|
US2466420A
(en)
*
|
1947-11-26 |
1949-04-05 |
Eastman Kodak Co |
Ketene condensation products with aldehydes
|
|
US3226394A
(en)
*
|
1964-06-16 |
1965-12-28 |
Shulton Inc |
Pyridylethylated anthranilamides and derivatives thereof
|
|
CH504416A
(de)
|
1966-12-05 |
1971-03-15 |
Ciba Geigy Ag |
Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen
|
|
US4551540A
(en)
*
|
1983-01-17 |
1985-11-05 |
Borg-Warner Chemicals, Inc. |
Substituted 2,5-dimethylpyrroles
|
|
US4574765A
(en)
*
|
1984-11-30 |
1986-03-11 |
Donald E. Goorhouse |
Supplemental air injection method and devices for carburetors of internal combustion engines
|
|
US5190541A
(en)
|
1990-10-17 |
1993-03-02 |
Boston Scientific Corporation |
Surgical instrument and method
|
|
EP0627940B1
(en)
*
|
1992-03-05 |
2003-05-07 |
Board of Regents, The University of Texas System |
Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors
|
|
US5474765A
(en)
|
1992-03-23 |
1995-12-12 |
Ut Sw Medical Ctr At Dallas |
Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
|
|
US5686472A
(en)
|
1992-10-29 |
1997-11-11 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5593992A
(en)
|
1993-07-16 |
1997-01-14 |
Smithkline Beecham Corporation |
Compounds
|
|
JPH10507185A
(ja)
|
1994-10-14 |
1998-07-14 |
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー |
２−（イミダゾール−４−イル）カルバペネム誘導体、その中間体および抗菌剤としての使用
|
|
JPH10506560A
(ja)
|
1995-04-19 |
1998-06-30 |
シュナイダー（ユーエスエー）インク |
薬品を放出する被覆されたステント
|
|
US6117432A
(en)
*
|
1995-04-20 |
2000-09-12 |
Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) |
Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
|
|
TW349948B
(en)
|
1995-10-31 |
1999-01-11 |
Janssen Pharmaceutica Nv |
Farnesyl transferase inhibiting 2-quinolone derivatives
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
EA000710B1
(ru)
*
|
1995-12-08 |
2000-02-28 |
Жансен Фармасетика Н.В. |
(имидазол-5-ил)метил-2-хинолиноновые производные, ингибирующие фарнезилпротеин-трансферазу
|
|
US5874442A
(en)
*
|
1995-12-22 |
1999-02-23 |
Schering-Plough Corporation |
Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
|
|
US6011029A
(en)
|
1996-02-26 |
2000-01-04 |
Bristol-Myers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US5702390A
(en)
|
1996-03-12 |
1997-12-30 |
Ethicon Endo-Surgery, Inc. |
Bioplar cutting and coagulation instrument
|
|
CA2262676A1
(en)
|
1996-08-09 |
1998-02-19 |
Merck & Co., Inc. |
Stereoselective deoxygenation reaction
|
|
ATE252104T1
(de)
|
1996-12-20 |
2003-11-15 |
Tovarischestvo S Ogranichennoi |
Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid
|
|
UA59384C2
(uk)
|
1996-12-20 |
2003-09-15 |
Пфайзер, Інк. |
Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
|
|
TW591030B
(en)
*
|
1997-03-10 |
2004-06-11 |
Janssen Pharmaceutica Nv |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
|
|
BR9809398A
(pt)
|
1997-04-25 |
2000-06-13 |
Janssen Pharmaceutica Nv |
Quinazolinonas que inibem a farnesil transferase
|
|
TW491872B
(en)
|
1997-05-27 |
2002-06-21 |
Ciba Sc Holding Ag |
Block oligomers containing l-hydrocarbyloxy-2,2,6,6-tetramethyl-4- piperidyl groups as stabilizers for lower polyolefin
|
|
US6100254A
(en)
|
1997-10-10 |
2000-08-08 |
Board Of Regents, The University Of Texas System |
Inhibitors of protein tyrosine kinases
|
|
CA2322798C
(en)
|
1998-03-05 |
2008-05-13 |
Formula One Administration Limited |
Data communication system
|
|
US6303654B1
(en)
|
1998-03-12 |
2001-10-16 |
Wisconsin Alumni Research Foundation |
Acyclic monoterpenoid derivatives
|
|
AU5086499A
(en)
|
1998-07-01 |
2000-01-24 |
Merck & Co., Inc. |
Process for making farnesyl-protein transferase inhibitors
|
|
JP2002520324A
(ja)
|
1998-07-10 |
2002-07-09 |
メルク エンド カムパニー インコーポレーテッド |
新規な血管形成インヒビター
|
|
HK1039123A1
(zh)
|
1998-08-27 |
2002-04-12 |
辉瑞产品公司 |
用作抗癌剂的炔基取代的喹啉-2-酮衍生物
|
|
JP3494409B2
(ja)
|
1998-08-27 |
2004-02-09 |
ファイザー・プロダクツ・インク |
抗がん剤として有用なアルキニル置換キノリン−２−オン誘導体
|
|
GB9824579D0
(en)
|
1998-11-10 |
1999-01-06 |
Novartis Ag |
Organic compounds
|
|
ES2200591T3
(es)
*
|
1998-12-23 |
2004-03-01 |
Janssen Pharmaceutica N.V. |
Derivados de 1,2-quinolina anelados.
