JP2009534403A5 - - Google Patents
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- JP2009534403A5 JP2009534403A5 JP2009506739A JP2009506739A JP2009534403A5 JP 2009534403 A5 JP2009534403 A5 JP 2009534403A5 JP 2009506739 A JP2009506739 A JP 2009506739A JP 2009506739 A JP2009506739 A JP 2009506739A JP 2009534403 A5 JP2009534403 A5 JP 2009534403A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- spiro
- compound
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 4,4-dimethylcyclohexenyl Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000003386 piperidinyl group Chemical class 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003003 spiro group Chemical group 0.000 claims 2
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical class 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- PGPXRIFFCBCWEO-UHFFFAOYSA-N CN1CCC(CCO)CC1 Chemical compound CN1CCC(CCO)CC1 PGPXRIFFCBCWEO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79369706P | 2006-04-20 | 2006-04-20 | |
| US60/793,697 | 2006-04-20 | ||
| US88353907P | 2007-01-05 | 2007-01-05 | |
| US60/883,539 | 2007-01-05 | ||
| PCT/US2007/066860 WO2007124316A1 (en) | 2006-04-20 | 2007-04-18 | Heterocyclic compounds as inhibitors of c-fms kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534403A JP2009534403A (ja) | 2009-09-24 |
| JP2009534403A5 true JP2009534403A5 (enExample) | 2010-05-13 |
| JP5089681B2 JP5089681B2 (ja) | 2012-12-05 |
Family
ID=38353368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506739A Expired - Fee Related JP5089681B2 (ja) | 2006-04-20 | 2007-04-18 | ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US7414050B2 (enExample) |
| EP (1) | EP2021335B1 (enExample) |
| JP (1) | JP5089681B2 (enExample) |
| KR (1) | KR101367645B1 (enExample) |
| AR (1) | AR060608A1 (enExample) |
| AT (1) | ATE510832T1 (enExample) |
| AU (1) | AU2007240437B2 (enExample) |
| CA (1) | CA2649736C (enExample) |
| CY (1) | CY1111749T1 (enExample) |
| DK (1) | DK2021335T3 (enExample) |
| MX (1) | MX2008013533A (enExample) |
| NZ (1) | NZ572073A (enExample) |
| PL (1) | PL2021335T3 (enExample) |
| PT (1) | PT2021335E (enExample) |
| SI (1) | SI2021335T1 (enExample) |
| TW (1) | TW200811162A (enExample) |
| WO (1) | WO2007124316A1 (enExample) |
Families Citing this family (27)
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| US20020171789A1 (en) * | 1995-12-04 | 2002-11-21 | Minolta Co., Ltd. | Layered type reflective full-color liquid crystal display element and display device having the element |
| US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
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| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| EP2397138B1 (en) * | 2006-04-20 | 2013-12-11 | Janssen Pharmaceutica NV | Aromatic amide derivatives as C-KIT kinase inhibitors |
| EP2021329B1 (en) * | 2006-04-20 | 2016-04-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| KR101367645B1 (ko) * | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
| WO2010047372A1 (ja) * | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体 |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| CA2816285A1 (en) | 2010-10-29 | 2012-05-03 | Shionogi & Co., Ltd. | Naphthyridine derivative |
| US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
| WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| WO2013157540A1 (ja) * | 2012-04-17 | 2013-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物またはその塩 |
| AU2013299922B2 (en) | 2012-08-07 | 2018-06-21 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| ES2607807T3 (es) | 2012-08-07 | 2017-04-04 | Janssen Pharmaceutica Nv | Procedimiento para la preparación de los inibidores de las quinasas c-fms |
| JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
| CN106674084B (zh) * | 2016-12-20 | 2019-03-01 | 山东轩德医药科技有限公司 | 一种2-异丙基氧基-5-甲基-4-(哌啶-4-基)苯胺二盐酸盐的制备方法 |
| CN109776512A (zh) * | 2018-01-30 | 2019-05-21 | 成都安诺晨创医药科技有限公司 | 一种n-取代咪唑甲酸酯类衍生物及其用途 |
| WO2021144360A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
| CN111646945A (zh) * | 2020-05-29 | 2020-09-11 | 凯美克(上海)医药科技有限公司 | 一种4-溴-2-硝基-1h-咪唑的合成方法 |
| CN118515637B (zh) * | 2024-05-17 | 2025-02-07 | 合亚医药科技(武汉)有限公司 | 一种一锅法合成3-取代戊二酸的方法 |
| WO2026041138A1 (zh) * | 2024-08-22 | 2026-02-26 | 武汉人福创新药物研发中心有限公司 | 作为vav1降解剂的苯并杂环类化合物及其用途 |
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| CH504416A (de) | 1966-12-05 | 1971-03-15 | Ciba Geigy Ag | Verfahren zur Herstellung von aromatischen Sulfamoylverbindungen |
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| US4574765A (en) * | 1984-11-30 | 1986-03-11 | Donald E. Goorhouse | Supplemental air injection method and devices for carburetors of internal combustion engines |
| US5190541A (en) | 1990-10-17 | 1993-03-02 | Boston Scientific Corporation | Surgical instrument and method |
| EP1306095A3 (en) * | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5474765A (en) | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
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| US20060281755A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators |
| US20060281700A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators |
| US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| AU2006304897B2 (en) * | 2005-10-18 | 2012-07-12 | Janssen Pharmaceutica N.V. | Method of inhibiting FLT3 kinase |
| US8697716B2 (en) * | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| KR101367645B1 (ko) * | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| EP2016070B1 (en) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| EP2021329B1 (en) | 2006-04-20 | 2016-04-13 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| WO2009058968A2 (en) | 2007-10-31 | 2009-05-07 | Janssen Pharmaceutica N.V. | Biomarker for assessing response to fms treatment |
-
2007
- 2007-04-18 KR KR1020087028249A patent/KR101367645B1/ko not_active Expired - Fee Related
- 2007-04-18 WO PCT/US2007/066860 patent/WO2007124316A1/en not_active Ceased
- 2007-04-18 AT AT07760833T patent/ATE510832T1/de active
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- 2007-04-18 AU AU2007240437A patent/AU2007240437B2/en not_active Ceased
- 2007-04-18 EP EP07760833A patent/EP2021335B1/en active Active
- 2007-04-18 SI SI200730671T patent/SI2021335T1/sl unknown
- 2007-04-18 DK DK07760833.9T patent/DK2021335T3/da active
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