JP5927201B2 - Ａｓｋ１阻害ピロロピリミジン誘導体 - Google Patents

Ａｓｋ１阻害ピロロピリミジン誘導体 Download PDF

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JP5927201B2
JP5927201B2 JP2013543883A JP2013543883A JP5927201B2 JP 5927201 B2 JP5927201 B2 JP 5927201B2 JP 2013543883 A JP2013543883 A JP 2013543883A JP 2013543883 A JP2013543883 A JP 2013543883A JP 5927201 B2 JP5927201 B2 JP 5927201B2
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pyrrolo
pyrimidin
piperidinyl
methyl
benzamide
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JP2014505037A (ja
JP2014505037A5 (enExample
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アール．ウイトトイ ダビド
アール．ウイトトイ ダビド
ノルトン ダビド
ノルトン ダビド
パウル トイエルネイ ジャソン
パウル トイエルネイ ジャソン
ロルトヒオイル グヒスライネ
ロルトヒオイル グヒスライネ
シメ マイリ
シメ マイリ
ロウイセ プヒルポトト カレン
ロウイセ プヒルポトト カレン
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カルチャン リミテッド
カルチャン リミテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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JP2013543883A 2010-12-16 2011-12-15 Ａｓｋ１阻害ピロロピリミジン誘導体 Expired - Fee Related JP5927201B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42386510P 2010-12-16 2010-12-16
US61/423,865 2010-12-16
PCT/GB2011/052484 WO2012080735A1 (en) 2010-12-16 2011-12-15 Ask1 inhibiting pyrrolopyrimidine derivatives

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JP2014505037A JP2014505037A (ja) 2014-02-27
JP2014505037A5 JP2014505037A5 (enExample) 2016-01-07
JP5927201B2 true JP5927201B2 (ja) 2016-06-01

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US (3) US9045485B2 (enExample)
EP (1) EP2651417B1 (enExample)
JP (1) JP5927201B2 (enExample)
ES (1) ES2617339T3 (enExample)
PL (1) PL2651417T3 (enExample)
WO (1) WO2012080735A1 (enExample)

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TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
PL2651417T3 (pl) * 2010-12-16 2017-08-31 Calchan Limited Pochodne pirolopirymidyny hamujące ASK1
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
JP6318156B2 (ja) * 2012-09-06 2018-04-25 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼをモジュレートするための化合物および方法、ならびにその指標
CN104119342A (zh) * 2013-04-25 2014-10-29 苏州科捷生物医药有限公司 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法
WO2015187499A1 (en) * 2014-06-03 2015-12-10 Gilead Sciences, Inc. Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
BR112017004589A2 (pt) * 2014-09-10 2018-01-23 Epizyme Inc composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd
US10238636B2 (en) 2014-09-24 2019-03-26 Gilead Sciences, Inc. Methods of treating liver disease
US9586933B2 (en) 2014-12-23 2017-03-07 Gilead Sciences, Inc. Processes for preparing ASK1 inhibitors
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
ES2886840T3 (es) 2016-08-31 2021-12-21 Eisai R&D Man Co Ltd Compuesto de pirazolo[1,5-a]pirimidina
JOP20190221A1 (ar) 2017-04-05 2019-09-23 Seal Rock Therapeutics Inc مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها
PL3621615T3 (pl) 2017-05-12 2024-03-25 Enanta Pharmaceuticals, Inc. Inhibitory regulujące sygnał apoptozy kinazy 1 i sposoby ich stosowania
WO2018218042A1 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
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