|
US7037916B2
(en)
*
|
1999-07-15 |
2006-05-02 |
Pharmacopeia Drug Discovery, Inc. |
Pyrimidine derivatives as IL-8 receptor antagonists
|
|
GB0016877D0
(en)
*
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
|
US6867300B2
(en)
|
2000-11-17 |
2005-03-15 |
Bristol-Myers Squibb Company |
Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
|
|
US6670357B2
(en)
*
|
2000-11-17 |
2003-12-30 |
Bristol-Myers Squibb Company |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
|
|
HUP0401711A3
(en)
*
|
2001-06-26 |
2009-07-28 |
Bristol Myers Squibb Co |
N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them
|
|
IL161663A0
(en)
*
|
2001-11-01 |
2004-09-27 |
Janssen Pharmaceutica Nv |
AMINOBENZAMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3beta INHIBITORS
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
BR0309669A
(pt)
|
2002-04-23 |
2005-03-01 |
Bristol Myers Squibb Co |
Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase
|
|
WO2003091229A1
(en)
|
2002-04-23 |
2003-11-06 |
Bristol-Myers Squibb Company |
Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
|
|
HRP20050089B1
(hr)
*
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
EA200500721A1
(ru)
*
|
2002-11-28 |
2005-12-29 |
Шеринг Акциенгезельшафт |
Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
|
|
BR0317183A
(pt)
*
|
2002-12-12 |
2005-11-01 |
Pharmacia Corp |
Método de usar compostos de aminocianopiridina como inibidores de proteìna quinase-2 ativada por proteìna quinase ativada por mitógeno
|
|
US6909001B2
(en)
|
2002-12-12 |
2005-06-21 |
Pharmacia Corporation |
Method of making tricyclic aminocyanopyridine compounds
|
|
WO2004069829A1
(en)
*
|
2003-01-10 |
2004-08-19 |
Pharmacopeia Drug Discovery, Inc. |
(2s)-2-((pyrimidin-4-yl)amino)-4-methylpentanoic acid aminoethylamid derivatives as il-8 receptor modulators for the treatment of atherosclerosis and rheumatoid arthritis
|
|
KR101078098B1
(ko)
*
|
2003-01-14 |
2011-10-28 |
아레나 파마슈티칼스, 인크. |
대사 조절제로서의 1,2,3-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료
|
|
EP1927594A1
(en)
*
|
2003-01-14 |
2008-06-04 |
Arena Pharmaceuticals, Inc. |
1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
|
|
CN1835943B
(zh)
*
|
2003-01-14 |
2012-03-07 |
阿伦纳药品公司 |
作为代谢调节剂的1,2,3-三取代的芳基和杂芳基衍生物及其应用
|
|
BRPI0407282A
(pt)
|
2003-02-05 |
2006-01-31 |
Bristol Myers Squibb Co |
Processo para preparação de inibidores de pirrolotriazina cinase
|
|
US20050014753A1
(en)
*
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
AU2004236240C1
(en)
*
|
2003-05-01 |
2010-11-04 |
Bristol-Myers Squibb Company |
Aryl-substituted pyrazole compounds useful as kinase inhibitors
|
|
ATE439837T1
(de)
|
2003-06-03 |
2009-09-15 |
Novartis Ag |
5-gliedrige heterocyclische p-38 inhibitoren
|
|
US7465738B2
(en)
|
2003-06-16 |
2008-12-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as promoters of SMN2
|
|
US7504396B2
(en)
*
|
2003-06-24 |
2009-03-17 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
JP4886511B2
(ja)
|
2003-07-30 |
2012-02-29 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
|
|
BR122019017579B8
(pt)
*
|
2003-08-15 |
2021-07-27 |
Novartis Ag |
2,4-pirimidinadiaminas, seus usos, combinação e composição farmacêutica
|
|
PE20050483A1
(es)
|
2003-10-31 |
2005-08-25 |
Arena Pharm Inc |
Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
|
|
CA2545048A1
(en)
*
|
2003-11-20 |
2005-06-02 |
Warner-Lambert Company Llc |
Androgen receptor modulators
|
|
US7459562B2
(en)
*
|
2004-04-23 |
2008-12-02 |
Bristol-Myers Squibb Company |
Monocyclic heterocycles as kinase inhibitors
|
|
JP4812763B2
(ja)
*
|
2004-05-18 |
2011-11-09 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
|
|
EP1598343A1
(de)
*
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
HRP20090093T3
(en)
*
|
2004-06-04 |
2009-03-31 |
Arena Pharmaceuticals Inc. |
Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
TW200600513A
(en)
*
|
2004-06-30 |
2006-01-01 |
Bristol Myers Squibb Co |
A method for preparing pyrrolotriazine compounds
|
|
US7253167B2
(en)
*
|
2004-06-30 |
2007-08-07 |
Bristol-Myers Squibb Company |
Tricyclic-heteroaryl compounds useful as kinase inhibitors
|
|
US7504521B2
(en)
*
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
|
US7148348B2
(en)
|
2004-08-12 |
2006-12-12 |
Bristol-Myers Squibb Company |
Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
|
|
AU2005286593A1
(en)
*
|
2004-09-23 |
2006-03-30 |
Reddy Us Therapeutics, Inc. |
Novel pyridine compounds, process for their preparation and compositions containing them
|
|
AU2005289426A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
GB2420559B
