ATE252104T1 - Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid - Google Patents
Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochloridInfo
- Publication number
- ATE252104T1 ATE252104T1 AT97947981T AT97947981T ATE252104T1 AT E252104 T1 ATE252104 T1 AT E252104T1 AT 97947981 T AT97947981 T AT 97947981T AT 97947981 T AT97947981 T AT 97947981T AT E252104 T1 ATE252104 T1 AT E252104T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrochloride
- production
- waste material
- walls
- separation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 238000000926 separation method Methods 0.000 abstract 3
- 239000002699 waste material Substances 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- UVJYAKBJSGRTHA-ZCRGAIPPSA-N arglabin Chemical compound C1C[C@H]2C(=C)C(=O)O[C@@H]2[C@@H]2C(C)=CC[C@]32O[C@]31C UVJYAKBJSGRTHA-ZCRGAIPPSA-N 0.000 abstract 2
- UVJYAKBJSGRTHA-UHFFFAOYSA-N arglabin Natural products C1CC2C(=C)C(=O)OC2C2C(C)=CCC32OC31C UVJYAKBJSGRTHA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 238000004566 IR spectroscopy Methods 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 239000005445 natural material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000009423 ventilation Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0215—Solid material in other stationary receptacles
- B01D11/0223—Moving bed of solid material
- B01D11/0226—Moving bed of solid material with the general transport direction of the solids parallel to the rotation axis of the conveyor, e.g. worm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Extraction Or Liquid Replacement (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KZ960995 | 1996-12-20 | ||
| KZ970397 | 1997-04-26 | ||
| PCT/KZ1997/000006 WO1998028303A1 (en) | 1996-12-20 | 1997-12-19 | METHOD AND DEVICE FOR PRODUCTION OF LYOPHILIZED HYDROCHLORIDE-1β,10β-EPOXY-13-DIMETHYLAMINO-GUAIA-3(4)-EN-6,12-OLIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252104T1 true ATE252104T1 (de) | 2003-11-15 |
Family
ID=26639596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947981T ATE252104T1 (de) | 1996-12-20 | 1997-12-19 | Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0946565B1 (de) |
| JP (2) | JP2001505548A (de) |
| CN (1) | CN1095845C (de) |
| AT (1) | ATE252104T1 (de) |
| DE (1) | DE69725604T2 (de) |
| WO (1) | WO1998028303A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994388A (en) | 1997-03-18 | 1999-11-30 | The Children's Medical Center Corporation | Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis |
| ATE375794T1 (de) | 2000-02-24 | 2007-11-15 | Janssen Pharmaceutica Nv | Dosierschema enthaldend farnesyl protein transferase inhibitoren für die behandlung von krebs |
| JP3737816B2 (ja) * | 2002-03-20 | 2006-01-25 | 松下電器産業株式会社 | 抽出装置 |
| DE10326152A1 (de) * | 2003-06-06 | 2005-01-05 | Aventis Pharma Deutschland Gmbh | Verfahren und Vorrichtung zur quantitativen Analyse von Lösungen und Dispersionen mittels Nahinfrarot-Spektroskopie |
| US20050003422A1 (en) | 2003-07-01 | 2005-01-06 | Mitch Reponi | Methods for assessing and treating cancer |
| DE102004037002B4 (de) * | 2004-07-30 | 2006-06-14 | Chemieanlagenbau Chemnitz Gmbh | Verfahren zur Herstellung von Dimethylaminoarglabin-Hydrochlorid |
| EP2362218B1 (de) | 2004-11-05 | 2014-08-27 | Janssen Pharmaceutica N.V. | Methoden zur überwachung der wirksamkeit von farnesyltransferase-hemmern |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| KR101367646B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제 |
| KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| EP2069357B1 (de) * | 2006-09-19 | 2015-08-26 | Sergazy Mynzhasarovich Adekenov | Verfahren zur herstellung von 1(10)-beta-epoxy-13-dimethylamino-5,7-alpha-6,11-beta-(h-guaia-3(4)-en-6,12-olidhydrochlorid, der lyophilisierten antitumorzubereitung arglabin |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| CN102190663B (zh) * | 2010-03-02 | 2013-11-13 | 石药集团中奇制药技术（石家庄）有限公司 | 一种二甲氨基阿格拉宾盐酸盐晶型 |
| CN102190662B (zh) * | 2010-03-02 | 2014-06-25 | 石药集团中奇制药技术（石家庄）有限公司 | 一种二甲氨基阿格拉宾盐酸盐的制备方法 |
| CN102372723B (zh) * | 2010-08-19 | 2014-03-26 | 石药集团中奇制药技术（石家庄）有限公司 | 一种从多花蒿中提取阿格拉宾的方法 |
| US9303046B2 (en) | 2012-08-07 | 2016-04-05 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| CN102850372A (zh) * | 2012-10-15 | 2013-01-02 | 河北医科大学 | 一种蓍草倍半萜内酯化合物及其提取方法和应用 |
| CN103833766B (zh) * | 2012-11-23 | 2016-12-21 | 天津尚德药缘科技股份有限公司 | 阿格拉滨二甲胺富马酸盐及其在药物制备中的用途 |
| HRP20191424T2 (hr) | 2015-08-17 | 2021-06-25 | Kura Oncology, Inc. | Metode liječenja pacijenata oboljelih od raka pomoću inhibitora farnezil transferaze |