|
|
EP1140938B1
(en)
|
1999-01-11 |
2003-08-27 |
Princeton University |
High affinity inhibitors for target validation and uses thereof
|
|
US7125875B2
(en)
|
1999-04-15 |
2006-10-24 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
|
EP2308833A3
(en)
|
1999-04-15 |
2011-09-28 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
|
AU763954B2
(en)
*
|
1999-04-28 |
2003-08-07 |
Board Of Regents, The University Of Texas System |
Compositions and methods for cancer treatment by selectively inhibiting VEGF
|
|
US6346625B1
(en)
|
1999-06-23 |
2002-02-12 |
Astrazeneca Ab |
Protein kinase inhibitors
|
|
DE19962924A1
(de)
|
1999-12-24 |
2001-07-05 |
Bayer Ag |
Substituierte Oxazolidinone und ihre Verwendung
|
|
CA2396693A1
(en)
|
1999-12-28 |
2001-07-05 |
Stephen T. Wrobleski |
Cytokine, especially tnf-alpha, inhibitors
|
|
FR2803592A1
(fr)
*
|
2000-01-06 |
2001-07-13 |
Aventis Cropscience Sa |
Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant.
|
|
US6558385B1
(en)
|
2000-09-22 |
2003-05-06 |
Tissuelink Medical, Inc. |
Fluid-assisted medical device
|
|
US6692491B1
(en)
|
2000-03-24 |
2004-02-17 |
Scimed Life Systems, Inc. |
Surgical methods and apparatus for positioning a diagnostic or therapeutic element around one or more pulmonary veins or other body structures
|
|
US6776796B2
(en)
*
|
2000-05-12 |
2004-08-17 |
Cordis Corportation |
Antiinflammatory drug and delivery device
|
|
WO2002032861A2
(en)
|
2000-10-17 |
2002-04-25 |
Merck & Co., Inc. |
Orally active salts with tyrosine kinase activity
|
|
US7105682B2
(en)
|
2001-01-12 |
2006-09-12 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
|
WO2003024969A1
(en)
|
2001-09-14 |
2003-03-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2003024931A1
(en)
|
2001-09-14 |
2003-03-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
TWI259081B
(en)
|
2001-10-26 |
2006-08-01 |
Sugen Inc |
Treatment of acute myeloid leukemia with indolinone compounds
|
|
TWI302836B
(en)
|
2001-10-30 |
2008-11-11 |
Novartis Ag |
Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
|
|
MXPA04006271A
(es)
|
2001-12-27 |
2004-10-04 |
Theravance Inc |
Derivados de indolinona utiles como inhibidores de la proteina cinasa.
|
|
IL165264A0
(en)
|
2002-05-23 |
2005-12-18 |
Cytopia Pty Ltd |
Protein kinase inhibitors
|
|
PE20040522A1
(es)
|
2002-05-29 |
2004-09-28 |
Novartis Ag |
Derivados de diarilurea dependientes de la cinasa de proteina
|
|
MY141867A
(en)
*
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
|
MXPA05001804A
(es)
|
2002-08-14 |
2005-05-27 |
Vertex Pharma |
Inhibidores de proteinas cinasas y usos de los mismos.
