCT/GB2011/052484 WO2012080735A1 (en) 2010-12-16 2011-12-15 Ask1 inhibiting pyrrolopyrimidine derivatives

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JP2014505037A JP2014505037A (ja) 2014-02-27
JP2014505037A5 JP2014505037A5 (enExample) 2016-01-07
JP5927201B2 true JP5927201B2 (ja) 2016-06-01

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US (3) US9045485B2 (enExample)
EP (1) EP2651417B1 (enExample)
JP (1) JP5927201B2 (enExample)
ES (1) ES2617339T3 (enExample)
PL (1) PL2651417T3 (enExample)
WO (1) WO2012080735A1 (enExample)

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TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2651417B1 (en) 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN104981247A (zh) * 2012-09-06 2015-10-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
CN104119342A (zh) * 2013-04-25 2014-10-29 苏州科捷生物医药有限公司 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法
US20150342943A1 (en) * 2014-06-03 2015-12-03 Gilead Sciences, Inc. Methods of treating liver disease
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
CA2960280A1 (en) * 2014-09-10 2016-03-17 Epizyme, Inc. Substituted piperidine compounds
JP2017528471A (ja) 2014-09-24 2017-09-28 ギリアード サイエンシーズ， インコーポレイテッド 肝疾患を処置する方法
ES2842749T3 (es) 2014-12-23 2021-07-14 Gilead Sciences Inc Procesos para preparar inhibidores de ASK1
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
CA3021675C (en) 2016-08-31 2024-06-25 Eisai R&D Management Co., Ltd. Pyrazolo[1,5-a]pyrimidine compound
JOP20190221A1 (ar) * 2017-04-05 2019-09-23 Seal Rock Therapeutics Inc مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها
AU2018266911C1 (en) 2017-05-12 2022-10-20 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218044A2 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals Inc Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10450301B2 (en) 2017-05-25 2019-10-22 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10253018B2 (en) 2017-05-25 2019-04-09 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
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