JP4510442B2 - ＴＮＦ−α発現のＮ−ヘテロ環インヒビター - Google Patents

ＴＮＦ−α発現のＮ−ヘテロ環インヒビター Download PDF

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Publication number
JP4510442B2
JP4510442B2 JP2003508925A JP2003508925A JP4510442B2 JP 4510442 B2 JP4510442 B2 JP 4510442B2 JP 2003508925 A JP2003508925 A JP 2003508925A JP 2003508925 A JP2003508925 A JP 2003508925A JP 4510442 B2 JP4510442 B2 JP 4510442B2
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methyl
dimethyl
mmol
alkyl
ylamino
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JP2004535447A (ja
JP2004535447A5 (enExample
Inventor
グルザール・アーメッド
アクセル・メッツガー
スティーブン・ティ・ロブルスキー
イアン・ヘンダーソン
ジェイムズ・ウェン
デイビッド・ジェイ・ディラー
カテリナ・レフセリス
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Bristol Myers Squibb Co
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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JP2003508925A 2001-06-26 2002-06-26 ＴＮＦ−α発現のＮ−ヘテロ環インヒビター Expired - Fee Related JP4510442B2 (ja)

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Application Number Priority Date Filing Date Title
US30102001P 2001-06-26 2001-06-26
PCT/US2002/020341 WO2003002544A1 (en) 2001-06-26 2002-06-26 N-heterocyclic inhibitors of tnf-alpha expression

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JP2004535447A JP2004535447A (ja) 2004-11-25
JP2004535447A5 JP2004535447A5 (enExample) 2006-01-05
JP4510442B2 true JP4510442B2 (ja) 2010-07-21

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US (3) US20030139435A1 (enExample)
EP (1) EP1406875B1 (enExample)
JP (1) JP4510442B2 (enExample)
AU (1) AU2002316421B2 (enExample)
CA (1) CA2451128A1 (enExample)
HU (1) HUP0401711A3 (enExample)
WO (1) WO2003002544A1 (enExample)

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US7037916B2 (en) * 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
JP4510442B2 (ja) * 2001-06-26 2010-07-21 ブリストル−マイヤーズ スクイブ カンパニー ＴＮＦ−α発現のＮ−ヘテロ環インヒビター
NZ531854A (en) * 2001-11-01 2006-03-31 Janssen Pharmaceutica Nv Aminobenzamide derivatives as glycogen synthase kinase 3beta inhibitors
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
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