|
US7037916B2
(en)
*
|
1999-07-15 |
2006-05-02 |
Pharmacopeia Drug Discovery, Inc. |
Pyrimidine derivatives as IL-8 receptor antagonists
|
|
GB0016877D0
(en)
*
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
|
US6867300B2
(en)
*
|
2000-11-17 |
2005-03-15 |
Bristol-Myers Squibb Company |
Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
|
|
US6670357B2
(en)
*
|
2000-11-17 |
2003-12-30 |
Bristol-Myers Squibb Company |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
|
|
CA2451128A1
(en)
*
|
2001-06-26 |
2003-01-09 |
Bristol-Myers Squibb Company |
N-heterocyclic inhibitors of tnf-alpha expression
|
|
DK1442024T3
(da)
*
|
2001-11-01 |
2008-06-30 |
Janssen Pharmaceutica Nv |
Aminobenzamidderivater som glycogensystasekinase 3 beta-inhibitorer
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
JP2005529890A
(ja)
|
2002-04-23 |
2005-10-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なアリールケトンピロロトリアジン化合物
|
|
EP1497019B1
(en)
*
|
2002-04-23 |
2015-05-20 |
Bristol-Myers Squibb Company |
Pyrrolo-triazine aniline compounds useful as kinase inhibitors
|
|
BR0313059B8
(pt)
|
2002-07-29 |
2021-07-27 |
Rigel Pharmaceuticals |
composto, e, composição farmacêutica
|
|
KR20050084027A
(ko)
*
|
2002-11-28 |
2005-08-26 |
쉐링 악티엔게젤샤프트 |
Chk-, pdk- 및 akt-억제성 피리미딘, 그의제조방법 및 약제로서의 그의 용도
|
|
MXPA05006367A
(es)
*
|
2002-12-12 |
2005-08-29 |
Pharmacia Corp |
Metodo de uso de compuestos de aminocianopiridina como inhibidores de cinasa-2 de proteina activada de cinasa de proteina activada por mitogeno.
|
|
US6909001B2
(en)
|
2002-12-12 |
2005-06-21 |
Pharmacia Corporation |
Method of making tricyclic aminocyanopyridine compounds
|
|
WO2004069829A1
(en)
*
|
2003-01-10 |
2004-08-19 |
Pharmacopeia Drug Discovery, Inc. |
(2s)-2-((pyrimidin-4-yl)amino)-4-methylpentanoic acid aminoethylamid derivatives as il-8 receptor modulators for the treatment of atherosclerosis and rheumatoid arthritis
|
|
CN102558155A
(zh)
*
|
2003-01-14 |
2012-07-11 |
阿伦纳药品公司 |
作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
|
|
UA92450C2
(ru)
*
|
2003-01-14 |
2010-11-10 |
Арена Фармасьютикалз, Инк. |
1,2,3-тризамещенные арильные и гетероарильные производные как модуляторы метаболизма, профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия
|
|
EP1927594A1
(en)
*
|
2003-01-14 |
2008-06-04 |
Arena Pharmaceuticals, Inc. |
1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
|
|
MXPA05008183A
(es)
|
2003-02-05 |
2005-10-05 |
Bristol Myers Squibb Co |
Proceso para preparar pirrolotriazina como inhibidores de cinasa.
|
|
US20050014753A1
(en)
*
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
ES2350837T3
(es)
*
|
2003-05-01 |
2011-01-27 |
Bristol-Myers Squibb Company |
Compuestos de pirazol-amida sustituidos con arilo útiles como inhibidores de quinasas.
|
|
AU2004251668B2
(en)
*
|
2003-06-03 |
2008-03-20 |
Triad Therapeutics, Inc |
5-membered heterocycle-based p-38 inhibitors
|
|
WO2004113305A2
(en)
|
2003-06-16 |
2004-12-29 |
Vertex Pharmaceuticals Incorporated |
Diamino substituted quinazoline derivatives as promoters of smn2
|
|
US7504396B2
(en)
|
2003-06-24 |
2009-03-17 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
AR045047A1
(es)
*
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
CN102358738A
(zh)
|
2003-07-30 |
2012-02-22 |
里格尔药品股份有限公司 |
2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
|
|
TWI378923B
(en)
*
|
2003-08-15 |
2012-12-11 |
Novartis Ag |
Pyrimidine derivatives
|
|
TWI258478B
(en)
|
2003-10-31 |
2006-07-21 |
Arena Pharm Inc |
Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
|
|
BRPI0416208A
(pt)
*
|
2003-11-20 |
2006-12-26 |
Warner Lambert Co |
moduladores de receptores de androgênio
|
|
US7459562B2
(en)
*
|
2004-04-23 |
2008-12-02 |
Bristol-Myers Squibb Company |
Monocyclic heterocycles as kinase inhibitors
|
|
US7754714B2
(en)
*
|
2004-05-18 |
2010-07-13 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
EP1598343A1
(de)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
HRP20090093T3
(en)
*
|
2004-06-04 |
2009-03-31 |
Arena Pharmaceuticals Inc. |
Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
TW200600513A
(en)
*
|
2004-06-30 |
2006-01-01 |
Bristol Myers Squibb Co |
A method for preparing pyrrolotriazine compounds
|
|
US7253167B2
(en)
*
|
2004-06-30 |
2007-08-07 |
Bristol-Myers Squibb Company |
Tricyclic-heteroaryl compounds useful as kinase inhibitors
|
|
US7504521B2
(en)
*
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
|
TW200618803A
(en)
|
2004-08-12 |
2006-06-16 |
Bristol Myers Squibb Co |
Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
|
|
CA2581623A1
(en)
*
|
2004-09-23 |
2006-03-30 |
Reddy Us Therapeutics, Inc. |