|
|
CA2496164C
(en)
|
2002-08-23 |
2010-11-09 |
Chiron Corporation |
Benzimidazole quinolinones and uses thereof
|
|
AU2003258491A1
(en)
|
2002-09-05 |
2004-03-29 |
Neurosearch A/S |
Amide derivatives and their use as chloride channel blockers
|
|
EP1549614A4
(en)
|
2002-10-03 |
2008-04-16 |
Targegen Inc |
VASCULATORY AGENTS AND METHODS FOR THEIR APPLICATION
|
|
US20080207617A1
(en)
|
2002-10-29 |
2008-08-28 |
Kirin Beer Kabushiki Kaisha |
Quinoline Derivatives and Quinazoline Derivatives Inhibiting Autophosphrylation of Flt3 and Medicinal Compositions Containing the Same
|
|
US7838527B2
(en)
|
2002-11-13 |
2010-11-23 |
Novartis Vaccines And Diagnostics, Inc. |
Methods of treating cancer and related methods
|
|
AR042052A1
(es)
|
2002-11-15 |
2005-06-08 |
Vertex Pharma |
Diaminotriazoles utiles como inhibidores de proteinquinasas
|
|
AU2003297160A1
(en)
|
2002-12-18 |
2004-07-22 |
Vertex Pharmaceuticals Incorporated |
Benzisoxazole derivatives useful as inhibitors of protein kinases
|
|
CA2521830A1
(en)
|
2003-04-09 |
2004-10-21 |
Japan Tobacco Inc. |
Heteroaromatic pentacyclic compound and medicinal use thereof
|
|
US7427683B2
(en)
*
|
2003-04-25 |
2008-09-23 |
Ortho-Mcneil Pharmaceutical, Inc. |
c-fms kinase inhibitors
|
|
US20050113566A1
(en)
*
|
2003-04-25 |
2005-05-26 |
Player Mark R. |
Inhibitors of C-FMS kinase
|
|
EP1631560A2
(en)
|
2003-04-25 |
2006-03-08 |
3-Dimensional Pharmaceuticals, Inc. |
C-fms kinase inhibitors
|
|
US7790724B2
(en)
|
2003-04-25 |
2010-09-07 |
Janssen Pharmaceutica N.V. |
c-fms kinase inhibitors
|
|
RU2345981C2
(ru)
|
2003-07-28 |
2009-02-10 |
Смитклайн Бичем Корпорейшн |
ЦИКЛОАЛКИЛИДЕНОВЫЕ СОЕДИНЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ИХ ПРИМЕНЕНИЕ И СПОСОБ СЕЛЕКТИВНОГО СВЯЗЫВАНИЯ ERα- И ERβ-ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ
|
|
CA2542909C
(en)
|
2003-10-23 |
2012-07-10 |
Ab Science |
2-aminoaryloxazole compounds as tyrosine kinase inhibitors
|
|
GB0326601D0
(en)
|
2003-11-14 |
2003-12-17 |
Novartis Ag |
Organic compounds
|
|
NZ548884A
(en)
|
2004-01-30 |
2010-06-25 |
Ab Science |
2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors
|
|
JP5008569B2
(ja)
*
|
2004-10-22 |
2012-08-22 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
Ｃ−ｆｍｓキナーゼのインヒビターとしての芳香族アミド
|
|
US7645755B2
(en)
*
|
2004-10-22 |
2010-01-12 |
Janssen Pharmaceutical N.V. |
Inhibitors of c-fms kinase
|
|
ES2611604T3
(es)
|
2004-10-22 |
2017-05-09 |
Janssen Pharmaceutica Nv |
Inhibidores de la c fms quinasa
|
|
US7662837B2
(en)
|
2004-10-22 |
2010-02-16 |
Janssen Pharmaceutica N.V. |
Inhibitors of c-fms kinase
|
|
US20060281755A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
|
|
US20060281788A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
|
|
US20060281700A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
|
|
US20060281769A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators
|
|
US20060281771A1
(en)
|
2005-06-10 |
2006-12-14 |
Baumann Christian A |
Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators
|
|
EP1951234A2
(en)
|
2005-10-18 |
2008-08-06 |
Janssen Pharmaceutica N.V. |
Method of inhibiting flt3 kinase
|
|
KR101367646B1
(ko)
|
2006-04-20 |
2014-02-27 |
얀센 파마슈티카 엔.브이. |
Ｃ-ｆｍｓ 키나제의 저해제
|
|
US8697716B2
(en)
*
|
2006-04-20 |
2014-04-15 |
Janssen Pharmaceutica Nv |
Method of inhibiting C-KIT kinase
|
|
AU2007240439B2
(en)
|
2006-04-20 |
2012-10-11 |
Janssen Pharmaceutica N.V. |
Inhibitors of c-fms kinase
|
|
KR101367645B1
(ko)
*
|
2006-04-20 |
2014-02-27 |
얀센 파마슈티카 엔.브이. |
Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물
|
|
JO3240B1
(ar)
*
|
2007-10-17 |
2018-03-08 |
Janssen Pharmaceutica Nv |
c-fms مثبطات كيناز
|
|
EP2215482A2
(en)
|
2007-10-31 |
2010-08-11 |
Janssen Pharmaceutica N.V. |
Biomarker for assessing response to fms treatment
|