CA2451128A1 - N-heterocyclic inhibitors of tnf-alpha expression - Google Patents

N-heterocyclic inhibitors of tnf-alpha expression Download PDF

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Publication number
CA2451128A1
CA2451128A1 CA002451128A CA2451128A CA2451128A1 CA 2451128 A1 CA2451128 A1 CA 2451128A1 CA 002451128 A CA002451128 A CA 002451128A CA 2451128 A CA2451128 A CA 2451128A CA 2451128 A1 CA2451128 A1 CA 2451128A1
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CA
Canada
Prior art keywords
alkyl
hydrogen
substituted
heterocyclyl
methyl
Prior art date
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Abandoned
Application number
CA002451128A
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English (en)
French (fr)
Inventor
Gulzar Ahmed
Axel Metzger
Stephen T. Wrobleski
Ian Henderson
James Wen
David J. Diller
Katerina Leftheris
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Bristol Myers Squibb Co
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Individual
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Publication of CA2451128A1 publication Critical patent/CA2451128A1/en
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
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  • Molecular Biology (AREA)
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CA002451128A 2001-06-26 2002-06-26 N-heterocyclic inhibitors of tnf-alpha expression Abandoned CA2451128A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30102001P 2001-06-26 2001-06-26
US60/301,020 2001-06-26
PCT/US2002/020341 WO2003002544A1 (en) 2001-06-26 2002-06-26 N-heterocyclic inhibitors of tnf-alpha expression

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CA2451128A1 true CA2451128A1 (en) 2003-01-09

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CA002451128A Abandoned CA2451128A1 (en) 2001-06-26 2002-06-26 N-heterocyclic inhibitors of tnf-alpha expression

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US (3) US20030139435A1 (enExample)
EP (1) EP1406875B1 (enExample)
JP (1) JP4510442B2 (enExample)
AU (1) AU2002316421B2 (enExample)
CA (1) CA2451128A1 (enExample)
HU (1) HUP0401711A3 (enExample)
WO (1) WO2003002544A1 (enExample)

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WO2004048343A1 (en) * 2002-11-28 2004-06-10 Schering Aktiengesellschaft Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
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