Novel pyridine compounds, process for their preparation and compositions containing them
|
|
EP1794135A1
(en)
*
|
2004-09-27 |
2007-06-13 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
GB2420559B
(en)
*
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
JP5095409B2
(ja)
|
2004-11-24 |
2012-12-12 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
スピロ2,4−ピリミジンジアミン化合物およびその使用
|
|
MY148521A
(en)
*
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
JP4801096B2
(ja)
|
2005-01-19 |
2011-10-26 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
2,4−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用
|
|
US20060247263A1
(en)
*
|
2005-04-19 |
2006-11-02 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
US8278446B2
(en)
*
|
2005-12-21 |
2012-10-02 |
Janssen Pharmaceutica N.V. |
Process for preparing substituted diaminopyrimidine oximes
|
|
US8153791B2
(en)
|
2005-12-21 |
2012-04-10 |
Janssen Pharmaceutica N.V. |
Substituted pyrimidinyl oxime kinase inhibitors
|
|
WO2007081630A2
(en)
*
|
2005-12-21 |
2007-07-19 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidinyl kinase inhibitors
|
|
WO2007109783A2
(en)
*
|
2006-03-23 |
2007-09-27 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidine kinase inhibitors
|
|
EP2046763A2
(en)
|
2006-07-31 |
2009-04-15 |
Praecis Pharmaceuticals Incorporated |
Aurora kinase inhibitors from an encoded small molecule library
|
|
WO2008016675A1
(en)
*
|
2006-08-01 |
2008-02-07 |
Praecis Pharmaceuticals Incorporated |
P38 kinase inhibitors
|
|
ES2555803T3
(es)
|
2006-10-23 |
2016-01-08 |
Cephalon, Inc. |
Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met
|
|
US20100137398A1
(en)
*
|
2007-05-04 |
2010-06-03 |
Novartis Ag |
Use of hdac inhibitors for the treatment of gastrointestinal cancers
|
|
CN101903357A
(zh)
*
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|
|
EP2203173B1
(en)
|
2007-10-26 |
2015-12-23 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
HRP20170050T1
(hr)
|
2008-02-22 |
2017-03-10 |
Rigel Pharmaceuticals, Inc. |
Uporaba 2,4-pirimidindiamina za liječenje ateroskleroze
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
WO2010077740A2
(en)
*
|
2008-12-09 |
2010-07-08 |
Cytokine Pharmasciences, Inc. |
Novel antiviral compounds, compositions, and methods of use
|
|
AT509266B1
(de)
*
|
2009-12-28 |
2014-07-15 |
Univ Wien Tech |
Substituierte pyridine und pyrimidine
|
|
EA201290642A1
(ru)
*
|
2010-01-13 |
2013-05-30 |
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи |
Соединения и способы
|
|
US8354420B2
(en)
|
2010-06-04 |
2013-01-15 |
Genentech, Inc. |
Aminopyrimidine derivatives as LRRK2 inhibitors
|
|
MX2013003184A
(es)
|
2010-09-22 |
2013-06-07 |
Arena Pharm Inc |
Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo.
|
|
SI2638031T1
(en)
|
2010-11-10 |
2018-02-28 |
Genentech, Inc. |
Pyrazole aminopyrimidine derivatives as LRRK2 modulators
|
|
CN118581086A
(zh)
|
2012-01-27 |
2024-09-03 |
比奥马林技术公司 |
用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
CN102952084A
(zh)
*
|
2012-11-15 |
2013-03-06 |
大连九信生物化工科技有限公司 |
一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法
|
|
AR099376A1
(es)
|
2013-12-20 |
2016-07-20 |
Signal Pharm Llc |
Compuestos de diaminopirimidilo sustituidos, sus composiciones y métodos de tratamiento con aquellos
|
|
AU2016205361C1
(en)
|
2015-01-06 |
2021-04-08 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
PL3310760T3
(pl)
|
2015-06-22 |
2023-03-06 |
Arena Pharmaceuticals, Inc. |
Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
|
|
US20190060286A1
(en)
|
2016-02-29 |
2019-02-28 |
University Of Florida Research Foundation, Incorpo |
Chemotherapeutic Methods
|
|
IL307931A
(en)
*
|
2016-04-15 |
2023-12-01 |
Epizyme Inc |
Amine-substituted aryl or heteroaryl compounds as ehmt1 and ehmt2 inhibitors
|
|
KR20190116416A
(ko)
|
2017-02-16 |
2019-10-14 |
아레나 파마슈티칼스, 인크. |
원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
|
|
JP6722365B1
(ja)
*
|
2017-07-18 |
2020-07-15 |
ロンザ リミテッドLonza Limited |
塩素化s−プロピル−チオバルビツル酸の製造方法
|
|
WO2019071144A1
(en)
|
2017-10-05 |
2019-04-11 |
Fulcrum Therapeutics, Inc. |
USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION
|
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|
|
AU2019280822A1
(en)
|
2018-06-06 |
2021-01-07 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
EP3966207B1
(en)
|
2019-05-10 |
2023-11-01 |
Deciphera Pharmaceuticals, LLC |
Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
EP3966206B1
(en)
|
2019-05-10 |
2023-08-09 |
Deciphera Pharmaceuticals, LLC |
Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
JP7626722B2
(ja)
|
2019-06-17 |
2025-02-04 |
デシフェラ・ファーマシューティカルズ,エルエルシー |
アミノピリミジンアミドオートファジー阻害剤およびその使用方法
|