(en)
*
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
ATE540035T1
(de)
|
2004-11-24 |
2012-01-15 |
Rigel Pharmaceuticals Inc |
Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
|
|
MY148521A
(en)
*
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
CN101115761B
(zh)
|
2005-01-19 |
2012-07-18 |
里格尔药品股份有限公司 |
2,4-嘧啶二胺化合物的前药及其应用
|
|
US20060247263A1
(en)
*
|
2005-04-19 |
2006-11-02 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
US8153791B2
(en)
|
2005-12-21 |
2012-04-10 |
Janssen Pharmaceutica N.V. |
Substituted pyrimidinyl oxime kinase inhibitors
|
|
US8278446B2
(en)
*
|
2005-12-21 |
2012-10-02 |
Janssen Pharmaceutica N.V. |
Process for preparing substituted diaminopyrimidine oximes
|
|
WO2007081630A2
(en)
*
|
2005-12-21 |
2007-07-19 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidinyl kinase inhibitors
|
|
WO2007109783A2
(en)
*
|
2006-03-23 |
2007-09-27 |
Janssen Pharmaceutica, N.V. |
Substituted pyrimidine kinase inhibitors
|
|
EP2441757A1
(en)
|
2006-07-31 |
2012-04-18 |
Praecis Pharmaceuticals Incorporated |
Aurora kinase inhibitors from an encoded small molecule library
|
|
WO2008016675A1
(en)
*
|
2006-08-01 |
2008-02-07 |
Praecis Pharmaceuticals Incorporated |
P38 kinase inhibitors
|
|
EP2222647B1
(en)
|
2006-10-23 |
2015-08-05 |
Cephalon, Inc. |
Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors
|
|
US20100137398A1
(en)
*
|
2007-05-04 |
2010-06-03 |
Novartis Ag |
Use of hdac inhibitors for the treatment of gastrointestinal cancers
|
|
AU2008275918B2
(en)
*
|
2007-07-17 |
2014-01-30 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as PKC inhibitors
|
|
DK2203173T3
(en)
|
2007-10-26 |
2016-02-29 |
Academisch Ziekenhuis Leiden |
Materials and methods for prevention of muscle diseases
|
|
LT2252300T
(lt)
*
|
2008-02-22 |
2017-02-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pirimidindiaminų panaudojimas aterosklerozės gydymui
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110245156A1
(en)
*
|
2008-12-09 |
2011-10-06 |
Cytokine Pharmasciences, Inc. |
Novel antiviral compounds, compositions, and methods of use
|
|
AT509266B1
(de)
*
|
2009-12-28 |
2014-07-15 |
Univ Wien Tech |
Substituierte pyridine und pyrimidine
|
|
SG182351A1
(en)
*
|
2010-01-13 |
2012-08-30 |
Glaxosmithkline Llc |
Compounds and methods
|
|
HUE029196T2
(en)
|
2010-06-04 |
2017-02-28 |
Hoffmann La Roche |
Aminoprimidine derivatives as LRRK2 modulators
|
|
SG188548A1
(en)
|
2010-09-22 |
2013-04-30 |
Arena Pharm Inc |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
SG189043A1
(en)
|
2010-11-10 |
2013-05-31 |
Hoffmann La Roche |
Pyrazole aminopyrimidine derivatives as lrrk2 modulators
|
|
ES2907250T3
(es)
|
2012-01-27 |
2022-04-22 |
Biomarin Tech Bv |
Oligonucleótidos de modulación de ARN con características mejoradas para el tratamiento de la distrofia muscular de Duchenne y de Becker
|
|
CN102952084A
(zh)
*
|
2012-11-15 |
2013-03-06 |
大连九信生物化工科技有限公司 |
一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法
|
|
RU2016129380A
(ru)
|
2013-12-20 |
2018-01-25 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Замещенные диаминопиримидильные соединения, их композиции и способы лечения с их участием
|
|
PL3242666T3
(pl)
|
2015-01-06 |
2025-02-17 |
Arena Pharmaceuticals, Inc. |
Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
|
|
HUE060476T2
(hu)
|
2015-06-22 |
2023-03-28 |
Arena Pharm Inc |
(R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra
|
|
US20190060286A1
(en)
|
2016-02-29 |
2019-02-28 |
University Of Florida Research Foundation, Incorpo |
Chemotherapeutic Methods
|
|
KR102571679B1
(ko)
*
|
2016-04-15 |
2023-08-29 |
에피자임, 인코포레이티드 |
Ehmt1 및 ehmt2 저해제로서의 아민-치환된 아릴 또는 헤테로아릴 화합물
|
|
WO2018151873A1
(en)
|
2017-02-16 |
2018-08-23 |
Arena Pharmaceuticals, Inc. |
Compounds and methods for treatment of primary biliary cholangitis
|
|
US10689350B1
(en)
*
|
2017-07-18 |
2020-06-23 |
Lonza Ltd |
Method for preparation of chlorinated s-propylthiobarbituric acid
|
|
JP2021501130A
(ja)
|
2017-10-05 |
2021-01-14 |
フルクラム セラピューティクス,インコーポレイテッド |
DUX4の発現を低減するためのp38阻害剤の使用
|
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|
|
US12156866B2
(en)
|
2018-06-06 |
2024-12-03 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
|
AU2020274011B2
(en)
|
2019-05-10 |
2024-02-15 |
Deciphera Pharmaceuticals, Llc |
Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
RS65019B1
(sr)
|
2019-05-10 |
2024-01-31 |
Deciphera Pharmaceuticals Llc |
Fenilaminopirimidin amidni inhibitori autofagije i postupci njihove primene
|
|
CN119241444A
(zh)
|
2019-06-17 |
2025-01-03 |
德西费拉制药有限责任公司 |
氨基嘧啶酰胺自噬抑制剂及其使用方法
|