| CN105251236B (zh) * | 2015-11-02 | 2018-01-16 | 济宁金百特生物机械有限公司 | 逆流提取装置 |
| US20190119758A1 (en) | 2016-04-22 | 2019-04-25 | Kura Oncology, Inc. | Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors |
| HRP20210544T1 (hr) | 2016-11-03 | 2021-08-20 | Kura Oncology, Inc. | Inhibitori farneziltransferaze za uporabu u liječenju raka |
| US10137121B2 (en) | 2017-02-21 | 2018-11-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| KR102003179B1 (ko) | 2017-02-21 | 2019-07-23 | 쿠라 온콜로지, 인크. | 파르네실트랜스퍼라제 억제제를 사용하는 암 환자의 치료 방법 |
| KR20200051601A (ko) | 2017-08-07 | 2020-05-13 | 쿠라 온콜로지, 인크. | 파르네실전달효소 억제제를 이용하여 암을 치료하는 방법 |
| US10806730B2 (en) | 2017-08-07 | 2020-10-20 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| WO2019113269A1 (en) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| WO2020092720A2 (en) | 2018-11-01 | 2020-05-07 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| CA3124616A1 (en) | 2018-12-21 | 2020-06-25 | Kura Oncology, Inc. | Therapies for squamous cell carcinomas |
| US20220142983A1 (en) | 2019-03-01 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| CA3134825A1 (en) | 2019-03-29 | 2020-10-08 | Kura Oncology, Inc. | Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors |
| WO2020205387A1 (en) | 2019-04-01 | 2020-10-08 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220305001A1 (en) | 2019-05-02 | 2022-09-29 | Kura Oncology, Inc. | Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1627208A1 (ru) * | 1988-05-24 | 1991-02-15 | Всесоюзный научно-исследовательский институт консервной и овощесушильной промышленности | Секционный лопастной экстрактор дл сухого растительного сырь |
-
1997
- 1997-12-19 AT AT97947981T patent/ATE252104T1/de not_active IP Right Cessation
- 1997-12-19 DE DE69725604T patent/DE69725604T2/de not_active Expired - Lifetime
- 1997-12-19 CN CN97181524A patent/CN1095845C/zh not_active Expired - Lifetime
- 1997-12-19 WO PCT/KZ1997/000006 patent/WO1998028303A1/en not_active Ceased
- 1997-12-19 EP EP97947981A patent/EP0946565B1/de not_active Expired - Lifetime
- 1997-12-19 JP JP51603098A patent/JP2001505548A/ja not_active Ceased
-
2007
- 2007-01-31 JP JP2007020702A patent/JP2007137890A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69725604D1 (de) | 2003-11-20 |
| EP0946565B1 (de) | 2003-10-15 |
| WO1998028303A1 (en) | 1998-07-02 |
| CN1095845C (zh) | 2002-12-11 |
| CN1245501A (zh) | 2000-02-23 |
| EP0946565A1 (de) | 1999-10-06 |
| JP2007137890A (ja) | 2007-06-07 |
| DE69725604T2 (de) | 2005-03-03 |
| JP2001505548A (ja) | 2001-04-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE252104T1 (de) | Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid | |
| RU95122435A (ru) | Способ получения желатина из коллаген-содержащего сырья | |
| DE3567814D1 (en) | Process and device for cleaning a gas stream containing solid or liquid particles in suspension | |
| JPH029875A (ja) | トコフェロール及びトコトリエノールの製造方法 | |
| NO883234D0 (no) | Fremgangsmaate ved fremstilling av soetningsmiddel. | |
| GR3035183T3 (en) | Method and roll mill for drying and grinding moist feed material | |
| SE9702938L (sv) | Tvåstegsförfarande för torkning av träråvara | |
| FI972764A0 (fi) | Menetelmä liuosten muodostamiseksi | |
| ATE315586T1 (de) | Kontinuierliches verfahren und vorrichtung zur trocknung und gelbildung von lösungsmittelhaltigen gelbildenden polymeren | |
| SE8601606D0 (sv) | Forfarande och anordning for raffinering av fibermaterial | |
| DE69032537D1 (de) | Verbindungen zur Behandlung von Bauchentzündungen | |
| DE69841553D1 (de) | Verfahren zur herstellung von entölten phosphtiden | |
| GR3007446T3 (de) | ||
| ATE160589T1 (de) | Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid | |
| FR2598937B1 (fr) | Procede et installation pour assecher des fumees avant leur evacuation | |
| EA200100251A1 (ru) | Обработка сырья для усовершенствования процесса производства оксида алюминия | |
| GR3003014T3 (en) | Process and device for the cooling of fine dust | |
| SU1526627A1 (ru) | Способ производства гранулированного комбикорма | |
| JPS57186493A (en) | Treatment of fermented solution, etc. | |
| JPS57125687A (en) | Method and apparatus for treating steamed rice for preparation of refined sake | |
| RU2027766C1 (ru) | Способ нейтрализации гидролизата растительного сырья | |
| SU823783A1 (ru) | Способ сушки материалов во встречныхСОудАР ющиХС СТРу Х | |
| RU1822786C (ru) | Способ получени коллагенового порошка из отходов кожевенного сырь | |
| SU1611899A1 (ru) | Способ абсорбции фтористых газов в производстве суперфосфата | |
| SU765610A1 (ru) | Способ очистки аргона |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |