JP5089681B2 - ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 - Google Patents

ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 Download PDF

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JP5089681B2
JP5089681B2 JP2009506739A JP2009506739A JP5089681B2 JP 5089681 B2 JP5089681 B2 JP 5089681B2 JP 2009506739 A JP2009506739 A JP 2009506739A JP 2009506739 A JP2009506739 A JP 2009506739A JP 5089681 B2 JP5089681 B2 JP 5089681B2
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phenyl
mmol
alkyl
enyl
imidazole
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JP2009534403A5 (enExample
JP2009534403A (ja
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イリグ，カール・アール
バレンタイン，シエリー・ケイ
チエン，ジンシエング
デスジヤーレイス，レネー・ルイーズ
メーガラ，サナス・ケイ
ウオール，マーク
ウイルソン，ケネス
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
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JP2009506739A 2006-04-20 2007-04-18 ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 Expired - Fee Related JP5089681B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79369706P 2006-04-20 2006-04-20
US60/793,697 2006-04-20
US88353907P 2007-01-05 2007-01-05
US60/883,539 2007-01-05
PCT/US2007/066860 WO2007124316A1 (en) 2006-04-20 2007-04-18 Heterocyclic compounds as inhibitors of c-fms kinase

Publications (3)

Publication Number Publication Date
JP2009534403A JP2009534403A (ja) 2009-09-24
JP2009534403A5 JP2009534403A5 (enExample) 2010-05-13
JP5089681B2 true JP5089681B2 (ja) 2012-12-05

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JP2009506739A Expired - Fee Related JP5089681B2 (ja) 2006-04-20 2007-04-18 ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物

Country Status (17)

Country Link
US (6) US7414050B2 (enExample)
EP (1) EP2021335B1 (enExample)
JP (1) JP5089681B2 (enExample)
KR (1) KR101367645B1 (enExample)
AR (1) AR060608A1 (enExample)
AT (1) ATE510832T1 (enExample)
AU (1) AU2007240437B2 (enExample)
CA (1) CA2649736C (enExample)
CY (1) CY1111749T1 (enExample)
DK (1) DK2021335T3 (enExample)
MX (1) MX2008013533A (enExample)
NZ (1) NZ572073A (enExample)
PL (1) PL2021335T3 (enExample)
PT (1) PT2021335E (enExample)
SI (1) SI2021335T1 (enExample)
TW (1) TW200811162A (enExample)
WO (1) WO2007124316A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534418A (ja) * 2006-04-20 2009-09-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｋｉｔキナーゼ阻害法

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US20020171789A1 (en) * 1995-12-04 2002-11-21 Minolta Co., Ltd. Layered type reflective full-color liquid crystal display element and display device having the element
US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
ES2537898T3 (es) 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
EP2016070B1 (en) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
EP2021329B1 (en) * 2006-04-20 2016-04-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
KR101367645B1 (ko) * 2006-04-20 2014-02-27 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
AU2008245082B8 (en) 2007-04-24 2012-09-13 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
WO2010047372A1 (ja) * 2008-10-22 2010-04-29 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
CA2816285A1 (en) 2010-10-29 2012-05-03 Shionogi & Co., Ltd. Naphthyridine derivative
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
WO2012147763A1 (ja) 2011-04-26 2012-11-01 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
WO2013157540A1 (ja) * 2012-04-17 2013-10-24 富士フイルム株式会社 含窒素複素環化合物またはその塩
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